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The map label for this gene is yiaY [H]

Identifier: 59711795

GI number: 59711795

Start: 1319944

End: 1321089

Strand: Direct

Name: yiaY [H]

Synonym: VF_1188

Alternate gene names: 59711795

Gene position: 1319944-1321089 (Clockwise)

Preceding gene: 59711794

Following gene: 59711796

Centisome position: 45.55

GC content: 40.92

Gene sequence:

>1146_bases
ATGAGTGCATTTTTTATCCCTACAGTAAACTTAATGGGTGCAGGTTGTCTTACAGAAGCGATGGACAGCATTAAATCACA
AGGTTACAAAAAGGGTCTTATCGTTACTGATAACGTACTAGTTGCAATTGGTATGGTTAAACAAGTATCAGATTTATTAG
CAGAGCGCGGTGTTGAAGTTGCTGTGTTTGATGGTACGCAACCAAACCCAACAATCGGTAACGTAAATGCAGGTTTAAAA
ATTCTTAAAGATAATGAGTGTGACTTCGTTATCTCTTTAGGTGGTGGTTCTCCTCACGATTGTGCTAAAGGTATTGCTTT
AGTTGCTGCAAATGGTGGTGAGATTGCTGATTATGAAGGTGTTGATCAGTCAGCTAAGCCACAATTGCCTCTAATTGCAA
TTAATACAACGGCTGGTACGGCATCTGAAATGACGCGTTTCTGTATCATTACTGATGAAGCTCGTCACATTAAGATGGCG
ATTGTAGATAAGCACACGACACCATTGATGTCTGTAAATGATCCTGAATTAATGCTTGCTAAACCTGCATCATTAACAGC
AGCAACAGGTATGGATGCGTTAACGCACGCTATTGAAGCATACGTATCAATTGCAGCAACACCAGTAACTGATGCTGTAG
CAATTAAAGCAATGGAACTTATCCAAGCGCATTTACGTACAGCGGTTAACGACGGTCAAAACCTAGAAGCTCGTGAGCAA
ATGGCTTATGCACAATTCATGGCGGGCATGGCATTTAACAATGCGTCTTTAGGTTATGTTCACGCAATGGCACACCAACT
AGGTGGTTTCTACGACCTTCCACACGGCGTATGTAATGCGATTCTTCTTCCTCACGTACAAAGCTACAATGCTAAAGTAT
GTCCAGAACGTCTAAAAGACGTTGCAAAAGCAATGGGCGTAAACGTTGAAGGCATGACAAATGAAGAAGGCGCTCAAGCT
GCATTAGAAGCGATTAAACAATTATCACAAGATGTTGGTATTCCTTCTGGTCTAACAGAGCTTAACGCTAAAGAAGAAGA
TTTTGATACGCTTGCTGAAAATGCATTAAAAGATGCATGTGGTTTTACTAACCCTAAACAAGCGACGCACGAAGAAATCG
TAAGTATCTTCAAAGCAGCAATGTAA

Upstream 100 bases:

>100_bases
TTATTGCAGTTTTTGTCTTAGATCAAAAAGTTATTACCTGTATCAATGTTAAAACATAAACAGTTCTTAAAAATTTATAT
AAATACTAATGGAGTTGGTT

Downstream 100 bases:

>100_bases
TTATTATAGATAAAAGTATTAATTAGTTTTAGAAAGGTCTAACAATAGTTAGGCCTTTTTTTTGATTCTTGCTTCCACGT
TAGGGTATGCTTATGATCTT

Product: Fe-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MSAFFIPTVNLMGAGCLTEAMDSIKSQGYKKGLIVTDNVLVAIGMVKQVSDLLAERGVEVAVFDGTQPNPTIGNVNAGLK
ILKDNECDFVISLGGGSPHDCAKGIALVAANGGEIADYEGVDQSAKPQLPLIAINTTAGTASEMTRFCIITDEARHIKMA
IVDKHTTPLMSVNDPELMLAKPASLTAATGMDALTHAIEAYVSIAATPVTDAVAIKAMELIQAHLRTAVNDGQNLEAREQ
MAYAQFMAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNAILLPHVQSYNAKVCPERLKDVAKAMGVNVEGMTNEEGAQA
ALEAIKQLSQDVGIPSGLTELNAKEEDFDTLAENALKDACGFTNPKQATHEEIVSIFKAAM

Sequences:

>Translated_381_residues
MSAFFIPTVNLMGAGCLTEAMDSIKSQGYKKGLIVTDNVLVAIGMVKQVSDLLAERGVEVAVFDGTQPNPTIGNVNAGLK
ILKDNECDFVISLGGGSPHDCAKGIALVAANGGEIADYEGVDQSAKPQLPLIAINTTAGTASEMTRFCIITDEARHIKMA
IVDKHTTPLMSVNDPELMLAKPASLTAATGMDALTHAIEAYVSIAATPVTDAVAIKAMELIQAHLRTAVNDGQNLEAREQ
MAYAQFMAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNAILLPHVQSYNAKVCPERLKDVAKAMGVNVEGMTNEEGAQA
ALEAIKQLSQDVGIPSGLTELNAKEEDFDTLAENALKDACGFTNPKQATHEEIVSIFKAAM
>Mature_380_residues
SAFFIPTVNLMGAGCLTEAMDSIKSQGYKKGLIVTDNVLVAIGMVKQVSDLLAERGVEVAVFDGTQPNPTIGNVNAGLKI
LKDNECDFVISLGGGSPHDCAKGIALVAANGGEIADYEGVDQSAKPQLPLIAINTTAGTASEMTRFCIITDEARHIKMAI
VDKHTTPLMSVNDPELMLAKPASLTAATGMDALTHAIEAYVSIAATPVTDAVAIKAMELIQAHLRTAVNDGQNLEAREQM
AYAQFMAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNAILLPHVQSYNAKVCPERLKDVAKAMGVNVEGMTNEEGAQAA
LEAIKQLSQDVGIPSGLTELNAKEEDFDTLAENALKDACGFTNPKQATHEEIVSIFKAAM

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=409, Percent_Identity=25.4278728606357, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI48994951, Length=380, Percent_Identity=71.5789473684211, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1789163, Length=374, Percent_Identity=45.9893048128342, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI87082107, Length=377, Percent_Identity=37.1352785145889, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI1787493, Length=407, Percent_Identity=32.9238329238329, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1789386, Length=312, Percent_Identity=27.5641025641026, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=410, Percent_Identity=24.8780487804878, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321181, Length=383, Percent_Identity=55.3524804177546, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24657991, Length=410, Percent_Identity=29.0243902439024, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40233; Mature: 40101

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFFIPTVNLMGAGCLTEAMDSIKSQGYKKGLIVTDNVLVAIGMVKQVSDLLAERGVEV
CCEEEECCHHHHCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEE
AVFDGTQPNPTIGNVNAGLKILKDNECDFVISLGGGSPHDCAKGIALVAANGGEIADYEG
EEECCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCHHHHHCCEEEEEECCCCCCCCCC
VDQSAKPQLPLIAINTTAGTASEMTRFCIITDEARHIKMAIVDKHTTPLMSVNDPELMLA
CCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEECCCCCCEECCCCCEEEE
KPASLTAATGMDALTHAIEAYVSIAATPVTDAVAIKAMELIQAHLRTAVNDGQNLEAREQ
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
MAYAQFMAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNAILLPHVQSYNAKVCPERLKD
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHCCCCCCCHHHHHH
VAKAMGVNVEGMTNEEGAQAALEAIKQLSQDVGIPSGLTELNAKEEDFDTLAENALKDAC
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHHH
GFTNPKQATHEEIVSIFKAAM
CCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAFFIPTVNLMGAGCLTEAMDSIKSQGYKKGLIVTDNVLVAIGMVKQVSDLLAERGVEV
CEEEECCHHHHCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEE
AVFDGTQPNPTIGNVNAGLKILKDNECDFVISLGGGSPHDCAKGIALVAANGGEIADYEG
EEECCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCHHHHHCCEEEEEECCCCCCCCCC
VDQSAKPQLPLIAINTTAGTASEMTRFCIITDEARHIKMAIVDKHTTPLMSVNDPELMLA
CCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEECCCCCCEECCCCCEEEE
KPASLTAATGMDALTHAIEAYVSIAATPVTDAVAIKAMELIQAHLRTAVNDGQNLEAREQ
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
MAYAQFMAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNAILLPHVQSYNAKVCPERLKD
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHCCCCCCCHHHHHH
VAKAMGVNVEGMTNEEGAQAALEAIKQLSQDVGIPSGLTELNAKEEDFDTLAENALKDAC
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHHH
GFTNPKQATHEEIVSIFKAAM
CCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]