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The map label for this gene is metC [H]

Identifier: 59711793

GI number: 59711793

Start: 1318017

End: 1319207

Strand: Reverse

Name: metC [H]

Synonym: VF_1186

Alternate gene names: 59711793

Gene position: 1319207-1318017 (Counterclockwise)

Preceding gene: 59711803

Following gene: 59711786

Centisome position: 45.53

GC content: 42.23

Gene sequence:

>1191_bases
ATGTCAGAAAAACTAGATACCAAATACGTCATCGCTGGTCGTAGCAAAAAATGGACAAAAGGCGTAGTTAACCCACCAGT
ACAACGAGCTTCTACAGTGGTGTTTAATACGGTTGCAGAAAAAAATCACGCTATGGTCAACCGTGCGAAACAAACGCTTT
TCTATGGGCGTCGTGGGACCGAAACCCACTTTGCTCTACAAGATGCCATGGTTGAGCTTGAAGGTGGTGCAGGCTGTGCT
TTATACCCTTGTGGTACGGCTGCTATCGCTAATACCATTTTAGCCTTTGTTAAAACAGGTGATCACATTTTAATGGTGGA
CGGTTGTTATGAACCGACCCGTGACTATTGTGAAACCGTCTTGAAACGAATGGGGATAGAAACCACCTATTATGACCCAA
TGATTGGTGAAGGTATTCGCGAACTTATCCGCCCAAATACAACGGTTTTATTTACTGAATCTCCGTGTTCTATCACCATG
GAAGTTCAAGATTTACCTACCCTTAGTCGTATTGCGCACGAAACAGATATTACAGTAATACTCGATAATACATGGGGTGC
GGGTGTTAATCTTGCCCCTTTTGAGCACGGTGTAGATATTTCTGTACAAGCAGCAACCAAATACATCGTTGGTCACTCGG
ATGTGATGTTAGGCACTGCAGTTGCTAACGAAAAACATTGGGATCAACTGCGTGAGCAAAGTTATTTAATGGGGCAATGT
ATTTCTCCTGATGATGCGTATCTTGCAATGCGTGGTATTCGCACCATGGGCGTTCGATTAAAACAACATGAAAAGAGCAG
CATCAAAGTCGCTAAATGGTTAGAAGCACATCCATTAGTGGATCATGTTCGCCACCCTGCTCTTGCTAGTTGCCCAGGTC
ATGAGTTTTACCAACGTGATTTCAAAGGCTGTAATGGTTTATTTTCCTTTGTTTTAAAACAATCAGATACTAAAGCTACC
ACAGCACTGTTAGATGGTATGACACATTTTAGTATGGGGTATTCATGGGGAGGATTTGAAAGCCTTATTCTTGCCAATGA
GCCTCGAAGCTTCAATGCATTAAGAACCATAGCTAATCCAAACTTTAAAGGAACGTTAATCCGTGTTCACATTGGATTAG
AAGATGTTGAAGATCTGATTCACGATCTTGAAGAAGGGTTACACCGCTATCAAGACGCATTAAACGCTTAA

Upstream 100 bases:

>100_bases
AAAAAAAATTTATTCGACCTCAATTCACTTTATTCCTTGATATTTGGTGCTCATTTTGGCTTTATGGGTGTATTGCTTAC
TTTTTATTGAATGGATTCAT

Downstream 100 bases:

>100_bases
CAATAAATTAAAGGCGATATTGCATAAGCCGTATCGCCTTTAATTTCTAATAATTAACGTTTTCTTTCTTGTTTTGTTAA
TTCAAAATCAAACTCGTCAG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSEKLDTKYVIAGRSKKWTKGVVNPPVQRASTVVFNTVAEKNHAMVNRAKQTLFYGRRGTETHFALQDAMVELEGGAGCA
LYPCGTAAIANTILAFVKTGDHILMVDGCYEPTRDYCETVLKRMGIETTYYDPMIGEGIRELIRPNTTVLFTESPCSITM
EVQDLPTLSRIAHETDITVILDNTWGAGVNLAPFEHGVDISVQAATKYIVGHSDVMLGTAVANEKHWDQLREQSYLMGQC
ISPDDAYLAMRGIRTMGVRLKQHEKSSIKVAKWLEAHPLVDHVRHPALASCPGHEFYQRDFKGCNGLFSFVLKQSDTKAT
TALLDGMTHFSMGYSWGGFESLILANEPRSFNALRTIANPNFKGTLIRVHIGLEDVEDLIHDLEEGLHRYQDALNA

Sequences:

>Translated_396_residues
MSEKLDTKYVIAGRSKKWTKGVVNPPVQRASTVVFNTVAEKNHAMVNRAKQTLFYGRRGTETHFALQDAMVELEGGAGCA
LYPCGTAAIANTILAFVKTGDHILMVDGCYEPTRDYCETVLKRMGIETTYYDPMIGEGIRELIRPNTTVLFTESPCSITM
EVQDLPTLSRIAHETDITVILDNTWGAGVNLAPFEHGVDISVQAATKYIVGHSDVMLGTAVANEKHWDQLREQSYLMGQC
ISPDDAYLAMRGIRTMGVRLKQHEKSSIKVAKWLEAHPLVDHVRHPALASCPGHEFYQRDFKGCNGLFSFVLKQSDTKAT
TALLDGMTHFSMGYSWGGFESLILANEPRSFNALRTIANPNFKGTLIRVHIGLEDVEDLIHDLEEGLHRYQDALNA
>Mature_395_residues
SEKLDTKYVIAGRSKKWTKGVVNPPVQRASTVVFNTVAEKNHAMVNRAKQTLFYGRRGTETHFALQDAMVELEGGAGCAL
YPCGTAAIANTILAFVKTGDHILMVDGCYEPTRDYCETVLKRMGIETTYYDPMIGEGIRELIRPNTTVLFTESPCSITME
VQDLPTLSRIAHETDITVILDNTWGAGVNLAPFEHGVDISVQAATKYIVGHSDVMLGTAVANEKHWDQLREQSYLMGQCI
SPDDAYLAMRGIRTMGVRLKQHEKSSIKVAKWLEAHPLVDHVRHPALASCPGHEFYQRDFKGCNGLFSFVLKQSDTKATT
ALLDGMTHFSMGYSWGGFESLILANEPRSFNALRTIANPNFKGTLIRVHIGLEDVEDLIHDLEEGLHRYQDALNA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=363, Percent_Identity=32.5068870523416, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI299473759, Length=363, Percent_Identity=29.4765840220386, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI25453487, Length=362, Percent_Identity=29.2817679558011, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1789383, Length=390, Percent_Identity=55.8974358974359, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1790375, Length=392, Percent_Identity=31.3775510204082, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71980708, Length=373, Percent_Identity=32.171581769437, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17538055, Length=373, Percent_Identity=30.5630026809651, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=370, Percent_Identity=30.2702702702703, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321170, Length=335, Percent_Identity=43.2835820895522, Blast_Score=292, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6319307, Length=346, Percent_Identity=29.1907514450867, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323333, Length=352, Percent_Identity=26.1363636363636, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321904, Length=394, Percent_Identity=24.3654822335025, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321254, Length=402, Percent_Identity=23.3830845771144, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19922554, Length=390, Percent_Identity=32.0512820512821, Blast_Score=198, Evalue=6e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44010; Mature: 43879

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKLDTKYVIAGRSKKWTKGVVNPPVQRASTVVFNTVAEKNHAMVNRAKQTLFYGRRGT
CCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ETHFALQDAMVELEGGAGCALYPCGTAAIANTILAFVKTGDHILMVDGCYEPTRDYCETV
CHHHHHHHHHEEECCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHH
LKRMGIETTYYDPMIGEGIRELIRPNTTVLFTESPCSITMEVQDLPTLSRIAHETDITVI
HHHCCCCCEECCCHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCHHHHHHCCCCEEEE
LDNTWGAGVNLAPFEHGVDISVQAATKYIVGHSDVMLGTAVANEKHWDQLREQSYLMGQC
EECCCCCCCCCCCCCCCCCEEEEEHHEEEECCCCEEEEHHHCCHHHHHHHHHHHHHHCCC
ISPDDAYLAMRGIRTMGVRLKQHEKSSIKVAKWLEAHPLVDHVRHPALASCPGHEFYQRD
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHCCCCCCCCCCHHHHHHH
FKGCNGLFSFVLKQSDTKATTALLDGMTHFSMGYSWGGFESLILANEPRSFNALRTIANP
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHCCC
NFKGTLIRVHIGLEDVEDLIHDLEEGLHRYQDALNA
CCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEKLDTKYVIAGRSKKWTKGVVNPPVQRASTVVFNTVAEKNHAMVNRAKQTLFYGRRGT
CCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ETHFALQDAMVELEGGAGCALYPCGTAAIANTILAFVKTGDHILMVDGCYEPTRDYCETV
CHHHHHHHHHEEECCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHH
LKRMGIETTYYDPMIGEGIRELIRPNTTVLFTESPCSITMEVQDLPTLSRIAHETDITVI
HHHCCCCCEECCCHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCHHHHHHCCCCEEEE
LDNTWGAGVNLAPFEHGVDISVQAATKYIVGHSDVMLGTAVANEKHWDQLREQSYLMGQC
EECCCCCCCCCCCCCCCCCEEEEEHHEEEECCCCEEEEHHHCCHHHHHHHHHHHHHHCCC
ISPDDAYLAMRGIRTMGVRLKQHEKSSIKVAKWLEAHPLVDHVRHPALASCPGHEFYQRD
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHCCCCCCCCCCHHHHHHH
FKGCNGLFSFVLKQSDTKATTALLDGMTHFSMGYSWGGFESLILANEPRSFNALRTIANP
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHCCC
NFKGTLIRVHIGLEDVEDLIHDLEEGLHRYQDALNA
CCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]