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The map label for this gene is alr2 [H]

Identifier: 59711342

GI number: 59711342

Start: 800411

End: 801622

Strand: Direct

Name: alr2 [H]

Synonym: VF_0735

Alternate gene names: 59711342

Gene position: 800411-801622 (Clockwise)

Preceding gene: 59711341

Following gene: 59711344

Centisome position: 27.62

GC content: 36.72

Gene sequence:

>1212_bases
ATGAAGTTTACTAAATGTGCATTAGCGTTAAGTTTGGCATTACCAAGTATCGCTAATTCAGCTCCACTTCTTTCTTTAGA
TACATTAACAAATCAAGAAAAAATTCAACAAACTAACGCATGGTTAGAGATCGATACCCAAGCTTTCCAAAATAATATTG
ATACTTTAAGAGCATCATTAGAGCAAGACACAAAAGTGTGCGCCATAATGAAAGCGGATGCTTATGGTAATGGTATTGAA
GGTTTAATGGCCTCAGTTATTGAGCGCAATGTTGAATGTATTGGTATCACAAGTAATGAAGAAGCTCGTATTGTGCGTGC
TAAAGGTTTTGTCGGCGAACTAATGCGCGTTCGTGCGGCATCACCGAATGAAATTGAATCTGGTTTACAATATAAAATTG
AAGAGTTAATTGGTTCGAGTGAACAAGCTAATATTATTGCGAAATTAGCAAAACAGAACAACACGATTATTCCTGTGCAT
CTGGCTTTGAATGCTGGTGGTATGGGTCGCAATGGTTTGGATTTATCACAACCTCAGGGTAAGAAAGAAGCATTAAACAT
TGCCTTTAATGGGCATGTGAACATTGTTGGCATTATGACTCACTTCCCAAATGAATCTGTCGATGAAATCCGCACTAAAT
TAAACCTTTTTAAACAAGAGAGCCAATGGTTAATTGATGAAGCACAATTAAACCGTGATGATATTACACTGCATGTGGCA
AATTCATACACCACAATCAATCTACCTGAAGCGCACTTAGATATGGTTCGTCCTGGTGGTCTTCTTTATGGTGATATGCC
AAATAATCCTGAATACAAACGCATTGTTCAATTCAAAACATCTGTGGCTTCTTTAAACTATTTACCAAAAGGGAGTACTA
TTGGTTATAGCAGTACTTATGTGCTAGGGCGTGATTCTATTTTAGCTAATTTACCATTAGGTTATTCTGATGGTTACGTT
CGCTCTATTGGTAATAATGGTTACGTACTGATTAATGGCCAAAAAGCGAATGTTGTTGGTGTAACATCAATGAATACCAC
AATGGTAGATATCACTGATATTAAAAATGTGCAGCCTGGAGATGAGGTTGTATTATTTGGTAAGCAAAATGAATTCACTA
TTGAAGCAAAAGAAATGGAAGCTTTCAGTAGTCGTAGCATGCCAGAGCTTTATGTTATTTGGGGTTCTACAAATCCTAAG
ATCTACAAATAG

Upstream 100 bases:

>100_bases
TTGATTCTTATTTGCACTGTTTCTGTAGAGGTTAAAAAAACGACGATATATAATTCCCTTTCGAGTTTTCGAAATAATTA
TTATATAAAAACGGTTGTTT

Downstream 100 bases:

>100_bases
ACGTCGGGTTGCACCAATTTAAGTAAGAATAATTAGGTACTTATTTAAATTATAATTGCGTAAATAAAAAACGGTCAGCA
TGTGCTGACCGTTTATTATT

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKFTKCALALSLALPSIANSAPLLSLDTLTNQEKIQQTNAWLEIDTQAFQNNIDTLRASLEQDTKVCAIMKADAYGNGIE
GLMASVIERNVECIGITSNEEARIVRAKGFVGELMRVRAASPNEIESGLQYKIEELIGSSEQANIIAKLAKQNNTIIPVH
LALNAGGMGRNGLDLSQPQGKKEALNIAFNGHVNIVGIMTHFPNESVDEIRTKLNLFKQESQWLIDEAQLNRDDITLHVA
NSYTTINLPEAHLDMVRPGGLLYGDMPNNPEYKRIVQFKTSVASLNYLPKGSTIGYSSTYVLGRDSILANLPLGYSDGYV
RSIGNNGYVLINGQKANVVGVTSMNTTMVDITDIKNVQPGDEVVLFGKQNEFTIEAKEMEAFSSRSMPELYVIWGSTNPK
IYK

Sequences:

>Translated_403_residues
MKFTKCALALSLALPSIANSAPLLSLDTLTNQEKIQQTNAWLEIDTQAFQNNIDTLRASLEQDTKVCAIMKADAYGNGIE
GLMASVIERNVECIGITSNEEARIVRAKGFVGELMRVRAASPNEIESGLQYKIEELIGSSEQANIIAKLAKQNNTIIPVH
LALNAGGMGRNGLDLSQPQGKKEALNIAFNGHVNIVGIMTHFPNESVDEIRTKLNLFKQESQWLIDEAQLNRDDITLHVA
NSYTTINLPEAHLDMVRPGGLLYGDMPNNPEYKRIVQFKTSVASLNYLPKGSTIGYSSTYVLGRDSILANLPLGYSDGYV
RSIGNNGYVLINGQKANVVGVTSMNTTMVDITDIKNVQPGDEVVLFGKQNEFTIEAKEMEAFSSRSMPELYVIWGSTNPK
IYK
>Mature_403_residues
MKFTKCALALSLALPSIANSAPLLSLDTLTNQEKIQQTNAWLEIDTQAFQNNIDTLRASLEQDTKVCAIMKADAYGNGIE
GLMASVIERNVECIGITSNEEARIVRAKGFVGELMRVRAASPNEIESGLQYKIEELIGSSEQANIIAKLAKQNNTIIPVH
LALNAGGMGRNGLDLSQPQGKKEALNIAFNGHVNIVGIMTHFPNESVDEIRTKLNLFKQESQWLIDEAQLNRDDITLHVA
NSYTTINLPEAHLDMVRPGGLLYGDMPNNPEYKRIVQFKTSVASLNYLPKGSTIGYSSTYVLGRDSILANLPLGYSDGYV
RSIGNNGYVLINGQKANVVGVTSMNTTMVDITDIKNVQPGDEVVLFGKQNEFTIEAKEMEAFSSRSMPELYVIWGSTNPK
IYK

Specific function: Provides the D-alanine required for cell wall biosynthesis [H]

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family [H]

Homologues:

Organism=Escherichia coli, GI1787439, Length=338, Percent_Identity=25.7396449704142, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790487, Length=341, Percent_Identity=25.5131964809384, Blast_Score=93, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622 [H]

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N [H]

EC number: =5.1.1.1 [H]

Molecular weight: Translated: 44249; Mature: 44249

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFTKCALALSLALPSIANSAPLLSLDTLTNQEKIQQTNAWLEIDTQAFQNNIDTLRASL
CCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHCCCEEEEEHHHHHCCHHHHHHHH
EQDTKVCAIMKADAYGNGIEGLMASVIERNVECIGITSNEEARIVRAKGFVGELMRVRAA
HCCCEEEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEECCHHHHHHHHHCC
SPNEIESGLQYKIEELIGSSEQANIIAKLAKQNNTIIPVHLALNAGGMGRNGLDLSQPQG
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCC
KKEALNIAFNGHVNIVGIMTHFPNESVDEIRTKLNLFKQESQWLIDEAQLNRDDITLHVA
CCCEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHHHHCCCHHEEEHHHCCCCCEEEEEE
NSYTTINLPEAHLDMVRPGGLLYGDMPNNPEYKRIVQFKTSVASLNYLPKGSTIGYSSTY
CCEEEEECCHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCEEE
VLGRDSILANLPLGYSDGYVRSIGNNGYVLINGQKANVVGVTSMNTTMVDITDIKNVQPG
EEECCCEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEEEECCEEEEEEECCCCCCCC
DEVVLFGKQNEFTIEAKEMEAFSSRSMPELYVIWGSTNPKIYK
CCEEEEECCCCEEEEHHHHHHHHCCCCCEEEEEECCCCCCEEC
>Mature Secondary Structure
MKFTKCALALSLALPSIANSAPLLSLDTLTNQEKIQQTNAWLEIDTQAFQNNIDTLRASL
CCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHCCCEEEEEHHHHHCCHHHHHHHH
EQDTKVCAIMKADAYGNGIEGLMASVIERNVECIGITSNEEARIVRAKGFVGELMRVRAA
HCCCEEEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEECCHHHHHHHHHCC
SPNEIESGLQYKIEELIGSSEQANIIAKLAKQNNTIIPVHLALNAGGMGRNGLDLSQPQG
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCC
KKEALNIAFNGHVNIVGIMTHFPNESVDEIRTKLNLFKQESQWLIDEAQLNRDDITLHVA
CCCEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHHHHCCCHHEEEHHHCCCCCEEEEEE
NSYTTINLPEAHLDMVRPGGLLYGDMPNNPEYKRIVQFKTSVASLNYLPKGSTIGYSSTY
CCEEEEECCHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCEEE
VLGRDSILANLPLGYSDGYVRSIGNNGYVLINGQKANVVGVTSMNTTMVDITDIKNVQPG
EEECCCEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEEEECCEEEEEEECCCCCCCC
DEVVLFGKQNEFTIEAKEMEAFSSRSMPELYVIWGSTNPKIYK
CCEEEEECCCCEEEEHHHHHHHHCCCCCEEEEEECCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]