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The map label for this gene is yjcE [H]

Identifier: 59710943

GI number: 59710943

Start: 358299

End: 359576

Strand: Reverse

Name: yjcE [H]

Synonym: VF_0336

Alternate gene names: 59710943

Gene position: 359576-358299 (Counterclockwise)

Preceding gene: 59710945

Following gene: 59710938

Centisome position: 12.41

GC content: 35.92

Gene sequence:

>1278_bases
ATGTCCGTATATAACACACTCTGCTTTCTCGCAGCTGCTGCAATGTTAATCGCATTTTTCAATAGTAAAATTGGAAAAAT
GCAAACAACCATTGCTATTACTGCAGGTTCCATGATGCTTTCATTAGGCATTATCATTGCCGGTCAAAATAACTGGTTTA
ACCTTAGGGAAGTAGCAACTGAGACGTTAACAGATATTAACTTTGAAGATTTTTTATTAAAAGGGATTCTAGGTTTTCTG
CTTTTTGCTGGAGGCTTGGGCATAAAGCTACAAAACTTAAAAGATCAAAAATGGGAAATAACGGTTCTTGCCTTAGGAGC
TACATTATTTTCAACGTTCTTTATCGGCTTTATTTTATGGGCAATTTGTAATGTTATCGGCGTTAATTTAGATCTTATTT
ACTGCTTACTATTTGGTGCATTAATATCACCAACTGACCCAATAGCCGTTCTTGCTATCGTTAAAAAGATGAATGCTCCG
CAACGAATCTCAACTCAAATTGAAGGCGAATCATTATTCAACGATGGCTTTGGCCTTGTTATCTTTGTAACTCTCTTTAC
CATCGCTTTCGGTCATGAAACACCTACTGTAGGAAGTGTAACTGCATTATTCTTCCAAGAAGCTATTGGTGGGATTGCCT
ATGGATTTATTCTTGGGCTAGTTTTCCATTATCTAATAAGTTCAACCAATGACCATTCAATGGAGCTATTATTAACCATT
GGTATACCAACCGCTGGTTATGCTCTAGCAGAAGTGCTTCATGTTTCAGGTCCCCTAGCAATGGTTGTCTCTGGTATTAT
GATAGGAAACTGGACTCGATTTATTGGTTTTTCAAAAGAAAGTGAAGATCATTTAGATCACTTCTGGGAACTTGTCGACG
AATTCCTCAATGGCGTACTATTCCTATTAATTGGTATGTCTATGCTTTTATTCCAATTCCATCAAGAAGATTGGATATTA
ATGGCAATTTCTATTCCTTTAGTTTTAACAAGCCGTTATTTAAGTGTATTTATCTCATACATTGGCTTTAATCGATTTAG
AACTTACAACCCATTATCAGTACGTATTTTAACTTGGGGTGGCTTAAGAGGCGGTTTAGCATTAGCAATGGCACTAGCTA
TACCTGCTGGAATTATGGTTATACCCGAAAAAAATATAGATGTTAGAGAAATCATTCTTGTAATGACTTACTCTGTTGTT
GTTTTTTCAATTTTAGTACAAGGGTCAACAATCACTCCTATGATTGATAAAGCCAAGAAGCTTGAAAAAGAAATGTAG

Upstream 100 bases:

>100_bases
TTTCAACAAAATGAAAATAAAATTTGATATTTATCAAATAGAGCGGAAAATGATATAAATCACACTTTGTTACATTAAAT
AAAAATCTAGAGGTTAAGCA

Downstream 100 bases:

>100_bases
AAATTGAAATTAATAGAAGAGGCGCTTGTTCGCCTCTTTTTTTAGCTCAAATAATTAACAAACCTTCTCAGAAAGTTCCT
CAGTACAACAAACTGCTAAG

Product: cation/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSVYNTLCFLAAAAMLIAFFNSKIGKMQTTIAITAGSMMLSLGIIIAGQNNWFNLREVATETLTDINFEDFLLKGILGFL
LFAGGLGIKLQNLKDQKWEITVLALGATLFSTFFIGFILWAICNVIGVNLDLIYCLLFGALISPTDPIAVLAIVKKMNAP
QRISTQIEGESLFNDGFGLVIFVTLFTIAFGHETPTVGSVTALFFQEAIGGIAYGFILGLVFHYLISSTNDHSMELLLTI
GIPTAGYALAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVLFLLIGMSMLLFQFHQEDWIL
MAISIPLVLTSRYLSVFISYIGFNRFRTYNPLSVRILTWGGLRGGLALAMALAIPAGIMVIPEKNIDVREIILVMTYSVV
VFSILVQGSTITPMIDKAKKLEKEM

Sequences:

>Translated_425_residues
MSVYNTLCFLAAAAMLIAFFNSKIGKMQTTIAITAGSMMLSLGIIIAGQNNWFNLREVATETLTDINFEDFLLKGILGFL
LFAGGLGIKLQNLKDQKWEITVLALGATLFSTFFIGFILWAICNVIGVNLDLIYCLLFGALISPTDPIAVLAIVKKMNAP
QRISTQIEGESLFNDGFGLVIFVTLFTIAFGHETPTVGSVTALFFQEAIGGIAYGFILGLVFHYLISSTNDHSMELLLTI
GIPTAGYALAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVLFLLIGMSMLLFQFHQEDWIL
MAISIPLVLTSRYLSVFISYIGFNRFRTYNPLSVRILTWGGLRGGLALAMALAIPAGIMVIPEKNIDVREIILVMTYSVV
VFSILVQGSTITPMIDKAKKLEKEM
>Mature_424_residues
SVYNTLCFLAAAAMLIAFFNSKIGKMQTTIAITAGSMMLSLGIIIAGQNNWFNLREVATETLTDINFEDFLLKGILGFLL
FAGGLGIKLQNLKDQKWEITVLALGATLFSTFFIGFILWAICNVIGVNLDLIYCLLFGALISPTDPIAVLAIVKKMNAPQ
RISTQIEGESLFNDGFGLVIFVTLFTIAFGHETPTVGSVTALFFQEAIGGIAYGFILGLVFHYLISSTNDHSMELLLTIG
IPTAGYALAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVLFLLIGMSMLLFQFHQEDWILM
AISIPLVLTSRYLSVFISYIGFNRFRTYNPLSVRILTWGGLRGGLALAMALAIPAGIMVIPEKNIDVREIILVMTYSVVV
FSILVQGSTITPMIDKAKKLEKEM

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=335, Percent_Identity=27.1641791044776, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI15529998, Length=326, Percent_Identity=28.8343558282209, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI27777632, Length=352, Percent_Identity=26.7045454545455, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI41872703, Length=391, Percent_Identity=25.0639386189258, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI294997330, Length=414, Percent_Identity=22.9468599033816, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI110227626, Length=414, Percent_Identity=22.9468599033816, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI5454070, Length=353, Percent_Identity=24.0793201133144, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4759144, Length=341, Percent_Identity=26.6862170087977, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI14211919, Length=362, Percent_Identity=23.4806629834254, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI194239733, Length=302, Percent_Identity=25.4966887417219, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI27734935, Length=359, Percent_Identity=22.2841225626741, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790501, Length=384, Percent_Identity=27.0833333333333, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71999819, Length=356, Percent_Identity=25, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71999817, Length=358, Percent_Identity=25.4189944134078, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71999821, Length=358, Percent_Identity=25.4189944134078, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71987535, Length=341, Percent_Identity=24.0469208211144, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71987537, Length=341, Percent_Identity=24.0469208211144, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71990924, Length=354, Percent_Identity=25.7062146892655, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71990932, Length=354, Percent_Identity=25.7062146892655, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71980847, Length=351, Percent_Identity=25.3561253561254, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI25150332, Length=325, Percent_Identity=25.8461538461538, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71992107, Length=345, Percent_Identity=25.2173913043478, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71992101, Length=345, Percent_Identity=25.2173913043478, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25147678, Length=299, Percent_Identity=26.4214046822742, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71993582, Length=336, Percent_Identity=24.702380952381, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71993590, Length=336, Percent_Identity=24.702380952381, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320663, Length=329, Percent_Identity=22.4924012158055, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI221510740, Length=376, Percent_Identity=25.531914893617, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585580, Length=376, Percent_Identity=25.531914893617, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585578, Length=376, Percent_Identity=25.531914893617, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221510734, Length=353, Percent_Identity=25.7790368271955, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221510738, Length=360, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI281360447, Length=394, Percent_Identity=24.3654822335025, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221510736, Length=340, Percent_Identity=26.4705882352941, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI221510732, Length=340, Percent_Identity=26.4705882352941, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281364513, Length=352, Percent_Identity=23.2954545454545, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221473222, Length=352, Percent_Identity=23.2954545454545, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI221473212, Length=352, Percent_Identity=23.2954545454545, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221473215, Length=352, Percent_Identity=23.2954545454545, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 46762; Mature: 46631

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVYNTLCFLAAAAMLIAFFNSKIGKMQTTIAITAGSMMLSLGIIIAGQNNWFNLREVAT
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHEEEEEECCCCCCHHHHHHH
ETLTDINFEDFLLKGILGFLLFAGGLGIKLQNLKDQKWEITVLALGATLFSTFFIGFILW
HHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHH
AICNVIGVNLDLIYCLLFGALISPTDPIAVLAIVKKMNAPQRISTQIEGESLFNDGFGLV
HHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHCCCCCHHHCCCCHHH
IFVTLFTIAFGHETPTVGSVTALFFQEAIGGIAYGFILGLVFHYLISSTNDHSMELLLTI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
GIPTAGYALAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVL
CCCCHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
FLLIGMSMLLFQFHQEDWILMAISIPLVLTSRYLSVFISYIGFNRFRTYNPLSVRILTWG
HHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
GLRGGLALAMALAIPAGIMVIPEKNIDVREIILVMTYSVVVFSILVQGSTITPMIDKAKK
CCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LEKEM
HHHCC
>Mature Secondary Structure 
SVYNTLCFLAAAAMLIAFFNSKIGKMQTTIAITAGSMMLSLGIIIAGQNNWFNLREVAT
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHEEEEEECCCCCCHHHHHHH
ETLTDINFEDFLLKGILGFLLFAGGLGIKLQNLKDQKWEITVLALGATLFSTFFIGFILW
HHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHH
AICNVIGVNLDLIYCLLFGALISPTDPIAVLAIVKKMNAPQRISTQIEGESLFNDGFGLV
HHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHCCCCCHHHCCCCHHH
IFVTLFTIAFGHETPTVGSVTALFFQEAIGGIAYGFILGLVFHYLISSTNDHSMELLLTI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
GIPTAGYALAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVL
CCCCHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
FLLIGMSMLLFQFHQEDWILMAISIPLVLTSRYLSVFISYIGFNRFRTYNPLSVRILTWG
HHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
GLRGGLALAMALAIPAGIMVIPEKNIDVREIILVMTYSVVVFSILVQGSTITPMIDKAKK
CCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LEKEM
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]