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The map label for this gene is yhxA [H]

Identifier: 56965544

GI number: 56965544

Start: 3947915

End: 3949267

Strand: Direct

Name: yhxA [H]

Synonym: ABC3786

Alternate gene names: 56965544

Gene position: 3947915-3949267 (Clockwise)

Preceding gene: 56965543

Following gene: 56965565

Centisome position: 91.73

GC content: 50.41

Gene sequence:

>1353_bases
GTGAACACTGGAATGGAACCGACATTGGCCAAAAAAGACGGGCAATATGTCTGGCATGCGATGCAACGTCCAGGAGCCGC
GCCTCTTATCGCCGATTCAGGTGAAGGGTCGTGGTTTACGGATACAAATGGCAACCGCTACATGGACGGAGTCTCTGGGC
TATGGTGCCTAAATCTTGGTCATGGGCAAACGGAAATCATTGAAGCAGCGACTGAGCAAATGAACAAACTTGCCTACTTT
CCCCTTTCCCTTGGCCACCAGCCAGCGATCGCTCTGGCTGAAAAATTAGCCGCTTTGCTTGGTGGCGGGTTTCGCACCTT
TTTTGCCAACGGCGGCTCTGACGCGAACGAAACGGCCTTTAAAATCGCGCGCCAATACCATAAGCAAACCGGCTCCCCAG
AAAAACAAAAAATCATTTCCCGTTACCGCGGCTACCATGGCAACTCCCTTGGCGCCCTTGCGGCTACGGCCCAAGCAAAT
CGCAAAATAAAGTACGACGCTGCTTTGCCTGGCTTTTTGCATATTCCACCGCCTTACGCCTATCGATCAAGCTTTGGCTC
TGCTGCGGAAGACGACCAGCAGGCCGCTGATTTTCTTGAACAAACGATTTTATGGGAAGGCCCTGAAACAATCGCCGCGT
TTATAATGGAACCGATTATTTCCGGCGGCGGCGTCATTTACCCTCAATCAAACGACTATTACAAACGTGTCCGCGACATT
TGCGATCGCTATCAAGTGTTGCTCATTTTAGATGAAGTCGTCTCTGGCTTCGGCCGGACCGGCAAGCTATTCGGCTTTAT
GCATGGCGATGACGATTTCAAACCTGACATTATCACACTGGCAAAAGGGCTTACGAGCGGCTATCTCCCACTAGGCGCTA
CGTGCGTTGCCGAAAACGTATATCAAGCATTCGATGGAAAAGGCGAGACCAGCCATTTCCGCCACATCTCCACCTACGGC
GGACACCCGGCGTCTTGCGCGGTCGCGTTAAAAGCGATTGATATTATTGAGCGTGAACAGATTGTCAATCGAGTCGAAAC
GCTAGGCCATACCGTTCTTGGCAAATTGAAACAACTTGAACAACTTTCGATTGTCGGCGAAGTGCGCGGAATTGGCTTCC
TTTACGGCATAGAACTTGTTCAAGATAAACAGACCAAGGAGCCAGCTGATGACGATACGATGAAAGCGGTTGTAACCGCT
TGCCAAAAACAAGGGCTGATCATCGGCAAAAACAGCGACACGATTCCAGGAGGAGGCAATGTTTTAATTATCGCCCCACC
ACTCACTTCTAGCGAAGAAGATTTAGCATTTCTCGTCGATACCGTGTCCAGCGTTCTGCGTACATTTGCATAA

Upstream 100 bases:

>100_bases
CTGAGGAAGAATGGACTTCTTGGGAGGACTGCGAAAAGGGCGTCAATGTCCTATTAGAAACGGCATTGAAACGAACGATG
CACGAGGAGGCGATTAAACA

Downstream 100 bases:

>100_bases
GCATCAATCTAAGGCGAGCGCGTTTGCTCGCCTATTTCCACATCTGCCTTCCTGTTGGCACCCTTTACAGCAAGGAAATG
CATTTCAAATGTCAGCGTTC

Product: aminotransferase

Products: S-adenosyl-4-methylthio-2-oxobutanoate; 7,8-diaminononanoate

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MNTGMEPTLAKKDGQYVWHAMQRPGAAPLIADSGEGSWFTDTNGNRYMDGVSGLWCLNLGHGQTEIIEAATEQMNKLAYF
PLSLGHQPAIALAEKLAALLGGGFRTFFANGGSDANETAFKIARQYHKQTGSPEKQKIISRYRGYHGNSLGALAATAQAN
RKIKYDAALPGFLHIPPPYAYRSSFGSAAEDDQQAADFLEQTILWEGPETIAAFIMEPIISGGGVIYPQSNDYYKRVRDI
CDRYQVLLILDEVVSGFGRTGKLFGFMHGDDDFKPDIITLAKGLTSGYLPLGATCVAENVYQAFDGKGETSHFRHISTYG
GHPASCAVALKAIDIIEREQIVNRVETLGHTVLGKLKQLEQLSIVGEVRGIGFLYGIELVQDKQTKEPADDDTMKAVVTA
CQKQGLIIGKNSDTIPGGGNVLIIAPPLTSSEEDLAFLVDTVSSVLRTFA

Sequences:

>Translated_450_residues
MNTGMEPTLAKKDGQYVWHAMQRPGAAPLIADSGEGSWFTDTNGNRYMDGVSGLWCLNLGHGQTEIIEAATEQMNKLAYF
PLSLGHQPAIALAEKLAALLGGGFRTFFANGGSDANETAFKIARQYHKQTGSPEKQKIISRYRGYHGNSLGALAATAQAN
RKIKYDAALPGFLHIPPPYAYRSSFGSAAEDDQQAADFLEQTILWEGPETIAAFIMEPIISGGGVIYPQSNDYYKRVRDI
CDRYQVLLILDEVVSGFGRTGKLFGFMHGDDDFKPDIITLAKGLTSGYLPLGATCVAENVYQAFDGKGETSHFRHISTYG
GHPASCAVALKAIDIIEREQIVNRVETLGHTVLGKLKQLEQLSIVGEVRGIGFLYGIELVQDKQTKEPADDDTMKAVVTA
CQKQGLIIGKNSDTIPGGGNVLIIAPPLTSSEEDLAFLVDTVSSVLRTFA
>Mature_450_residues
MNTGMEPTLAKKDGQYVWHAMQRPGAAPLIADSGEGSWFTDTNGNRYMDGVSGLWCLNLGHGQTEIIEAATEQMNKLAYF
PLSLGHQPAIALAEKLAALLGGGFRTFFANGGSDANETAFKIARQYHKQTGSPEKQKIISRYRGYHGNSLGALAATAQAN
RKIKYDAALPGFLHIPPPYAYRSSFGSAAEDDQQAADFLEQTILWEGPETIAAFIMEPIISGGGVIYPQSNDYYKRVRDI
CDRYQVLLILDEVVSGFGRTGKLFGFMHGDDDFKPDIITLAKGLTSGYLPLGATCVAENVYQAFDGKGETSHFRHISTYG
GHPASCAVALKAIDIIEREQIVNRVETLGHTVLGKLKQLEQLSIVGEVRGIGFLYGIELVQDKQTKEPADDDTMKAVVTA
CQKQGLIIGKNSDTIPGGGNVLIIAPPLTSSEEDLAFLVDTVSSVLRTFA

Specific function: Essential for glycerol catabolism [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=430, Percent_Identity=30.6976744186047, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI13994255, Length=445, Percent_Identity=30.7865168539326, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI226442705, Length=430, Percent_Identity=30.9302325581395, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=31.5789473684211, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI4557809, Length=424, Percent_Identity=27.8301886792453, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI24119277, Length=426, Percent_Identity=27.4647887323944, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI284507298, Length=342, Percent_Identity=29.2397660818713, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI188536080, Length=458, Percent_Identity=22.4890829694323, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38679950, Length=458, Percent_Identity=22.4890829694323, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38679946, Length=458, Percent_Identity=22.4890829694323, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI145693181, Length=418, Percent_Identity=32.5358851674641, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI1788044, Length=429, Percent_Identity=31.2354312354312, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789759, Length=412, Percent_Identity=29.6116504854369, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789016, Length=411, Percent_Identity=31.6301703163017, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI1786991, Length=373, Percent_Identity=31.0991957104558, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI1787560, Length=408, Percent_Identity=31.1274509803922, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1786349, Length=359, Percent_Identity=24.5125348189415, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32564660, Length=452, Percent_Identity=31.858407079646, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI25144271, Length=425, Percent_Identity=28.4705882352941, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI71992977, Length=439, Percent_Identity=26.4236902050114, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25144274, Length=306, Percent_Identity=31.3725490196078, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=383, Percent_Identity=22.4543080939948, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=427, Percent_Identity=29.9765807962529, Blast_Score=176, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=27.9012345679012, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6324386, Length=405, Percent_Identity=27.6543209876543, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321456, Length=361, Percent_Identity=28.2548476454294, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI161085790, Length=445, Percent_Identity=31.2359550561798, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI28574759, Length=441, Percent_Identity=31.5192743764172, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21357415, Length=421, Percent_Identity=29.4536817102138, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI21356575, Length=417, Percent_Identity=28.7769784172662, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI281366494, Length=401, Percent_Identity=22.4438902743142, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667139, Length=401, Percent_Identity=22.4438902743142, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667143, Length=401, Percent_Identity=22.4438902743142, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62

Molecular weight: Translated: 48732; Mature: 48732

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTGMEPTLAKKDGQYVWHAMQRPGAAPLIADSGEGSWFTDTNGNRYMDGVSGLWCLNLG
CCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCEEECCCCCEEECCCCCEEEEECC
HGQTEIIEAATEQMNKLAYFPLSLGHQPAIALAEKLAALLGGGFRTFFANGGSDANETAF
CCHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCHHHHH
KIARQYHKQTGSPEKQKIISRYRGYHGNSLGALAATAQANRKIKYDAALPGFLHIPPPYA
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCCCCEECCCCHH
YRSSFGSAAEDDQQAADFLEQTILWEGPETIAAFIMEPIISGGGVIYPQSNDYYKRVRDI
HHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHH
CDRYQVLLILDEVVSGFGRTGKLFGFMHGDDDFKPDIITLAKGLTSGYLPLGATCVAENV
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHH
YQAFDGKGETSHFRHISTYGGHPASCAVALKAIDIIEREQIVNRVETLGHTVLGKLKQLE
HHHHCCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLSIVGEVRGIGFLYGIELVQDKQTKEPADDDTMKAVVTACQKQGLIIGKNSDTIPGGGN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCC
VLIIAPPLTSSEEDLAFLVDTVSSVLRTFA
EEEEECCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTGMEPTLAKKDGQYVWHAMQRPGAAPLIADSGEGSWFTDTNGNRYMDGVSGLWCLNLG
CCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCEEECCCCCEEECCCCCEEEEECC
HGQTEIIEAATEQMNKLAYFPLSLGHQPAIALAEKLAALLGGGFRTFFANGGSDANETAF
CCHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCHHHHH
KIARQYHKQTGSPEKQKIISRYRGYHGNSLGALAATAQANRKIKYDAALPGFLHIPPPYA
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCCCCEECCCCHH
YRSSFGSAAEDDQQAADFLEQTILWEGPETIAAFIMEPIISGGGVIYPQSNDYYKRVRDI
HHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHH
CDRYQVLLILDEVVSGFGRTGKLFGFMHGDDDFKPDIITLAKGLTSGYLPLGATCVAENV
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHH
YQAFDGKGETSHFRHISTYGGHPASCAVALKAIDIIEREQIVNRVETLGHTVLGKLKQLE
HHHHCCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLSIVGEVRGIGFLYGIELVQDKQTKEPADDDTMKAVVTACQKQGLIIGKNSDTIPGGGN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCC
VLIIAPPLTSSEEDLAFLVDTVSSVLRTFA
EEEEECCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; 8-amino-7-oxononanoate

Specific reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8969498; 8436953 [H]