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The map label for this gene is ribA

Identifier: 59711796

GI number: 59711796

Start: 1321249

End: 1321848

Strand: Direct

Name: ribA

Synonym: VF_1189

Alternate gene names: 59711796

Gene position: 1321249-1321848 (Clockwise)

Preceding gene: 59711795

Following gene: 59711797

Centisome position: 45.6

GC content: 36.17

Gene sequence:

>600_bases
ATGGCAAACGTAAGAGCTCGTATAGAGTTAATGGTAGGGCAAAAAAGTAATATCCCTGCGGAGATGCTTTCATTTGAAGG
GCTAGAGACTGACAAAGAGCACGTTGCTGTTGTTTTTAATCAAGCTGATAAACATCAATCCACTCCCTTAGTACGTATGC
ATTCTGAGTGTTTAACAGGGGATGTCTTTCATTCATCTCGTTGTGATTGTGGTGAACAATTAGAAGAAACTATTAATCGT
ATGTCTGAAAGTGGCGGTATTATTTTATACCTACGCCAAGAGGGACGCGGTATTGGTTTATATAATAAATTAGATGCTTA
TGAATTACAGAGCCAAGGTATGAATACCTATGAGGCAAATAATCATTTAGGATTTGGTGATGATTTACGTGACTTCAAAG
AAGCGGCACAAATGCTTGAAGCACTGAATATATCTAAGATAAAGCTAGTTACGAATAATCCAAAAAAGATTAAGGATATT
CAAAACTACGGTATTGAAATTGATGAAGTTGTTAATACTCATGCCCATGTAAAACAAGGCAACGAGCATTATTTACATTC
AAAGGCCGCACACGGGCATAAGTTAAATTTTGATAAATAA

Upstream 100 bases:

>100_bases
TTTTGATTCTTGCTTCCACGTTAGGGTATGCTTATGATCTTTTTATCTGATTAAGTCGTAGAAGATGTGATCTTCTCATT
AAAAAAGGCAGTAAATTAGC

Downstream 100 bases:

>100_bases
TATTGTCTTTATTATTAACTGTTAAAAACCTCACTTATTTGTGGGGTTTTTTTATGAGTTACACAAAATCGGTAAAATAA
ATGATAAGGATTTGCATTTA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MANVRARIELMVGQKSNIPAEMLSFEGLETDKEHVAVVFNQADKHQSTPLVRMHSECLTGDVFHSSRCDCGEQLEETINR
MSESGGIILYLRQEGRGIGLYNKLDAYELQSQGMNTYEANNHLGFGDDLRDFKEAAQMLEALNISKIKLVTNNPKKIKDI
QNYGIEIDEVVNTHAHVKQGNEHYLHSKAAHGHKLNFDK

Sequences:

>Translated_199_residues
MANVRARIELMVGQKSNIPAEMLSFEGLETDKEHVAVVFNQADKHQSTPLVRMHSECLTGDVFHSSRCDCGEQLEETINR
MSESGGIILYLRQEGRGIGLYNKLDAYELQSQGMNTYEANNHLGFGDDLRDFKEAAQMLEALNISKIKLVTNNPKKIKDI
QNYGIEIDEVVNTHAHVKQGNEHYLHSKAAHGHKLNFDK
>Mature_198_residues
ANVRARIELMVGQKSNIPAEMLSFEGLETDKEHVAVVFNQADKHQSTPLVRMHSECLTGDVFHSSRCDCGEQLEETINRM
SESGGIILYLRQEGRGIGLYNKLDAYELQSQGMNTYEANNHLGFGDDLRDFKEAAQMLEALNISKIKLVTNNPKKIKDIQ
NYGIEIDEVVNTHAHVKQGNEHYLHSKAAHGHKLNFDK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=178, Percent_Identity=50.561797752809, Blast_Score=163, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6319438, Length=150, Percent_Identity=44.6666666666667, Blast_Score=109, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_VIBF1 (Q5E5L2)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_204572.1
- HSSP:   P0A7I7
- ProteinModelPortal:   Q5E5L2
- SMR:   Q5E5L2
- STRING:   Q5E5L2
- GeneID:   3278427
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_1189
- NMPDR:   fig|312309.3.peg.1037
- eggNOG:   COG0807
- HOGENOM:   HBG735778
- OMA:   TDKEHVA
- PhylomeDB:   Q5E5L2
- ProtClustDB:   PRK00393
- BioCyc:   VFIS312309:VF1189-MONOMER
- HAMAP:   MF_00179
- InterPro:   IPR000926

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 22466; Mature: 22334

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: ACT_SITE 128-128 ACT_SITE 130-130 BINDING 73-73 BINDING 116-116 BINDING 151-151 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANVRARIELMVGQKSNIPAEMLSFEGLETDKEHVAVVFNQADKHQSTPLVRMHSECLTG
CCCCEEEEEEEECCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCC
DVFHSSRCDCGEQLEETINRMSESGGIILYLRQEGRGIGLYNKLDAYELQSQGMNTYEAN
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCEEECC
NHLGFGDDLRDFKEAAQMLEALNISKIKLVTNNPKKIKDIQNYGIEIDEVVNTHAHVKQG
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCC
NEHYLHSKAAHGHKLNFDK
CHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ANVRARIELMVGQKSNIPAEMLSFEGLETDKEHVAVVFNQADKHQSTPLVRMHSECLTG
CCCEEEEEEEECCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCC
DVFHSSRCDCGEQLEETINRMSESGGIILYLRQEGRGIGLYNKLDAYELQSQGMNTYEAN
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCEEECC
NHLGFGDDLRDFKEAAQMLEALNISKIKLVTNNPKKIKDIQNYGIEIDEVVNTHAHVKQG
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCC
NEHYLHSKAAHGHKLNFDK
CHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA