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The map label for this gene is hemH

Identifier: 56963304

GI number: 56963304

Start: 1661896

End: 1662834

Strand: Direct

Name: hemH

Synonym: ABC1539

Alternate gene names: 56963304

Gene position: 1661896-1662834 (Clockwise)

Preceding gene: 56963303

Following gene: 56963305

Centisome position: 38.61

GC content: 46.43

Gene sequence:

>939_bases
ATGGAGAAGAAAAAAATTGGATTGCTTGTCATGGCTTATGGCACGCCGCGCAAGAAAGAAGAAATCGAACCGTATTACAC
ACATATTCGCCACGGACGCAAGCCTTCAGAAGAGGCACTTGCTGATTTGCAGGAACGCTATGAAGCAATTGGGGGCACAA
GCCCTTTGGCTCGCATTACGGATGAGCAAGCAAACGGGCTTGCTGCTGTTTTAAATGAGCAGCAAGAAGACATCGTTTTT
GTGCCTTATTTAGGCCTTAAACACATTGATCCGTTTATTGAAGATGCGGTTCAAAAAATGAAGAACGATGGCATAGAAAC
GGCTGTTTCGATTGTCCTTGCGCCTCATTTTTCTACGTTTAGCGTGCAGTCTTACAATAAGCGCGCTCAGGAAGAAGCGG
ACCGAATTGGCGGGCCTACAATTTATACAATCGAAAGCTGGTATAAAGAGCCGGGATTTTTGCAGTTTTGGAAAGAGCAA
ATTGAAAATGAAATGAAGAAGGCCGATTCTATTGATGACCTTTGTGTCATTTTTTCCGCGCATAGCTTACCGGAGAAAAT
CATTCAAGCAAATGACCCTTATCCAGAGCAATTGCGGGAAACGGCAGACTTGCTTGCGGACATGGCCAATGTACCGAATT
ATGAAATTGGGTGGCAAAGCGAAGGGAACACCCCTGAGCCATGGCTTGGGCCGGATGTCCAAGACCTAACACGGGAACTA
TATGCAAAAAAAGGCTACAAAACCTTTATGTACTGTCCAGTCGGCTTTGTGGCAGAGCACTTGGAGGTGCTTTACGACAA
TGATTATGAATGCAAGTTGGTTACAGACGAACTAGGCGTTCGCTATTTGCGCCCGCCGATGCCAAATGCAGACACTCGTT
TCTTAAAGGCGCTCGCCGATGTAGTGACAAAACGCCTGGCCGCTGTGGTGACCAAATGA

Upstream 100 bases:

>100_bases
CAAGGCGTCTTTCCAGAAGTGAAACCTGAAACATTGAGACGACTCACTGCGTTTGTTCACGAGTACTCATCAGAAAAAAA
ACAACAGAAAGGATAGGACA

Downstream 100 bases:

>100_bases
AGCAAAAGCGTGTTGCCATCGTTGGAGCTGGAGCGACAGGGCTGTCAGCTGCACTCTGGCTCCATGATCATAGCGACTTA
CAATACGATGTATATGAAGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MEKKKIGLLVMAYGTPRKKEEIEPYYTHIRHGRKPSEEALADLQERYEAIGGTSPLARITDEQANGLAAVLNEQQEDIVF
VPYLGLKHIDPFIEDAVQKMKNDGIETAVSIVLAPHFSTFSVQSYNKRAQEEADRIGGPTIYTIESWYKEPGFLQFWKEQ
IENEMKKADSIDDLCVIFSAHSLPEKIIQANDPYPEQLRETADLLADMANVPNYEIGWQSEGNTPEPWLGPDVQDLTREL
YAKKGYKTFMYCPVGFVAEHLEVLYDNDYECKLVTDELGVRYLRPPMPNADTRFLKALADVVTKRLAAVVTK

Sequences:

>Translated_312_residues
MEKKKIGLLVMAYGTPRKKEEIEPYYTHIRHGRKPSEEALADLQERYEAIGGTSPLARITDEQANGLAAVLNEQQEDIVF
VPYLGLKHIDPFIEDAVQKMKNDGIETAVSIVLAPHFSTFSVQSYNKRAQEEADRIGGPTIYTIESWYKEPGFLQFWKEQ
IENEMKKADSIDDLCVIFSAHSLPEKIIQANDPYPEQLRETADLLADMANVPNYEIGWQSEGNTPEPWLGPDVQDLTREL
YAKKGYKTFMYCPVGFVAEHLEVLYDNDYECKLVTDELGVRYLRPPMPNADTRFLKALADVVTKRLAAVVTK
>Mature_312_residues
MEKKKIGLLVMAYGTPRKKEEIEPYYTHIRHGRKPSEEALADLQERYEAIGGTSPLARITDEQANGLAAVLNEQQEDIVF
VPYLGLKHIDPFIEDAVQKMKNDGIETAVSIVLAPHFSTFSVQSYNKRAQEEADRIGGPTIYTIESWYKEPGFLQFWKEQ
IENEMKKADSIDDLCVIFSAHSLPEKIIQANDPYPEQLRETADLLADMANVPNYEIGWQSEGNTPEPWLGPDVQDLTREL
YAKKGYKTFMYCPVGFVAEHLEVLYDNDYECKLVTDELGVRYLRPPMPNADTRFLKALADVVTKRLAAVVTK

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=275, Percent_Identity=29.4545454545455, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI60499021, Length=275, Percent_Identity=29.4545454545455, Blast_Score=131, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6324750, Length=273, Percent_Identity=25.2747252747253, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17864156, Length=329, Percent_Identity=26.1398176291793, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45552018, Length=170, Percent_Identity=31.7647058823529, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24651774, Length=254, Percent_Identity=23.2283464566929, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_BACSK (Q5WHT1)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175035.1
- ProteinModelPortal:   Q5WHT1
- SMR:   Q5WHT1
- STRING:   Q5WHT1
- EnsemblBacteria:   EBBACT00000048396
- GeneID:   3204570
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1539
- NMPDR:   fig|66692.3.peg.1913
- eggNOG:   COG0276
- GeneTree:   EBGT00050000002085
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- ProtClustDB:   PRK12435
- BioCyc:   BCLA66692:ABC1539-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 35496; Mature: 35496

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKKIGLLVMAYGTPRKKEEIEPYYTHIRHGRKPSEEALADLQERYEAIGGTSPLARIT
CCCCCEEEEEEECCCCCCCHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHC
DEQANGLAAVLNEQQEDIVFVPYLGLKHIDPFIEDAVQKMKNDGIETAVSIVLAPHFSTF
CHHCCCHHHHHCCCCCCEEEECCCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCE
SVQSYNKRAQEEADRIGGPTIYTIESWYKEPGFLQFWKEQIENEMKKADSIDDLCVIFSA
EHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
HSLPEKIIQANDPYPEQLRETADLLADMANVPNYEIGWQSEGNTPEPWLGPDVQDLTREL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
YAKKGYKTFMYCPVGFVAEHLEVLYDNDYECKLVTDELGVRYLRPPMPNADTRFLKALAD
HHHCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEHHHHCCEECCCCCCCCHHHHHHHHHH
VVTKRLAAVVTK
HHHHHHHHHHCC
>Mature Secondary Structure
MEKKKIGLLVMAYGTPRKKEEIEPYYTHIRHGRKPSEEALADLQERYEAIGGTSPLARIT
CCCCCEEEEEEECCCCCCCHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHC
DEQANGLAAVLNEQQEDIVFVPYLGLKHIDPFIEDAVQKMKNDGIETAVSIVLAPHFSTF
CHHCCCHHHHHCCCCCCEEEECCCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCE
SVQSYNKRAQEEADRIGGPTIYTIESWYKEPGFLQFWKEQIENEMKKADSIDDLCVIFSA
EHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
HSLPEKIIQANDPYPEQLRETADLLADMANVPNYEIGWQSEGNTPEPWLGPDVQDLTREL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
YAKKGYKTFMYCPVGFVAEHLEVLYDNDYECKLVTDELGVRYLRPPMPNADTRFLKALAD
HHHCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEHHHHCCEECCCCCCCCHHHHHHHHHH
VVTKRLAAVVTK
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA