Click here to switch to the map view.

The map label for this gene is frdA [H]

Identifier: 59712941

GI number: 59712941

Start: 2623783

End: 2625588

Strand: Direct

Name: frdA [H]

Synonym: VF_2334

Alternate gene names: 59712941

Gene position: 2623783-2625588 (Clockwise)

Preceding gene: 59712939

Following gene: 59712942

Centisome position: 90.55

GC content: 44.8

Gene sequence:

>1806_bases
GTGAAGACTATAACCACAGATATCGCAGTAATCGGCGCGGGCGGTGCAGGTTTACGTACTGCCATTGCAGCTGCAGAAGC
TAACCCAGAGCTGGAGATTGCTCTGATTTCAAAAGTATACCCAATGCGTTCACATACAGTGGCTGCAGAAGGTGGTTCCG
CTGCCGTGACCAAGGAAGAAGATACACTAGACAATCACTTCAACGATACTGTTGGTGGTGGTGATTGGCTGTGTGAACAG
GATGTTGTTGAGTACTTTGTAGAAAATGCATACCGTGAAATGACCCAATTAGAACAATGGGGTTGTCCATGGAGCCGTAA
AGAAAATGGTGAAGTTAACGTTCGCCGTTTTGGTGGTATGAAAGTTGAACGTACATGGTTTGCTGCGGATAAAACCGGCT
TCCACATGCTTCACACTCTATTCCAAACATCAATGAAATACCCTCAAATCAACCGTTTTGATGAGTACTTCGTTGTTGAC
CTTCTTGTGGAAGAAGGCCAAGTTCAAGGTCTAATTGCTATTCATATGGCAGAAGGCGAACTTATCTGTATTAAAGCAAA
ATCTGTTGTTCTTGCAACAGGTGGTGCAGGTCGTGTTTACCACTGTAACACCAATGGCGGTATCGTTACTGGTGATGGTA
TGGCGATGGCATTCCGTCACGGTGTTCCACTACGTGATATGGAATTCGTACAATACCACCCAACAGGTCTGCCAGGCACT
GGTATTCTTATGACTGAAGGTTGTCGTGGTGAAGGCGGTATCATCGTAAACAAAAACGGTTACCGTTACCTACAAGATTA
CGGCATGGGTCCTGAGACTCCTGTTGGCGAGCCTAAGAACAAATACATGGAACTGGGTCCTCGTGACAAAGTATCTCAAG
CGTTCTGGCATGAACTACAAAAAGGCAACACAATTAAGCACCCTCTAGGTGATGTTGTGCATCTAGATCTTCGTCACCTT
GGTGAAGAATATCTACATGAGCGCCTACCATTTATCTGTGAATTAGCAAAAGCATACGTAAACGTTGACCCAGCTAAAGA
GCCAATCCCAATCCGTCCAACGGTTCACTACACTATGGGTGGTATCGAAACGGATAAGAACAATGAAACAAGCATCAAAG
GTCTATTTGCTGTTGGTGAATGTTCTTCTGTTGGTCTTCACGGTGCAAACCGTCTAGGTTCAAACTCTCTAGCTGAGCTA
GTTGTATTCGGTCGCCTTGCTGGTGAAAAAGCCGCGGAACGCGCTGCTGAATTCACATCTTGGAATGAAGAATCAATCCA
AAAACAAATTACTGAAGTTCAAGCTCGCATTGATGCACTAATGGCGCAAGAAGGCGACGAAAACTGGGCAACTATCCGTA
CTGAAATGGGTCACTCTATGGAAGCGGGTTGTGGTATCTATCGTAAAGAGCATGAAATGCAAGATACGATTGATAAACTG
GCTGAACTAAAAGAACGTTACAAGAAAATCAGCATCAAAGATAAAGGTAAAGTGTTCAACACTGACCTTCTATACGCAAT
CGAAGTTGGTTACGGTCTTGAAGTTGCAGAAGCAATGGCTCACTCAGCGATTCTACGTAAAGAATCTCGTGGTGCACACC
AACGTCTAGATGAAGGTTGTACAGAGCGTGATGATGAGAACTTCCTAAAACACTCATTAGCGTTCTACAACAAAGATGCA
GCGCCTACTATCAAGTACAGCGATGTAACGATCACTAAATCACAACCAAAAGCTCGCCTATATGGTGAAGCTGCTGAAAA
AGCAGCAGCAGAAGAAGCGGCGAAGAACGCAGAGGAGCACGCATAA

Upstream 100 bases:

>100_bases
TTATTTGCTCTTTTTTGTCATATGAGCAGGTTGAATTCTCATAATTAGTCACAATTGAGTGATTAGTTTAATTTTTTATC
TTTTATCCCGGAGGATAACT

Downstream 100 bases:

>100_bases
TGACGGGTGGCAATCGAATCCAAAAAGTAAGCATCCTGCGTTACGACCCAATGAAAGATGAGAAGCCTTATCTTCAAACG
TTTGATGTTCCTTGTGATGA

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MKTITTDIAVIGAGGAGLRTAIAAAEANPELEIALISKVYPMRSHTVAAEGGSAAVTKEEDTLDNHFNDTVGGGDWLCEQ
DVVEYFVENAYREMTQLEQWGCPWSRKENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMKYPQINRFDEYFVVD
LLVEEGQVQGLIAIHMAEGELICIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAFRHGVPLRDMEFVQYHPTGLPGT
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGEPKNKYMELGPRDKVSQAFWHELQKGNTIKHPLGDVVHLDLRHL
GEEYLHERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMGGIETDKNNETSIKGLFAVGECSSVGLHGANRLGSNSLAEL
VVFGRLAGEKAAERAAEFTSWNEESIQKQITEVQARIDALMAQEGDENWATIRTEMGHSMEAGCGIYRKEHEMQDTIDKL
AELKERYKKISIKDKGKVFNTDLLYAIEVGYGLEVAEAMAHSAILRKESRGAHQRLDEGCTERDDENFLKHSLAFYNKDA
APTIKYSDVTITKSQPKARLYGEAAEKAAAEEAAKNAEEHA

Sequences:

>Translated_601_residues
MKTITTDIAVIGAGGAGLRTAIAAAEANPELEIALISKVYPMRSHTVAAEGGSAAVTKEEDTLDNHFNDTVGGGDWLCEQ
DVVEYFVENAYREMTQLEQWGCPWSRKENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMKYPQINRFDEYFVVD
LLVEEGQVQGLIAIHMAEGELICIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAFRHGVPLRDMEFVQYHPTGLPGT
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGEPKNKYMELGPRDKVSQAFWHELQKGNTIKHPLGDVVHLDLRHL
GEEYLHERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMGGIETDKNNETSIKGLFAVGECSSVGLHGANRLGSNSLAEL
VVFGRLAGEKAAERAAEFTSWNEESIQKQITEVQARIDALMAQEGDENWATIRTEMGHSMEAGCGIYRKEHEMQDTIDKL
AELKERYKKISIKDKGKVFNTDLLYAIEVGYGLEVAEAMAHSAILRKESRGAHQRLDEGCTERDDENFLKHSLAFYNKDA
APTIKYSDVTITKSQPKARLYGEAAEKAAAEEAAKNAEEHA
>Mature_601_residues
MKTITTDIAVIGAGGAGLRTAIAAAEANPELEIALISKVYPMRSHTVAAEGGSAAVTKEEDTLDNHFNDTVGGGDWLCEQ
DVVEYFVENAYREMTQLEQWGCPWSRKENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMKYPQINRFDEYFVVD
LLVEEGQVQGLIAIHMAEGELICIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAFRHGVPLRDMEFVQYHPTGLPGT
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGEPKNKYMELGPRDKVSQAFWHELQKGNTIKHPLGDVVHLDLRHL
GEEYLHERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMGGIETDKNNETSIKGLFAVGECSSVGLHGANRLGSNSLAEL
VVFGRLAGEKAAERAAEFTSWNEESIQKQITEVQARIDALMAQEGDENWATIRTEMGHSMEAGCGIYRKEHEMQDTIDKL
AELKERYKKISIKDKGKVFNTDLLYAIEVGYGLEVAEAMAHSAILRKESRGAHQRLDEGCTERDDENFLKHSLAFYNKDA
APTIKYSDVTITKSQPKARLYGEAAEKAAAEEAAKNAEEHA

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=529, Percent_Identity=39.5085066162571, Blast_Score=360, Evalue=2e-99,
Organism=Escherichia coli, GI1790597, Length=582, Percent_Identity=74.914089347079, Blast_Score=892, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=543, Percent_Identity=41.4364640883978, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1788928, Length=558, Percent_Identity=31.3620071684588, Blast_Score=249, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17550100, Length=599, Percent_Identity=37.5626043405676, Blast_Score=355, Evalue=5e-98,
Organism=Caenorhabditis elegans, GI17505833, Length=604, Percent_Identity=36.9205298013245, Blast_Score=354, Evalue=8e-98,
Organism=Caenorhabditis elegans, GI71986328, Length=433, Percent_Identity=27.0207852193995, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322701, Length=561, Percent_Identity=39.3939393939394, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6322416, Length=561, Percent_Identity=38.5026737967914, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320788, Length=488, Percent_Identity=25.8196721311475, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17137288, Length=581, Percent_Identity=37.6936316695353, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24655642, Length=581, Percent_Identity=37.6936316695353, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24655647, Length=581, Percent_Identity=37.6936316695353, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24663005, Length=597, Percent_Identity=36.1809045226131, Blast_Score=345, Evalue=5e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66454; Mature: 66454

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTITTDIAVIGAGGAGLRTAIAAAEANPELEIALISKVYPMRSHTVAAEGGSAAVTKEE
CCEEEEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEEHHCCCCCCEEEECCCCEEEECCC
DTLDNHFNDTVGGGDWLCEQDVVEYFVENAYREMTQLEQWGCPWSRKENGEVNVRRFGGM
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCE
KVERTWFAADKTGFHMLHTLFQTSMKYPQINRFDEYFVVDLLVEEGQVQGLIAIHMAEGE
EEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHEEEEEEECCCCCCEEEEEEEECCC
LICIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAFRHGVPLRDMEFVQYHPTGLPGT
EEEEEECEEEEEECCCCEEEEECCCCCEEECCCCEEHHHCCCCCCCCCEEEECCCCCCCC
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGEPKNKYMELGPRDKVSQAFWHELQ
CEEEECCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
KGNTIKHPLGDVVHLDLRHLGEEYLHERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
GIETDKNNETSIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRLAGEKAAERAAEFTS
CEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCC
WNEESIQKQITEVQARIDALMAQEGDENWATIRTEMGHSMEAGCGIYRKEHEMQDTIDKL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHCCCHHHHHHHHHHHHHHH
AELKERYKKISIKDKGKVFNTDLLYAIEVGYGLEVAEAMAHSAILRKESRGAHQRLDEGC
HHHHHHHHCCCCCCCCCEECCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHCC
TERDDENFLKHSLAFYNKDAAPTIKYSDVTITKSQPKARLYGEAAEKAAAEEAAKNAEEH
CCCCHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
A
C
>Mature Secondary Structure
MKTITTDIAVIGAGGAGLRTAIAAAEANPELEIALISKVYPMRSHTVAAEGGSAAVTKEE
CCEEEEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEEHHCCCCCCEEEECCCCEEEECCC
DTLDNHFNDTVGGGDWLCEQDVVEYFVENAYREMTQLEQWGCPWSRKENGEVNVRRFGGM
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCE
KVERTWFAADKTGFHMLHTLFQTSMKYPQINRFDEYFVVDLLVEEGQVQGLIAIHMAEGE
EEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHEEEEEEECCCCCCEEEEEEEECCC
LICIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAFRHGVPLRDMEFVQYHPTGLPGT
EEEEEECEEEEEECCCCEEEEECCCCCEEECCCCEEHHHCCCCCCCCCEEEECCCCCCCC
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGEPKNKYMELGPRDKVSQAFWHELQ
CEEEECCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
KGNTIKHPLGDVVHLDLRHLGEEYLHERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
GIETDKNNETSIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRLAGEKAAERAAEFTS
CEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCC
WNEESIQKQITEVQARIDALMAQEGDENWATIRTEMGHSMEAGCGIYRKEHEMQDTIDKL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHCCCHHHHHHHHHHHHHHH
AELKERYKKISIKDKGKVFNTDLLYAIEVGYGLEVAEAMAHSAILRKESRGAHQRLDEGC
HHHHHHHHCCCCCCCCCEECCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHCC
TERDDENFLKHSLAFYNKDAAPTIKYSDVTITKSQPKARLYGEAAEKAAAEEAAKNAEEH
CCCCHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3308458 [H]