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The map label for this gene is frdB [H]

Identifier: 59712942

GI number: 59712942

Start: 2625588

End: 2626331

Strand: Direct

Name: frdB [H]

Synonym: VF_2335

Alternate gene names: 59712942

Gene position: 2625588-2626331 (Clockwise)

Preceding gene: 59712941

Following gene: 59712943

Centisome position: 90.61

GC content: 42.88

Gene sequence:

>744_bases
ATGACGGGTGGCAATCGAATCCAAAAAGTAAGCATCCTGCGTTACGACCCAATGAAAGATGAGAAGCCTTATCTTCAAAC
GTTTGATGTTCCTTGTGATGAAACAACGTCTGTATTAGACGCTATTGGTTACATCAAAGATAACCTAGATAAAGACCTAT
CTTACCGTTGGTCTTGTCGTATGGCGATCTGTGGTTCTTGTGGCATGATGGTAAACAATGTGCCAAAACTGGCTTGTAAA
GCGTTCTTACGTGATTACCCAGATGGTTTAACATTAGAGCCATTAGCAAACTTCCCAATTGAAAAAGATTTAATTGTTGA
TATGACGCCATTCATTGAGCGTTTAGAAGCAATCAAACCTTACATTTTAGGAAATGACCGTACACCAGAACAAGGTCCAA
ACACTCAGACTCCTGAGCAAATGGCGAAATACAAACAATTCGCTGGTTGTATCAACTGTGGTTTATGTTACGCAGCATGT
CCTCAATTTGGTCTAAACCCTGAGTTCATCGGTCCTGCAGCACTGACTCTTGCACACCGTTATAACCTTGATAGCCGTGA
CAACGGCTCAGCTGAGCGTATGAAGCTAATCAATGGTGACAACGGCGCATGGGGCTGTACATTTGTTGGTTACTGTTCTG
AAGTGTGTCCAAAACACGTTGACCCAGCAGCAGCTGTAAACCAAGGTAAGATCGCATCGTCTCAAGACTTTGTTATCGCA
ATGCTTAAACCTCAGGAGGCATAA

Upstream 100 bases:

>100_bases
TAACGATCACTAAATCACAACCAAAAGCTCGCCTATATGGTGAAGCTGCTGAAAAAGCAGCAGCAGAAGAAGCGGCGAAG
AACGCAGAGGAGCACGCATA

Downstream 100 bases:

>100_bases
GGATGAGCAATCGTAAACCTTACGTTCGCGAAATGACACGTACTTGGTGGAAAGATCACCCTTTCTACCGCTTCTACATG
GTTCGTGAAGCAACGGTTCT

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MTGGNRIQKVSILRYDPMKDEKPYLQTFDVPCDETTSVLDAIGYIKDNLDKDLSYRWSCRMAICGSCGMMVNNVPKLACK
AFLRDYPDGLTLEPLANFPIEKDLIVDMTPFIERLEAIKPYILGNDRTPEQGPNTQTPEQMAKYKQFAGCINCGLCYAAC
PQFGLNPEFIGPAALTLAHRYNLDSRDNGSAERMKLINGDNGAWGCTFVGYCSEVCPKHVDPAAAVNQGKIASSQDFVIA
MLKPQEA

Sequences:

>Translated_247_residues
MTGGNRIQKVSILRYDPMKDEKPYLQTFDVPCDETTSVLDAIGYIKDNLDKDLSYRWSCRMAICGSCGMMVNNVPKLACK
AFLRDYPDGLTLEPLANFPIEKDLIVDMTPFIERLEAIKPYILGNDRTPEQGPNTQTPEQMAKYKQFAGCINCGLCYAAC
PQFGLNPEFIGPAALTLAHRYNLDSRDNGSAERMKLINGDNGAWGCTFVGYCSEVCPKHVDPAAAVNQGKIASSQDFVIA
MLKPQEA
>Mature_246_residues
TGGNRIQKVSILRYDPMKDEKPYLQTFDVPCDETTSVLDAIGYIKDNLDKDLSYRWSCRMAICGSCGMMVNNVPKLACKA
FLRDYPDGLTLEPLANFPIEKDLIVDMTPFIERLEAIKPYILGNDRTPEQGPNTQTPEQMAKYKQFAGCINCGLCYAACP
QFGLNPEFIGPAALTLAHRYNLDSRDNGSAERMKLINGDNGAWGCTFVGYCSEVCPKHVDPAAAVNQGKIASSQDFVIAM
LKPQEA

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=230, Percent_Identity=33.4782608695652, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1790596, Length=237, Percent_Identity=74.6835443037975, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1786943, Length=228, Percent_Identity=36.4035087719298, Blast_Score=143, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17533915, Length=234, Percent_Identity=35.042735042735, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322987, Length=232, Percent_Identity=34.051724137931, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17137106, Length=232, Percent_Identity=34.051724137931, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24643156, Length=230, Percent_Identity=31.304347826087, Blast_Score=128, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27326; Mature: 27194

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGNRIQKVSILRYDPMKDEKPYLQTFDVPCDETTSVLDAIGYIKDNLDKDLSYRWSCR
CCCCCCEEEEEEEEECCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEH
MAICGSCGMMVNNVPKLACKAFLRDYPDGLTLEPLANFPIEKDLIVDMTPFIERLEAIKP
HHHHCCCCHHHHCHHHHHHHHHHHHCCCCCEECHHHCCCCCCCCEECHHHHHHHHHHHCC
YILGNDRTPEQGPNTQTPEQMAKYKQFAGCINCGLCYAACPQFGLNPEFIGPAALTLAHR
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
YNLDSRDNGSAERMKLINGDNGAWGCTFVGYCSEVCPKHVDPAAAVNQGKIASSQDFVIA
CCCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCEEEE
MLKPQEA
EECCCCC
>Mature Secondary Structure 
TGGNRIQKVSILRYDPMKDEKPYLQTFDVPCDETTSVLDAIGYIKDNLDKDLSYRWSCR
CCCCCEEEEEEEEECCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEH
MAICGSCGMMVNNVPKLACKAFLRDYPDGLTLEPLANFPIEKDLIVDMTPFIERLEAIKP
HHHHCCCCHHHHCHHHHHHHHHHHHCCCCCEECHHHCCCCCCCCEECHHHHHHHHHHHCC
YILGNDRTPEQGPNTQTPEQMAKYKQFAGCINCGLCYAACPQFGLNPEFIGPAALTLAHR
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
YNLDSRDNGSAERMKLINGDNGAWGCTFVGYCSEVCPKHVDPAAAVNQGKIASSQDFVIA
CCCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCEEEE
MLKPQEA
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3308458 [H]