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The map label for this gene is hipA [H]

Identifier: 59712077

GI number: 59712077

Start: 1627960

End: 1629279

Strand: Direct

Name: hipA [H]

Synonym: VF_1470

Alternate gene names: 59712077

Gene position: 1627960-1629279 (Clockwise)

Preceding gene: 59712076

Following gene: 59712080

Centisome position: 56.18

GC content: 37.2

Gene sequence:

>1320_bases
ATGGCTATATTAATTGCATACATGAATGGTGAGCGCGTTGGAGAATTTACTAAACTCAGTAACGGTGCACACCAGTTTCA
ATACGATAAATCATGGATTGAAAGCACGGTAGGAAGACCTCTTTCATTATCCCTCCCCCTACAGTATCCAAAGATAACCA
GTGATTGCGTTATTAATTACTTCGACAACCTATTACCTGATTTATCAGAAGTCAGAGATCGCATCGTTGCCAGATACCAA
GCTAAATCTCGTCAAACGTTCGATTTACTTCATGAAGTTGGAAAAGACAGCGTCGGTGCAATTTCTTTATTAACTAACGA
TGAAGAACCAAATACCAAACAACTGGATTATGAAGTTTTAACTCCAGCACGGCTCAAACAAGTACTCTCAGCCTATCAGT
CCAATATCCCATTAGGAATGTTAGAAGATGAATCAGACTTTCGAATTTCGGTTGCCGGAGCACAAGAAAAAACAGCATTA
CTCAGAATAAATAATGAATGGTGTATACCTAAGGCATCAACGCCAACAACACATATTATCAAATTACCCATAGGTAAAAT
TCAGCAACCTAATGCCACTCTCGATATGAGTGATAGTGTAGAAAATGAATACCTGTGCATCCAATTAGCGAAGAAGCTAG
GATTCAATGTACCTAATGTTGAAATAATTCATAGTGATGGAATAAAAGCCATTGCTGTAGAACGATTTGATAGACGATGG
ATTAAAAATAACACCAAGCTATTAAGATTACCGCAAGAAGATATGTGCCAAGCATTTGGATTGCCATCATCAATCAAATA
TGAAGCAGATGGAGGCCCAAGTATAAAAACCATTATGGATCTTCTAATGGGCTCAAGCCAATCACTAAAAGATCGTGATG
CTTTCATGCGATTTCAGGTATTTCAATGGTTAATCGGTGCAACAGATGGACACGCAAAAAACTTCTCCATTTTTATTAAT
GCACAAGGCAGTTATCACCTTACGCCCTTTTATGACATTTTATCCGCCTACCCAATCTTAGGTGGTAAAGGGATGAATAT
TCGCTCATTAAAACTAGCAATGGGACTAACAGCATCGAAAGGAAAGAAATACCCTATTGATAAAATATACACACGTCATT
TTATTGATACGGCTAAAGCTGTTGGATTTGATACTGCGAGAATGGAGGAAATAATGAAAGAATTTGCGATAAATATGCCT
AATGCCATTAAGGAATTAGAAGCACAATTACCAAGCGATTTTCCAAAAGATATCTCTGACAGCATATTCAGTAATGCTTT
GAGAATGGTAAATAAGATCCGCTTGAGTAATGATTTATAA

Upstream 100 bases:

>100_bases
AGACACTCTTTAAGATCCTTCATGCATTAGAAGTTCATTGCATTATTCAAGAGCAAGTCCCAGCAAGTCACGAAGACAAT
CTAGACGATGAGGCGTGGTA

Downstream 100 bases:

>100_bases
TTCGAGTGATTAAAAAATGGATGTAGGTATTGCCGGCATCCACTTTTCTAGTTAGCGAACTTGTTTTTGGAGAAAAATGA
GTTAGAAAAAACTAACTCAT

Product: HipA serine kinase, regulator with HipB, putative TA-system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MAILIAYMNGERVGEFTKLSNGAHQFQYDKSWIESTVGRPLSLSLPLQYPKITSDCVINYFDNLLPDLSEVRDRIVARYQ
AKSRQTFDLLHEVGKDSVGAISLLTNDEEPNTKQLDYEVLTPARLKQVLSAYQSNIPLGMLEDESDFRISVAGAQEKTAL
LRINNEWCIPKASTPTTHIIKLPIGKIQQPNATLDMSDSVENEYLCIQLAKKLGFNVPNVEIIHSDGIKAIAVERFDRRW
IKNNTKLLRLPQEDMCQAFGLPSSIKYEADGGPSIKTIMDLLMGSSQSLKDRDAFMRFQVFQWLIGATDGHAKNFSIFIN
AQGSYHLTPFYDILSAYPILGGKGMNIRSLKLAMGLTASKGKKYPIDKIYTRHFIDTAKAVGFDTARMEEIMKEFAINMP
NAIKELEAQLPSDFPKDISDSIFSNALRMVNKIRLSNDL

Sequences:

>Translated_439_residues
MAILIAYMNGERVGEFTKLSNGAHQFQYDKSWIESTVGRPLSLSLPLQYPKITSDCVINYFDNLLPDLSEVRDRIVARYQ
AKSRQTFDLLHEVGKDSVGAISLLTNDEEPNTKQLDYEVLTPARLKQVLSAYQSNIPLGMLEDESDFRISVAGAQEKTAL
LRINNEWCIPKASTPTTHIIKLPIGKIQQPNATLDMSDSVENEYLCIQLAKKLGFNVPNVEIIHSDGIKAIAVERFDRRW
IKNNTKLLRLPQEDMCQAFGLPSSIKYEADGGPSIKTIMDLLMGSSQSLKDRDAFMRFQVFQWLIGATDGHAKNFSIFIN
AQGSYHLTPFYDILSAYPILGGKGMNIRSLKLAMGLTASKGKKYPIDKIYTRHFIDTAKAVGFDTARMEEIMKEFAINMP
NAIKELEAQLPSDFPKDISDSIFSNALRMVNKIRLSNDL
>Mature_438_residues
AILIAYMNGERVGEFTKLSNGAHQFQYDKSWIESTVGRPLSLSLPLQYPKITSDCVINYFDNLLPDLSEVRDRIVARYQA
KSRQTFDLLHEVGKDSVGAISLLTNDEEPNTKQLDYEVLTPARLKQVLSAYQSNIPLGMLEDESDFRISVAGAQEKTALL
RINNEWCIPKASTPTTHIIKLPIGKIQQPNATLDMSDSVENEYLCIQLAKKLGFNVPNVEIIHSDGIKAIAVERFDRRWI
KNNTKLLRLPQEDMCQAFGLPSSIKYEADGGPSIKTIMDLLMGSSQSLKDRDAFMRFQVFQWLIGATDGHAKNFSIFINA
QGSYHLTPFYDILSAYPILGGKGMNIRSLKLAMGLTASKGKKYPIDKIYTRHFIDTAKAVGFDTARMEEIMKEFAINMPN
AIKELEAQLPSDFPKDISDSIFSNALRMVNKIRLSNDL

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=433, Percent_Identity=63.9722863741339, Blast_Score=590, Evalue=1e-170,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 49373; Mature: 49242

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILIAYMNGERVGEFTKLSNGAHQFQYDKSWIESTVGRPLSLSLPLQYPKITSDCVINY
CEEEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHH
FDNLLPDLSEVRDRIVARYQAKSRQTFDLLHEVGKDSVGAISLLTNDEEPNTKQLDYEVL
HHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEC
TPARLKQVLSAYQSNIPLGMLEDESDFRISVAGAQEKTALLRINNEWCIPKASTPTTHII
CHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEE
KLPIGKIQQPNATLDMSDSVENEYLCIQLAKKLGFNVPNVEIIHSDGIKAIAVERFDRRW
ECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEHHHHHHHHH
IKNNTKLLRLPQEDMCQAFGLPSSIKYEADGGPSIKTIMDLLMGSSQSLKDRDAFMRFQV
HHCCCEEEECCHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
FQWLIGATDGHAKNFSIFINAQGSYHLTPFYDILSAYPILGGKGMNIRSLKLAMGLTASK
HHHHHCCCCCCCCEEEEEEECCCCEECCHHHHHHHHCCCCCCCCCCEEEEHEEECCCCCC
GKKYPIDKIYTRHFIDTAKAVGFDTARMEEIMKEFAINMPNAIKELEAQLPSDFPKDISD
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHH
SIFSNALRMVNKIRLSNDL
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AILIAYMNGERVGEFTKLSNGAHQFQYDKSWIESTVGRPLSLSLPLQYPKITSDCVINY
EEEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHH
FDNLLPDLSEVRDRIVARYQAKSRQTFDLLHEVGKDSVGAISLLTNDEEPNTKQLDYEVL
HHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEC
TPARLKQVLSAYQSNIPLGMLEDESDFRISVAGAQEKTALLRINNEWCIPKASTPTTHII
CHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEE
KLPIGKIQQPNATLDMSDSVENEYLCIQLAKKLGFNVPNVEIIHSDGIKAIAVERFDRRW
ECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEHHHHHHHHH
IKNNTKLLRLPQEDMCQAFGLPSSIKYEADGGPSIKTIMDLLMGSSQSLKDRDAFMRFQV
HHCCCEEEECCHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
FQWLIGATDGHAKNFSIFINAQGSYHLTPFYDILSAYPILGGKGMNIRSLKLAMGLTASK
HHHHHCCCCCCCCEEEEEEECCCCEECCHHHHHHHHCCCCCCCCCCEEEEHEEECCCCCC
GKKYPIDKIYTRHFIDTAKAVGFDTARMEEIMKEFAINMPNAIKELEAQLPSDFPKDISD
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHH
SIFSNALRMVNKIRLSNDL
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]