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The map label for this gene is parC [H]

Identifier: 59712834

GI number: 59712834

Start: 2498000

End: 2500276

Strand: Reverse

Name: parC [H]

Synonym: VF_2227

Alternate gene names: 59712834

Gene position: 2500276-2498000 (Counterclockwise)

Preceding gene: 59712835

Following gene: 59712830

Centisome position: 86.29

GC content: 41.02

Gene sequence:

>2277_bases
ATGAGTACAGAAATGTCCTTAGAAGGTGTTGAACAGCTGCCACTGCGCAAGTTTACAGAAGACGCTTATCTAAATTATTC
CATGTACGTAATCATGGACCGTGCATTACCGTATATCGGTGATGGTTTAAAACCGGTTCAACGTCGTATTATTTACGCGA
TGTCTGAACTTGGATTATCAGCAAACGCAAAGTATAAGAAATCAGCACGTACCGTTGGTGATGTATTAGGTAAGTACCAC
CCACACGGTGACTCTGCGTGTTATGAAGCCATGGTATTAATGGCTCAGCCTTTCTCTTATCGTTATCCACTAGTTGATGG
TCAAGGTAACTGGGGTGCTCCAGATGATCCGAAATCATTTGCTGCGATGCGTTATACGGAATCAAAACTGTCTAAGTTTG
CTGATGTATTGCTAGGCGAAATTGGTCAAGGTACGGTTGATTGGCAACCAAACTTTGATGGCACAATGAAAGAGCCAACG
ATATTACCTTCACGTTTACCTCATATTTTATTGAATGGTATTACTGGTATCGCGGTTGGTATGGCAACAGACATTCCACC
CCACAATGTACGTGAAGTCGCAAATGCAACAGTTCACCTATTAGAAAATCCAAAAGCGGATTTAGATGAGGTGATGGATT
TTGTAAAAGGTCCAGATTACCCAACCAAAGCTGAAATTATTTCACCATCAAGTGAAATTAAAAAGATTTACCGTTCAGGT
AGAGGCAGCATTAAAATGCGTGCGGTATGGCATAAAGAAGAGGGTGATATTGTTATTACCGCTCTGCCACATCAAGTATC
TGGTAGTAAATTATTAGAGCAAATCGCAAACCAAATGCGAGCGAAGAAGTTACCTATGGTAGATGATCTTCGTGATGAAT
CTGATCATGAGAATCCAACACGTATCGTTATTGTTCCTCGCTCAAACCGAGTGGATGCGGAACCATTAATGAACCATTTA
TTTGCTTCGACAGATCTTGAAAAAAGCTACCGTGTTAACTTAAACATGATTGGTTTGGATCAGCGTCCTCAAGTGAAAGG
TTTGGTATCTATTCTTTCTGAATGGATTGAATTCCGTCGCACAACAGTGCGTAAACGTCTTCAACACCGTTTAGATAAAG
TGCTGGCTCGTCTACATATTTTAGAAGGTCTTTTAGCGGCTTACTTAAATATCGATGAAGTGATTGAAATCATCCGTACT
GAAGATGATCCAAAGCATGAGTTAATGACTCGCTTTGATTTATCTGAGAAACAAGCGGAAGCGATTTTAGAAATTAAACT
TCGTCAGTTAGCTAAACTGGAAGAGATTAAGATCCGTGGTGAACAAGATGAGTTAGCTAAAGAGCGTGATTATCTTGAGA
AACTATTAGGTTCAGAGCGTCGTTTAAACACATTAATTAAGAAAGAAATCTTAGCGGATGCTGAGAAGTTTGGTGATGAT
CGCCGTTCTCCATTGGTTGAGCGTGCAGAAGCGAAAGCGATGACAGAGCGTGACTTGATCCCAAGTGAAGCGATTACGGT
TGTTCTTTCTGATAAAGGTTGGATTCGTCATGCTAAAGGTCATGATGTTGATCCAACAACATTGAACTATAAATCAGGTG
ATAAATACTTAGCCCATGCGCGTGGTAAGAGTAACGCGCCAGCTGTCTTTATGGGCAGTAATGGTCGAAGCTACGCGCTT
GAATCGCATACATTGCCTTCAGCAAGAAGTCAGGGTGAGCCAATTACAGGTCGCTTAAATATTACAGCGGGCAGTCAAAT
TACGCATGTGGTTATGGGTGAAGAAGAGCAGACATGGTTAATCAGCTCTGATGCTGGTTACGGTTTTGTTTGTAAGGGTG
CAGATTTACTGTCTAAAAATAAAAACGGTAAAGCCCTATTAACGCTTCCTGAAAACTCACAAGTAATGAACCCAGAAGCG
GTATCTGACTTAGAAAGTGATGAAATTCTAGCTATCACTAACGAAGGTCGAATGCTTTTATTCCCTATTAAAGATTTACC
ACAGTTAGGTAAAGGTAAGGGTAATAAGATCATTAATATTCCGGCAGCGCGTTCGAAATCTCGTGAAGAGTTTTTGTCTC
ACTTATTACCATTACCTCAAGGTGCAACCATTACCTTATACGCAGGTAAACGTAAGTTAGGATTGAAACCTACGGATTTA
GATAACTTCCGTGGGGAGCGTGGTCGCCGTGGTAGCTTACTGCCAAGAGGCCTACAACGAGTTACTCGTATTGATATTAA
TGGTGAGAGCACAACGACTGAAGAAGAAAGTGAATAA

Upstream 100 bases:

>100_bases
AACAAACTGATGAAATGATGGATATGCTTTTAGGCAAGAAACGTGCAGACGATCGTCGCTCTTGGCTACAATCTAATGGC
GATCAGGCAGAGGTATAAAA

Downstream 100 bases:

>100_bases
CCTTTAGTCATTGCGATTGCTTAGATACAAAATAGCGCATTTTTTAATGCGCTATTTTTTTATTAATTGTTTGGGTCTTC
TTCAATAGTTACTTTAATCG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 758; Mature: 757

Protein sequence:

>758_residues
MSTEMSLEGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSANAKYKKSARTVGDVLGKYH
PHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESKLSKFADVLLGEIGQGTVDWQPNFDGTMKEPT
ILPSRLPHILLNGITGIAVGMATDIPPHNVREVANATVHLLENPKADLDEVMDFVKGPDYPTKAEIISPSSEIKKIYRSG
RGSIKMRAVWHKEEGDIVITALPHQVSGSKLLEQIANQMRAKKLPMVDDLRDESDHENPTRIVIVPRSNRVDAEPLMNHL
FASTDLEKSYRVNLNMIGLDQRPQVKGLVSILSEWIEFRRTTVRKRLQHRLDKVLARLHILEGLLAAYLNIDEVIEIIRT
EDDPKHELMTRFDLSEKQAEAILEIKLRQLAKLEEIKIRGEQDELAKERDYLEKLLGSERRLNTLIKKEILADAEKFGDD
RRSPLVERAEAKAMTERDLIPSEAITVVLSDKGWIRHAKGHDVDPTTLNYKSGDKYLAHARGKSNAPAVFMGSNGRSYAL
ESHTLPSARSQGEPITGRLNITAGSQITHVVMGEEEQTWLISSDAGYGFVCKGADLLSKNKNGKALLTLPENSQVMNPEA
VSDLESDEILAITNEGRMLLFPIKDLPQLGKGKGNKIINIPAARSKSREEFLSHLLPLPQGATITLYAGKRKLGLKPTDL
DNFRGERGRRGSLLPRGLQRVTRIDINGESTTTEEESE

Sequences:

>Translated_758_residues
MSTEMSLEGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSANAKYKKSARTVGDVLGKYH
PHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESKLSKFADVLLGEIGQGTVDWQPNFDGTMKEPT
ILPSRLPHILLNGITGIAVGMATDIPPHNVREVANATVHLLENPKADLDEVMDFVKGPDYPTKAEIISPSSEIKKIYRSG
RGSIKMRAVWHKEEGDIVITALPHQVSGSKLLEQIANQMRAKKLPMVDDLRDESDHENPTRIVIVPRSNRVDAEPLMNHL
FASTDLEKSYRVNLNMIGLDQRPQVKGLVSILSEWIEFRRTTVRKRLQHRLDKVLARLHILEGLLAAYLNIDEVIEIIRT
EDDPKHELMTRFDLSEKQAEAILEIKLRQLAKLEEIKIRGEQDELAKERDYLEKLLGSERRLNTLIKKEILADAEKFGDD
RRSPLVERAEAKAMTERDLIPSEAITVVLSDKGWIRHAKGHDVDPTTLNYKSGDKYLAHARGKSNAPAVFMGSNGRSYAL
ESHTLPSARSQGEPITGRLNITAGSQITHVVMGEEEQTWLISSDAGYGFVCKGADLLSKNKNGKALLTLPENSQVMNPEA
VSDLESDEILAITNEGRMLLFPIKDLPQLGKGKGNKIINIPAARSKSREEFLSHLLPLPQGATITLYAGKRKLGLKPTDL
DNFRGERGRRGSLLPRGLQRVTRIDINGESTTTEEESE
>Mature_757_residues
STEMSLEGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSANAKYKKSARTVGDVLGKYHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESKLSKFADVLLGEIGQGTVDWQPNFDGTMKEPTI
LPSRLPHILLNGITGIAVGMATDIPPHNVREVANATVHLLENPKADLDEVMDFVKGPDYPTKAEIISPSSEIKKIYRSGR
GSIKMRAVWHKEEGDIVITALPHQVSGSKLLEQIANQMRAKKLPMVDDLRDESDHENPTRIVIVPRSNRVDAEPLMNHLF
ASTDLEKSYRVNLNMIGLDQRPQVKGLVSILSEWIEFRRTTVRKRLQHRLDKVLARLHILEGLLAAYLNIDEVIEIIRTE
DDPKHELMTRFDLSEKQAEAILEIKLRQLAKLEEIKIRGEQDELAKERDYLEKLLGSERRLNTLIKKEILADAEKFGDDR
RSPLVERAEAKAMTERDLIPSEAITVVLSDKGWIRHAKGHDVDPTTLNYKSGDKYLAHARGKSNAPAVFMGSNGRSYALE
SHTLPSARSQGEPITGRLNITAGSQITHVVMGEEEQTWLISSDAGYGFVCKGADLLSKNKNGKALLTLPENSQVMNPEAV
SDLESDEILAITNEGRMLLFPIKDLPQLGKGKGNKIINIPAARSKSREEFLSHLLPLPQGATITLYAGKRKLGLKPTDLD
NFRGERGRRGSLLPRGLQRVTRIDINGESTTTEEESE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=748, Percent_Identity=68.5828877005348, Blast_Score=1092, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=746, Percent_Identity=34.4504021447721, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI212645845, Length=390, Percent_Identity=24.1025641025641, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=371, Percent_Identity=24.5283018867925, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84773; Mature: 84642

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEMSLEGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLS
CCCCCCCCCHHHCCHHHHCHHHHCCEEEEEEEEHHCHHHCCCHHHHHHHHHHHHHHCCCC
ANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSF
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHH
AAMRYTESKLSKFADVLLGEIGQGTVDWQPNFDGTMKEPTILPSRLPHILLNGITGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHH
MATDIPPHNVREVANATVHLLENPKADLDEVMDFVKGPDYPTKAEIISPSSEIKKIYRSG
HCCCCCCHHHHHHHHHHEEEECCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCC
RGSIKMRAVWHKEEGDIVITALPHQVSGSKLLEQIANQMRAKKLPMVDDLRDESDHENPT
CCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCC
RIVIVPRSNRVDAEPLMNHLFASTDLEKSYRVNLNMIGLDQRPQVKGLVSILSEWIEFRR
EEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
TTVRKRLQHRLDKVLARLHILEGLLAAYLNIDEVIEIIRTEDDPKHELMTRFDLSEKQAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHH
AILEIKLRQLAKLEEIKIRGEQDELAKERDYLEKLLGSERRLNTLIKKEILADAEKFGDD
HHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
RRSPLVERAEAKAMTERDLIPSEAITVVLSDKGWIRHAKGHDVDPTTLNYKSGDKYLAHA
CCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCCCCCEEECCCCCCEEEEC
RGKSNAPAVFMGSNGRSYALESHTLPSARSQGEPITGRLNITAGSQITHVVMGEEEQTWL
CCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCEEE
ISSDAGYGFVCKGADLLSKNKNGKALLTLPENSQVMNPEAVSDLESDEILAITNEGRMLL
EECCCCCEEEECCHHHHHCCCCCCEEEEECCCCCCCCCHHHHCCCCCCEEEEECCCCEEE
FPIKDLPQLGKGKGNKIINIPAARSKSREEFLSHLLPLPQGATITLYAGKRKLGLKPTDL
EECCCCHHHCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCEEEEEECCEECCCCCCCC
DNFRGERGRRGSLLPRGLQRVTRIDINGESTTTEEESE
HHCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCCCCC
>Mature Secondary Structure 
STEMSLEGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLS
CCCCCCCCHHHCCHHHHCHHHHCCEEEEEEEEHHCHHHCCCHHHHHHHHHHHHHHCCCC
ANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSF
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHH
AAMRYTESKLSKFADVLLGEIGQGTVDWQPNFDGTMKEPTILPSRLPHILLNGITGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHH
MATDIPPHNVREVANATVHLLENPKADLDEVMDFVKGPDYPTKAEIISPSSEIKKIYRSG
HCCCCCCHHHHHHHHHHEEEECCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCC
RGSIKMRAVWHKEEGDIVITALPHQVSGSKLLEQIANQMRAKKLPMVDDLRDESDHENPT
CCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCC
RIVIVPRSNRVDAEPLMNHLFASTDLEKSYRVNLNMIGLDQRPQVKGLVSILSEWIEFRR
EEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
TTVRKRLQHRLDKVLARLHILEGLLAAYLNIDEVIEIIRTEDDPKHELMTRFDLSEKQAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHH
AILEIKLRQLAKLEEIKIRGEQDELAKERDYLEKLLGSERRLNTLIKKEILADAEKFGDD
HHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
RRSPLVERAEAKAMTERDLIPSEAITVVLSDKGWIRHAKGHDVDPTTLNYKSGDKYLAHA
CCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCCCCCEEECCCCCCEEEEC
RGKSNAPAVFMGSNGRSYALESHTLPSARSQGEPITGRLNITAGSQITHVVMGEEEQTWL
CCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCEEE
ISSDAGYGFVCKGADLLSKNKNGKALLTLPENSQVMNPEAVSDLESDEILAITNEGRMLL
EECCCCCEEEECCHHHHHCCCCCCEEEEECCCCCCCCCHHHHCCCCCCEEEEECCCCEEE
FPIKDLPQLGKGKGNKIINIPAARSKSREEFLSHLLPLPQGATITLYAGKRKLGLKPTDL
EECCCCHHHCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCEEEEEECCEECCCCCCCC
DNFRGERGRRGSLLPRGLQRVTRIDINGESTTTEEESE
HHCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]