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The map label for this gene is msrA [H]

Identifier: 59710938

GI number: 59710938

Start: 340108

End: 340686

Strand: Reverse

Name: msrA [H]

Synonym: VF_0331

Alternate gene names: 59710938

Gene position: 340686-340108 (Counterclockwise)

Preceding gene: 59710943

Following gene: 59710936

Centisome position: 11.76

GC content: 37.13

Gene sequence:

>579_bases
ATGACAACTAAACAACCAACGTCACCACCACTTCATTTTATTTCTCAACGTAATTTAGAATTCATACCGCCAAATTTTGA
GCAAATATTTTTTGGTATGGGTTGCTTCTGGGGTGCTGAACGTCTTTTTTGGCAGTTAGAAGGTGTCTACTCTACTGCGG
TTGGATACAGTGGAGGAGTAACATCACACCCTACTTATAAAGAAGTCTGTACAGGAACAACCAATCATACTGAAGTTGTA
AAAGTCATTTTTGACCCAACAATAATTTCATTAAATACCTTATTACATTCTTTCTGGCAAAAACACGACCCGACAGAAGG
AATGCGACAAGGTAACGATATTGGGTCACAATATCGTTCAGCTATTTATACAACATCTAAAGCGCAACAGGAAACAGCGA
AACAAACGCAACAGCAATACCAAGCAGCTTTAGAAAAACAAGGTATCATGCGAATTATTACGACGGAAATTGTACCACTC
CAAACCTTTTACTTTGCCGAAGAATACCACCAACAATATTTAGCTAAAAATCCTGATGGTTATTGTGGTTTAAAAGGTAC
TGGTGTTTGTTTTATATAA

Upstream 100 bases:

>100_bases
TATTGATTCATTAATACATTATATGCAATGGTAATTTACTCGTTTTATAGAGTAGCACAAGATAAATGTCTTCTATATTA
ACTCAGTTGAAGGATGCAAC

Downstream 100 bases:

>100_bases
ACAAAAAAGGTGCTCATGACCACGAGCACCTCTTATTAACTATTACTATAATTTTAAGCTGGCATCATTGATAGTTGACG
AATATGTTGATTCACTTCAC

Product: peptide-methionine (S)-S-oxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 192; Mature: 191

Protein sequence:

>192_residues
MTTKQPTSPPLHFISQRNLEFIPPNFEQIFFGMGCFWGAERLFWQLEGVYSTAVGYSGGVTSHPTYKEVCTGTTNHTEVV
KVIFDPTIISLNTLLHSFWQKHDPTEGMRQGNDIGSQYRSAIYTTSKAQQETAKQTQQQYQAALEKQGIMRIITTEIVPL
QTFYFAEEYHQQYLAKNPDGYCGLKGTGVCFI

Sequences:

>Translated_192_residues
MTTKQPTSPPLHFISQRNLEFIPPNFEQIFFGMGCFWGAERLFWQLEGVYSTAVGYSGGVTSHPTYKEVCTGTTNHTEVV
KVIFDPTIISLNTLLHSFWQKHDPTEGMRQGNDIGSQYRSAIYTTSKAQQETAKQTQQQYQAALEKQGIMRIITTEIVPL
QTFYFAEEYHQQYLAKNPDGYCGLKGTGVCFI
>Mature_191_residues
TTKQPTSPPLHFISQRNLEFIPPNFEQIFFGMGCFWGAERLFWQLEGVYSTAVGYSGGVTSHPTYKEVCTGTTNHTEVVK
VIFDPTIISLNTLLHSFWQKHDPTEGMRQGNDIGSQYRSAIYTTSKAQQETAKQTQQQYQAALEKQGIMRIITTEIVPLQ
TFYFAEEYHQQYLAKNPDGYCGLKGTGVCFI

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=184, Percent_Identity=57.0652173913043, Blast_Score=220, Evalue=5e-58,
Organism=Homo sapiens, GI208609995, Length=183, Percent_Identity=57.3770491803279, Blast_Score=220, Evalue=7e-58,
Organism=Homo sapiens, GI208609993, Length=116, Percent_Identity=58.6206896551724, Blast_Score=142, Evalue=1e-34,
Organism=Escherichia coli, GI1790665, Length=181, Percent_Identity=53.5911602209945, Blast_Score=202, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=39.1891891891892, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320881, Length=173, Percent_Identity=35.2601156069364, Blast_Score=114, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24664627, Length=143, Percent_Identity=41.2587412587413, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=40.4255319148936, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24664631, Length=143, Percent_Identity=40.5594405594406, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 21796; Mature: 21665

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKQPTSPPLHFISQRNLEFIPPNFEQIFFGMGCFWGAERLFWQLEGVYSTAVGYSGGV
CCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TSHPTYKEVCTGTTNHTEVVKVIFDPTIISLNTLLHSFWQKHDPTEGMRQGNDIGSQYRS
CCCCCHHHHHCCCCCHHHEEHEECCCHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHH
AIYTTSKAQQETAKQTQQQYQAALEKQGIMRIITTEIVPLQTFYFAEEYHQQYLAKNPDG
HHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YCGLKGTGVCFI
CCCCCCCCEEEC
>Mature Secondary Structure 
TTKQPTSPPLHFISQRNLEFIPPNFEQIFFGMGCFWGAERLFWQLEGVYSTAVGYSGGV
CCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TSHPTYKEVCTGTTNHTEVVKVIFDPTIISLNTLLHSFWQKHDPTEGMRQGNDIGSQYRS
CCCCCHHHHHCCCCCHHHEEHEECCCHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHH
AIYTTSKAQQETAKQTQQQYQAALEKQGIMRIITTEIVPLQTFYFAEEYHQQYLAKNPDG
HHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YCGLKGTGVCFI
CCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]