Click here to switch to the map view.

The map label for this gene is adk

Identifier: 55981640

GI number: 55981640

Start: 1580253

End: 1580813

Strand: Reverse

Name: adk

Synonym: TTHA1671

Alternate gene names: 55981640

Gene position: 1580813-1580253 (Counterclockwise)

Preceding gene: 55981641

Following gene: 55981639

Centisome position: 85.46

GC content: 70.77

Gene sequence:

>561_bases
GTGGACGTGGGACAGGCGGTGATCTTCCTGGGACCTCCGGGGGCGGGCAAGGGCACCCAGGCCTCGAGGCTCGCCCAGGA
GCTCGGCTTCAAGAAGCTCTCCACGGGGGACATCCTCCGGGACCACGTGGCCCGGGGGACCCCTTTGGGCGAGCGGGTGA
GGCCCATCATGGAGCGGGGGGACCTGGTCCCCGACGACCTCATCCTGGAGCTTATCCGGGAGGAGCTGGCCGAGCGGGTG
ATCTTTGACGGCTTCCCCCGCACCCTGGCCCAGGCCGAGGCCTTGGACCGCCTCCTTTCGGAGACCGGCACCCGGCTCCT
CGGGGTGGTGCTGGTGGAGGTCCCCGAGGAGGAGCTCGTCCGGCGCATCCTCAGGCGGGCCGAGCTCGAGGGCCGCTCCG
ACGACAACGAGGAGACCGTGAGGCGCCGCCTCGAGGTCTACCGGGAGAAAACCGAGCCCCTGGTGGGCTACTATGAGGCC
AGGGGGGTGCTGAAGCGGGTGGACGGGCTCGGCACCCCGGACGAGGTCTACGCCCGGATCCGGGCGGCGTTAGGGATCTG
A

Upstream 100 bases:

>100_bases
GGCCTTGGACACCCTGAGGCAGGTGGAGAGCCAGCTCATGCTCAGGAGCTACGAGGGCTTCCTCTCCCGCGGGCGCCTGC
GGGGGCGGAACCGGTAGGAG

Downstream 100 bases:

>100_bases
TGGCCATCAAGCTGAAAAGCCCCTGGGAGATTGAGCGCATGCGGGAGGCGGGGGCCCTCCTCACCGAGGTGGTGGAGGAG
GTGGCCCGCCACGTGGAGCC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MDVGQAVIFLGPPGAGKGTQASRLAQELGFKKLSTGDILRDHVARGTPLGERVRPIMERGDLVPDDLILELIREELAERV
IFDGFPRTLAQAEALDRLLSETGTRLLGVVLVEVPEEELVRRILRRAELEGRSDDNEETVRRRLEVYREKTEPLVGYYEA
RGVLKRVDGLGTPDEVYARIRAALGI

Sequences:

>Translated_186_residues
MDVGQAVIFLGPPGAGKGTQASRLAQELGFKKLSTGDILRDHVARGTPLGERVRPIMERGDLVPDDLILELIREELAERV
IFDGFPRTLAQAEALDRLLSETGTRLLGVVLVEVPEEELVRRILRRAELEGRSDDNEETVRRRLEVYREKTEPLVGYYEA
RGVLKRVDGLGTPDEVYARIRAALGI
>Mature_186_residues
MDVGQAVIFLGPPGAGKGTQASRLAQELGFKKLSTGDILRDHVARGTPLGERVRPIMERGDLVPDDLILELIREELAERV
IFDGFPRTLAQAEALDRLLSETGTRLLGVVLVEVPEEELVRRILRRAELEGRSDDNEETVRRRLEVYREKTEPLVGYYEA
RGVLKRVDGLGTPDEVYARIRAALGI

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502011, Length=185, Percent_Identity=38.9189189189189, Blast_Score=146, Evalue=8e-36,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=38.3177570093458, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=38.3177570093458, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=32.6086956521739, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=32.6086956521739, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI19923437, Length=208, Percent_Identity=34.1346153846154, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI7706497, Length=186, Percent_Identity=30.6451612903226, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI310110345, Length=196, Percent_Identity=34.1836734693878, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI53832003, Length=196, Percent_Identity=34.1836734693878, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI8051579, Length=196, Percent_Identity=34.1836734693878, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI53832001, Length=196, Percent_Identity=34.1836734693878, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI22749187, Length=129, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=36.5740740740741, Blast_Score=120, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=189, Percent_Identity=37.5661375661376, Blast_Score=143, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17552384, Length=206, Percent_Identity=39.8058252427184, Blast_Score=126, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17533833, Length=183, Percent_Identity=31.1475409836066, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=179, Percent_Identity=29.608938547486, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25147457, Length=183, Percent_Identity=29.5081967213115, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17537943, Length=196, Percent_Identity=30.1020408163265, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=212, Percent_Identity=37.7358490566038, Blast_Score=141, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6322828, Length=188, Percent_Identity=33.5106382978723, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=35.3846153846154, Blast_Score=104, Evalue=7e-24,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=36.4928909952607, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI221459597, Length=180, Percent_Identity=31.6666666666667, Blast_Score=106, Evalue=9e-24,
Organism=Drosophila melanogaster, GI21356893, Length=180, Percent_Identity=31.6666666666667, Blast_Score=106, Evalue=9e-24,
Organism=Drosophila melanogaster, GI17647141, Length=163, Percent_Identity=32.5153374233129, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24663208, Length=163, Percent_Identity=32.5153374233129, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17737899, Length=196, Percent_Identity=29.0816326530612, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24645822, Length=196, Percent_Identity=29.0816326530612, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_THET2 (Q72I25)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_005276.1
- ProteinModelPortal:   Q72I25
- SMR:   Q72I25
- STRING:   Q72I25
- GeneID:   2774802
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   APLLEFY
- ProtClustDB:   PRK14527
- BioCyc:   TTHE262724:TT_C1307-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20754; Mature: 20754

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVGQAVIFLGPPGAGKGTQASRLAQELGFKKLSTGDILRDHVARGTPLGERVRPIMERG
CCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCC
DLVPDDLILELIREELAERVIFDGFPRTLAQAEALDRLLSETGTRLLGVVLVEVPEEELV
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RRILRRAELEGRSDDNEETVRRRLEVYREKTEPLVGYYEARGVLKRVDGLGTPDEVYARI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
RAALGI
HHHHCC
>Mature Secondary Structure
MDVGQAVIFLGPPGAGKGTQASRLAQELGFKKLSTGDILRDHVARGTPLGERVRPIMERG
CCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCC
DLVPDDLILELIREELAERVIFDGFPRTLAQAEALDRLLSETGTRLLGVVLVEVPEEELV
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RRILRRAELEGRSDDNEETVRRRLEVYREKTEPLVGYYEARGVLKRVDGLGTPDEVYARI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
RAALGI
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA