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The map label for this gene is grxD [H]

Identifier: 59711529

GI number: 59711529

Start: 1017585

End: 1017920

Strand: Direct

Name: grxD [H]

Synonym: VF_0922

Alternate gene names: 59711529

Gene position: 1017585-1017920 (Clockwise)

Preceding gene: 59711525

Following gene: 59711533

Centisome position: 35.12

GC content: 40.48

Gene sequence:

>336_bases
ATGGAAACTATCGATAAGATCAAACAACAAATTTCTGAAAACCACATCCTTTTATACATGAAAGGTTCTCCTAAGCTACC
TAGCTGTGGTTTCTCTTCTCAAGCTGCACAAGCTTTAATGAATTGTGGTGAGAAATTTGCGTACGTAGATATTCTACAAA
ACCCTGATATTCGTGCTGAGCTTCCAGCATACGCACAATGGCCAACATTCCCACAATTATGGGTTGAAGGCGAACTAGTT
GGTGGCTGTGACATTATCATTGAAATGTTCCAAAAGGGTGAACTTCAGCCATTAATTAAAGAAGCTGCAGAGCGTAACGC
ACCAGCTGCTGAATAA

Upstream 100 bases:

>100_bases
TTTTTCAATAAATAATAACACTACAAATAATAGGTATTTTTTTCTTCACACATAACAAGTAGAATGGATACAACTTAAAT
GTCGACCATTAGAGGATACA

Downstream 100 bases:

>100_bases
TCAGAATATTAAAAAAGCCACGTTATTTAACGTGGCTTTTTTTTATCTTTAAAACGAAGACGATGATTTTTGTTGCTTTA
TGAATGCCATCGTTTGTAAC

Product: glutaredoxin 4

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin [H]

Number of amino acids: Translated: 111; Mature: 111

Protein sequence:

>111_residues
METIDKIKQQISENHILLYMKGSPKLPSCGFSSQAAQALMNCGEKFAYVDILQNPDIRAELPAYAQWPTFPQLWVEGELV
GGCDIIIEMFQKGELQPLIKEAAERNAPAAE

Sequences:

>Translated_111_residues
METIDKIKQQISENHILLYMKGSPKLPSCGFSSQAAQALMNCGEKFAYVDILQNPDIRAELPAYAQWPTFPQLWVEGELV
GGCDIIIEMFQKGELQPLIKEAAERNAPAAE
>Mature_111_residues
METIDKIKQQISENHILLYMKGSPKLPSCGFSSQAAQALMNCGEKFAYVDILQNPDIRAELPAYAQWPTFPQLWVEGELV
GGCDIIIEMFQKGELQPLIKEAAERNAPAAE

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters [H]

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI95113651, Length=96, Percent_Identity=40.625, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI42516576, Length=98, Percent_Identity=35.7142857142857, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787943, Length=103, Percent_Identity=80.5825242718447, Blast_Score=181, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17556042, Length=105, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71988153, Length=84, Percent_Identity=38.0952380952381, Blast_Score=81, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71988159, Length=80, Percent_Identity=38.75, Blast_Score=78, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6325198, Length=99, Percent_Identity=41.4141414141414, Blast_Score=91, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321022, Length=73, Percent_Identity=46.5753424657534, Blast_Score=82, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320303, Length=77, Percent_Identity=44.1558441558442, Blast_Score=82, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24642023, Length=101, Percent_Identity=39.6039603960396, Blast_Score=95, Evalue=8e-21,
Organism=Drosophila melanogaster, GI19921242, Length=96, Percent_Identity=36.4583333333333, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 12367; Mature: 12367

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIDKIKQQISENHILLYMKGSPKLPSCGFSSQAAQALMNCGEKFAYVDILQNPDIRAE
CCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
LPAYAQWPTFPQLWVEGELVGGCDIIIEMFQKGELQPLIKEAAERNAPAAE
CCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
METIDKIKQQISENHILLYMKGSPKLPSCGFSSQAAQALMNCGEKFAYVDILQNPDIRAE
CCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
LPAYAQWPTFPQLWVEGELVGGCDIIIEMFQKGELQPLIKEAAERNAPAAE
CCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]