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The map label for this gene is mrdA [H]

Identifier: 59712088

GI number: 59712088

Start: 1638591

End: 1640501

Strand: Direct

Name: mrdA [H]

Synonym: VF_1481

Alternate gene names: 59712088

Gene position: 1638591-1640501 (Clockwise)

Preceding gene: 59712085

Following gene: 59712089

Centisome position: 56.55

GC content: 36.42

Gene sequence:

>1911_bases
ATGTCTAAACAAAAAACACCATTTCGAAACCACCAATTTGAAACATCATTATTTAATCAGCGTGTGATTGTTGCTTTTCT
ATTTATGTTGGTTGCTATTGGCGGTTTGGTTTTTAATTTATATCACTTACAAGTAAGAAATCACGATAGGTATCAGGTTC
GCTCAAATAGAAATCGCATTAAAATAATTCCTGTAGCACCAAATCGTGGCCTCATTTACGACCGAAATGGCGTCGTATTA
GCGCAAAATATACCCGTTTCAACTCTAGAGTTAACCCCGGCAAAAATTGATGATATCAACGCAACTCTTACCTCATTACA
AAAATTATTAAATTTAAGTGACCATGACATAGCGAAATTTAAAAAATTAATGCATCGAACCCGAAGTACCAAGCCTATTA
CTCTCATAGAGCAAATGAGTGAAGTACAAATTGCTAAATTTTCTGTGAATCAATTTCATTATAATGGCACTAACATTAAC
GCCTATCTTGAACGATATTACCCATATGGTGAAAGCCTCACTCACGTTTTGGGCTATGTCGGAAAGATTAACGACCGCGA
TATTCGAACTCTTAAAAAAGACAATAGATACACAAATTATGAAGGAACTCATGCTATAGGAAAGTTAGGTATTGAGCTCT
ATTATGAAAGCACATTACATGGTAAATCAGGCTATCAAAAGGTAGAAATAAACAGCCATGGACGCATAGTACGAACTCTT
GACTATGTGGCACCAATACCAGGTAAAGACATTAAATTAAATATTGATTTAGGCTTGCAGTTATACGCCTACAACCAACT
AAAAATAAAAAAAGAAAACCCAATCACTCATAAAATGGAAGATTATCATCGTCGTGGTTCTATTGTTGTTTTAGACCCTA
GAGATGACTCTGTATTGGCCATGGTATCGAGCCCTAGCTATGATCCAAATCTATTTGTTCATGGCATTTCTTCAAAACAT
TACAATGCATTATTAAACAACCCTGATCTTCCATTATTAAATAGAACAACTTTAGGTATTTATCCTCCTGGCTCTACCGT
AAAACCACAAATAGCAGTAGCTGCATTAAGTGAAAAAGTCATCACACCGAATACAACCACCAACTTTCCTGGTTGGTGGC
GAATTCCACACTCAAAAAGTCGTAAATTTAGAGATGATATACGTTGGGGTCATGGTGAAGTTAATGTCGTAAAAGCCATT
GAAAAATCAGTAGATACCTTCTTTTATCAAGTTGCATACGATATGGGAATAGACCGATTATCAACATGGATGAATAAATT
TGGTTATGGTAAACCATCAGGGATTGATATAAGAGAAGAGAGCCCTGCCAATATGCCTACTCGGGATTGGAAACACTCAA
ACTATCACCAAGCTTGGTATAAAGGCGATACTATCCCTGTTGGAATTGGACAAGGTTATTGGACTGCAACCCCAATGCAA
ATTGCAAAAGCCACTGCGGTTATAGCAGATGAAGGCATTGTTCACCGACCACACTTATTAAAATCAGTCATGGAAGATGG
GAAGTTTAAGCCAATAATATTTAAAGATTTCCCGAAAGTTAATCACACTAAAAAACAGTATTGGAATTTAGCAAAAGAAG
GAATGCATCGAGTAATTGTATCTGGTACTGCTCGAAAATTATTTCAAAATTTAGCTTATAAAGCTGGTGGTAAAACAGGA
ACAAGTCAGGTATTTGGTTTAGATAAAGGGGAGGAATATAATTCTGAAGACGTCGCTGAACACCTTCGTGATCATGCTTT
GTTTACTAGCTTTGCTCCTTTAGATAAGCCCAAAGTTTTAGTTGCGGCGGTATTAGAGAATGCTGGTTGGGGGAAATATG
CAGCCCCTATTGGTCGTAACATAATGGATTACGTATTAATCAATCCCAAAATTAGTTTAGATCATACTTAG

Upstream 100 bases:

>100_bases
TAAGTATATTGACAGCATATTCATTACATTCTCACGCATAGCAAATTTTAATTAATATTAAAGAGAAGTATTCAGCATTT
GATGCCATTTAAGAGTTTTC

Downstream 100 bases:

>100_bases
TACCGAACAACTGCCTTATCAATATAACACGAGTAGTTATACCTCAATCATCGAAATTAAATGCCGTTTGCAAATAAAAA
ATATATTTACAAGCGGCACA

Product: penicillin binding protein transpeptidase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MSKQKTPFRNHQFETSLFNQRVIVAFLFMLVAIGGLVFNLYHLQVRNHDRYQVRSNRNRIKIIPVAPNRGLIYDRNGVVL
AQNIPVSTLELTPAKIDDINATLTSLQKLLNLSDHDIAKFKKLMHRTRSTKPITLIEQMSEVQIAKFSVNQFHYNGTNIN
AYLERYYPYGESLTHVLGYVGKINDRDIRTLKKDNRYTNYEGTHAIGKLGIELYYESTLHGKSGYQKVEINSHGRIVRTL
DYVAPIPGKDIKLNIDLGLQLYAYNQLKIKKENPITHKMEDYHRRGSIVVLDPRDDSVLAMVSSPSYDPNLFVHGISSKH
YNALLNNPDLPLLNRTTLGIYPPGSTVKPQIAVAALSEKVITPNTTTNFPGWWRIPHSKSRKFRDDIRWGHGEVNVVKAI
EKSVDTFFYQVAYDMGIDRLSTWMNKFGYGKPSGIDIREESPANMPTRDWKHSNYHQAWYKGDTIPVGIGQGYWTATPMQ
IAKATAVIADEGIVHRPHLLKSVMEDGKFKPIIFKDFPKVNHTKKQYWNLAKEGMHRVIVSGTARKLFQNLAYKAGGKTG
TSQVFGLDKGEEYNSEDVAEHLRDHALFTSFAPLDKPKVLVAAVLENAGWGKYAAPIGRNIMDYVLINPKISLDHT

Sequences:

>Translated_636_residues
MSKQKTPFRNHQFETSLFNQRVIVAFLFMLVAIGGLVFNLYHLQVRNHDRYQVRSNRNRIKIIPVAPNRGLIYDRNGVVL
AQNIPVSTLELTPAKIDDINATLTSLQKLLNLSDHDIAKFKKLMHRTRSTKPITLIEQMSEVQIAKFSVNQFHYNGTNIN
AYLERYYPYGESLTHVLGYVGKINDRDIRTLKKDNRYTNYEGTHAIGKLGIELYYESTLHGKSGYQKVEINSHGRIVRTL
DYVAPIPGKDIKLNIDLGLQLYAYNQLKIKKENPITHKMEDYHRRGSIVVLDPRDDSVLAMVSSPSYDPNLFVHGISSKH
YNALLNNPDLPLLNRTTLGIYPPGSTVKPQIAVAALSEKVITPNTTTNFPGWWRIPHSKSRKFRDDIRWGHGEVNVVKAI
EKSVDTFFYQVAYDMGIDRLSTWMNKFGYGKPSGIDIREESPANMPTRDWKHSNYHQAWYKGDTIPVGIGQGYWTATPMQ
IAKATAVIADEGIVHRPHLLKSVMEDGKFKPIIFKDFPKVNHTKKQYWNLAKEGMHRVIVSGTARKLFQNLAYKAGGKTG
TSQVFGLDKGEEYNSEDVAEHLRDHALFTSFAPLDKPKVLVAAVLENAGWGKYAAPIGRNIMDYVLINPKISLDHT
>Mature_635_residues
SKQKTPFRNHQFETSLFNQRVIVAFLFMLVAIGGLVFNLYHLQVRNHDRYQVRSNRNRIKIIPVAPNRGLIYDRNGVVLA
QNIPVSTLELTPAKIDDINATLTSLQKLLNLSDHDIAKFKKLMHRTRSTKPITLIEQMSEVQIAKFSVNQFHYNGTNINA
YLERYYPYGESLTHVLGYVGKINDRDIRTLKKDNRYTNYEGTHAIGKLGIELYYESTLHGKSGYQKVEINSHGRIVRTLD
YVAPIPGKDIKLNIDLGLQLYAYNQLKIKKENPITHKMEDYHRRGSIVVLDPRDDSVLAMVSSPSYDPNLFVHGISSKHY
NALLNNPDLPLLNRTTLGIYPPGSTVKPQIAVAALSEKVITPNTTTNFPGWWRIPHSKSRKFRDDIRWGHGEVNVVKAIE
KSVDTFFYQVAYDMGIDRLSTWMNKFGYGKPSGIDIREESPANMPTRDWKHSNYHQAWYKGDTIPVGIGQGYWTATPMQI
AKATAVIADEGIVHRPHLLKSVMEDGKFKPIIFKDFPKVNHTKKQYWNLAKEGMHRVIVSGTARKLFQNLAYKAGGKTGT
SQVFGLDKGEEYNSEDVAEHLRDHALFTSFAPLDKPKVLVAAVLENAGWGKYAAPIGRNIMDYVLINPKISLDHT

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=627, Percent_Identity=51.1961722488038, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=642, Percent_Identity=23.0529595015576, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 72315; Mature: 72184

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQKTPFRNHQFETSLFNQRVIVAFLFMLVAIGGLVFNLYHLQVRNHDRYQVRSNRNRI
CCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEECCCCEE
KIIPVAPNRGLIYDRNGVVLAQNIPVSTLELTPAKIDDINATLTSLQKLLNLSDHDIAKF
EEEEECCCCCEEEECCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHH
KKLMHRTRSTKPITLIEQMSEVQIAKFSVNQFHYNGTNINAYLERYYPYGESLTHVLGYV
HHHHHHHCCCCCCHHHHHHHHHEEEEEEEEEEEECCCCCEEHHHHHCCCCHHHHHHHHHH
GKINDRDIRTLKKDNRYTNYEGTHAIGKLGIELYYESTLHGKSGYQKVEINSHGRIVRTL
CCCCCCHHHHHHCCCCCCCCCCCHHHHHHCEEEEEECCCCCCCCCEEEEECCCCCEEEEE
DYVAPIPGKDIKLNIDLGLQLYAYNQLKIKKENPITHKMEDYHRRGSIVVLDPRDDSVLA
HHHCCCCCCCEEEEEEECEEEEEEEEEEEECCCCCCCCHHHHHHCCCEEEECCCCCCEEE
MVSSPSYDPNLFVHGISSKHYNALLNNPDLPLLNRTTLGIYPPGSTVKPQIAVAALSEKV
EEECCCCCCCEEEEECCCCCHHHHCCCCCCCEECCCEEEEECCCCCCCCCEEEEEHHCCE
ITPNTTTNFPGWWRIPHSKSRKFRDDIRWGHGEVNVVKAIEKSVDTFFYQVAYDMGIDRL
ECCCCCCCCCCEEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHH
STWMNKFGYGKPSGIDIREESPANMPTRDWKHSNYHQAWYKGDTIPVGIGQGYWTATPMQ
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCEEEEECCCCCCCCCHHH
IAKATAVIADEGIVHRPHLLKSVMEDGKFKPIIFKDFPKVNHTKKQYWNLAKEGMHRVIV
HHHHHEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHEEEE
SGTARKLFQNLAYKAGGKTGTSQVFGLDKGEEYNSEDVAEHLRDHALFTSFAPLDKPKVL
CHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
VAAVLENAGWGKYAAPIGRNIMDYVLINPKISLDHT
HHHHHHCCCCCCCCCHHCCCCEEEEEECCEEECCCC
>Mature Secondary Structure 
SKQKTPFRNHQFETSLFNQRVIVAFLFMLVAIGGLVFNLYHLQVRNHDRYQVRSNRNRI
CCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEECCCCEE
KIIPVAPNRGLIYDRNGVVLAQNIPVSTLELTPAKIDDINATLTSLQKLLNLSDHDIAKF
EEEEECCCCCEEEECCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHH
KKLMHRTRSTKPITLIEQMSEVQIAKFSVNQFHYNGTNINAYLERYYPYGESLTHVLGYV
HHHHHHHCCCCCCHHHHHHHHHEEEEEEEEEEEECCCCCEEHHHHHCCCCHHHHHHHHHH
GKINDRDIRTLKKDNRYTNYEGTHAIGKLGIELYYESTLHGKSGYQKVEINSHGRIVRTL
CCCCCCHHHHHHCCCCCCCCCCCHHHHHHCEEEEEECCCCCCCCCEEEEECCCCCEEEEE
DYVAPIPGKDIKLNIDLGLQLYAYNQLKIKKENPITHKMEDYHRRGSIVVLDPRDDSVLA
HHHCCCCCCCEEEEEEECEEEEEEEEEEEECCCCCCCCHHHHHHCCCEEEECCCCCCEEE
MVSSPSYDPNLFVHGISSKHYNALLNNPDLPLLNRTTLGIYPPGSTVKPQIAVAALSEKV
EEECCCCCCCEEEEECCCCCHHHHCCCCCCCEECCCEEEEECCCCCCCCCEEEEEHHCCE
ITPNTTTNFPGWWRIPHSKSRKFRDDIRWGHGEVNVVKAIEKSVDTFFYQVAYDMGIDRL
ECCCCCCCCCCEEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHH
STWMNKFGYGKPSGIDIREESPANMPTRDWKHSNYHQAWYKGDTIPVGIGQGYWTATPMQ
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCEEEEECCCCCCCCCHHH
IAKATAVIADEGIVHRPHLLKSVMEDGKFKPIIFKDFPKVNHTKKQYWNLAKEGMHRVIV
HHHHHEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHEEEE
SGTARKLFQNLAYKAGGKTGTSQVFGLDKGEEYNSEDVAEHLRDHALFTSFAPLDKPKVL
CHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
VAAVLENAGWGKYAAPIGRNIMDYVLINPKISLDHT
HHHHHHCCCCCCCCCHHCCCCEEEEEECCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]