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The map label for this gene is malY [H]

Identifier: 59712325

GI number: 59712325

Start: 1934522

End: 1935694

Strand: Reverse

Name: malY [H]

Synonym: VF_1718

Alternate gene names: 59712325

Gene position: 1935694-1934522 (Counterclockwise)

Preceding gene: 59712326

Following gene: 59712323

Centisome position: 66.8

GC content: 39.39

Gene sequence:

>1173_bases
ATGTTTAATTTCTCTGAACAGATTAATCGTAAAGGCAGTTACTGCACTCAATGGGATTATGTTGAGGATCGATTTGGGGA
GGCGGATTTGCTTCCATTTACTATTTCGGATATGGATTTTGCAGCACCTCCTGCTGTGATTGAAGCCTTAAACTCTCGTA
TCAATCATCCTGTGTTTGGCTATAGTCGATGGAATCACAGTGATTTTAAAGAAGCTGTTATCCATTGGTTTAAGAGCCGT
TTTGATGCTGAGTTTAATGATGATCATTTAGTGTATGGTCCTTCCGTTATTTATATTGTTTCTCAATTAATACGTGAATG
GAGTCAACCGAATCAAGGGGTGATTATCCATACTCCTGCTTATGATGCTTTTGACAAAATGATTTTAGGGTTAGGGCGTA
CAATCGTCGCCAATAAGTTACAAGCAACGGACTCTGGTTATCAGATTAATTGGGAACAATTTGAAACACAGTTAGCGGAT
CCAAATAACACGATTTTGCTTCTATGTAGCCCGCATAATCCAACGGGAAGGGTTTGGACATCTGCGGAATTAACTCGTAT
GGCTTCGTTGTGTCAAAAGCATAATGTGGCTGTGATTAGTGATGAGATCCACATGGATGTTTCATTTAAGCCTCATACGC
CATGGCAGGGTTTTGGTGCAGGGGAACGTTGGGCGTTAGTCAGTTCAGCATCAAAATCATTTAATATCCCTGCGCTAAAT
GGATCTTATGCATTTATTGCAGAAGAATCGGCACGAGATAATTACCTGTTTAATCTTAAGCAAGTCGATGGCTTATCATC
ACCATCGATCCTTGGTGTTATTGGTTTAATGGCGGCGTATCAAAAAGGAGCGCCTTGGTTAGACGAATTAAAAACCTATC
TTTATGAAAATCATCATTATGTTGCACAAACCTTAGCAGAACAGTTACCGAGCGTTGGTTACCAAATTCCAGATGCAACT
TATCTTGCTTGGATTGATCTATCTTCGCTTTCTATTGATATGGATAAACTAAATCAGTGTCTTATTAAGAAACATAAGGT
AGCGATAATGCAAGGGAGTACCTATGGTGAGGTTGGGAAATATTTTGTCCGTTTGAATTTAGGTTGTCCAAGAGAAAAAG
TAGAAAAAGGGCTTATGGCGCTGATTTCTGCGGTTAAAGAGTTGACTGAATAA

Upstream 100 bases:

>100_bases
CGTTAATCTATGTTTAGGTTGGTATTCATTGCGGAGTTTATTTAACTCCGCTTTTTCTTTTTGTTTCTATTTCTGGATTG
TTTTTTGGGAGTATTTACCT

Downstream 100 bases:

>100_bases
AAGTGATGCACCTCTTTATAGTTAGAGGTGCATATTCTTTGATAATTGCTTGTGCTGCCTGACATTAAACAACTTTTTCT
GAGAGTGCAGTTTGCATTGA

Product: bifunctional beta-cystathionase, PLP-dependent/ regulator of maltose regulon

Products: NA

Alternate protein names: Cystathionine beta-lyase MalY; CBL; Beta-cystathionase; Cysteine lyase; Maltose regulon modulator [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MFNFSEQINRKGSYCTQWDYVEDRFGEADLLPFTISDMDFAAPPAVIEALNSRINHPVFGYSRWNHSDFKEAVIHWFKSR
FDAEFNDDHLVYGPSVIYIVSQLIREWSQPNQGVIIHTPAYDAFDKMILGLGRTIVANKLQATDSGYQINWEQFETQLAD
PNNTILLLCSPHNPTGRVWTSAELTRMASLCQKHNVAVISDEIHMDVSFKPHTPWQGFGAGERWALVSSASKSFNIPALN
GSYAFIAEESARDNYLFNLKQVDGLSSPSILGVIGLMAAYQKGAPWLDELKTYLYENHHYVAQTLAEQLPSVGYQIPDAT
YLAWIDLSSLSIDMDKLNQCLIKKHKVAIMQGSTYGEVGKYFVRLNLGCPREKVEKGLMALISAVKELTE

Sequences:

>Translated_390_residues
MFNFSEQINRKGSYCTQWDYVEDRFGEADLLPFTISDMDFAAPPAVIEALNSRINHPVFGYSRWNHSDFKEAVIHWFKSR
FDAEFNDDHLVYGPSVIYIVSQLIREWSQPNQGVIIHTPAYDAFDKMILGLGRTIVANKLQATDSGYQINWEQFETQLAD
PNNTILLLCSPHNPTGRVWTSAELTRMASLCQKHNVAVISDEIHMDVSFKPHTPWQGFGAGERWALVSSASKSFNIPALN
GSYAFIAEESARDNYLFNLKQVDGLSSPSILGVIGLMAAYQKGAPWLDELKTYLYENHHYVAQTLAEQLPSVGYQIPDAT
YLAWIDLSSLSIDMDKLNQCLIKKHKVAIMQGSTYGEVGKYFVRLNLGCPREKVEKGLMALISAVKELTE
>Mature_390_residues
MFNFSEQINRKGSYCTQWDYVEDRFGEADLLPFTISDMDFAAPPAVIEALNSRINHPVFGYSRWNHSDFKEAVIHWFKSR
FDAEFNDDHLVYGPSVIYIVSQLIREWSQPNQGVIIHTPAYDAFDKMILGLGRTIVANKLQATDSGYQINWEQFETQLAD
PNNTILLLCSPHNPTGRVWTSAELTRMASLCQKHNVAVISDEIHMDVSFKPHTPWQGFGAGERWALVSSASKSFNIPALN
GSYAFIAEESARDNYLFNLKQVDGLSSPSILGVIGLMAAYQKGAPWLDELKTYLYENHHYVAQTLAEQLPSVGYQIPDAT
YLAWIDLSSLSIDMDKLNQCLIKKHKVAIMQGSTYGEVGKYFVRLNLGCPREKVEKGLMALISAVKELTE

Specific function: Acts as a beta-cystathionase and as a repressor of the maltose regulon [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787909, Length=390, Percent_Identity=54.8717948717949, Blast_Score=451, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44020; Mature: 44020

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNFSEQINRKGSYCTQWDYVEDRFGEADLLPFTISDMDFAAPPAVIEALNSRINHPVFG
CCCCHHHHCCCCCCCCCCCCHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEC
YSRWNHSDFKEAVIHWFKSRFDAEFNDDHLVYGPSVIYIVSQLIREWSQPNQGVIIHTPA
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEECCC
YDAFDKMILGLGRTIVANKLQATDSGYQINWEQFETQLADPNNTILLLCSPHNPTGRVWT
HHHHHHHHHHCCHHHHHHHHHCCCCCCEEEHHHHHHHHCCCCCEEEEEECCCCCCCCEEC
SAELTRMASLCQKHNVAVISDEIHMDVSFKPHTPWQGFGAGERWALVSSASKSFNIPALN
HHHHHHHHHHHHHCCEEEEECCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCC
GSYAFIAEESARDNYLFNLKQVDGLSSPSILGVIGLMAAYQKGAPWLDELKTYLYENHHY
CCEEEEEECCCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHH
VAQTLAEQLPSVGYQIPDATYLAWIDLSSLSIDMDKLNQCLIKKHKVAIMQGSTYGEVGK
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCEECHHHHHHHHHHHHHEEEEECCCHHCCCE
YFVRLNLGCPREKVEKGLMALISAVKELTE
EEEEEECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFNFSEQINRKGSYCTQWDYVEDRFGEADLLPFTISDMDFAAPPAVIEALNSRINHPVFG
CCCCHHHHCCCCCCCCCCCCHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEC
YSRWNHSDFKEAVIHWFKSRFDAEFNDDHLVYGPSVIYIVSQLIREWSQPNQGVIIHTPA
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEECCC
YDAFDKMILGLGRTIVANKLQATDSGYQINWEQFETQLADPNNTILLLCSPHNPTGRVWT
HHHHHHHHHHCCHHHHHHHHHCCCCCCEEEHHHHHHHHCCCCCEEEEEECCCCCCCCEEC
SAELTRMASLCQKHNVAVISDEIHMDVSFKPHTPWQGFGAGERWALVSSASKSFNIPALN
HHHHHHHHHHHHHCCEEEEECCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCC
GSYAFIAEESARDNYLFNLKQVDGLSSPSILGVIGLMAAYQKGAPWLDELKTYLYENHHY
CCEEEEEECCCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHH
VAQTLAEQLPSVGYQIPDATYLAWIDLSSLSIDMDKLNQCLIKKHKVAIMQGSTYGEVGK
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCEECHHHHHHHHHHHHHEEEEECCCHHCCCE
YFVRLNLGCPREKVEKGLMALISAVKELTE
EEEEEECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1856179; 9097039; 9278503; 7665481; 10698925 [H]