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The map label for this gene is ilvD

Identifier: 59713166

GI number: 59713166

Start: 2880495

End: 2882336

Strand: Direct

Name: ilvD

Synonym: VF_2559

Alternate gene names: 59713166

Gene position: 2880495-2882336 (Clockwise)

Preceding gene: 59713165

Following gene: 59713167

Centisome position: 99.41

GC content: 44.57

Gene sequence:

>1842_bases
ATGCCAACTTATCGTTCAGCCACCACCACTCACGGACGTAACATGGCCGGAGCACGCGCTTTATGGCGTGCAACTGGCGT
TAAAGAAGATGACTTTGGTAAACCCATCATTGCTGTTGTTAACTCATTTACTCAATTTGTTCCGGGTCACGTACATCTTA
AAGACATGGGACAACTTGTTGCTGGCGAAATAGAAAAAGCCGGCGGTATCGCCAAAGAGTTTAATACTATCGCCGTTGAT
GATGGTATCGCTATGGGTCACGGTGGCATGCTTTATTCTCTGCCATCACGCGAACTCATTGCAGACTCTGTTGAATACAT
GGTTAATGCTCACTGTGCTGATGCTATGGTATGTATTTCTAACTGCGACAAAATTACCCCAGGAATGATGATGGCTGCAA
TGCGTCTTAACATTCCAGTAATTTTTGTGTCAGGCGGCCCAATGGAAGCAGGAAAAACTAAGCTTTCAGATCAAATAATC
AAACTGGATCTTGTTGATGCAATGATCCAAGGTGCCGATCCTACGGTTTCCGATGCTCAAAGTGAGCAGATCGAGCGTTC
AGCTTGTCCAACTTGTGGATCGTGTTCAGGAATGTTCACGGCTAACTCAATGAACTGTTTAACCGAAGCGCTCGGTTTAT
CTCAACCAGGTAATGGCTCAATGCTCGCTACTCACGCCGACCGCGAGCAGCTGTTTATTAATGCAGGTAAACGTATTGTT
GAATTAACAAAGCGTTATTATGAGCAAGATGATGAATCAGCACTTCCAAGAAATATTGCCGACCGTGCTGCATTTGAAAA
TGCCATGGCACTTGATATCGCAATGGGTGGTTCTAGTAATACCGTTCTTCACCTTTTAGCTTCTGCTCAAGAAGGCGAAA
TTGATTTCGATATGGGTGACATTGATGAGATGTCTCGTCGAGTACCTCACTTGTGTAAAGTCGCTCCATCAACGCCTAAA
TATCATATGGAAGATGTTCACCGAGCAGGTGGTGTAATGGCTATCCTTGGTGAGTTAGATAGAGCTGGGCTTCTGAATAA
TCAAACAAAAACGGTTCTTGGCTTAACCATGCAAGAGCAACTTGCACAATACGATATTATGCAAACTGAAGACGAAGAGA
TCCTTAAATTCTTCCGTGCAGGACCTGCAGGGATCCGAACAACAAAAGCATTCTCGCAAGATTGCCGTTGGGATCGCCTT
GATGACGACCGAAAAGAAGGGTGTATTCGAACCAAAGAAAATGCCTTTAGCCAAGAAGGTGGTCTCGCCGTTCTATCTGG
CAATATAGCGGTTGATGGTTGTATTGTAAAAACCGCCGGCGTTGATGAAGAAAATCTAAAGTTCCAAGGTCCAGCCATTG
TTTTTGAAAGCCAAGACTCAGCGGTAGAAGGCATTTTAGGTGGAAAAGTTAAAGCGGGTGAAGTCGTTGTTATTCGCTAC
GAAGGTCCAAAGGGTGGTCCAGGTATGCAAGAAATGCTTTACCCAACCACTTACTTGAAATCAATGGGCTTAGGCAAAGC
ATGTGCGCTTCTAACTGATGGTCGATTCTCTGGTGGTACATCAGGCCTATCTATAGGTCACGCATCTCCAGAAGCTGCAA
GTGGTGGCACAATAGGTTTAGTTAACGATGGTGATATCATTACCATCGATATCCCAAGCCGCTCAATTACGCTTGATGTA
CCAGAATCAGAACTGCAAGCTCGTCGAGCGAAACAAGATGAACTCGGTTGGAAACCTGTGAATCGTCAACGTGAAGTCTC
TTTTGCATTAAAAGCCTATGCAAGTATGGCAACAAGTGCAGATAAAGGTGCTGTTCGTGATAAATCTAAGTTAGAAGGGT
AA

Upstream 100 bases:

>100_bases
TTGGTCTGTTCAATGGAACAACCGAAGATAAATGGGGTTGGTTAGATTACGTATACCCAGAAAATGCACCATCAGCTAAA
TAATTTATAAGGATATAAGA

Downstream 100 bases:

>100_bases
GCCTATGAGCAACTCTTCATATCAAACTGGCGCAGAATATCTGCGTCAGATCTTACGAGCACCAATCTATGAAGTGGCAA
CAGTAACACCACTTCAAGAT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MPTYRSATTTHGRNMAGARALWRATGVKEDDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAGEIEKAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQII
KLDLVDAMIQGADPTVSDAQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREQLFINAGKRIV
ELTKRYYEQDDESALPRNIADRAAFENAMALDIAMGGSSNTVLHLLASAQEGEIDFDMGDIDEMSRRVPHLCKVAPSTPK
YHMEDVHRAGGVMAILGELDRAGLLNNQTKTVLGLTMQEQLAQYDIMQTEDEEILKFFRAGPAGIRTTKAFSQDCRWDRL
DDDRKEGCIRTKENAFSQEGGLAVLSGNIAVDGCIVKTAGVDEENLKFQGPAIVFESQDSAVEGILGGKVKAGEVVVIRY
EGPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAASGGTIGLVNDGDIITIDIPSRSITLDV
PESELQARRAKQDELGWKPVNRQREVSFALKAYASMATSADKGAVRDKSKLEG

Sequences:

>Translated_613_residues
MPTYRSATTTHGRNMAGARALWRATGVKEDDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAGEIEKAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQII
KLDLVDAMIQGADPTVSDAQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREQLFINAGKRIV
ELTKRYYEQDDESALPRNIADRAAFENAMALDIAMGGSSNTVLHLLASAQEGEIDFDMGDIDEMSRRVPHLCKVAPSTPK
YHMEDVHRAGGVMAILGELDRAGLLNNQTKTVLGLTMQEQLAQYDIMQTEDEEILKFFRAGPAGIRTTKAFSQDCRWDRL
DDDRKEGCIRTKENAFSQEGGLAVLSGNIAVDGCIVKTAGVDEENLKFQGPAIVFESQDSAVEGILGGKVKAGEVVVIRY
EGPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAASGGTIGLVNDGDIITIDIPSRSITLDV
PESELQARRAKQDELGWKPVNRQREVSFALKAYASMATSADKGAVRDKSKLEG
>Mature_612_residues
PTYRSATTTHGRNMAGARALWRATGVKEDDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAGEIEKAGGIAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQIIK
LDLVDAMIQGADPTVSDAQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREQLFINAGKRIVE
LTKRYYEQDDESALPRNIADRAAFENAMALDIAMGGSSNTVLHLLASAQEGEIDFDMGDIDEMSRRVPHLCKVAPSTPKY
HMEDVHRAGGVMAILGELDRAGLLNNQTKTVLGLTMQEQLAQYDIMQTEDEEILKFFRAGPAGIRTTKAFSQDCRWDRLD
DDRKEGCIRTKENAFSQEGGLAVLSGNIAVDGCIVKTAGVDEENLKFQGPAIVFESQDSAVEGILGGKVKAGEVVVIRYE
GPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAASGGTIGLVNDGDIITIDIPSRSITLDVP
ESELQARRAKQDELGWKPVNRQREVSFALKAYASMATSADKGAVRDKSKLEG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=616, Percent_Identity=81.9805194805195, Blast_Score=1062, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=573, Percent_Identity=28.9703315881326, Blast_Score=196, Evalue=5e-51,
Organism=Escherichia coli, GI2367371, Length=590, Percent_Identity=28.4745762711864, Blast_Score=169, Evalue=6e-43,
Organism=Escherichia coli, GI1786464, Length=550, Percent_Identity=28.7272727272727, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6322476, Length=609, Percent_Identity=36.9458128078818, Blast_Score=330, Evalue=3e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_VIBF1 (Q5E1P2)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_205942.1
- STRING:   Q5E1P2
- GeneID:   3279704
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_2559
- NMPDR:   fig|312309.3.peg.2562
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   Q5E1P2
- ProtClustDB:   PRK12448
- BioCyc:   VFIS312309:VF2559-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65621; Mature: 65490

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTYRSATTTHGRNMAGARALWRATGVKEDDFGKPIIAVVNSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AGEIEKAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPTVSDAQ
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
SEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREQLFINAGKRIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHCCHHHH
ELTKRYYEQDDESALPRNIADRAAFENAMALDIAMGGSSNTVLHLLASAQEGEIDFDMGD
HHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCCEECCCCC
IDEMSRRVPHLCKVAPSTPKYHMEDVHRAGGVMAILGELDRAGLLNNQTKTVLGLTMQEQ
HHHHHHHCCHHHHCCCCCCCHHHHHHHHCCCCEEEEHHHHHCCCCCCCCCEEEEEHHHHH
LAQYDIMQTEDEEILKFFRAGPAGIRTTKAFSQDCRWDRLDDDRKEGCIRTKENAFSQEG
HHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHCCEECHHHCCCCCC
GLAVLSGNIAVDGCIVKTAGVDEENLKFQGPAIVFESQDSAVEGILGGKVKAGEVVVIRY
CEEEEECCEEEEEEEEEECCCCCCCCEECCCEEEEECCCCHHHHHHCCCEECCCEEEEEE
EGPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAASGGTIGL
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEE
VNDGDIITIDIPSRSITLDVPESELQARRAKQDELGWKPVNRQREVSFALKAYASMATSA
ECCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
DKGAVRDKSKLEG
CCCCCCCHHHCCC
>Mature Secondary Structure 
PTYRSATTTHGRNMAGARALWRATGVKEDDFGKPIIAVVNSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AGEIEKAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPTVSDAQ
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
SEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREQLFINAGKRIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHCCHHHH
ELTKRYYEQDDESALPRNIADRAAFENAMALDIAMGGSSNTVLHLLASAQEGEIDFDMGD
HHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCCEECCCCC
IDEMSRRVPHLCKVAPSTPKYHMEDVHRAGGVMAILGELDRAGLLNNQTKTVLGLTMQEQ
HHHHHHHCCHHHHCCCCCCCHHHHHHHHCCCCEEEEHHHHHCCCCCCCCCEEEEEHHHHH
LAQYDIMQTEDEEILKFFRAGPAGIRTTKAFSQDCRWDRLDDDRKEGCIRTKENAFSQEG
HHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHCCEECHHHCCCCCC
GLAVLSGNIAVDGCIVKTAGVDEENLKFQGPAIVFESQDSAVEGILGGKVKAGEVVVIRY
CEEEEECCEEEEEEEEEECCCCCCCCEECCCEEEEECCCCHHHHHHCCCEECCCEEEEEE
EGPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAASGGTIGL
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEE
VNDGDIITIDIPSRSITLDVPESELQARRAKQDELGWKPVNRQREVSFALKAYASMATSA
ECCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
DKGAVRDKSKLEG
CCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA