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The map label for this gene is malX [H]

Identifier: 59712326

GI number: 59712326

Start: 1935817

End: 1937394

Strand: Reverse

Name: malX [H]

Synonym: VF_1719

Alternate gene names: 59712326

Gene position: 1937394-1935817 (Counterclockwise)

Preceding gene: 59712328

Following gene: 59712325

Centisome position: 66.86

GC content: 40.68

Gene sequence:

>1578_bases
ATGCAACAAAAAGCTAATAAAACTACTCTGTGGGAGTTCTTACAGAGCTTAGGTAAAACCTTTATGGTTCCTGTCGCTTT
GCTCGCTTTTTCGGGTATTCTTCTTGGTATCGGGAGCTCTTTTTCTAGTGCAGCCTTAAAAGAGGCAATGCCTTTTTTTG
ATAATGTGATTCTTCAATATATCTTCATTTGGATGACAAAAATTGGTTTAGTGGCTTTTATCTACTTACCAGTAATGTTT
GCGATTGCGATTCCAATGGGACTTGCTCGTGAAGAAAAAGGGGTTGCAGCATTTTCAGGTCTAGTTGGTTACGCCGCGCT
TAACCTTTCAATCAATTTCTATTTAACCGTAACAGGTGCGCTAGATAGTGAAGCTTTACGTCAATCATATGGTGTAACTT
CTATTTTGGGTACAGAATCAATTGATACGGGTATTTTAGGTGCTGTTATCGTTGGTATTATTGTTGCGAAACTGCATACT
CGTTTCTACACATTTAAAATGCCAGATGCGTTAGCTTTCTTTGGTGGCGCTCGTTTTGTTCCAATTATCTCTTCACTTAC
ACTTGGTGTTGTTGGTCTGCTTGTTCCTTTTATTTGGCCTTATTTTGCAGCTGGCATTAACGGTATTGGTTATGCAATAG
CAGGTGCAGGAGATTTTGGACCTTTCTTATTTGGTGCTGGTGAGCGTTTACTGCTTCCTATCGGTCTTCACCATATTTTA
GTTGCGCTGATTCGATTTACTGAAGCGGGCGGCACGATGGAAGTGTGTGGTGACACAGTATCTGGCGCTCTTAATATTTT
CTACTCAGAATTATCTTGTCCAGACACACAAGGTTTTACACCGTCTGTGACTGCCTTCTTATCTCAAGGTAAGATGCCAG
CTTTCTTAGGTGGTCTTCCTGGTGCAGCTCTGGCTATGTACCACTGTTCTAAAGTTGAAAACCGAAGCAAGATTAAAGCG
TTATTAATCTCTGGTGTTGTGGCTTGTGTCGTTGGTGGTATCACCGAACCTCTTGAATTCTTATTCCTATTTGTTGCTCC
AGTACTGTATTTCATTCATGCGATGCTAACGGGCTTAGGTTTCATGGTAATGGGGATGTTAGATGTCACTATCGGTAATA
CTGATGGCAACATTATTGATTTCTTAGTCTTTGGTGTGCTTCAAGGTACTGCAACGAAATGGTACTTGGTTCCTGTTGTT
GCTGGTGTTTGGTTCACTATTTACTACTTCGTATTTAAGTTTGCGATTCTTAAGTTCAATTTGAAAACTCCTGGACGTGA
AACAAACGAAGTTCCTGTATCGGCTGAAGCTGAAACGATTCTAGCGACTGAAGGCGGTAAAGGGGCGTTAATCCTTTCGG
CTCTTGGTGGTGCAGAAAACATTACTTCACTTGATAACTGTATTACACGTTTACGTTTAACCGTTGCTGATATGAGACTG
GTAAATGATGCGGAACTAAAGGCTTACGGTGCTCTTGGTGTTGTGAAACTTGATGAACACAGTTTACAAGTGGTTATTGG
TACTCAAGTTCATATGGTTAAAAATGAAATTCAATCATTAATGGCAACGCCAGCTTAG

Upstream 100 bases:

>100_bases
CATGTGTATTGTGTCGATAAATACGAAAGCGTACTCAACAAATTTAAAGCTGTTGAATTACCTCCTGTTGTCTATTTGAT
TTATTTAATGGAGAAATCCT

Downstream 100 bases:

>100_bases
TTCGATGCCAATCTAGATAAGTCGTTAATCTATGTTTAGGTTGGTATTCATTGCGGAGTTTATTTAACTCCGCTTTTTCT
TTTTGTTTCTATTTCTGGAT

Product: bifunctional PTS system maltose and glucose-specific transporter subunits IICB

Products: NA

Alternate protein names: Maltose and glucose permease IIC component; PTS system maltose- and glucose-specific EIIC component; Maltose- and glucose-specific phosphotransferase enzyme IIB component; PTS system maltose- and glucose-specific EIIB component [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MQQKANKTTLWEFLQSLGKTFMVPVALLAFSGILLGIGSSFSSAALKEAMPFFDNVILQYIFIWMTKIGLVAFIYLPVMF
AIAIPMGLAREEKGVAAFSGLVGYAALNLSINFYLTVTGALDSEALRQSYGVTSILGTESIDTGILGAVIVGIIVAKLHT
RFYTFKMPDALAFFGGARFVPIISSLTLGVVGLLVPFIWPYFAAGINGIGYAIAGAGDFGPFLFGAGERLLLPIGLHHIL
VALIRFTEAGGTMEVCGDTVSGALNIFYSELSCPDTQGFTPSVTAFLSQGKMPAFLGGLPGAALAMYHCSKVENRSKIKA
LLISGVVACVVGGITEPLEFLFLFVAPVLYFIHAMLTGLGFMVMGMLDVTIGNTDGNIIDFLVFGVLQGTATKWYLVPVV
AGVWFTIYYFVFKFAILKFNLKTPGRETNEVPVSAEAETILATEGGKGALILSALGGAENITSLDNCITRLRLTVADMRL
VNDAELKAYGALGVVKLDEHSLQVVIGTQVHMVKNEIQSLMATPA

Sequences:

>Translated_525_residues
MQQKANKTTLWEFLQSLGKTFMVPVALLAFSGILLGIGSSFSSAALKEAMPFFDNVILQYIFIWMTKIGLVAFIYLPVMF
AIAIPMGLAREEKGVAAFSGLVGYAALNLSINFYLTVTGALDSEALRQSYGVTSILGTESIDTGILGAVIVGIIVAKLHT
RFYTFKMPDALAFFGGARFVPIISSLTLGVVGLLVPFIWPYFAAGINGIGYAIAGAGDFGPFLFGAGERLLLPIGLHHIL
VALIRFTEAGGTMEVCGDTVSGALNIFYSELSCPDTQGFTPSVTAFLSQGKMPAFLGGLPGAALAMYHCSKVENRSKIKA
LLISGVVACVVGGITEPLEFLFLFVAPVLYFIHAMLTGLGFMVMGMLDVTIGNTDGNIIDFLVFGVLQGTATKWYLVPVV
AGVWFTIYYFVFKFAILKFNLKTPGRETNEVPVSAEAETILATEGGKGALILSALGGAENITSLDNCITRLRLTVADMRL
VNDAELKAYGALGVVKLDEHSLQVVIGTQVHMVKNEIQSLMATPA
>Mature_525_residues
MQQKANKTTLWEFLQSLGKTFMVPVALLAFSGILLGIGSSFSSAALKEAMPFFDNVILQYIFIWMTKIGLVAFIYLPVMF
AIAIPMGLAREEKGVAAFSGLVGYAALNLSINFYLTVTGALDSEALRQSYGVTSILGTESIDTGILGAVIVGIIVAKLHT
RFYTFKMPDALAFFGGARFVPIISSLTLGVVGLLVPFIWPYFAAGINGIGYAIAGAGDFGPFLFGAGERLLLPIGLHHIL
VALIRFTEAGGTMEVCGDTVSGALNIFYSELSCPDTQGFTPSVTAFLSQGKMPAFLGGLPGAALAMYHCSKVENRSKIKA
LLISGVVACVVGGITEPLEFLFLFVAPVLYFIHAMLTGLGFMVMGMLDVTIGNTDGNIIDFLVFGVLQGTATKWYLVPVV
AGVWFTIYYFVFKFAILKFNLKTPGRETNEVPVSAEAETILATEGGKGALILSALGGAENITSLDNCITRLRLTVADMRL
VNDAELKAYGALGVVKLDEHSLQVVIGTQVHMVKNEIQSLMATPA

Specific function: MalX encodes a phosphotransferase system enzyme II that can recognize glucose and maltose as substrates even though these sugars may not represent the natural substrates of the system [H]

COG id: COG1263

COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787908, Length=527, Percent_Identity=66.4136622390892, Blast_Score=704, Evalue=0.0,
Organism=Escherichia coli, GI1787343, Length=510, Percent_Identity=35.0980392156863, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1786894, Length=514, Percent_Identity=33.6575875486381, Blast_Score=217, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018113
- InterPro:   IPR004719
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013
- InterPro:   IPR011535
- InterPro:   IPR011301 [H]

Pfam domain/function: PF00367 PTS_EIIB; PF02378 PTS_EIIC [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 56040; Mature: 56040

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS01035 PTS_EIIB_TYPE_1_CYS ; PS51098 PTS_EIIB_TYPE_1 ; PS51103 PTS_EIIC_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQKANKTTLWEFLQSLGKTFMVPVALLAFSGILLGIGSSFSSAALKEAMPFFDNVILQY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IFIWMTKIGLVAFIYLPVMFAIAIPMGLAREEKGVAAFSGLVGYAALNLSINFYLTVTGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEEEEEEEEEEEECC
LDSEALRQSYGVTSILGTESIDTGILGAVIVGIIVAKLHTRFYTFKMPDALAFFGGARFV
CCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHCCCHHH
PIISSLTLGVVGLLVPFIWPYFAAGINGIGYAIAGAGDFGPFLFGAGERLLLPIGLHHIL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHCCCCCEEEHHHHHHHH
VALIRFTEAGGTMEVCGDTVSGALNIFYSELSCPDTQGFTPSVTAFLSQGKMPAFLGGLP
HHHHHHHCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHCCCC
GAALAMYHCSKVENRSKIKALLISGVVACVVGGITEPLEFLFLFVAPVLYFIHAMLTGLG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FMVMGMLDVTIGNTDGNIIDFLVFGVLQGTATKWYLVPVVAGVWFTIYYFVFKFAILKFN
HHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEE
LKTPGRETNEVPVSAEAETILATEGGKGALILSALGGAENITSLDNCITRLRLTVADMRL
CCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
VNDAELKAYGALGVVKLDEHSLQVVIGTQVHMVKNEIQSLMATPA
CCCCHHHHHCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQQKANKTTLWEFLQSLGKTFMVPVALLAFSGILLGIGSSFSSAALKEAMPFFDNVILQY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IFIWMTKIGLVAFIYLPVMFAIAIPMGLAREEKGVAAFSGLVGYAALNLSINFYLTVTGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEEEEEEEEEEEECC
LDSEALRQSYGVTSILGTESIDTGILGAVIVGIIVAKLHTRFYTFKMPDALAFFGGARFV
CCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHCCCHHH
PIISSLTLGVVGLLVPFIWPYFAAGINGIGYAIAGAGDFGPFLFGAGERLLLPIGLHHIL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHCCCCCEEEHHHHHHHH
VALIRFTEAGGTMEVCGDTVSGALNIFYSELSCPDTQGFTPSVTAFLSQGKMPAFLGGLP
HHHHHHHCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHCCCC
GAALAMYHCSKVENRSKIKALLISGVVACVVGGITEPLEFLFLFVAPVLYFIHAMLTGLG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FMVMGMLDVTIGNTDGNIIDFLVFGVLQGTATKWYLVPVVAGVWFTIYYFVFKFAILKFN
HHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEE
LKTPGRETNEVPVSAEAETILATEGGKGALILSALGGAENITSLDNCITRLRLTVADMRL
CCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
VNDAELKAYGALGVVKLDEHSLQVVIGTQVHMVKNEIQSLMATPA
CCCCHHHHHCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1856179; 9097039; 9278503; 2670898 [H]