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The map label for this gene is yeiA [H]

Identifier: 56965540

GI number: 56965540

Start: 3943650

End: 3944909

Strand: Direct

Name: yeiA [H]

Synonym: ABC3782

Alternate gene names: 56965540

Gene position: 3943650-3944909 (Clockwise)

Preceding gene: 56965539

Following gene: 56965541

Centisome position: 91.63

GC content: 51.35

Gene sequence:

>1260_bases
ATGGCTGACCTCATTAGCAATTTAGCTGGCATTACATCGCCTAACCCATTTTGGCTTGCCAGCGCTCCGCCGACCAACTC
TGGCTATCAAGTGCAGCGGGCGTTTGAGGCTGGTTGGGGTGGGGCCGTCTGGAAGACGCTTGGCGAACCGATTATGAACT
CCACCTCCCGTTTCGCTGCCCTCCACTTCAATGGCAAGCGCGTGGCAGGTTTTAATAACATTGAACTGATTTCAGACCGT
CCGCTGGATGTTAATTTACGAGAAATCGCCGATACAAAAAAACGTTTCCCCAACCATGCCATTGTCGCCTCATTAATGGT
GGAACCTAAACAGGAAAAATGGCATGAGATTGTCAAACGCGTCGAGGCAGTAGGAGTGGACGGTCTTGAACTAAATTTTG
GCTGTCCCCATGGCATGGCGGAACGAGGCATGGGTTCGGCCTCTGGCCAAGTGCCTGCGCTCGTTGAACAGCAAACCGTT
TGGGTAAAAGAAGTGGCAAGGACACCTGTTATCGTCAAACTGACGCCAAATATTACTGATATTACCGCCACGGCCGAGGC
CGCTGCTCAAGGAGGCGCTGATGCCATTAGTTTGATTAACACAATCAACAGCCTGGCCGGCGTCGACATCGACACTTGGC
AAACGATACCGAATGTCGATGGCCTAGGCACTCATGGCGGCTACTGCGGCCCAGCTGTTAAGCCCATTGCCTTGCATATG
CTTGGCGATTGTGCCCGCCATCCGAATGTCAATATACCGATTTCAGGAATTGGCGGCATTGCTACTTGGCAAGATGCGGT
GCAATTTTTACTGATGGGCGCTTCAAACGTGCAAGTGTGCACCGCTGCCATGCACCATGGCTTTCGCATTGTCGAAGATT
TGCTTGATGGGCTATCCGCCTATTTAGAGGAAAAAGGGCTTGCTTCCGTGCAAGAATTAGTTGGCCAATCGGTTCATCGC
TATTCTGAATGGGGCAACCTCAATTTAAACCATCAAGTCGTTGCTCGAATCAATCGGGATGTATGCATCAACTGCAACAA
ATGCCACATCTCCTGTGAAGATACGGCCCACCAATGCATTGGCCGCTATACAGACGAGAACGGTGCTCCTTACTTGAAAG
TGGATGAAGACGAATGTGTTGGCTGCAACTTGTGCTCCATTGTTTGCCCAGTAGAGGGCGCGATTGCCATGGTGCCAAAA
CCGAACGGGCTGCCGCCAATGTCTTGGAATGAACGGCAGGCTGCTATAGCCAATGACTGA

Upstream 100 bases:

>100_bases
TGGTAGTTGCGGCTGCCGAACAAGGAAAGCAAGTGGCGTACGCAATTGATAAAAAACGACGCAGCCAACGGGCTGAAACG
AGCGCATAAGGAGGAATTCG

Downstream 100 bases:

>100_bases
ACCGAGCTTAAACACAAGCGGCCGAAAAAAGAGATGGTAGGGGGAAAACAATGAAACGACTTATACAAAACGGGACGATC
GTGACTGCTTCTGATACGTA

Product: dihydropyrimidine dehydrogenase

Products: uracil; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MADLISNLAGITSPNPFWLASAPPTNSGYQVQRAFEAGWGGAVWKTLGEPIMNSTSRFAALHFNGKRVAGFNNIELISDR
PLDVNLREIADTKKRFPNHAIVASLMVEPKQEKWHEIVKRVEAVGVDGLELNFGCPHGMAERGMGSASGQVPALVEQQTV
WVKEVARTPVIVKLTPNITDITATAEAAAQGGADAISLINTINSLAGVDIDTWQTIPNVDGLGTHGGYCGPAVKPIALHM
LGDCARHPNVNIPISGIGGIATWQDAVQFLLMGASNVQVCTAAMHHGFRIVEDLLDGLSAYLEEKGLASVQELVGQSVHR
YSEWGNLNLNHQVVARINRDVCINCNKCHISCEDTAHQCIGRYTDENGAPYLKVDEDECVGCNLCSIVCPVEGAIAMVPK
PNGLPPMSWNERQAAIAND

Sequences:

>Translated_419_residues
MADLISNLAGITSPNPFWLASAPPTNSGYQVQRAFEAGWGGAVWKTLGEPIMNSTSRFAALHFNGKRVAGFNNIELISDR
PLDVNLREIADTKKRFPNHAIVASLMVEPKQEKWHEIVKRVEAVGVDGLELNFGCPHGMAERGMGSASGQVPALVEQQTV
WVKEVARTPVIVKLTPNITDITATAEAAAQGGADAISLINTINSLAGVDIDTWQTIPNVDGLGTHGGYCGPAVKPIALHM
LGDCARHPNVNIPISGIGGIATWQDAVQFLLMGASNVQVCTAAMHHGFRIVEDLLDGLSAYLEEKGLASVQELVGQSVHR
YSEWGNLNLNHQVVARINRDVCINCNKCHISCEDTAHQCIGRYTDENGAPYLKVDEDECVGCNLCSIVCPVEGAIAMVPK
PNGLPPMSWNERQAAIAND
>Mature_418_residues
ADLISNLAGITSPNPFWLASAPPTNSGYQVQRAFEAGWGGAVWKTLGEPIMNSTSRFAALHFNGKRVAGFNNIELISDRP
LDVNLREIADTKKRFPNHAIVASLMVEPKQEKWHEIVKRVEAVGVDGLELNFGCPHGMAERGMGSASGQVPALVEQQTVW
VKEVARTPVIVKLTPNITDITATAEAAAQGGADAISLINTINSLAGVDIDTWQTIPNVDGLGTHGGYCGPAVKPIALHML
GDCARHPNVNIPISGIGGIATWQDAVQFLLMGASNVQVCTAAMHHGFRIVEDLLDGLSAYLEEKGLASVQELVGQSVHRY
SEWGNLNLNHQVVARINRDVCINCNKCHISCEDTAHQCIGRYTDENGAPYLKVDEDECVGCNLCSIVCPVEGAIAMVPKP
NGLPPMSWNERQAAIAND

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=448, Percent_Identity=32.8125, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI87082059, Length=391, Percent_Identity=41.6879795396419, Blast_Score=309, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI71984108, Length=324, Percent_Identity=37.6543209876543, Blast_Score=211, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6322633, Length=238, Percent_Identity=26.0504201680672, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640763, Length=313, Percent_Identity=42.1725239616613, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI18858217, Length=313, Percent_Identity=42.1725239616613, Blast_Score=232, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: 1.3.1.2

Molecular weight: Translated: 45010; Mature: 44878

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLISNLAGITSPNPFWLASAPPTNSGYQVQRAFEAGWGGAVWKTLGEPIMNSTSRFAA
CHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHCHHHHCCCCCEEE
LHFNGKRVAGFNNIELISDRPLDVNLREIADTKKRFPNHAIVASLMVEPKQEKWHEIVKR
EEECCEEECCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHH
VEAVGVDGLELNFGCPHGMAERGMGSASGQVPALVEQQTVWVKEVARTPVIVKLTPNITD
HHHCCCCCEEEECCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCE
ITATAEAAAQGGADAISLINTINSLAGVDIDTWQTIPNVDGLGTHGGYCGPAVKPIALHM
EEHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
LGDCARHPNVNIPISGIGGIATWQDAVQFLLMGASNVQVCTAAMHHGFRIVEDLLDGLSA
HHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHH
YLEEKGLASVQELVGQSVHRYSEWGNLNLNHQVVARINRDVCINCNKCHISCEDTAHQCI
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCEEEECCEEEEECHHHHHHHH
GRYTDENGAPYLKVDEDECVGCNLCSIVCPVEGAIAMVPKPNGLPPMSWNERQAAIAND
HCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADLISNLAGITSPNPFWLASAPPTNSGYQVQRAFEAGWGGAVWKTLGEPIMNSTSRFAA
HHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHCHHHHCCCCCEEE
LHFNGKRVAGFNNIELISDRPLDVNLREIADTKKRFPNHAIVASLMVEPKQEKWHEIVKR
EEECCEEECCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHH
VEAVGVDGLELNFGCPHGMAERGMGSASGQVPALVEQQTVWVKEVARTPVIVKLTPNITD
HHHCCCCCEEEECCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCE
ITATAEAAAQGGADAISLINTINSLAGVDIDTWQTIPNVDGLGTHGGYCGPAVKPIALHM
EEHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
LGDCARHPNVNIPISGIGGIATWQDAVQFLLMGASNVQVCTAAMHHGFRIVEDLLDGLSA
HHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHH
YLEEKGLASVQELVGQSVHRYSEWGNLNLNHQVVARINRDVCINCNKCHISCEDTAHQCI
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCEEEECCEEEEECHHHHHHHH
GRYTDENGAPYLKVDEDECVGCNLCSIVCPVEGAIAMVPKPNGLPPMSWNERQAAIAND
HCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,6-dihydrouracil; NADP+

Specific reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]