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The map label for this gene is trpF

Identifier: 56963663

GI number: 56963663

Start: 2015042

End: 2015695

Strand: Direct

Name: trpF

Synonym: ABC1898

Alternate gene names: 56963663

Gene position: 2015042-2015695 (Clockwise)

Preceding gene: 56963662

Following gene: 56963664

Centisome position: 46.82

GC content: 48.62

Gene sequence:

>654_bases
ATGAAACTAAAATATTGTGGACTGCATCAGCAAGAGGATGTCGAAGTGGCAGCAGCTTCTCATTGTGATTACATGGGCTT
CGTATTGGCAAACAGCAAGCGCAAAGTTGCCCTTCCGGACGTGGCGCAATGGTTGGCTACAACTGACATGAGCACGAAGC
AAACGGTAGCACTTTTTGTGAATGAATCACTTGACACAATCGCACAAGTTGCCAGCAGCGACCTATTTGATGTGATCCAG
TTACATGGCACCGAAACGCCTGCTTTTTTGCAGGCCGTCAAGGACCGCACACAAAAGCAGGTATGGAAAGCGATCCATCA
TTCAAGCAGCGCGCTCGGCATCATGCAGGCTTTTGCAGGCATTGCCGATGGCTATGTAATTGATTGTAAAAGTGCCAAAG
GCTGGGGCGGAACAGGCGAATCATTCGACTGGAAACAGATACCTTCTTATAAGGAAGAAGGAGTTCGGCAAGGTACGCAA
GTGCTTATTGCAGGCGGAATTACGCCTGAAAACGTCGTCGAGCTTGCCCGCTACCAAGTAGACGGACTGGATGTATCGAG
CGGAATTGAAGAGAACGGAAAAAAAAGCGTCGCAAAAATAGCGCGCCTTGAACAAGAAGCGGGGGTCCATTATGCAAGAA
ACAATACCAGATAG

Upstream 100 bases:

>100_bases
AAGCTGGAGCGAACGCTGTGTTGATTGGCGAACAGTTGATGCGTAAAGACGATAAAAGGCAAGCGATCATCGACTTGTTT
TCTGAAAGTGCGATAAACCA

Downstream 100 bases:

>100_bases
CCGCGGCCGTTTTGGCGAGTTTGGCGGCAAATATGTTCCCGAAACATTAATGTCGGCAATTGAAGAGTTGGAAGCTGGGC
TGGCAAAAGCGATGGTTGAT

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MKLKYCGLHQQEDVEVAAASHCDYMGFVLANSKRKVALPDVAQWLATTDMSTKQTVALFVNESLDTIAQVASSDLFDVIQ
LHGTETPAFLQAVKDRTQKQVWKAIHHSSSALGIMQAFAGIADGYVIDCKSAKGWGGTGESFDWKQIPSYKEEGVRQGTQ
VLIAGGITPENVVELARYQVDGLDVSSGIEENGKKSVAKIARLEQEAGVHYARNNTR

Sequences:

>Translated_217_residues
MKLKYCGLHQQEDVEVAAASHCDYMGFVLANSKRKVALPDVAQWLATTDMSTKQTVALFVNESLDTIAQVASSDLFDVIQ
LHGTETPAFLQAVKDRTQKQVWKAIHHSSSALGIMQAFAGIADGYVIDCKSAKGWGGTGESFDWKQIPSYKEEGVRQGTQ
VLIAGGITPENVVELARYQVDGLDVSSGIEENGKKSVAKIARLEQEAGVHYARNNTR
>Mature_217_residues
MKLKYCGLHQQEDVEVAAASHCDYMGFVLANSKRKVALPDVAQWLATTDMSTKQTVALFVNESLDTIAQVASSDLFDVIQ
LHGTETPAFLQAVKDRTQKQVWKAIHHSSSALGIMQAFAGIADGYVIDCKSAKGWGGTGESFDWKQIPSYKEEGVRQGTQ
VLIAGGITPENVVELARYQVDGLDVSSGIEENGKKSVAKIARLEQEAGVHYARNNTR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=190, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320210, Length=215, Percent_Identity=27.4418604651163, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_BACSK (Q5WGS2)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175394.1
- HSSP:   Q56320
- ProteinModelPortal:   Q5WGS2
- STRING:   Q5WGS2
- EnsemblBacteria:   EBBACT00000047559
- GeneID:   3203565
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1898
- NMPDR:   fig|66692.3.peg.1942
- eggNOG:   COG0135
- GeneTree:   EBGT00050000002322
- HOGENOM:   HBG554803
- OMA:   IQLHGRE
- ProtClustDB:   PRK01222
- BioCyc:   BCLA66692:ABC1898-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 23645; Mature: 23645

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKYCGLHQQEDVEVAAASHCDYMGFVLANSKRKVALPDVAQWLATTDMSTKQTVALFV
CCCCCCCCCCCCCHHHHHHHCCCHHEEEEECCCCCEECHHHHHHHHHCCCCCCCEEEEEE
NESLDTIAQVASSDLFDVIQLHGTETPAFLQAVKDRTQKQVWKAIHHSSSALGIMQAFAG
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IADGYVIDCKSAKGWGGTGESFDWKQIPSYKEEGVRQGTQVLIAGGITPENVVELARYQV
HCCCEEEECCCCCCCCCCCCCCCHHHCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHC
DGLDVSSGIEENGKKSVAKIARLEQEAGVHYARNNTR
CCCCCCCCCHHCHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKLKYCGLHQQEDVEVAAASHCDYMGFVLANSKRKVALPDVAQWLATTDMSTKQTVALFV
CCCCCCCCCCCCCHHHHHHHCCCHHEEEEECCCCCEECHHHHHHHHHCCCCCCCEEEEEE
NESLDTIAQVASSDLFDVIQLHGTETPAFLQAVKDRTQKQVWKAIHHSSSALGIMQAFAG
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IADGYVIDCKSAKGWGGTGESFDWKQIPSYKEEGVRQGTQVLIAGGITPENVVELARYQV
HCCCEEEECCCCCCCCCCCCCCCHHHCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHC
DGLDVSSGIEENGKKSVAKIARLEQEAGVHYARNNTR
CCCCCCCCCHHCHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA