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The map label for this gene is nuoI

Identifier: 58617106

GI number: 58617106

Start: 627131

End: 627637

Strand: Reverse

Name: nuoI

Synonym: ERGA_CDS_03790

Alternate gene names: 58617106

Gene position: 627637-627131 (Counterclockwise)

Preceding gene: 58617107

Following gene: 58617100

Centisome position: 41.84

GC content: 30.97

Gene sequence:

>507_bases
ATGATTAATAAAAGATCATTACTGGCAAGTTTTATAAATTTACCGTATAGCTTATTCATTACCTTTAAAGGTATGTATAT
AACATTACGTTATATGTTCAAACCAAAGGTTACGTTAAATTATCCACTAGAAAAGAACCCATTAAGTACAAGGTTTAGAG
GTGAACATGCGTTACGAACATATAAAAATGGTGAAGAACGTTGTATAGCATGCAAATTATGTGAAGCTATATGTCCAGCA
CAGGCAATTACAATTGAAGCACAAGAACGTGATACTGATAATAGTAGACGTACAGTTAGATATGATATAGATATGACAAA
ATGCATATACTGCGGATTTTGTCAAGAAGCATGTCCTGTAGATGCTATTGTAGAAGGACCAAATTTTGAGTATGCCACAG
AAACAAGAGAAGAGCTTATGTATAATAAAAGTAAGCTATTACATAATGGACAAATATGGGAAGAAGCTATTGATTTAAGA
ATCAAGAAAAATAGTAAGTTTTATTAA

Upstream 100 bases:

>100_bases
ATGTAATAGCATTATCATTCACAAAATCTAAAGATGGCAGTTTTTTGCCATTTAAATTAAGATCAGATAGAGTATGGCAT
GCAATTAATTAAGATATATT

Downstream 100 bases:

>100_bases
CTATATAATTCATACTTTTACTGTATTTTTATCAAATTATTATATTCAAAATCATGTATGTCATTTTGGTAATCAAAGTT
ATCAGGTGTTTTTTTATCTT

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MINKRSLLASFINLPYSLFITFKGMYITLRYMFKPKVTLNYPLEKNPLSTRFRGEHALRTYKNGEERCIACKLCEAICPA
QAITIEAQERDTDNSRRTVRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEYATETREELMYNKSKLLHNGQIWEEAIDLR
IKKNSKFY

Sequences:

>Translated_168_residues
MINKRSLLASFINLPYSLFITFKGMYITLRYMFKPKVTLNYPLEKNPLSTRFRGEHALRTYKNGEERCIACKLCEAICPA
QAITIEAQERDTDNSRRTVRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEYATETREELMYNKSKLLHNGQIWEEAIDLR
IKKNSKFY
>Mature_168_residues
MINKRSLLASFINLPYSLFITFKGMYITLRYMFKPKVTLNYPLEKNPLSTRFRGEHALRTYKNGEERCIACKLCEAICPA
QAITIEAQERDTDNSRRTVRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEYATETREELMYNKSKLLHNGQIWEEAIDLR
IKKNSKFY

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=143, Percent_Identity=72.7272727272727, Blast_Score=223, Evalue=5e-59,
Organism=Escherichia coli, GI1788617, Length=128, Percent_Identity=35.9375, Blast_Score=90, Evalue=7e-20,
Organism=Escherichia coli, GI1789075, Length=129, Percent_Identity=27.906976744186, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555194, Length=141, Percent_Identity=72.3404255319149, Blast_Score=215, Evalue=8e-57,
Organism=Drosophila melanogaster, GI17864306, Length=143, Percent_Identity=72.027972027972, Blast_Score=221, Evalue=2e-58,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI_EHRRG (Q5FHN1)

Other databases:

- EMBL:   CR925677
- RefSeq:   YP_196305.1
- HSSP:   P00198
- ProteinModelPortal:   Q5FHN1
- SMR:   Q5FHN1
- STRING:   Q5FHN1
- GeneID:   3268530
- GenomeReviews:   CR925677_GR
- KEGG:   erg:ERGA_CDS_03790
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   QWEVEIS
- ProtClustDB:   PRK05888
- BioCyc:   ERUM302409:ERGA_CDS_03790-MONOMER
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 19681; Mature: 19681

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINKRSLLASFINLPYSLFITFKGMYITLRYMFKPKVTLNYPLEKNPLSTRFRGEHALRT
CCCHHHHHHHHHCCCEEEEEEECCEEEEEEEEECCCEEEECCCCCCCCCCCCCCCHHHHH
YKNGEERCIACKLCEAICPAQAITIEAQERDTDNSRRTVRYDIDMTKCIYCGFCQEACPV
HCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEECCCHHHHEECCCCCCCCC
DAIVEGPNFEYATETREELMYNKSKLLHNGQIWEEAIDLRIKKNSKFY
CEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCEEEECCCCCC
>Mature Secondary Structure
MINKRSLLASFINLPYSLFITFKGMYITLRYMFKPKVTLNYPLEKNPLSTRFRGEHALRT
CCCHHHHHHHHHCCCEEEEEEECCEEEEEEEEECCCEEEECCCCCCCCCCCCCCCHHHHH
YKNGEERCIACKLCEAICPAQAITIEAQERDTDNSRRTVRYDIDMTKCIYCGFCQEACPV
HCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEECCCHHHHEECCCCCCCCC
DAIVEGPNFEYATETREELMYNKSKLLHNGQIWEEAIDLRIKKNSKFY
CEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA