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The map label for this gene is cueR [H]

Identifier: 59711389

GI number: 59711389

Start: 856036

End: 856437

Strand: Direct

Name: cueR [H]

Synonym: VF_0782

Alternate gene names: 59711389

Gene position: 856036-856437 (Clockwise)

Preceding gene: 59711385

Following gene: 59711396

Centisome position: 29.54

GC content: 34.83

Gene sequence:

>402_bases
ATGAATATAAGTGAAGTAGCGAAATTAACTGGATTAACAGCAAAAGCAATTCGTTTTTATGAAAGTAAAGGGATAATAAA
AGAGGCGAGTCGTGGCGCAAATGGATATCGTCAATATACACAACATCAAGTGGATGAGTTGTTACTTATCCGTCGCTCAA
GGTTAGTTGGATTTAGCTTAGATGAATGTCAAGAGCTGTTAAATTTATCGAATAATCCAAATAGACGAAGTGCGGATGTA
AAACAAAAAACACTAGAAAAGGTTTCAGAAATAGAAACTAAGATAGAAGAGCTAGAAAGGATGAAGAAAACGTTATTAGA
TCTAGCTGATGCATGCCCTGGAGATGATAGTAACGATTGTCCAATTATTAAAGGATTAACCTGTTGCCATGAGAAGAAAT
AA

Upstream 100 bases:

>100_bases
GAATTCTTGACTCATAATAACCTCGATAACTTATCTTGATATTAGATATCATAAACCTTACAGTTAATGGAAGGTCAAGA
AGAAAAGTAAAGAGAGTAGT

Downstream 100 bases:

>100_bases
CAACAGGTTAAATAATGACAGGTTATATGCTTTACTTTAATAAAGTAGAGAATAGAGTTGGCGACGGAATTTACCTGCGA
TAGGGTTACCTTGACCTAGA

Product: DNA-binding transcriptional activator of copper-responsive regulon genes

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 133; Mature: 133

Protein sequence:

>133_residues
MNISEVAKLTGLTAKAIRFYESKGIIKEASRGANGYRQYTQHQVDELLLIRRSRLVGFSLDECQELLNLSNNPNRRSADV
KQKTLEKVSEIETKIEELERMKKTLLDLADACPGDDSNDCPIIKGLTCCHEKK

Sequences:

>Translated_133_residues
MNISEVAKLTGLTAKAIRFYESKGIIKEASRGANGYRQYTQHQVDELLLIRRSRLVGFSLDECQELLNLSNNPNRRSADV
KQKTLEKVSEIETKIEELERMKKTLLDLADACPGDDSNDCPIIKGLTCCHEKK
>Mature_133_residues
MNISEVAKLTGLTAKAIRFYESKGIIKEASRGANGYRQYTQHQVDELLLIRRSRLVGFSLDECQELLNLSNNPNRRSADV
KQKTLEKVSEIETKIEELERMKKTLLDLADACPGDDSNDCPIIKGLTCCHEKK

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=133, Percent_Identity=62.406015037594, Blast_Score=175, Evalue=9e-46,
Organism=Escherichia coli, GI1789687, Length=127, Percent_Identity=34.6456692913386, Blast_Score=80, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15040; Mature: 15040

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISEVAKLTGLTAKAIRFYESKGIIKEASRGANGYRQYTQHQVDELLLIRRSRLVGFSL
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
DECQELLNLSNNPNRRSADVKQKTLEKVSEIETKIEELERMKKTLLDLADACPGDDSNDC
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PIIKGLTCCHEKK
CHHHHHHHHCCCC
>Mature Secondary Structure
MNISEVAKLTGLTAKAIRFYESKGIIKEASRGANGYRQYTQHQVDELLLIRRSRLVGFSL
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
DECQELLNLSNNPNRRSADVKQKTLEKVSEIETKIEELERMKKTLLDLADACPGDDSNDC
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PIIKGLTCCHEKK
CHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796; 12147073 [H]