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The map label for this gene is trpC

Identifier: 56963662

GI number: 56963662

Start: 2014278

End: 2015045

Strand: Direct

Name: trpC

Synonym: ABC1897

Alternate gene names: 56963662

Gene position: 2014278-2015045 (Clockwise)

Preceding gene: 56963661

Following gene: 56963663

Centisome position: 46.8

GC content: 45.31

Gene sequence:

>768_bases
ATGCTTGAGAAAATTTTGGCGACAAAACGAGAGGAAATCAGCCAACTCCAGTTGCCTGAAAAGCAGTATTTTCCAAAAAA
AAGCCTGAAAGCGTCCTTACAAAAAACATCTTTGCCACTAGGGCTAATTGCAGAAATTAAACAGGCCTCCCCGTCAAAAG
GGGTTTTATGTGAGACGATTTCACCAACAGCGATTGCACGGGTTTATGAAGAAGGCGGAGCAAGCGCAATTAGCGTTTTG
ACAGACCGTACGTATTTTCAAGGGGACACTGCTTATGTGGCTGAAGTGAAAAAGACCGTGTCTTTGCCGGTATTGCGGAA
GGATTTTATTCTGTCGCCCCTTCAAGTAGAGGAAACAGCGTGCATTGGCGCAGACGCCATGTTGTTAATAGCCGGTGCAA
TGGAAGCGAAGCAGCTCCACGAACTATATGAATTAGCGTATAGCAAAGGGTTGGAGTGTTTAGTTGAAGTCCATAGCGAA
GAAGAGCTAGAGTCGCTTCTTGCTGTTTTTACCCCAGAAGTGATAGGCATCAATAATCGCAATTTAAAAACGTTCCAAAC
GTCGGTTTCCCAAACCGAGCAGATTGCAAAAATGGTGCCGAAAGAAGCGTTGCTTGTGTCCGAGAGTGGCATCCATACAC
CTGATGACATTGCGCGTGTGAAGAAAGCTGGAGCGAACGCTGTGTTGATTGGCGAACAGTTGATGCGTAAAGACGATAAA
AGGCAAGCGATCATCGACTTGTTTTCTGAAAGTGCGATAAACCAATGA

Upstream 100 bases:

>100_bases
CACATTGCTGAAGGCGTTCACTATGCCAGCAAAGCGATAGAGAGCAAACGAGTGTTTCGCTATTTGCAATCATTGCAACA
ACAGGGAAGGGGAATCAAGC

Downstream 100 bases:

>100_bases
AACTAAAATATTGTGGACTGCATCAGCAAGAGGATGTCGAAGTGGCAGCAGCTTCTCATTGTGATTACATGGGCTTCGTA
TTGGCAAACAGCAAGCGCAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MLEKILATKREEISQLQLPEKQYFPKKSLKASLQKTSLPLGLIAEIKQASPSKGVLCETISPTAIARVYEEGGASAISVL
TDRTYFQGDTAYVAEVKKTVSLPVLRKDFILSPLQVEETACIGADAMLLIAGAMEAKQLHELYELAYSKGLECLVEVHSE
EELESLLAVFTPEVIGINNRNLKTFQTSVSQTEQIAKMVPKEALLVSESGIHTPDDIARVKKAGANAVLIGEQLMRKDDK
RQAIIDLFSESAINQ

Sequences:

>Translated_255_residues
MLEKILATKREEISQLQLPEKQYFPKKSLKASLQKTSLPLGLIAEIKQASPSKGVLCETISPTAIARVYEEGGASAISVL
TDRTYFQGDTAYVAEVKKTVSLPVLRKDFILSPLQVEETACIGADAMLLIAGAMEAKQLHELYELAYSKGLECLVEVHSE
EELESLLAVFTPEVIGINNRNLKTFQTSVSQTEQIAKMVPKEALLVSESGIHTPDDIARVKKAGANAVLIGEQLMRKDDK
RQAIIDLFSESAINQ
>Mature_255_residues
MLEKILATKREEISQLQLPEKQYFPKKSLKASLQKTSLPLGLIAEIKQASPSKGVLCETISPTAIARVYEEGGASAISVL
TDRTYFQGDTAYVAEVKKTVSLPVLRKDFILSPLQVEETACIGADAMLLIAGAMEAKQLHELYELAYSKGLECLVEVHSE
EELESLLAVFTPEVIGINNRNLKTFQTSVSQTEQIAKMVPKEALLVSESGIHTPDDIARVKKAGANAVLIGEQLMRKDDK
RQAIIDLFSESAINQ

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=205, Percent_Identity=39.0243902439024, Blast_Score=129, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322638, Length=214, Percent_Identity=39.7196261682243, Blast_Score=145, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_BACSK (Q5WGS3)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175393.1
- HSSP:   Q56319
- ProteinModelPortal:   Q5WGS3
- SMR:   Q5WGS3
- STRING:   Q5WGS3
- EnsemblBacteria:   EBBACT00000049279
- GeneID:   3203562
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1897
- NMPDR:   fig|66692.3.peg.1941
- eggNOG:   COG0134
- GeneTree:   EBGT00050000001798
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   BCLA66692:ABC1897-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27960; Mature: 27960

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKILATKREEISQLQLPEKQYFPKKSLKASLQKTSLPLGLIAEIKQASPSKGVLCETI
CCHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECC
SPTAIARVYEEGGASAISVLTDRTYFQGDTAYVAEVKKTVSLPVLRKDFILSPLQVEETA
CHHHHHHHHHHCCCCEEHHHHCCCEECCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHH
CIGADAMLLIAGAMEAKQLHELYELAYSKGLECLVEVHSEEELESLLAVFTPEVIGINNR
HCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHCCHHEECCCC
NLKTFQTSVSQTEQIAKMVPKEALLVSESGIHTPDDIARVKKAGANAVLIGEQLMRKDDK
CCHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHCCCCEEEECHHHHCCCHH
RQAIIDLFSESAINQ
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MLEKILATKREEISQLQLPEKQYFPKKSLKASLQKTSLPLGLIAEIKQASPSKGVLCETI
CCHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECC
SPTAIARVYEEGGASAISVLTDRTYFQGDTAYVAEVKKTVSLPVLRKDFILSPLQVEETA
CHHHHHHHHHHCCCCEEHHHHCCCEECCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHH
CIGADAMLLIAGAMEAKQLHELYELAYSKGLECLVEVHSEEELESLLAVFTPEVIGINNR
HCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHCCHHEECCCC
NLKTFQTSVSQTEQIAKMVPKEALLVSESGIHTPDDIARVKKAGANAVLIGEQLMRKDDK
CCHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHCCCCEEEECHHHHCCCHH
RQAIIDLFSESAINQ
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA