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The map label for this gene is tyrA [H]

Identifier: 59711161

GI number: 59711161

Start: 601787

End: 602920

Strand: Direct

Name: tyrA [H]

Synonym: VF_0554

Alternate gene names: 59711161

Gene position: 601787-602920 (Clockwise)

Preceding gene: 59711160

Following gene: 59711165

Centisome position: 20.77

GC content: 37.92

Gene sequence:

>1134_bases
ATGGCGGTAGAACTAAGTCATTTACGCGATCAAATTGATGCGGTAGATAAACAGATGTTGGATCTTTTAGCTCAACGCTT
ACATTTAGTTGAGCTGGTTGGTGAAGTAAAAAGTGCACATGGATTGCCTATTTATGATCCAAGCCGAGAAGCGGCAATGT
TAGCATCAAGACGCTCAGAGGCTGAAAAAAAAGGCGTACCGCCCTCATTAATTGAAGATATTCTTCGCAGAACAATGCGT
GAGTCTTATAGCAGTGAAAATGATTCTGGTTTTAAGTGTTTAAAACCAGAGTTAAGGCCGATCGTTGTTGTTGGTGGTAA
TGGGCAACTTGGTGGTTTATTCGCAAAAATGTTTAAATTATCTGGTTATCAAGTTCGAATTCTCGGTAGTAAAGATTGGG
ATAATTCTGATGAGATCCTAGATAATGCAGGTATGGTTGTTGTTACGGTTCCTATCAACTTAACCATTGATGTAATTAAT
AAACTATCAAGGTTACCTGAGGATTGCATCCTTTGTGATTTAACCTCAATTAAGCAAAAACCTCTTGCTGCAATGATGGA
AGTTCATAAAGGCCCTGTTGTTGGATTGCACCCAATGTTTGGTCCTGATGTTCCAAGCCTTGCAAAGCAAGTTATTGTTA
TGTGTGATGGTCGAGGTAAAGAGCACTATAGTTGGTTGAAGAACCAATTTGAGATTTGGGGGGCAATCGTACGTGATATT
TCTGCGAATGAGCATGATCATGGTATGACTCTAATTCAAGCATTACGTCACTTTACTTCGTTTGCTTATGGACAGCATTT
AGCAAAAGAGAATCCTGATATTGAACAGCTGCTTAACTTAAGTTCTCCAATTTATCGTTTGGAGTTATTGATGGTTGGTC
GATTGTTTGCTCAAGACCCAAATTTATACGCAGATATCATTCTTTCTTCTGATGAAAATATTGAAATGATAAAGCGATTC
CATCAACGTTTTGGTGATGCAATCTCATTGCTAGAAGAACATAATCGTTCAGGATTCATTAAAAACTTTGAAGAAGTAGA
AGCTTGGTTTGGTGATTATGCTGAACAGTTTTTAATTGAAAGCAAAAGTTTACTCAGACAAGCGAATGATTCGATTCACC
GTGAACGTAATTAG

Upstream 100 bases:

>100_bases
AGATGCCTGTATCAATTGGGAATCAACTGAGGCACTATTACGTCATACTCACAAAGAATTAACTCCGATATTGGAAGAGC
GTTTAAAAGGATAGATTGAG

Downstream 100 bases:

>100_bases
TGTAGGTAAGAAGGCATAGAATGTAAAAAGGGTGAGCCATGAGCTAACCCTTTTTGTATTGATTAAACGGTGTTTATTGT
GTCAATTGTTGGCTACTTTC

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAVELSHLRDQIDAVDKQMLDLLAQRLHLVELVGEVKSAHGLPIYDPSREAAMLASRRSEAEKKGVPPSLIEDILRRTMR
ESYSSENDSGFKCLKPELRPIVVVGGNGQLGGLFAKMFKLSGYQVRILGSKDWDNSDEILDNAGMVVVTVPINLTIDVIN
KLSRLPEDCILCDLTSIKQKPLAAMMEVHKGPVVGLHPMFGPDVPSLAKQVIVMCDGRGKEHYSWLKNQFEIWGAIVRDI
SANEHDHGMTLIQALRHFTSFAYGQHLAKENPDIEQLLNLSSPIYRLELLMVGRLFAQDPNLYADIILSSDENIEMIKRF
HQRFGDAISLLEEHNRSGFIKNFEEVEAWFGDYAEQFLIESKSLLRQANDSIHRERN

Sequences:

>Translated_377_residues
MAVELSHLRDQIDAVDKQMLDLLAQRLHLVELVGEVKSAHGLPIYDPSREAAMLASRRSEAEKKGVPPSLIEDILRRTMR
ESYSSENDSGFKCLKPELRPIVVVGGNGQLGGLFAKMFKLSGYQVRILGSKDWDNSDEILDNAGMVVVTVPINLTIDVIN
KLSRLPEDCILCDLTSIKQKPLAAMMEVHKGPVVGLHPMFGPDVPSLAKQVIVMCDGRGKEHYSWLKNQFEIWGAIVRDI
SANEHDHGMTLIQALRHFTSFAYGQHLAKENPDIEQLLNLSSPIYRLELLMVGRLFAQDPNLYADIILSSDENIEMIKRF
HQRFGDAISLLEEHNRSGFIKNFEEVEAWFGDYAEQFLIESKSLLRQANDSIHRERN
>Mature_376_residues
AVELSHLRDQIDAVDKQMLDLLAQRLHLVELVGEVKSAHGLPIYDPSREAAMLASRRSEAEKKGVPPSLIEDILRRTMRE
SYSSENDSGFKCLKPELRPIVVVGGNGQLGGLFAKMFKLSGYQVRILGSKDWDNSDEILDNAGMVVVTVPINLTIDVINK
LSRLPEDCILCDLTSIKQKPLAAMMEVHKGPVVGLHPMFGPDVPSLAKQVIVMCDGRGKEHYSWLKNQFEIWGAIVRDIS
ANEHDHGMTLIQALRHFTSFAYGQHLAKENPDIEQLLNLSSPIYRLELLMVGRLFAQDPNLYADIILSSDENIEMIKRFH
QRFGDAISLLEEHNRSGFIKNFEEVEAWFGDYAEQFLIESKSLLRQANDSIHRERN

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=371, Percent_Identity=65.4986522911051, Blast_Score=504, Evalue=1e-144,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42600; Mature: 42468

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVELSHLRDQIDAVDKQMLDLLAQRLHLVELVGEVKSAHGLPIYDPSREAAMLASRRSE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AEKKGVPPSLIEDILRRTMRESYSSENDSGFKCLKPELRPIVVVGGNGQLGGLFAKMFKL
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHC
SGYQVRILGSKDWDNSDEILDNAGMVVVTVPINLTIDVINKLSRLPEDCILCDLTSIKQK
CCCEEEEECCCCCCCHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCHHHEECCHHHHHHH
PLAAMMEVHKGPVVGLHPMFGPDVPSLAKQVIVMCDGRGKEHYSWLKNQFEIWGAIVRDI
HHHHHHHHHCCCEEEECCCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHC
SANEHDHGMTLIQALRHFTSFAYGQHLAKENPDIEQLLNLSSPIYRLELLMVGRLFAQDP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCC
NLYADIILSSDENIEMIKRFHQRFGDAISLLEEHNRSGFIKNFEEVEAWFGDYAEQFLIE
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
SKSLLRQANDSIHRERN
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVELSHLRDQIDAVDKQMLDLLAQRLHLVELVGEVKSAHGLPIYDPSREAAMLASRRSE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AEKKGVPPSLIEDILRRTMRESYSSENDSGFKCLKPELRPIVVVGGNGQLGGLFAKMFKL
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHC
SGYQVRILGSKDWDNSDEILDNAGMVVVTVPINLTIDVINKLSRLPEDCILCDLTSIKQK
CCCEEEEECCCCCCCHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCHHHEECCHHHHHHH
PLAAMMEVHKGPVVGLHPMFGPDVPSLAKQVIVMCDGRGKEHYSWLKNQFEIWGAIVRDI
HHHHHHHHHCCCEEEECCCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHC
SANEHDHGMTLIQALRHFTSFAYGQHLAKENPDIEQLLNLSSPIYRLELLMVGRLFAQDP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCC
NLYADIILSSDENIEMIKRFHQRFGDAISLLEEHNRSGFIKNFEEVEAWFGDYAEQFLIE
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
SKSLLRQANDSIHRERN
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1512561 [H]