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The map label for this gene is hemE [H]

Identifier: 59713009

GI number: 59713009

Start: 2688787

End: 2689854

Strand: Reverse

Name: hemE [H]

Synonym: VF_2402

Alternate gene names: 59713009

Gene position: 2689854-2688787 (Counterclockwise)

Preceding gene: 59713010

Following gene: 59713008

Centisome position: 92.83

GC content: 40.82

Gene sequence:

>1068_bases
ATGACAGAACTAAAAAATGACCGTTATTTACGTGCATTATTAAAACAACCAGTAGATTACACACCAGTTTGGATGATGCG
CCAAGCAGGTCGTTACCTTCCAGAATACAAAGCTACGCGTGCAGAAGCCGGTGACTTTATGTCTTTGTGTAAAAATGCAG
AGTTAGCATCAGAAGTGACTCTTCAGCCTTTACGCCGTTTTCCTCTAGATGCTGCTATTTTATTCTCTGACATTTTAACT
ATCCCAGATGCTATGGGTCTTGGTCTGTACTTTGAAACAGGTGAAGGTCCTAAGTTTGAACGTCCAATTACTTGTAAAGC
GGATGTTGATAAGATCGGTCTTCCTGATCCTGAAGGTGAACTGCAGTATGTGATGAATGCAGTACGTCAGATCCGTAAAG
ATCTAAAAGGCGAAGTTCCACTAATTGGTTTCTCTGGTAGTCCGTGGACATTAGCAACTTATATGGTTGAAGGTGGAAGT
TCAAAAGCATTCACTAAAATCAAAAAAATGATGTATGCAGAACCTGCAACGCTTCATTTACTATTAGATAAATTAGCTGA
CAGTGTTATTGAGTACTTAAATGCGCAGATTAAAGCCGGTGCTCAATCTGTAATGGTATTTGATACATGGGGTGGTGTAT
TAACCCCTCGTGACTATAACGAGTTCTCATTACGTTACATGCACAAAATTGTTGATGGCTTGATCCGTGAAAACGAAGGT
CGCCGTGTACCAGTGACTCTATTTACCAAAAATGGTGGCATGTGGTTAGAATCAATTGCAGCAACTGGTTGTGATGCAGT
TGGTCTTGATTGGACTATTAATATTGCCGATGCGAAAGCTCGTATTGGAGATAAAGTCGCTCTACAAGGAAACATGGATC
CATCAATATTGTATGCACAACCTGAGCGTATTCGCCAAGAAGTTGGAACCATCCTTGAAGGTTTTGGTGATGCTGGTACA
GGACATGTATTCAATCTAGGTCATGGTATTCACCTAGACGTTCCACCTGAAAACGCGGGTGTGTTTGTTGATGCTGTTCA
TGACTTATCTAAGCCGTATCATAAATAA

Upstream 100 bases:

>100_bases
TTAATCACAAGATTGGTTAAATATGATCTCGATAGCAAAGGTAGGCTTTTGTTCAGTGAATTGAGTGCTACAATAGCGGA
ATCAAATATGAGGGAAGATC

Downstream 100 bases:

>100_bases
AATCTTAAATTAAGATTCTAGATAAAAAGGAGACTCAATGAGGTCTCCTTTTTTATTGGAACAGAGCTATAATTTTATTG
TCATAATTAAAGATAAGAGC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAELASEVTLQPLRRFPLDAAILFSDILT
IPDAMGLGLYFETGEGPKFERPITCKADVDKIGLPDPEGELQYVMNAVRQIRKDLKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTKIKKMMYAEPATLHLLLDKLADSVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNEFSLRYMHKIVDGLIRENEG
RRVPVTLFTKNGGMWLESIAATGCDAVGLDWTINIADAKARIGDKVALQGNMDPSILYAQPERIRQEVGTILEGFGDAGT
GHVFNLGHGIHLDVPPENAGVFVDAVHDLSKPYHK

Sequences:

>Translated_355_residues
MTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAELASEVTLQPLRRFPLDAAILFSDILT
IPDAMGLGLYFETGEGPKFERPITCKADVDKIGLPDPEGELQYVMNAVRQIRKDLKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTKIKKMMYAEPATLHLLLDKLADSVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNEFSLRYMHKIVDGLIRENEG
RRVPVTLFTKNGGMWLESIAATGCDAVGLDWTINIADAKARIGDKVALQGNMDPSILYAQPERIRQEVGTILEGFGDAGT
GHVFNLGHGIHLDVPPENAGVFVDAVHDLSKPYHK
>Mature_354_residues
TELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAELASEVTLQPLRRFPLDAAILFSDILTI
PDAMGLGLYFETGEGPKFERPITCKADVDKIGLPDPEGELQYVMNAVRQIRKDLKGEVPLIGFSGSPWTLATYMVEGGSS
KAFTKIKKMMYAEPATLHLLLDKLADSVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNEFSLRYMHKIVDGLIRENEGR
RVPVTLFTKNGGMWLESIAATGCDAVGLDWTINIADAKARIGDKVALQGNMDPSILYAQPERIRQEVGTILEGFGDAGTG
HVFNLGHGIHLDVPPENAGVFVDAVHDLSKPYHK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=355, Percent_Identity=47.887323943662, Blast_Score=325, Evalue=4e-89,
Organism=Escherichia coli, GI2367337, Length=355, Percent_Identity=81.9718309859155, Blast_Score=611, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=39.0934844192635, Blast_Score=267, Evalue=2e-72,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=41.7867435158501, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=41.7867435158501, Blast_Score=283, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39356; Mature: 39225

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAELASEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
LQPLRRFPLDAAILFSDILTIPDAMGLGLYFETGEGPKFERPITCKADVDKIGLPDPEGE
HHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEECCCCCCCCCCCCCCHH
LQYVMNAVRQIRKDLKGEVPLIGFSGSPWTLATYMVEGGSSKAFTKIKKMMYAEPATLHL
HHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCCHHHHH
LLDKLADSVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNEFSLRYMHKIVDGLIRENEG
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKNGGMWLESIAATGCDAVGLDWTINIADAKARIGDKVALQGNMDPSILYAQ
CEEEEEEEECCCCHHHHHHHHCCCCEECCCEEEEEECHHHHCCCEEEEECCCCCCEEEEC
PERIRQEVGTILEGFGDAGTGHVFNLGHGIHLDVPPENAGVFVDAVHDLSKPYHK
HHHHHHHHHHHHHCCCCCCCCCEEECCCEEEEECCCCCCCEEEEEHHHHCCCCCC
>Mature Secondary Structure 
TELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAELASEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
LQPLRRFPLDAAILFSDILTIPDAMGLGLYFETGEGPKFERPITCKADVDKIGLPDPEGE
HHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEECCCCCCCCCCCCCCHH
LQYVMNAVRQIRKDLKGEVPLIGFSGSPWTLATYMVEGGSSKAFTKIKKMMYAEPATLHL
HHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCCHHHHH
LLDKLADSVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNEFSLRYMHKIVDGLIRENEG
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKNGGMWLESIAATGCDAVGLDWTINIADAKARIGDKVALQGNMDPSILYAQ
CEEEEEEEECCCCHHHHHHHHCCCCEECCCEEEEEECHHHHCCCEEEEECCCCCCEEEEC
PERIRQEVGTILEGFGDAGTGHVFNLGHGIHLDVPPENAGVFVDAVHDLSKPYHK
HHHHHHHHHHHHHCCCCCCCCCEEECCCEEEEECCCCCCCEEEEEHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA