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The map label for this gene is hemE [H]

Identifier: 56963303

GI number: 56963303

Start: 1660839

End: 1661891

Strand: Direct

Name: hemE [H]

Synonym: ABC1538

Alternate gene names: 56963303

Gene position: 1660839-1661891 (Clockwise)

Preceding gene: 56963302

Following gene: 56963304

Centisome position: 38.59

GC content: 44.92

Gene sequence:

>1053_bases
ATGAACACCAAAACATTTAATGACACGTTCTTGAAAGCGTGCAAAGGGGAAAAACATGGCCATGTGCCTGTGTGGTATAT
GAGGCAGGCAGGAAGGTCGCAACCTGAATACCGGAAAATTAAAGAAACGCATTCGTTATTCGATATTACCCATGATCCGG
AGCTTTGCGCGTATGTGACAAAGCTGCCAGTTGACCAATACAACAATGATGCGGCTATTTTGTACAAAGACATAATGACA
CCGCTTCCTTTTATCGGCGTTGAAGTGGACATAAAGTCTGGAATTGGACCAGTGATTGACAATCCAATCCACGGCCTCAG
TGATGTTGAGCGCTTAGGGGAAATCGATCCTGAACATGATGTGAAACATGTCCTTGATACGATTAAGCTGTTGCGCACAC
AGCTTGACGTGCCATTGATTAGCTTTGCCGGTGCACCGTTTACGCTTGCTAGCTATATGATTGAAGGCGGGCCTTCTCGG
AATTACCATAAAACAAAAGCATTTATGCATGCAGAACCGGAAGCATGGCAGCGTCTAATGGACAAGCTTGCGAAGATGAC
AATCGACTACATAAAAGCACAGATACAAGCTGGTGCCCAAGCAATTCAGTTGTTTGATTCCTGGATTGGCGCCGTGAGCG
TTGCTGATTATAAACGATTGATTAAACCGGTGATGGTACGAATTCTGGCTGAAGTTCAGACAGAGGGTGTACCGCTCATT
TTACATGGAGTCGGAACCCCTCATTTATTGTCCGAATGGAAAGACATGCCAGTTGATGTGATAGGCATTGATTGGCGTAC
GACTGTTTCGGAAGCGAGACGCCTTGGCATTAACAAAACATTGCAAGGCAATATGGACCCTTCCCTTTTGCTTGCGCCAT
GGCCTGTAATTGAGGCGGAAGCCAAAGCTATTCTAGATGAAGGCATGGAGTCAAATCGGTTTATTTTTAATCTTGGACAA
GGCGTCTTTCCAGAAGTGAAACCTGAAACATTGAGACGACTCACTGCGTTTGTTCACGAGTACTCATCAGAAAAAAAACA
ACAGAAAGGATAG

Upstream 100 bases:

>100_bases
GAGGAAGAGATCGAGTATAGGCAGATTAATCGAATTTTAAATAGGTTTCGCGTAAAATGGAAAACGATTTGTCACGCCAG
ATGCATGAAAGGTGGAAAAG

Downstream 100 bases:

>100_bases
GACAATGGAGAAGAAAAAAATTGGATTGCTTGTCATGGCTTATGGCACGCCGCGCAAGAAAGAAGAAATCGAACCGTATT
ACACACATATTCGCCACGGA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MNTKTFNDTFLKACKGEKHGHVPVWYMRQAGRSQPEYRKIKETHSLFDITHDPELCAYVTKLPVDQYNNDAAILYKDIMT
PLPFIGVEVDIKSGIGPVIDNPIHGLSDVERLGEIDPEHDVKHVLDTIKLLRTQLDVPLISFAGAPFTLASYMIEGGPSR
NYHKTKAFMHAEPEAWQRLMDKLAKMTIDYIKAQIQAGAQAIQLFDSWIGAVSVADYKRLIKPVMVRILAEVQTEGVPLI
LHGVGTPHLLSEWKDMPVDVIGIDWRTTVSEARRLGINKTLQGNMDPSLLLAPWPVIEAEAKAILDEGMESNRFIFNLGQ
GVFPEVKPETLRRLTAFVHEYSSEKKQQKG

Sequences:

>Translated_350_residues
MNTKTFNDTFLKACKGEKHGHVPVWYMRQAGRSQPEYRKIKETHSLFDITHDPELCAYVTKLPVDQYNNDAAILYKDIMT
PLPFIGVEVDIKSGIGPVIDNPIHGLSDVERLGEIDPEHDVKHVLDTIKLLRTQLDVPLISFAGAPFTLASYMIEGGPSR
NYHKTKAFMHAEPEAWQRLMDKLAKMTIDYIKAQIQAGAQAIQLFDSWIGAVSVADYKRLIKPVMVRILAEVQTEGVPLI
LHGVGTPHLLSEWKDMPVDVIGIDWRTTVSEARRLGINKTLQGNMDPSLLLAPWPVIEAEAKAILDEGMESNRFIFNLGQ
GVFPEVKPETLRRLTAFVHEYSSEKKQQKG
>Mature_350_residues
MNTKTFNDTFLKACKGEKHGHVPVWYMRQAGRSQPEYRKIKETHSLFDITHDPELCAYVTKLPVDQYNNDAAILYKDIMT
PLPFIGVEVDIKSGIGPVIDNPIHGLSDVERLGEIDPEHDVKHVLDTIKLLRTQLDVPLISFAGAPFTLASYMIEGGPSR
NYHKTKAFMHAEPEAWQRLMDKLAKMTIDYIKAQIQAGAQAIQLFDSWIGAVSVADYKRLIKPVMVRILAEVQTEGVPLI
LHGVGTPHLLSEWKDMPVDVIGIDWRTTVSEARRLGINKTLQGNMDPSLLLAPWPVIEAEAKAILDEGMESNRFIFNLGQ
GVFPEVKPETLRRLTAFVHEYSSEKKQQKG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=354, Percent_Identity=35.8757062146893, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI2367337, Length=350, Percent_Identity=38, Blast_Score=231, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6320252, Length=356, Percent_Identity=32.5842696629214, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI19921920, Length=345, Percent_Identity=35.6521739130435, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI221330099, Length=345, Percent_Identity=35.6521739130435, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39420; Mature: 39420

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTKTFNDTFLKACKGEKHGHVPVWYMRQAGRSQPEYRKIKETHSLFDITHDPELCAYVT
CCCCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
KLPVDQYNNDAAILYKDIMTPLPFIGVEVDIKSGIGPVIDNPIHGLSDVERLGEIDPEHD
HCCHHHCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCHH
VKHVLDTIKLLRTQLDVPLISFAGAPFTLASYMIEGGPSRNYHKTKAFMHAEPEAWQRLM
HHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHH
DKLAKMTIDYIKAQIQAGAQAIQLFDSWIGAVSVADYKRLIKPVMVRILAEVQTEGVPLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LHGVGTPHLLSEWKDMPVDVIGIDWRTTVSEARRLGINKTLQGNMDPSLLLAPWPVIEAE
EECCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHH
AKAILDEGMESNRFIFNLGQGVFPEVKPETLRRLTAFVHEYSSEKKQQKG
HHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTKTFNDTFLKACKGEKHGHVPVWYMRQAGRSQPEYRKIKETHSLFDITHDPELCAYVT
CCCCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
KLPVDQYNNDAAILYKDIMTPLPFIGVEVDIKSGIGPVIDNPIHGLSDVERLGEIDPEHD
HCCHHHCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCHH
VKHVLDTIKLLRTQLDVPLISFAGAPFTLASYMIEGGPSRNYHKTKAFMHAEPEAWQRLM
HHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHH
DKLAKMTIDYIKAQIQAGAQAIQLFDSWIGAVSVADYKRLIKPVMVRILAEVQTEGVPLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LHGVGTPHLLSEWKDMPVDVIGIDWRTTVSEARRLGINKTLQGNMDPSLLLAPWPVIEAE
EECCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHH
AKAILDEGMESNRFIFNLGQGVFPEVKPETLRRLTAFVHEYSSEKKQQKG
HHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA