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The map label for this gene is folP [H]

Identifier: 59711087

GI number: 59711087

Start: 516129

End: 516965

Strand: Direct

Name: folP [H]

Synonym: VF_0480

Alternate gene names: 59711087

Gene position: 516129-516965 (Clockwise)

Preceding gene: 59711086

Following gene: 172087666

Centisome position: 17.81

GC content: 40.14

Gene sequence:

>837_bases
ATGAAACTAATAAGTAAAAATAAATCCCTTTTATTAGATCGCTCTCATGTCATGGGAATACTTAACGTAACACCTGACTC
TTTTTCTGACGGTGGCCAGTTTACCCATTTAGATGCGGCGCTTAAGCAAGCCGAAAAAATGGTTAAAGCTGGAGTAAGTT
TTATTGATATTGGTGGCGAGTCAACGCGACCTGGAGCCCCTGAAGTATCATTACAAGAAGAGCTAGATAGAGTATTACCA
ATCATCGAAGCCATCCATCAACGTTTTGATACTTGGATATCTATTGATACAAGTAAAGCTGTTGTTATGGAAGAGGCAGT
AAAAGTTGGTGCTGATTTAATTAATGATGTGAGAGCACTACAAGAGCCAAATGCTTTGAAAGTCGCAGCAGAAGCGAATG
TTCCTGTTTGTTTGATGCATATGCAAGGGCAACCTCGAACTATGCAAACTAATCCTTCTTATCAAGACTTATTTACCGAC
ATCTCGAGCTTTTTAAGTGAAAGAATCGATGCATGCCAATCGGTTGGTATCGCAAAAGATAAGTTAATTCTCGATCCTGG
ATTTGGTTTTGGTAAAACCTTGGCGCATAATTACCAGCTTCTTGCTGAGCTAGAGCGTTTTCATCAATTCGGTTTACCGC
TTCTCGCTGGAATGTCGAGAAAATCGATGGTTTTTAAGTTACTAGATGTAGAGCCGAAAATGGCACTATCTGGTAGCTTG
GCTTGTGCAACGATTGCAGCCATGAAAGGGGCGCAAATTATTCGTGTTCATGATTTTGAACAAACGATGGATATCGTAAA
GGTTTGCCAAGCAACTTTAGAGCAATCTCCTCATTAA

Upstream 100 bases:

>100_bases
CAAAAAACGATTCTGAATCATCTGAAAAGTAAGATGAAATAAGATAAATGAAACCCCGAGTTATGCTCGGGGTTTTTGTA
TTTATTAAAGGTGTAGAGTA

Downstream 100 bases:

>100_bases
AGAGTTGTTCAATTTAAATAAATTATTAAAAAAAACATGGAGTACAACATGGCTGAACGTAAATATTTCGGAACTGATGG
CGTTCGAGGATTAGTAGGGC

Product: 7,8-dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MKLISKNKSLLLDRSHVMGILNVTPDSFSDGGQFTHLDAALKQAEKMVKAGVSFIDIGGESTRPGAPEVSLQEELDRVLP
IIEAIHQRFDTWISIDTSKAVVMEEAVKVGADLINDVRALQEPNALKVAAEANVPVCLMHMQGQPRTMQTNPSYQDLFTD
ISSFLSERIDACQSVGIAKDKLILDPGFGFGKTLAHNYQLLAELERFHQFGLPLLAGMSRKSMVFKLLDVEPKMALSGSL
ACATIAAMKGAQIIRVHDFEQTMDIVKVCQATLEQSPH

Sequences:

>Translated_278_residues
MKLISKNKSLLLDRSHVMGILNVTPDSFSDGGQFTHLDAALKQAEKMVKAGVSFIDIGGESTRPGAPEVSLQEELDRVLP
IIEAIHQRFDTWISIDTSKAVVMEEAVKVGADLINDVRALQEPNALKVAAEANVPVCLMHMQGQPRTMQTNPSYQDLFTD
ISSFLSERIDACQSVGIAKDKLILDPGFGFGKTLAHNYQLLAELERFHQFGLPLLAGMSRKSMVFKLLDVEPKMALSGSL
ACATIAAMKGAQIIRVHDFEQTMDIVKVCQATLEQSPH
>Mature_278_residues
MKLISKNKSLLLDRSHVMGILNVTPDSFSDGGQFTHLDAALKQAEKMVKAGVSFIDIGGESTRPGAPEVSLQEELDRVLP
IIEAIHQRFDTWISIDTSKAVVMEEAVKVGADLINDVRALQEPNALKVAAEANVPVCLMHMQGQPRTMQTNPSYQDLFTD
ISSFLSERIDACQSVGIAKDKLILDPGFGFGKTLAHNYQLLAELERFHQFGLPLLAGMSRKSMVFKLLDVEPKMALSGSL
ACATIAAMKGAQIIRVHDFEQTMDIVKVCQATLEQSPH

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=273, Percent_Identity=61.1721611721612, Blast_Score=360, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=27.9874213836478, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30461; Mature: 30461

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLISKNKSLLLDRSHVMGILNVTPDSFSDGGQFTHLDAALKQAEKMVKAGVSFIDIGGE
CCCCCCCCHHEEEHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCC
STRPGAPEVSLQEELDRVLPIIEAIHQRFDTWISIDTSKAVVMEEAVKVGADLINDVRAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHH
QEPNALKVAAEANVPVCLMHMQGQPRTMQTNPSYQDLFTDISSFLSERIDACQSVGIAKD
CCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
KLILDPGFGFGKTLAHNYQLLAELERFHQFGLPLLAGMSRKSMVFKLLDVEPKMALSGSL
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHCCCCCHHHCCCH
ACATIAAMKGAQIIRVHDFEQTMDIVKVCQATLEQSPH
HHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLISKNKSLLLDRSHVMGILNVTPDSFSDGGQFTHLDAALKQAEKMVKAGVSFIDIGGE
CCCCCCCCHHEEEHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCC
STRPGAPEVSLQEELDRVLPIIEAIHQRFDTWISIDTSKAVVMEEAVKVGADLINDVRAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHH
QEPNALKVAAEANVPVCLMHMQGQPRTMQTNPSYQDLFTDISSFLSERIDACQSVGIAKD
CCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
KLILDPGFGFGKTLAHNYQLLAELERFHQFGLPLLAGMSRKSMVFKLLDVEPKMALSGSL
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHCCCCCHHHCCCH
ACATIAAMKGAQIIRVHDFEQTMDIVKVCQATLEQSPH
HHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]