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The map label for this gene is hemY [H]

Identifier: 56963305

GI number: 56963305

Start: 1662831

End: 1664207

Strand: Direct

Name: hemY [H]

Synonym: ABC1540

Alternate gene names: 56963305

Gene position: 1662831-1664207 (Clockwise)

Preceding gene: 56963304

Following gene: 56963306

Centisome position: 38.64

GC content: 47.06

Gene sequence:

>1377_bases
ATGAAGCAAAAGCGTGTTGCCATCGTTGGAGCTGGAGCGACAGGGCTGTCAGCTGCACTCTGGCTCCATGATCATAGCGA
CTTACAATACGATGTATATGAAGCTTCAAATCAAGTTGGCGGCAAAATTGTTACGTACAAAGACCGTGGTTTTGTAATAG
AGGGAGGCGCTGACTCTTATTTAGAGCGAAAAGCGAGCATGACTCATTTCATTCAGCGAGTAGGCCTTGGCGATTCCCTT
GTTCGCAATGAAGTGGGGCAATCCTATATTTTAAAGAGCGGTACGCTTTTTCCGACTCCAAAAAATACGGTGTTAGGCAT
TCCGACAGACATAGATGCGTTTTTGGAAACGAAACTGATTTCGGATGAAGGGAAACGCAATTTATTAAAAGAATATGAGA
AGCCGCGATTTGCAAAACCAGGAGAAGACGTCTCAGCAGGTGCTTTTTTTGAATACCGCTTAGGAAAAGAAATGGTCGAT
TCGCTCATTGAGCCTTTGCTCGGCGGCATCTACGGCGGCAATATTTATGAACTAAGCATGAAAGCGATATTTCCTCATTT
CCTTCAATATGAAGCAGAATACGGCAGCCTTTTAAAAGGGGTAGCCGCAACGAAATCAACAAGTAAGCAGGCGAAAAAGC
AAGGAATGTTTTTAACAGTCAAATCCGGGTTGGCGTCGGTGCTGGAGGCTGCTGCCGAACAGCTTCGCCCTGGGTCTGTT
CATTTAAATGCAGCGGTAGAACGGATTGATGTGCTCGACGACGGGGCTTTTACCGTGTTTGTTAACGGTACCCAAAAACG
GTATGATGCTGTGATTGTTACGATTCCGCCACAACAAGCGGCAAAATTGTTTGTAGAGATTAACCCGTTTAGCGATATTG
GAAGCATCGAGGCGACTTCATGCGCCACTGTCGCCATGATCTTTCCTGAGGGCGCTGTTGACAATGAGCATGAAGGAACA
GGATTTGTTGTCGCCAGAGGAGGCGATGAAACGATTACTGCTTGCACATGGACCGATTTAAAATGGCCTCATACAAGCCC
TTCTCGCGAAACATTGTTGCGCGCTTATGTTGGCCGGCCAGGCGAAGAGGCAATCGTAGAAGCAAATGATCAGACCATTG
TAAATGCTGTTTTAGCCGATTTGCAGAACGTCATGGCGATCCGTACCCGACCCACTTTTTATCGTGTCACGCGCTGGAAA
AAGGCGATGCCTCAATATCAAGTTGGCCATCTTCAGCGGATTGAACGCTTTAAAAAAGCCTGTGCCAAACATCCAGGCTT
GTACGTGACGGGTGCTTATTTTGGCGGAGTAGGTGTGCCCGATTGTATTGACCAAGGGCAGGCATGCGCGAAGCAACTAA
TGAACGAAACGACGTAA

Upstream 100 bases:

>100_bases
GCGTTCGCTATTTGCGCCCGCCGATGCCAAATGCAGACACTCGTTTCTTAAAGGCGCTCGCCGATGTAGTGACAAAACGC
CTGGCCGCTGTGGTGACCAA

Downstream 100 bases:

>100_bases
GGCAAAGCCCTACGTCGTTTTTCTCATTAATTAAAGGTGATGCAAATAGCGTGTTTTTAGCTGTTCGTATTCCTGCTCCA
TTTTTTCGGCATGAATAAAA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKQKRVAIVGAGATGLSAALWLHDHSDLQYDVYEASNQVGGKIVTYKDRGFVIEGGADSYLERKASMTHFIQRVGLGDSL
VRNEVGQSYILKSGTLFPTPKNTVLGIPTDIDAFLETKLISDEGKRNLLKEYEKPRFAKPGEDVSAGAFFEYRLGKEMVD
SLIEPLLGGIYGGNIYELSMKAIFPHFLQYEAEYGSLLKGVAATKSTSKQAKKQGMFLTVKSGLASVLEAAAEQLRPGSV
HLNAAVERIDVLDDGAFTVFVNGTQKRYDAVIVTIPPQQAAKLFVEINPFSDIGSIEATSCATVAMIFPEGAVDNEHEGT
GFVVARGGDETITACTWTDLKWPHTSPSRETLLRAYVGRPGEEAIVEANDQTIVNAVLADLQNVMAIRTRPTFYRVTRWK
KAMPQYQVGHLQRIERFKKACAKHPGLYVTGAYFGGVGVPDCIDQGQACAKQLMNETT

Sequences:

>Translated_458_residues
MKQKRVAIVGAGATGLSAALWLHDHSDLQYDVYEASNQVGGKIVTYKDRGFVIEGGADSYLERKASMTHFIQRVGLGDSL
VRNEVGQSYILKSGTLFPTPKNTVLGIPTDIDAFLETKLISDEGKRNLLKEYEKPRFAKPGEDVSAGAFFEYRLGKEMVD
SLIEPLLGGIYGGNIYELSMKAIFPHFLQYEAEYGSLLKGVAATKSTSKQAKKQGMFLTVKSGLASVLEAAAEQLRPGSV
HLNAAVERIDVLDDGAFTVFVNGTQKRYDAVIVTIPPQQAAKLFVEINPFSDIGSIEATSCATVAMIFPEGAVDNEHEGT
GFVVARGGDETITACTWTDLKWPHTSPSRETLLRAYVGRPGEEAIVEANDQTIVNAVLADLQNVMAIRTRPTFYRVTRWK
KAMPQYQVGHLQRIERFKKACAKHPGLYVTGAYFGGVGVPDCIDQGQACAKQLMNETT
>Mature_458_residues
MKQKRVAIVGAGATGLSAALWLHDHSDLQYDVYEASNQVGGKIVTYKDRGFVIEGGADSYLERKASMTHFIQRVGLGDSL
VRNEVGQSYILKSGTLFPTPKNTVLGIPTDIDAFLETKLISDEGKRNLLKEYEKPRFAKPGEDVSAGAFFEYRLGKEMVD
SLIEPLLGGIYGGNIYELSMKAIFPHFLQYEAEYGSLLKGVAATKSTSKQAKKQGMFLTVKSGLASVLEAAAEQLRPGSV
HLNAAVERIDVLDDGAFTVFVNGTQKRYDAVIVTIPPQQAAKLFVEINPFSDIGSIEATSCATVAMIFPEGAVDNEHEGT
GFVVARGGDETITACTWTDLKWPHTSPSRETLLRAYVGRPGEEAIVEANDQTIVNAVLADLQNVMAIRTRPTFYRVTRWK
KAMPQYQVGHLQRIERFKKACAKHPGLYVTGAYFGGVGVPDCIDQGQACAKQLMNETT

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=485, Percent_Identity=24.3298969072165, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4506001, Length=485, Percent_Identity=24.3298969072165, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24649745, Length=454, Percent_Identity=23.568281938326, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 50045; Mature: 50045

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKRVAIVGAGATGLSAALWLHDHSDLQYDVYEASNQVGGKIVTYKDRGFVIEGGADSY
CCCCEEEEEECCCCCCEEEEEEECCCCCEEEHHHCCCCCCCEEEEEECCCEEEECCCHHH
LERKASMTHFIQRVGLGDSLVRNEVGQSYILKSGTLFPTPKNTVLGIPTDIDAFLETKLI
HHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEECCCCCCCCCCCEEECCCCHHHHHHHHHH
SDEGKRNLLKEYEKPRFAKPGEDVSAGAFFEYRLGKEMVDSLIEPLLGGIYGGNIYELSM
CCCHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEH
KAIFPHFLQYEAEYGSLLKGVAATKSTSKQAKKQGMFLTVKSGLASVLEAAAEQLRPGSV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCE
HLNAAVERIDVLDDGAFTVFVNGTQKRYDAVIVTIPPQQAAKLFVEINPFSDIGSIEATS
EEHHHHHHHHEECCCEEEEEECCCCCCCCEEEEEECCHHHEEEEEEECCCCCCCCCCCCC
CATVAMIFPEGAVDNEHEGTGFVVARGGDETITACTWTDLKWPHTSPSRETLLRAYVGRP
CEEEEEEECCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCC
GEEAIVEANDQTIVNAVLADLQNVMAIRTRPTFYRVTRWKKAMPQYQVGHLQRIERFKKA
CCHHEEECCCHHHHHHHHHHHHHHHHECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
CAKHPGLYVTGAYFGGVGVPDCIDQGQACAKQLMNETT
HHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQKRVAIVGAGATGLSAALWLHDHSDLQYDVYEASNQVGGKIVTYKDRGFVIEGGADSY
CCCCEEEEEECCCCCCEEEEEEECCCCCEEEHHHCCCCCCCEEEEEECCCEEEECCCHHH
LERKASMTHFIQRVGLGDSLVRNEVGQSYILKSGTLFPTPKNTVLGIPTDIDAFLETKLI
HHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEECCCCCCCCCCCEEECCCCHHHHHHHHHH
SDEGKRNLLKEYEKPRFAKPGEDVSAGAFFEYRLGKEMVDSLIEPLLGGIYGGNIYELSM
CCCHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEH
KAIFPHFLQYEAEYGSLLKGVAATKSTSKQAKKQGMFLTVKSGLASVLEAAAEQLRPGSV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCE
HLNAAVERIDVLDDGAFTVFVNGTQKRYDAVIVTIPPQQAAKLFVEINPFSDIGSIEATS
EEHHHHHHHHEECCCEEEEEECCCCCCCCEEEEEECCHHHEEEEEEECCCCCCCCCCCCC
CATVAMIFPEGAVDNEHEGTGFVVARGGDETITACTWTDLKWPHTSPSRETLLRAYVGRP
CEEEEEEECCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCC
GEEAIVEANDQTIVNAVLADLQNVMAIRTRPTFYRVTRWKKAMPQYQVGHLQRIERFKKA
CCHHEEECCCHHHHHHHHHHHHHHHHECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
CAKHPGLYVTGAYFGGVGVPDCIDQGQACAKQLMNETT
HHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]