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The map label for this gene is can [H]

Identifier: 59712781

GI number: 59712781

Start: 2444045

End: 2444728

Strand: Direct

Name: can [H]

Synonym: VF_2174

Alternate gene names: 59712781

Gene position: 2444045-2444728 (Clockwise)

Preceding gene: 59712777

Following gene: 59712784

Centisome position: 84.35

GC content: 36.4

Gene sequence:

>684_bases
ATGTATTTAAGGGATGAAAAATTTAAAATGCCAGAAATTAAAGAACTTTTTGAGAATAATTCTAAATGGGCTAAATCAAT
AAAAGCAGAACGCCCTGAATATTTTGCAAAATTAGAAGAAGGTCAACACCCAGGTTTTTTATGGATAGGTTGCTCAGATA
GTCGAGTACCAGCAGAACGCCTAACTGGGTTATATTCCGGCGAACTATTTGTGCATCGAAATGTAGCAAACCAAGTTATT
CATACAGATTTAAACTGCTTATCCGTTCTTCAATATGCTGTCGATGTTTTGAAAATCAGACACATTATTGTTTGTGGCCA
TTATGGCTGTGGTGGTGTAAATGCAGCTATCGATAATCCTCCTTTAGGCTTAATCAATAACTGGCTACTGCACATTAGAG
ATTTATTCCTAAAACACAGAACTGTATTTGGTAAATTACCTCGTGAAGAATGGGGTGATAAATTATGTGAAATTAACGTC
GCAGAGCAAGTATATAACGTAGGTAACTCAACCATTATGCAAAACGCATGGGAACGTGGACAAGACGTTCAAATTCATGG
TGTTGTGTATGGCATGGGGGATGGCGTTTTAAATGATCTTGGCGTAAAAGGTCATAGTCGTGAATCATTAGAAATATCAT
ATCAAGCAGCAATGTCTAATATTACTAATGTTGGTGATGAATGA

Upstream 100 bases:

>100_bases
AAAGCATTTTTTAGCAGATTGAAATTGTAACATTGTGTATAGTAAATAAACCTGTTGAGGTTTTTAACAGAAAGAAGTTT
AGGTAATACCCTTCCTTCTT

Downstream 100 bases:

>100_bases
TAAAAGGGAAATAATATCGTTCCCTTTTATCATAATAAATATATACACTGCATTATAACAAACACAGATAATATAAGTTG
CCAGAGAAAGCATTCACCAT

Product: carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase 2 [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MYLRDEKFKMPEIKELFENNSKWAKSIKAERPEYFAKLEEGQHPGFLWIGCSDSRVPAERLTGLYSGELFVHRNVANQVI
HTDLNCLSVLQYAVDVLKIRHIIVCGHYGCGGVNAAIDNPPLGLINNWLLHIRDLFLKHRTVFGKLPREEWGDKLCEINV
AEQVYNVGNSTIMQNAWERGQDVQIHGVVYGMGDGVLNDLGVKGHSRESLEISYQAAMSNITNVGDE

Sequences:

>Translated_227_residues
MYLRDEKFKMPEIKELFENNSKWAKSIKAERPEYFAKLEEGQHPGFLWIGCSDSRVPAERLTGLYSGELFVHRNVANQVI
HTDLNCLSVLQYAVDVLKIRHIIVCGHYGCGGVNAAIDNPPLGLINNWLLHIRDLFLKHRTVFGKLPREEWGDKLCEINV
AEQVYNVGNSTIMQNAWERGQDVQIHGVVYGMGDGVLNDLGVKGHSRESLEISYQAAMSNITNVGDE
>Mature_227_residues
MYLRDEKFKMPEIKELFENNSKWAKSIKAERPEYFAKLEEGQHPGFLWIGCSDSRVPAERLTGLYSGELFVHRNVANQVI
HTDLNCLSVLQYAVDVLKIRHIIVCGHYGCGGVNAAIDNPPLGLINNWLLHIRDLFLKHRTVFGKLPREEWGDKLCEINV
AEQVYNVGNSTIMQNAWERGQDVQIHGVVYGMGDGVLNDLGVKGHSRESLEISYQAAMSNITNVGDE

Specific function: Unknown

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786318, Length=212, Percent_Identity=64.622641509434, Blast_Score=295, Evalue=2e-81,
Organism=Escherichia coli, GI1786534, Length=212, Percent_Identity=27.8301886792453, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324292, Length=199, Percent_Identity=29.1457286432161, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 25653; Mature: 25653

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1 ; PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLRDEKFKMPEIKELFENNSKWAKSIKAERPEYFAKLEEGQHPGFLWIGCSDSRVPAER
CCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHH
LTGLYSGELFVHRNVANQVIHTDLNCLSVLQYAVDVLKIRHIIVCGHYGCGGVNAAIDNP
HHHHHCCEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCC
PLGLINNWLLHIRDLFLKHRTVFGKLPREEWGDKLCEINVAEQVYNVGNSTIMQNAWERG
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHEEEHHHHHHHHCCCHHHHHHHHHCC
QDVQIHGVVYGMGDGVLNDLGVKGHSRESLEISYQAAMSNITNVGDE
CCEEEEEEEEECCCCHHHHCCCCCCCCCCCEEHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYLRDEKFKMPEIKELFENNSKWAKSIKAERPEYFAKLEEGQHPGFLWIGCSDSRVPAER
CCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHH
LTGLYSGELFVHRNVANQVIHTDLNCLSVLQYAVDVLKIRHIIVCGHYGCGGVNAAIDNP
HHHHHCCEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCC
PLGLINNWLLHIRDLFLKHRTVFGKLPREEWGDKLCEINVAEQVYNVGNSTIMQNAWERG
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHEEEHHHHHHHHCCCHHHHHHHHHCC
QDVQIHGVVYGMGDGVLNDLGVKGHSRESLEISYQAAMSNITNVGDE
CCEEEEEEEEECCCCHHHHCCCCCCCCCCCEEHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8202364; 9278503; 10493123 [H]