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The map label for this gene is cat2 [H]

Identifier: 55981417

GI number: 55981417

Start: 1375749

End: 1377083

Strand: Direct

Name: cat2 [H]

Synonym: TTHA1448

Alternate gene names: 55981417

Gene position: 1375749-1377083 (Clockwise)

Preceding gene: 55981416

Following gene: 55981418

Centisome position: 74.38

GC content: 69.14

Gene sequence:

>1335_bases
ATGAGCTACCGCAAGAAGCTCACCTCCCCCGAGGACGCCGTGGGCCTGATCCGCTCGGGGATGCGGGTCTTCGTCTCCGG
CAACGCCGCCACCCCCACGCCCCTCCTCAAGGCCCTCGCCGCCCGCAAGGACGAGCTGGAAAACGTGGAGCTCGTCCACC
TCCTGCAGATGGGGGAAGACCCCTTCGCCTCTTTGGAGATGGAGGGGCACTTCCGAAGGCGCTCCCTCTTCGTGGGCCCC
GCCGACCGGGAGGCGGTGAACCAGGGCCGGGCCGACTACGTGCCCGTCATGCTCCACCAGGTGCCCTGGCTCTTCAAGCG
GGGCATCCTCCCCTTGGACGCCGCCATCGTCCAGGTCTCCCCGCCCGACGAGCACGGCTTCTGCTCCTTGGGGGTGGAGG
TGATCGCCACGAAGGCCGCGGTGGAGGCCGCCCCCATCGTCATCGCCATGGTGAACCCCAGAATGCCGAGGACCCTGGGG
GACACCTTCGTCCACGTCTCCCGCTTCACCGCCATCGTGGAGGTGGACTGGCCCCTGCCCGAGCTCAAGCGGGAGGGGTT
TGGCGAGGTGGAGCGGAGGATCGGGGAGCACGTGGCGGGCCTCATTGAGGACGGGGCCACCCTGCAGATGGGCATCGGGG
CCATCCCCGACGCGGTCTTGGCGAGCCTGGAGGGCCGGAGGGACCTCGGGGTCCACACGGAGATGATCTCGGACGGGGTC
CTCGAGGCCTGGGAAAAGGGCCTCATCACCGGGGCGAAAAAGTCCCTCCACCCCGGGAAGATCGTGGGCACCTTCGTCCT
GGGCTCGGAGAGGCTCTACCGCTTCGTCCACGACAACCCCCTCTTTGAGCTCCACCCCGCCGACTACGTGAACGACCCCT
TCGTCATCGCCCAAAACCGCAAGATGGTGGCCATCAACTCGGCCATTGAGGTGGACCTCACGGGCCAGGTGGTGGCGGAC
TCCATCGGCACCCGGATCTACTCCGGCTTCGGCGGCCAGCTGGACTTCATCCGGGGGGCGGCGCGGAGCGAGGGGGGGAA
GCCCATCATCGCCCTGCCCTCCACCGCCAAGGGCCAAAGCCGCATCGTCCCCTTCCTCAAGCCGGGCGCGGGGGTGGTCA
CCACCCGGGCCGACGTGCACTACGTGGTCACCGAGTGGGGCGTGGCCGAGCTCTTCGGCCGCTCCCTAAGGGAAAGGGCC
AAAGCCCTCATCGCCATCGCCCACCCGGACTTCCGCGAGGCCCTCCTCCAGGGCGCCTGGGAGCGGGGCCTCCTCCCCCG
GGGCTACCCCGGCGTGGACCTGAAGGGGCTGGAGGAAAAGCGCGGGAGGCCGTAA

Upstream 100 bases:

>100_bases
TCCTCCCCTACCTGCTCCGGATCCAGGAAGACCCCCTGGCCCTTCCCGGGCTCCGCCAGGGGGCCTACCTCCTCTTCGGC
GAGAAAGGAGGCCACCTAGA

Downstream 100 bases:

>100_bases
TCCCACCCCATGCTGGCCCAAGCCAGCATGGGGGCCCCGGCAAAAGGTCCCTGGGAAGCCTCCCTGGGCCAGTCGGACGA
AGGAACCCGGAAGGGTATAA

Product: 4-hydroxybutyrate CoA-transferase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSYRKKLTSPEDAVGLIRSGMRVFVSGNAATPTPLLKALAARKDELENVELVHLLQMGEDPFASLEMEGHFRRRSLFVGP
ADREAVNQGRADYVPVMLHQVPWLFKRGILPLDAAIVQVSPPDEHGFCSLGVEVIATKAAVEAAPIVIAMVNPRMPRTLG
DTFVHVSRFTAIVEVDWPLPELKREGFGEVERRIGEHVAGLIEDGATLQMGIGAIPDAVLASLEGRRDLGVHTEMISDGV
LEAWEKGLITGAKKSLHPGKIVGTFVLGSERLYRFVHDNPLFELHPADYVNDPFVIAQNRKMVAINSAIEVDLTGQVVAD
SIGTRIYSGFGGQLDFIRGAARSEGGKPIIALPSTAKGQSRIVPFLKPGAGVVTTRADVHYVVTEWGVAELFGRSLRERA
KALIAIAHPDFREALLQGAWERGLLPRGYPGVDLKGLEEKRGRP

Sequences:

>Translated_444_residues
MSYRKKLTSPEDAVGLIRSGMRVFVSGNAATPTPLLKALAARKDELENVELVHLLQMGEDPFASLEMEGHFRRRSLFVGP
ADREAVNQGRADYVPVMLHQVPWLFKRGILPLDAAIVQVSPPDEHGFCSLGVEVIATKAAVEAAPIVIAMVNPRMPRTLG
DTFVHVSRFTAIVEVDWPLPELKREGFGEVERRIGEHVAGLIEDGATLQMGIGAIPDAVLASLEGRRDLGVHTEMISDGV
LEAWEKGLITGAKKSLHPGKIVGTFVLGSERLYRFVHDNPLFELHPADYVNDPFVIAQNRKMVAINSAIEVDLTGQVVAD
SIGTRIYSGFGGQLDFIRGAARSEGGKPIIALPSTAKGQSRIVPFLKPGAGVVTTRADVHYVVTEWGVAELFGRSLRERA
KALIAIAHPDFREALLQGAWERGLLPRGYPGVDLKGLEEKRGRP
>Mature_443_residues
SYRKKLTSPEDAVGLIRSGMRVFVSGNAATPTPLLKALAARKDELENVELVHLLQMGEDPFASLEMEGHFRRRSLFVGPA
DREAVNQGRADYVPVMLHQVPWLFKRGILPLDAAIVQVSPPDEHGFCSLGVEVIATKAAVEAAPIVIAMVNPRMPRTLGD
TFVHVSRFTAIVEVDWPLPELKREGFGEVERRIGEHVAGLIEDGATLQMGIGAIPDAVLASLEGRRDLGVHTEMISDGVL
EAWEKGLITGAKKSLHPGKIVGTFVLGSERLYRFVHDNPLFELHPADYVNDPFVIAQNRKMVAINSAIEVDLTGQVVADS
IGTRIYSGFGGQLDFIRGAARSEGGKPIIALPSTAKGQSRIVPFLKPGAGVVTTRADVHYVVTEWGVAELFGRSLRERAK
ALIAIAHPDFREALLQGAWERGLLPRGYPGVDLKGLEEKRGRP

Specific function: Unknown

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI32563853, Length=427, Percent_Identity=51.9906323185012, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17538151, Length=427, Percent_Identity=47.7751756440281, Blast_Score=403, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319456, Length=490, Percent_Identity=25.9183673469388, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358615, Length=424, Percent_Identity=51.1792452830189, Blast_Score=436, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro [H]

EC number: NA

Molecular weight: Translated: 48351; Mature: 48220

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYRKKLTSPEDAVGLIRSGMRVFVSGNAATPTPLLKALAARKDELENVELVHLLQMGED
CCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCC
PFASLEMEGHFRRRSLFVGPADREAVNQGRADYVPVMLHQVPWLFKRGILPLDAAIVQVS
CCCEEEECCCEEEEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEC
PPDEHGFCSLGVEVIATKAAVEAAPIVIAMVNPRMPRTLGDTFVHVSRFTAIVEVDWPLP
CCCCCCCHHHCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHEEEHEEEEEEECCCCH
ELKREGFGEVERRIGEHVAGLIEDGATLQMGIGAIPDAVLASLEGRRDLGVHTEMISDGV
HHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHH
LEAWEKGLITGAKKSLHPGKIVGTFVLGSERLYRFVHDNPLFELHPADYVNDPFVIAQNR
HHHHHHCCCCCCCCCCCCCCEEEEEEECHHHHHHHHCCCCCEEECCCCCCCCCEEEECCC
KMVAINSAIEVDLTGQVVADSIGTRIYSGFGGQLDFIRGAARSEGGKPIIALPSTAKGQS
EEEEECCEEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEECCCCCCCCC
RIVPFLKPGAGVVTTRADVHYVVTEWGVAELFGRSLRERAKALIAIAHPDFREALLQGAW
CCCCEECCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHH
ERGLLPRGYPGVDLKGLEEKRGRP
HHCCCCCCCCCCCCCCCHHHCCCC
>Mature Secondary Structure 
SYRKKLTSPEDAVGLIRSGMRVFVSGNAATPTPLLKALAARKDELENVELVHLLQMGED
CCCCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCC
PFASLEMEGHFRRRSLFVGPADREAVNQGRADYVPVMLHQVPWLFKRGILPLDAAIVQVS
CCCEEEECCCEEEEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEC
PPDEHGFCSLGVEVIATKAAVEAAPIVIAMVNPRMPRTLGDTFVHVSRFTAIVEVDWPLP
CCCCCCCHHHCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHEEEHEEEEEEECCCCH
ELKREGFGEVERRIGEHVAGLIEDGATLQMGIGAIPDAVLASLEGRRDLGVHTEMISDGV
HHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHH
LEAWEKGLITGAKKSLHPGKIVGTFVLGSERLYRFVHDNPLFELHPADYVNDPFVIAQNR
HHHHHHCCCCCCCCCCCCCCEEEEEEECHHHHHHHHCCCCCEEECCCCCCCCCEEEECCC
KMVAINSAIEVDLTGQVVADSIGTRIYSGFGGQLDFIRGAARSEGGKPIIALPSTAKGQS
EEEEECCEEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEECCCCCCCCC
RIVPFLKPGAGVVTTRADVHYVVTEWGVAELFGRSLRERAKALIAIAHPDFREALLQGAW
CCCCEECCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHH
ERGLLPRGYPGVDLKGLEEKRGRP
HHCCCCCCCCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]