Click here to switch to the map view.

The map label for this gene is thiL [H]

Identifier: 59711312

GI number: 59711312

Start: 772245

End: 773243

Strand: Direct

Name: thiL [H]

Synonym: VF_0705

Alternate gene names: 59711312

Gene position: 772245-773243 (Clockwise)

Preceding gene: 59711311

Following gene: 59711313

Centisome position: 26.65

GC content: 35.34

Gene sequence:

>999_bases
ATGTGTAGTGAATTTAATTTAATCGATCGATTTTTTGTTCAAGAAAATGTTTCGCGTGATGATGTTGATTTAGGTATTGG
GGATGATTGCGCATTAGTAACTGTACCTGAGGGTTACCAAGTAGCGATAACTACAGATACTTTAGCCGCCGGAACGCATT
TTTTAGCTGATGCAGATCCTGTTAGTGTAGGGCATAAAGCACTAGCGTCTAACTTAAGTGATTTAGCGGCTATGGGAGCA
AAACCAACGTGGGTGTCTTTAGCATTGACCCTACCTCAATCTGATGAAAAGTGGCTAGAAGGATTTTGTAAAGGGTTCTT
TGATTTAGCTAAGCAATATCAAGTTGAGCTCATTGGTGGTGATACAACAAAAGGACCTTTAAGCATAACGATTACGGTAC
AAGGAATTATACCTAAAGGAGCTGCATTAACTCGAAGTGCAGCACAAATAGGTGATGATATTTATGTTACTGGTAATTTA
GGTGATAGCGCCGCTGGTCTCGAAGTTATTTTAAATTCACACAAAAATGTGAAGGGGGAGTTAGAAAAGGAGTTAGAAAA
ACGTCATTATTACTCAACACCACAAGTTGAGCTTGCGCAAGATATTCGTCATCTATGTCATGCAGCATTAGATATTTCTG
ATGGTGTAATTTCGGATCTAGGCCACATATTAAAGCAATCAAATGTGAGTGCTGTTATTAATGTTAATAACTTACCTATT
TCAAGTGAACTTGTTACGTATTATCGCCAAGATAAAGAAAAATGTCAGAAACTTGCATTAACTAGTGGTGAAGAATATGA
ACTTTGTTTCACTGCATCTAAAAAAAATCGTAAAGCAATCAAACAAATAGCTACTATTTTAAATAAAAAAATTAGTATAA
TTGGCGAGATAATTGATAAACCATTTAACGGTTTACCAGATAGTGTACAATTGTTTGATAATAATAAACTATTAGATTGG
AAATTATTAGGTTACGACCACTTTAGGAGAGAACAATGA

Upstream 100 bases:

>100_bases
TTTACGTAAAAAGTAAGTTGGTCGTAGCATACTAATTAAATCGTAAAGGTCAGCCTCGTTGCTGGCCTTTTTTATAACTA
AAAAACAGTATTAATCGAAT

Downstream 100 bases:

>100_bases
CAAATCCTCTAGCCTTAATTAGTCTTAAAAATCCGTGGCATTTATTAGCTACTGGGTTTGGGAGTGGCCTCTCTCCAATA
ATTCCAGGAACAATGGGCAC

Product: thiamin-monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MCSEFNLIDRFFVQENVSRDDVDLGIGDDCALVTVPEGYQVAITTDTLAAGTHFLADADPVSVGHKALASNLSDLAAMGA
KPTWVSLALTLPQSDEKWLEGFCKGFFDLAKQYQVELIGGDTTKGPLSITITVQGIIPKGAALTRSAAQIGDDIYVTGNL
GDSAAGLEVILNSHKNVKGELEKELEKRHYYSTPQVELAQDIRHLCHAALDISDGVISDLGHILKQSNVSAVINVNNLPI
SSELVTYYRQDKEKCQKLALTSGEEYELCFTASKKNRKAIKQIATILNKKISIIGEIIDKPFNGLPDSVQLFDNNKLLDW
KLLGYDHFRREQ

Sequences:

>Translated_332_residues
MCSEFNLIDRFFVQENVSRDDVDLGIGDDCALVTVPEGYQVAITTDTLAAGTHFLADADPVSVGHKALASNLSDLAAMGA
KPTWVSLALTLPQSDEKWLEGFCKGFFDLAKQYQVELIGGDTTKGPLSITITVQGIIPKGAALTRSAAQIGDDIYVTGNL
GDSAAGLEVILNSHKNVKGELEKELEKRHYYSTPQVELAQDIRHLCHAALDISDGVISDLGHILKQSNVSAVINVNNLPI
SSELVTYYRQDKEKCQKLALTSGEEYELCFTASKKNRKAIKQIATILNKKISIIGEIIDKPFNGLPDSVQLFDNNKLLDW
KLLGYDHFRREQ
>Mature_332_residues
MCSEFNLIDRFFVQENVSRDDVDLGIGDDCALVTVPEGYQVAITTDTLAAGTHFLADADPVSVGHKALASNLSDLAAMGA
KPTWVSLALTLPQSDEKWLEGFCKGFFDLAKQYQVELIGGDTTKGPLSITITVQGIIPKGAALTRSAAQIGDDIYVTGNL
GDSAAGLEVILNSHKNVKGELEKELEKRHYYSTPQVELAQDIRHLCHAALDISDGVISDLGHILKQSNVSAVINVNNLPI
SSELVTYYRQDKEKCQKLALTSGEEYELCFTASKKNRKAIKQIATILNKKISIIGEIIDKPFNGLPDSVQLFDNNKLLDW
KLLGYDHFRREQ

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=328, Percent_Identity=49.0853658536585, Blast_Score=300, Evalue=7e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 36410; Mature: 36410

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSEFNLIDRFFVQENVSRDDVDLGIGDDCALVTVPEGYQVAITTDTLAAGTHFLADADP
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECHHHCCCHHCCCCCC
VSVGHKALASNLSDLAAMGAKPTWVSLALTLPQSDEKWLEGFCKGFFDLAKQYQVELIGG
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHEEEEEECC
DTTKGPLSITITVQGIIPKGAALTRSAAQIGDDIYVTGNLGDSAAGLEVILNSHKNVKGE
CCCCCCEEEEEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCCHH
LEKELEKRHYYSTPQVELAQDIRHLCHAALDISDGVISDLGHILKQSNVSAVINVNNLPI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
SSELVTYYRQDKEKCQKLALTSGEEYELCFTASKKNRKAIKQIATILNKKISIIGEIIDK
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PFNGLPDSVQLFDNNKLLDWKLLGYDHFRREQ
CCCCCCCCEEEECCCCEEEEEEECCHHHCCCC
>Mature Secondary Structure
MCSEFNLIDRFFVQENVSRDDVDLGIGDDCALVTVPEGYQVAITTDTLAAGTHFLADADP
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECHHHCCCHHCCCCCC
VSVGHKALASNLSDLAAMGAKPTWVSLALTLPQSDEKWLEGFCKGFFDLAKQYQVELIGG
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHEEEEEECC
DTTKGPLSITITVQGIIPKGAALTRSAAQIGDDIYVTGNLGDSAAGLEVILNSHKNVKGE
CCCCCCEEEEEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCCHH
LEKELEKRHYYSTPQVELAQDIRHLCHAALDISDGVISDLGHILKQSNVSAVINVNNLPI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
SSELVTYYRQDKEKCQKLALTSGEEYELCFTASKKNRKAIKQIATILNKKISIIGEIIDK
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PFNGLPDSVQLFDNNKLLDWKLLGYDHFRREQ
CCCCCCCCEEEECCCCEEEEEEECCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]