Click here to switch to the map view.

The map label for this gene is ygeZ [C]

Identifier: 56965541

GI number: 56965541

Start: 3944960

End: 3946375

Strand: Direct

Name: ygeZ [C]

Synonym: ABC3783

Alternate gene names: 56965541

Gene position: 3944960-3946375 (Clockwise)

Preceding gene: 56965540

Following gene: 56965542

Centisome position: 91.66

GC content: 50.07

Gene sequence:

>1416_bases
ATGAAACGACTTATACAAAACGGGACGATCGTGACTGCTTCTGATACGTATAAAGCTGACTTGTTGATCGAAGGTGAAAC
GATTGCGCAAATTGGCCAACAATTGGCTGTTCAAGGAGTAGACGAAATCATCGATGCAAGCGGCTGCTTTGTCTTTCCTG
GCGGCATTGACCCCCATACACACCTGGACATGCCGTTTGGAGGCACTGTCACAAAAGATGATTTTGAAACAGGAACGATT
GCCGCTGCCTATGGCGGGACAACGACAATCATTGATTTTTGCCTGACTGAGAAAGAAAAGCCGCTGCATACGGCAATAGA
AGCATGGCATAAAAAAGCAGCAGGAAAAGCAGCCATTGACTACGGCTTCCATTTAATGATCGGTGAAATCAACGAAGCTG
TGCTCAATGAATTGCCAGCAATCGTCTCAACGGAAGGCATTTCATCCTTTAAAGTATTTATGGCGTATAAGCATGTGTTC
CAAGCCGATGATGCCACTCTATTTGAGACGCTCACAAAAGCGAAAGAACTAGGCGCTTTAGTTATGGTCCATGCCGAGAA
TGGCGACGTCATTGATTATTTAACAAAGCAAGCGTTGAAAGAAGGAAAAACGGCGCCTATTTACCACGCTCTCACTCGCC
CTGTCGAAGCGGAAGGAGAAGCGACCGGGCGTGCTTGCCAGCTCGCCTCCCTTGCACAGTCGCAGCTTTATGTGGTCCAT
GTCACTTGCCAAGAGGCCGTCCAACAAATTGCCGAAGCGCGTAAGCAAGGGGCAGACATTTGGGGCGAAACATGCCCGCA
ATATTTAGTGCTTGATGAAAGCATGTTGCGAAAACCTGGATTTGAAGGAGCAAAATATGTATGGTCGCCGCCGCTGCGGG
AAAAACAGCACCAAGACGCCCTCTGGAAGGCACTAAAAACGGGGGCATTGCAAACCATTGGCAGCGACCAGTGTTCGTTT
GACTTCGCTGGCCAAAAAGACTTGGGCATTAACGACTTTACAAAAATCCCAAATGGCGGGCCTATTATTGAAGACCGCTT
TTCGCTCCTGTATTCAGAAGGCGTAGCCAAAGGGCGCATCGGCCTTAACGAGTTTGTGGACCTCGTCTCAACACGGGCAG
CCAAACTGTTCGGACTGTATCCGAAAAAAGGCTGCATCGCTGTCGGAGCCGATGCAGACATCGTCTTGTTTGACCCCCAA
GCAGAGCGTGTCCTGTCAGCTCGTACACACCACCTCGCTGTAGATTACAGCGCCTTTGAAGGAATGCGCGTAAAAGGGAC
GCCGCGGACTGTGCTGTCGCGGGGAAAAGTTATCGTCCGCGATCAAACCTATGTCGGCACTCCAGGAGAAGGAGCGTTTC
TAAAACGGGCGCGCTATGGGGAGTTATGGACGAACGATTTAGTAGGCCAGCGCTGA

Upstream 100 bases:

>100_bases
TGCCGCCAATGTCTTGGAATGAACGGCAGGCTGCTATAGCCAATGACTGAACCGAGCTTAAACACAAGCGGCCGAAAAAA
GAGATGGTAGGGGGAAAACA

Downstream 100 bases:

>100_bases
TATGTGGGCACTTGCCCATTTATTCCGCAAACATGAACAAGCGATGTCGAAAGGAGAGGTTTGATGGCGGAATATACCCA
CTTTCAAAAAGAAAAAGGAG

Product: phenylhydantoinase

Products: 3-ureidopropanoate

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKRLIQNGTIVTASDTYKADLLIEGETIAQIGQQLAVQGVDEIIDASGCFVFPGGIDPHTHLDMPFGGTVTKDDFETGTI
AAAYGGTTTIIDFCLTEKEKPLHTAIEAWHKKAAGKAAIDYGFHLMIGEINEAVLNELPAIVSTEGISSFKVFMAYKHVF
QADDATLFETLTKAKELGALVMVHAENGDVIDYLTKQALKEGKTAPIYHALTRPVEAEGEATGRACQLASLAQSQLYVVH
VTCQEAVQQIAEARKQGADIWGETCPQYLVLDESMLRKPGFEGAKYVWSPPLREKQHQDALWKALKTGALQTIGSDQCSF
DFAGQKDLGINDFTKIPNGGPIIEDRFSLLYSEGVAKGRIGLNEFVDLVSTRAAKLFGLYPKKGCIAVGADADIVLFDPQ
AERVLSARTHHLAVDYSAFEGMRVKGTPRTVLSRGKVIVRDQTYVGTPGEGAFLKRARYGELWTNDLVGQR

Sequences:

>Translated_471_residues
MKRLIQNGTIVTASDTYKADLLIEGETIAQIGQQLAVQGVDEIIDASGCFVFPGGIDPHTHLDMPFGGTVTKDDFETGTI
AAAYGGTTTIIDFCLTEKEKPLHTAIEAWHKKAAGKAAIDYGFHLMIGEINEAVLNELPAIVSTEGISSFKVFMAYKHVF
QADDATLFETLTKAKELGALVMVHAENGDVIDYLTKQALKEGKTAPIYHALTRPVEAEGEATGRACQLASLAQSQLYVVH
VTCQEAVQQIAEARKQGADIWGETCPQYLVLDESMLRKPGFEGAKYVWSPPLREKQHQDALWKALKTGALQTIGSDQCSF
DFAGQKDLGINDFTKIPNGGPIIEDRFSLLYSEGVAKGRIGLNEFVDLVSTRAAKLFGLYPKKGCIAVGADADIVLFDPQ
AERVLSARTHHLAVDYSAFEGMRVKGTPRTVLSRGKVIVRDQTYVGTPGEGAFLKRARYGELWTNDLVGQR
>Mature_471_residues
MKRLIQNGTIVTASDTYKADLLIEGETIAQIGQQLAVQGVDEIIDASGCFVFPGGIDPHTHLDMPFGGTVTKDDFETGTI
AAAYGGTTTIIDFCLTEKEKPLHTAIEAWHKKAAGKAAIDYGFHLMIGEINEAVLNELPAIVSTEGISSFKVFMAYKHVF
QADDATLFETLTKAKELGALVMVHAENGDVIDYLTKQALKEGKTAPIYHALTRPVEAEGEATGRACQLASLAQSQLYVVH
VTCQEAVQQIAEARKQGADIWGETCPQYLVLDESMLRKPGFEGAKYVWSPPLREKQHQDALWKALKTGALQTIGSDQCSF
DFAGQKDLGINDFTKIPNGGPIIEDRFSLLYSEGVAKGRIGLNEFVDLVSTRAAKLFGLYPKKGCIAVGADADIVLFDPQ
AERVLSARTHHLAVDYSAFEGMRVKGTPRTVLSRGKVIVRDQTYVGTPGEGAFLKRARYGELWTNDLVGQR

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin. Has no activity on dihydropyrimidines [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=466, Percent_Identity=41.8454935622318, Blast_Score=355, Evalue=6e-98,
Organism=Homo sapiens, GI4503379, Length=462, Percent_Identity=40.6926406926407, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI190194363, Length=463, Percent_Identity=40.6047516198704, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI4503377, Length=463, Percent_Identity=39.524838012959, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI4503051, Length=462, Percent_Identity=40.9090909090909, Blast_Score=331, Evalue=8e-91,
Organism=Homo sapiens, GI62422571, Length=460, Percent_Identity=41.0869565217391, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI19923821, Length=455, Percent_Identity=37.1428571428571, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI18105007, Length=455, Percent_Identity=23.5164835164835, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI87082175, Length=461, Percent_Identity=42.5162689804772, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1786722, Length=443, Percent_Identity=32.0541760722348, Blast_Score=195, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17539558, Length=460, Percent_Identity=42.6086956521739, Blast_Score=345, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI71989490, Length=456, Percent_Identity=40.5701754385965, Blast_Score=335, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI86575075, Length=469, Percent_Identity=29.8507462686567, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193204318, Length=461, Percent_Identity=22.1258134490239, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=462, Percent_Identity=26.1904761904762, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI221377917, Length=456, Percent_Identity=43.859649122807, Blast_Score=351, Evalue=5e-97,
Organism=Drosophila melanogaster, GI17137462, Length=453, Percent_Identity=41.9426048565121, Blast_Score=341, Evalue=5e-94,
Organism=Drosophila melanogaster, GI24644287, Length=294, Percent_Identity=43.1972789115646, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24644289, Length=227, Percent_Identity=44.0528634361233, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI18859883, Length=438, Percent_Identity=26.9406392694064, Blast_Score=105, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.2

Molecular weight: Translated: 51288; Mature: 51288

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLIQNGTIVTASDTYKADLLIEGETIAQIGQQLAVQGVDEIIDASGCFVFPGGIDPHT
CCCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
HLDMPFGGTVTKDDFETGTIAAAYGGTTTIIDFCLTEKEKPLHTAIEAWHKKAAGKAAID
EECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEC
YGFHLMIGEINEAVLNELPAIVSTEGISSFKVFMAYKHVFQADDATLFETLTKAKELGAL
CCEEEEEEHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEE
VMVHAENGDVIDYLTKQALKEGKTAPIYHALTRPVEAEGEATGRACQLASLAQSQLYVVH
EEEECCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEE
VTCQEAVQQIAEARKQGADIWGETCPQYLVLDESMLRKPGFEGAKYVWSPPLREKQHQDA
EEHHHHHHHHHHHHHCCCHHHHHCCCCEEEECHHHHHCCCCCCCCEEECCCCCHHHHHHH
LWKALKTGALQTIGSDQCSFDFAGQKDLGINDFTKIPNGGPIIEDRFSLLYSEGVAKGRI
HHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCC
GLNEFVDLVSTRAAKLFGLYPKKGCIAVGADADIVLFDPQAERVLSARTHHLAVDYSAFE
CHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCCHHHHHHHHHHEEEEEHHHHC
GMRVKGTPRTVLSRGKVIVRDQTYVGTPGEGAFLKRARYGELWTNDLVGQR
CEEECCCCHHHHHCCCEEEECCEEECCCCCCHHHHHCCCCCHHHHHHCCCC
>Mature Secondary Structure
MKRLIQNGTIVTASDTYKADLLIEGETIAQIGQQLAVQGVDEIIDASGCFVFPGGIDPHT
CCCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
HLDMPFGGTVTKDDFETGTIAAAYGGTTTIIDFCLTEKEKPLHTAIEAWHKKAAGKAAID
EECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEC
YGFHLMIGEINEAVLNELPAIVSTEGISSFKVFMAYKHVFQADDATLFETLTKAKELGAL
CCEEEEEEHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEE
VMVHAENGDVIDYLTKQALKEGKTAPIYHALTRPVEAEGEATGRACQLASLAQSQLYVVH
EEEECCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEE
VTCQEAVQQIAEARKQGADIWGETCPQYLVLDESMLRKPGFEGAKYVWSPPLREKQHQDA
EEHHHHHHHHHHHHHCCCHHHHHCCCCEEEECHHHHHCCCCCCCCEEECCCCCHHHHHHH
LWKALKTGALQTIGSDQCSFDFAGQKDLGINDFTKIPNGGPIIEDRFSLLYSEGVAKGRI
HHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCC
GLNEFVDLVSTRAAKLFGLYPKKGCIAVGADADIVLFDPQAERVLSARTHHLAVDYSAFE
CHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCCHHHHHHHHHHEEEEEHHHHC
GMRVKGTPRTVLSRGKVIVRDQTYVGTPGEGAFLKRARYGELWTNDLVGQR
CEEECCCCHHHHHCCCEEEECCEEECCCCCCHHHHHCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,6-dihydrouracil; H2O

Specific reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765480 [H]