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The map label for this gene is sbcB [H]

Identifier: 59712089

GI number: 59712089

Start: 1640693

End: 1642117

Strand: Direct

Name: sbcB [H]

Synonym: VF_1482

Alternate gene names: 59712089

Gene position: 1640693-1642117 (Clockwise)

Preceding gene: 59712088

Following gene: 59712090

Centisome position: 56.62

GC content: 40.35

Gene sequence:

>1425_bases
ATGCCACAAAACAATGCACCTAGTTTCTTCTTCTTTGATTATGAAACATGGGGAACTAGCCCTTCTCTTGATCGACCGTG
CCAATTTGCTGGTGTCCGCACTGATGAAGATTTCAATATTATCGGTGAGCCTTTAGTTATTTACTGCCGTCCTCCAGTTG
ATTACCTTCCCTCACCTGAAGCATGTTTGATTACGGGTATTACGCCACAAACAGCCGTTAATAAAGGGCTTTCTGAACCA
GAATTTATTGCCAAAATTCATCATGAATTATCACAGCCTAATACGTGTTCTTTAGGTTATAACAACATTCGTTTTGATGA
TGAGGTTTCTCGTTACACGCTTTATCGTAACTTCTTTGAGCCTTACGGTTGGAGCTGGCAAAACGGCAACTCTCGTTGGG
ATCTATTAGATGTAATGCGTGCGGTTTATGCACTTCGCCCTGAAGGCATTAATTGGCCTAAAGATGAAGAAGGCAGACCA
AGTTTTAAACTGGAAAACCTGTCTGTTGCTAATGGCATTGAACACGCCAATGCCCACGATGCAATGGCCGATGTTATCGC
AACCATTGAGCTGGCTAAAAAAGTAAAACAAGCGCAGCCAAAAATGTTTAACTATTTGCTTTCTATGCGTAACAAGAAGA
AAGCAGCAACATTAATCGACATAGTTGAAATGACACCACTGATGCATGTTTCAGGCATGTTTGGTGTAGATAGAGGTAAC
ATCAGTTGGATAGTGCCTGTGGCTTGGCATCCAACCAATAACAATGCCGTTATTACTATTGATTTGGCTTTAGATCCAAG
TGTTTTTCTTGAGTTGAATGTTGAAGAACTGCATCAGCGTATGTACACCAAACGTTCTGAACTTGGCCCTGATGAGCTTC
CTGTTCCTGTTAAATTAGTGCATTTAAATAAGTGCCCTGTTCTTGCGCCTGCAAAAACATTAACTGCTGAAAATGCCGCT
AATTTGAATGTTGACCGTGAAGCGTGTTTACGTAATCTTAAAGTGATACGTGAAAATCCTGAGATCAGACAAAAACTGAT
TGAGCTGTACAGCATTGAGCCAAACTACGAAAAATCAACTAATGTAGATACACTTCTTTACGATGGTTTCTTCTCTCATG
CTGATAAAGCGACCATTGATATTATTCGTCAATCAACGCCTGAGCAGTTAATTGACTTTGAACCAAACGTGACAGATCCA
CGTATCAAACCACTGTTATTCCGATACCGTGCACGTAACTTCCCGCACACATTAAACGAAGCTGAGCAATTAAGATGGCA
CGCTCACCTTCAAGACTATTTTCAAACTCACTTGCCAGATTATGAAGCGAGTTTTGAAAATCTATACCTTGAGTCCGAAG
GTAATGACAAAAAAGTGGCTATTTTAAAAGCCGTGTATAACTACGTACAACAATTAATATCATGA

Upstream 100 bases:

>100_bases
AGCGGCACACTAATTTTTCTTCACCTTCCCTCCCTAATGCCTTGCGATTGTGTGATAGATCTCTGATAATCAATGTATTG
CTTATCATTGGACATCACTT

Downstream 100 bases:

>100_bases
TTAAATATCTTTATTCTTTCGCTTGGATCTTCGCCTCGTTGTTTGCTGGTAACGGCATTCAATCTTGGTTGAACATATCT
GTTCCGGGAAGCATTATTGG

Product: exonuclease I

Products: NA

Alternate protein names: Exonuclease I; DNA deoxyribophosphodiesterase; dRPase [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MPQNNAPSFFFFDYETWGTSPSLDRPCQFAGVRTDEDFNIIGEPLVIYCRPPVDYLPSPEACLITGITPQTAVNKGLSEP
EFIAKIHHELSQPNTCSLGYNNIRFDDEVSRYTLYRNFFEPYGWSWQNGNSRWDLLDVMRAVYALRPEGINWPKDEEGRP
SFKLENLSVANGIEHANAHDAMADVIATIELAKKVKQAQPKMFNYLLSMRNKKKAATLIDIVEMTPLMHVSGMFGVDRGN
ISWIVPVAWHPTNNNAVITIDLALDPSVFLELNVEELHQRMYTKRSELGPDELPVPVKLVHLNKCPVLAPAKTLTAENAA
NLNVDREACLRNLKVIRENPEIRQKLIELYSIEPNYEKSTNVDTLLYDGFFSHADKATIDIIRQSTPEQLIDFEPNVTDP
RIKPLLFRYRARNFPHTLNEAEQLRWHAHLQDYFQTHLPDYEASFENLYLESEGNDKKVAILKAVYNYVQQLIS

Sequences:

>Translated_474_residues
MPQNNAPSFFFFDYETWGTSPSLDRPCQFAGVRTDEDFNIIGEPLVIYCRPPVDYLPSPEACLITGITPQTAVNKGLSEP
EFIAKIHHELSQPNTCSLGYNNIRFDDEVSRYTLYRNFFEPYGWSWQNGNSRWDLLDVMRAVYALRPEGINWPKDEEGRP
SFKLENLSVANGIEHANAHDAMADVIATIELAKKVKQAQPKMFNYLLSMRNKKKAATLIDIVEMTPLMHVSGMFGVDRGN
ISWIVPVAWHPTNNNAVITIDLALDPSVFLELNVEELHQRMYTKRSELGPDELPVPVKLVHLNKCPVLAPAKTLTAENAA
NLNVDREACLRNLKVIRENPEIRQKLIELYSIEPNYEKSTNVDTLLYDGFFSHADKATIDIIRQSTPEQLIDFEPNVTDP
RIKPLLFRYRARNFPHTLNEAEQLRWHAHLQDYFQTHLPDYEASFENLYLESEGNDKKVAILKAVYNYVQQLIS
>Mature_473_residues
PQNNAPSFFFFDYETWGTSPSLDRPCQFAGVRTDEDFNIIGEPLVIYCRPPVDYLPSPEACLITGITPQTAVNKGLSEPE
FIAKIHHELSQPNTCSLGYNNIRFDDEVSRYTLYRNFFEPYGWSWQNGNSRWDLLDVMRAVYALRPEGINWPKDEEGRPS
FKLENLSVANGIEHANAHDAMADVIATIELAKKVKQAQPKMFNYLLSMRNKKKAATLIDIVEMTPLMHVSGMFGVDRGNI
SWIVPVAWHPTNNNAVITIDLALDPSVFLELNVEELHQRMYTKRSELGPDELPVPVKLVHLNKCPVLAPAKTLTAENAAN
LNVDREACLRNLKVIRENPEIRQKLIELYSIEPNYEKSTNVDTLLYDGFFSHADKATIDIIRQSTPEQLIDFEPNVTDPR
IKPLLFRYRARNFPHTLNEAEQLRWHAHLQDYFQTHLPDYEASFENLYLESEGNDKKVAILKAVYNYVQQLIS

Specific function: Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase [H]

COG id: COG2925

COG function: function code L; Exonuclease I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788321, Length=467, Percent_Identity=55.6745182012848, Blast_Score=549, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013620
- InterPro:   IPR013520
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00929 Exonuc_X-T; PF08411 Exonuc_X-T_C [H]

EC number: =3.1.11.1 [H]

Molecular weight: Translated: 54356; Mature: 54225

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQNNAPSFFFFDYETWGTSPSLDRPCQFAGVRTDEDFNIIGEPLVIYCRPPVDYLPSPE
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCC
ACLITGITPQTAVNKGLSEPEFIAKIHHELSQPNTCSLGYNNIRFDDEVSRYTLYRNFFE
CEEEECCCCHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHC
PYGWSWQNGNSRWDLLDVMRAVYALRPEGINWPKDEEGRPSFKLENLSVANGIEHANAHD
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCHHCCCCCCCHHH
AMADVIATIELAKKVKQAQPKMFNYLLSMRNKKKAATLIDIVEMTPLMHVSGMFGVDRGN
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEECCCC
ISWIVPVAWHPTNNNAVITIDLALDPSVFLELNVEELHQRMYTKRSELGPDELPVPVKLV
EEEEEEEEEECCCCCEEEEEEEEECCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCEEEE
HLNKCPVLAPAKTLTAENAANLNVDREACLRNLKVIRENPEIRQKLIELYSIEPNYEKST
EECCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC
NVDTLLYDGFFSHADKATIDIIRQSTPEQLIDFEPNVTDPRIKPLLFRYRARNFPHTLNE
CCCEEEECCHHHCCCHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHCH
AEQLRWHAHLQDYFQTHLPDYEASFENLYLESEGNDKKVAILKAVYNYVQQLIS
HHHHHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
PQNNAPSFFFFDYETWGTSPSLDRPCQFAGVRTDEDFNIIGEPLVIYCRPPVDYLPSPE
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCC
ACLITGITPQTAVNKGLSEPEFIAKIHHELSQPNTCSLGYNNIRFDDEVSRYTLYRNFFE
CEEEECCCCHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHC
PYGWSWQNGNSRWDLLDVMRAVYALRPEGINWPKDEEGRPSFKLENLSVANGIEHANAHD
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCHHCCCCCCCHHH
AMADVIATIELAKKVKQAQPKMFNYLLSMRNKKKAATLIDIVEMTPLMHVSGMFGVDRGN
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEECCCC
ISWIVPVAWHPTNNNAVITIDLALDPSVFLELNVEELHQRMYTKRSELGPDELPVPVKLV
EEEEEEEEEECCCCCEEEEEEEEECCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCEEEE
HLNKCPVLAPAKTLTAENAANLNVDREACLRNLKVIRENPEIRQKLIELYSIEPNYEKST
EECCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC
NVDTLLYDGFFSHADKATIDIIRQSTPEQLIDFEPNVTDPRIKPLLFRYRARNFPHTLNE
CCCEEEECCHHHCCCHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHCH
AEQLRWHAHLQDYFQTHLPDYEASFENLYLESEGNDKKVAILKAVYNYVQQLIS
HHHHHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3539937; 9097040; 9278503; 1329027 [H]