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The map label for this gene is panC

Identifier: 59712777

GI number: 59712777

Start: 2439325

End: 2440200

Strand: Direct

Name: panC

Synonym: VF_2170

Alternate gene names: 59712777

Gene position: 2439325-2440200 (Clockwise)

Preceding gene: 59712776

Following gene: 59712781

Centisome position: 84.19

GC content: 42.01

Gene sequence:

>876_bases
ATGGACATTTTTTCTGAAATTTTACCATTACGCGAGCAGATCAAAGCTTGGAAACGCGAAGGTAAACGTATTGCTTTCGT
TCCAACAATGGGAAATCTACACGAAGGTCATTTAACTCTAATTCGAACAGCTCGCGAGCATGCAGATATTGTAGTTGCTA
GTATTTTTGTTAATCCAATGCAATTTAACAATGCTGATGACCTAACAAACTACCCAAGAACATTAGATGAAGATGTAGAA
AAACTCACTGCTGAAAACGTTGATCTTGTATTCACACCAACTCCTGAGATCATGTATCCAGAAGGGTTAGAGAAACAAAC
AACCGTTGACGTTCCTGTTATCTCTACTATTTTAGAAGGCGCTTCTCGTCCCGGTCACTTTAAAGGTGTCTCGACGGTTG
TTAATAAGCTATTCAATATTGTTCAACCTGATGTAGCTTGCTTTGGTGAAAAAGACTTCCAACAGCTTGCGCTTATTCGT
CAAATGGTTATCGATATGGCGTTAGATGTTGAAATCGTTGGCGTACCAACCGTTCGTGAGATGGATGGATTGGCAATGAG
CTCACGCAATAACCTATTAACACTTAATGAGCGTCAGCGTGCACCGGTTTTAGCTCGCACTATGCGTTGGATAAGCAGTC
AAATGCGTGGCGGCCGTAATGATTACCTATCTCTAATTGAAGATGCCAGTGATCAACTACGCGCAGCGGATCTGCAACCG
GATGAGATCTTCATTCGTGATGCAAGAACGCTACAAGAGCCAACAGAAGAGACAACTCAAGCCATTATTCTAATGGCAGC
GTTCCTTGGCCAAGTTCGTTTAATTGATAACTTAGTTGTTGAATTAGCAGCGGCATCGAACGACGAAGAAGAGTAA

Upstream 100 bases:

>100_bases
AGAAACTGGTGATATGCGTAAAGCGGTCACTAAATACATTCAAGATGTTGAGCAAGGTGTATTCCCTGTTGCTGAACATA
CATTTAACTAAGGAAACGTA

Downstream 100 bases:

>100_bases
TCTTTTCTAAAAGAAAAATAAAAGGGCTGAAGATAATCACTATCTTCAGCCCTTTTTTCATCTATGATTTACATATATGG
TCTCTAACTTCTTAATCCAA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MDIFSEILPLREQIKAWKREGKRIAFVPTMGNLHEGHLTLIRTAREHADIVVASIFVNPMQFNNADDLTNYPRTLDEDVE
KLTAENVDLVFTPTPEIMYPEGLEKQTTVDVPVISTILEGASRPGHFKGVSTVVNKLFNIVQPDVACFGEKDFQQLALIR
QMVIDMALDVEIVGVPTVREMDGLAMSSRNNLLTLNERQRAPVLARTMRWISSQMRGGRNDYLSLIEDASDQLRAADLQP
DEIFIRDARTLQEPTEETTQAIILMAAFLGQVRLIDNLVVELAAASNDEEE

Sequences:

>Translated_291_residues
MDIFSEILPLREQIKAWKREGKRIAFVPTMGNLHEGHLTLIRTAREHADIVVASIFVNPMQFNNADDLTNYPRTLDEDVE
KLTAENVDLVFTPTPEIMYPEGLEKQTTVDVPVISTILEGASRPGHFKGVSTVVNKLFNIVQPDVACFGEKDFQQLALIR
QMVIDMALDVEIVGVPTVREMDGLAMSSRNNLLTLNERQRAPVLARTMRWISSQMRGGRNDYLSLIEDASDQLRAADLQP
DEIFIRDARTLQEPTEETTQAIILMAAFLGQVRLIDNLVVELAAASNDEEE
>Mature_291_residues
MDIFSEILPLREQIKAWKREGKRIAFVPTMGNLHEGHLTLIRTAREHADIVVASIFVNPMQFNNADDLTNYPRTLDEDVE
KLTAENVDLVFTPTPEIMYPEGLEKQTTVDVPVISTILEGASRPGHFKGVSTVVNKLFNIVQPDVACFGEKDFQQLALIR
QMVIDMALDVEIVGVPTVREMDGLAMSSRNNLLTLNERQRAPVLARTMRWISSQMRGGRNDYLSLIEDASDQLRAADLQP
DEIFIRDARTLQEPTEETTQAIILMAAFLGQVRLIDNLVVELAAASNDEEE

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=279, Percent_Identity=58.0645161290323, Blast_Score=331, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6322046, Length=313, Percent_Identity=36.1022364217252, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_VIBF1 (Q5E2T1)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_205553.1
- ProteinModelPortal:   Q5E2T1
- SMR:   Q5E2T1
- STRING:   Q5E2T1
- GeneID:   3279398
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_2170
- NMPDR:   fig|312309.3.peg.2170
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   DEAHDAK
- PhylomeDB:   Q5E2T1
- ProtClustDB:   PRK00380
- BioCyc:   VFIS312309:VF2170-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32703; Mature: 32703

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIFSEILPLREQIKAWKREGKRIAFVPTMGNLHEGHLTLIRTAREHADIVVASIFVNPM
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHEEEHHHHCCCH
QFNNADDLTNYPRTLDEDVEKLTAENVDLVFTPTPEIMYPEGLEKQTTVDVPVISTILEG
HCCCCCHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCEECHHHHHHHHHC
ASRPGHFKGVSTVVNKLFNIVQPDVACFGEKDFQQLALIRQMVIDMALDVEIVGVPTVRE
CCCCCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHCEEEECCCCHHH
MDGLAMSSRNNLLTLNERQRAPVLARTMRWISSQMRGGRNDYLSLIEDASDQLRAADLQP
HCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
DEIFIRDARTLQEPTEETTQAIILMAAFLGQVRLIDNLVVELAAASNDEEE
CCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDIFSEILPLREQIKAWKREGKRIAFVPTMGNLHEGHLTLIRTAREHADIVVASIFVNPM
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHEEEHHHHCCCH
QFNNADDLTNYPRTLDEDVEKLTAENVDLVFTPTPEIMYPEGLEKQTTVDVPVISTILEG
HCCCCCHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCEECHHHHHHHHHC
ASRPGHFKGVSTVVNKLFNIVQPDVACFGEKDFQQLALIRQMVIDMALDVEIVGVPTVRE
CCCCCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHCEEEECCCCHHH
MDGLAMSSRNNLLTLNERQRAPVLARTMRWISSQMRGGRNDYLSLIEDASDQLRAADLQP
HCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
DEIFIRDARTLQEPTEETTQAIILMAAFLGQVRLIDNLVVELAAASNDEEE
CCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA