Click here to switch to the map view.

The map label for this gene is map [H]

Identifier: 55981639

GI number: 55981639

Start: 1579486

End: 1580253

Strand: Reverse

Name: map [H]

Synonym: TTHA1670

Alternate gene names: 55981639

Gene position: 1580253-1579486 (Counterclockwise)

Preceding gene: 55981640

Following gene: 55981638

Centisome position: 85.43

GC content: 69.27

Gene sequence:

>768_bases
ATGGCCATCAAGCTGAAAAGCCCCTGGGAGATTGAGCGCATGCGGGAGGCGGGGGCCCTCCTCACCGAGGTGGTGGAGGA
GGTGGCCCGCCACGTGGAGCCCGGCGTCTCCACCTGGGAGCTGGACCAGATCGCCTACGAGGCCATCCGCAAGCGCAAGG
CCAAGCCCGCCTTCCTCGGGCTCTACGGCTTCCCCGCCACCCTTTGCACCTCGGTGAACGAGGTGGTGGTCCACGGCATC
CCCTCCAAGGAGCCCCTGAAGGAAGGGGACATCCTCTCCGTGGACGTGGGCCTCATCTACCAGGGGTTCGCCGCCGACAT
GGCCCGCACCTTTCCCGTGGGCCGGGTCTCGCCGGAGGCGGAGAGGCTCATCCGGGACACGGAGGCCGCCTTCTGGGAGG
GGATGAAGTACCTGCGCCCGGGCTTCCGCCTCGGCGACGTGGGCCACGCCATCCAGACCTTCTTGGAGAGCCGGGGCTAC
GGGGTGGTCCGGGAGTTCGTGGGGCACGGGGTGGGCCGGGAGATCCACGAGGACCCCCAGGTGCCGAACTTCGGCAAGCC
CGGGACCGGGCCCAAGATCCGCCCCGGGATGACCCTGGCCCTCGAGCCCATGGTCACCTTAAGGCCCGCACCTGTGGTAA
TATTGGACGATGGCTGGGCGGCGAGCGCCGGCCGAGGCAACCTCGCCGCCCATTACGAGAACACCGTCCTGGTGACGGAA
GAAGGCCCCGAGCTTCTCACCGGGGTCGCCCTGGCGCGGGCCGAGTAG

Upstream 100 bases:

>100_bases
TGGTGGGCTACTATGAGGCCAGGGGGGTGCTGAAGCGGGTGGACGGGCTCGGCACCCCGGACGAGGTCTACGCCCGGATC
CGGGCGGCGTTAGGGATCTG

Downstream 100 bases:

>100_bases
GGAGGGGTATGGCGAAGGAGAAGGACACCATTCGGACGGAGGGCGTGGTCACCGAGGCGTTGCCCAACGCCACCTTTCGC
GTGAAGCTGGACTCGGGGCC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MAIKLKSPWEIERMREAGALLTEVVEEVARHVEPGVSTWELDQIAYEAIRKRKAKPAFLGLYGFPATLCTSVNEVVVHGI
PSKEPLKEGDILSVDVGLIYQGFAADMARTFPVGRVSPEAERLIRDTEAAFWEGMKYLRPGFRLGDVGHAIQTFLESRGY
GVVREFVGHGVGREIHEDPQVPNFGKPGTGPKIRPGMTLALEPMVTLRPAPVVILDDGWAASAGRGNLAAHYENTVLVTE
EGPELLTGVALARAE

Sequences:

>Translated_255_residues
MAIKLKSPWEIERMREAGALLTEVVEEVARHVEPGVSTWELDQIAYEAIRKRKAKPAFLGLYGFPATLCTSVNEVVVHGI
PSKEPLKEGDILSVDVGLIYQGFAADMARTFPVGRVSPEAERLIRDTEAAFWEGMKYLRPGFRLGDVGHAIQTFLESRGY
GVVREFVGHGVGREIHEDPQVPNFGKPGTGPKIRPGMTLALEPMVTLRPAPVVILDDGWAASAGRGNLAAHYENTVLVTE
EGPELLTGVALARAE
>Mature_254_residues
AIKLKSPWEIERMREAGALLTEVVEEVARHVEPGVSTWELDQIAYEAIRKRKAKPAFLGLYGFPATLCTSVNEVVVHGIP
SKEPLKEGDILSVDVGLIYQGFAADMARTFPVGRVSPEAERLIRDTEAAFWEGMKYLRPGFRLGDVGHAIQTFLESRGYG
VVREFVGHGVGREIHEDPQVPNFGKPGTGPKIRPGMTLALEPMVTLRPAPVVILDDGWAASAGRGNLAAHYENTVLVTEE
GPELLTGVALARAE

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=245, Percent_Identity=37.5510204081633, Blast_Score=181, Evalue=4e-46,
Organism=Homo sapiens, GI40385867, Length=246, Percent_Identity=30.8943089430894, Blast_Score=148, Evalue=4e-36,
Organism=Escherichia coli, GI1786364, Length=249, Percent_Identity=43.3734939759036, Blast_Score=223, Evalue=9e-60,
Organism=Escherichia coli, GI1788728, Length=249, Percent_Identity=27.710843373494, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1789275, Length=272, Percent_Identity=25, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=246, Percent_Identity=35.3658536585366, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6323273, Length=240, Percent_Identity=39.5833333333333, Blast_Score=188, Evalue=7e-49,
Organism=Drosophila melanogaster, GI21355531, Length=245, Percent_Identity=39.1836734693878, Blast_Score=197, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=33.1967213114754, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI19920384, Length=222, Percent_Identity=26.1261261261261, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27821; Mature: 27690

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKLKSPWEIERMREAGALLTEVVEEVARHVEPGVSTWELDQIAYEAIRKRKAKPAFLG
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEE
LYGFPATLCTSVNEVVVHGIPSKEPLKEGDILSVDVGLIYQGFAADMARTFPVGRVSPEA
ECCCHHHHHHHHHHHHEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCHHH
ERLIRDTEAAFWEGMKYLRPGFRLGDVGHAIQTFLESRGYGVVREFVGHGVGREIHEDPQ
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHCCCC
VPNFGKPGTGPKIRPGMTLALEPMVTLRPAPVVILDDGWAASAGRGNLAAHYENTVLVTE
CCCCCCCCCCCCCCCCCEEEECCCEEECCCCEEEECCCCCCCCCCCCEEEEECCEEEEEC
EGPELLTGVALARAE
CCHHHHHHHHHHCCC
>Mature Secondary Structure 
AIKLKSPWEIERMREAGALLTEVVEEVARHVEPGVSTWELDQIAYEAIRKRKAKPAFLG
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEE
LYGFPATLCTSVNEVVVHGIPSKEPLKEGDILSVDVGLIYQGFAADMARTFPVGRVSPEA
ECCCHHHHHHHHHHHHEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCHHH
ERLIRDTEAAFWEGMKYLRPGFRLGDVGHAIQTFLESRGYGVVREFVGHGVGREIHEDPQ
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHCCCC
VPNFGKPGTGPKIRPGMTLALEPMVTLRPAPVVILDDGWAASAGRGNLAAHYENTVLVTE
CCCCCCCCCCCCCCCCCEEEECCCEEECCCCEEEECCCCCCCCCCCCEEEEECCEEEEEC
EGPELLTGVALARAE
CCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842; 7559358 [H]