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The map label for this gene is tpm

Identifier: 59712119

GI number: 59712119

Start: 1686716

End: 1687357

Strand: Reverse

Name: tpm

Synonym: VF_1512

Alternate gene names: 59712119

Gene position: 1687357-1686716 (Counterclockwise)

Preceding gene: 59712121

Following gene: 59712118

Centisome position: 58.23

GC content: 38.79

Gene sequence:

>642_bases
ATGGAACATGAGTTTTGGCAAAAAAAATGGGCAAGTAATGTCATTGGTTTCCACCTGCCTGATACTAATCCAATTTTAAC
TCAATATTGGTCAGCTCTAGAGCCAAAAAGAAATGAAACTGTTTTTGTTCCATTGTGTGGTAAATCAATGGATCTTGATT
GGTTAGCTGAACGTCATAATTCAGTAACAGGGGTAGAGCTGAGTCAGATAGCCGTTCGTGCTTTCTTTGCTGAACGTTTG
TATACACCGACAGTGACACAATTAAGTAGCACCCTAGAACTTTATGAGTTTGATGAGTTCACTATTTATTCAGGTGATTA
CTTTGTTGCTCCTATTGAAGCCGCTGATTTAATTTATGATCGCGCCGCATTAGTTGCTCTACCAAAAGAGATGCGTGAAG
AATACGTTCAAGTGTTACGTAGTCGATTAAAAGAAGGTGGGCGTATATTATTAGTAACGCTAGATTACGACCAAAATGAA
ATGGCTGGACCTCCGTTCTCTGTACCTGAAAATGAGGTGCAAGCGTTGTTCTCGGGAATGAAAATTACACGATTACAACG
AGATGAAGCTGATGCAGAACACCCTAAAATTAAAAAAGGATTATCTCGTTTTGCTGAAGAAGTGTGGTTAATTGAAAGTT
AG

Upstream 100 bases:

>100_bases
ATTAAGTTATAGATATTGTCGTTATCGTTTAACACCTAGAACAAAAGTATGTGATGCGGTACCATTTCAGCATAAAAATA
AGCTAAATAAAGGAAAGTAA

Downstream 100 bases:

>100_bases
TCAATAAAAATGAAGTGATTATGTAAGAAGGCTATCAAGTTTGTTTGATGGCCTTTTTTGTTGTTAATGAGTTACGCATC
ATAAATTTGTAATTTGCCTT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MEHEFWQKKWASNVIGFHLPDTNPILTQYWSALEPKRNETVFVPLCGKSMDLDWLAERHNSVTGVELSQIAVRAFFAERL
YTPTVTQLSSTLELYEFDEFTIYSGDYFVAPIEAADLIYDRAALVALPKEMREEYVQVLRSRLKEGGRILLVTLDYDQNE
MAGPPFSVPENEVQALFSGMKITRLQRDEADAEHPKIKKGLSRFAEEVWLIES

Sequences:

>Translated_213_residues
MEHEFWQKKWASNVIGFHLPDTNPILTQYWSALEPKRNETVFVPLCGKSMDLDWLAERHNSVTGVELSQIAVRAFFAERL
YTPTVTQLSSTLELYEFDEFTIYSGDYFVAPIEAADLIYDRAALVALPKEMREEYVQVLRSRLKEGGRILLVTLDYDQNE
MAGPPFSVPENEVQALFSGMKITRLQRDEADAEHPKIKKGLSRFAEEVWLIES
>Mature_213_residues
MEHEFWQKKWASNVIGFHLPDTNPILTQYWSALEPKRNETVFVPLCGKSMDLDWLAERHNSVTGVELSQIAVRAFFAERL
YTPTVTQLSSTLELYEFDEFTIYSGDYFVAPIEAADLIYDRAALVALPKEMREEYVQVLRSRLKEGGRILLVTLDYDQNE
MAGPPFSVPENEVQALFSGMKITRLQRDEADAEHPKIKKGLSRFAEEVWLIES

Specific function: Unknown

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=217, Percent_Identity=31.7972350230415, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_VIBF1 (Q5E4N9)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_204895.1
- ProteinModelPortal:   Q5E4N9
- SMR:   Q5E4N9
- STRING:   Q5E4N9
- GeneID:   3278795
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_1512
- NMPDR:   fig|312309.3.peg.1512
- eggNOG:   COG0500
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- ProtClustDB:   PRK13255
- BioCyc:   VFIS312309:VF1512-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 24538; Mature: 24538

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHEFWQKKWASNVIGFHLPDTNPILTQYWSALEPKRNETVFVPLCGKSMDLDWLAERHN
CCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCC
SVTGVELSQIAVRAFFAERLYTPTVTQLSSTLELYEFDEFTIYSGDYFVAPIEAADLIYD
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCEEEECCCEEEECHHHHHHHHH
RAALVALPKEMREEYVQVLRSRLKEGGRILLVTLDYDQNEMAGPPFSVPENEVQALFSGM
HHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCC
KITRLQRDEADAEHPKIKKGLSRFAEEVWLIES
HHEEHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEHEFWQKKWASNVIGFHLPDTNPILTQYWSALEPKRNETVFVPLCGKSMDLDWLAERHN
CCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCC
SVTGVELSQIAVRAFFAERLYTPTVTQLSSTLELYEFDEFTIYSGDYFVAPIEAADLIYD
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCEEEECCCEEEECHHHHHHHHH
RAALVALPKEMREEYVQVLRSRLKEGGRILLVTLDYDQNEMAGPPFSVPENEVQALFSGM
HHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCC
KITRLQRDEADAEHPKIKKGLSRFAEEVWLIES
HHEEHHCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA