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The map label for this gene is ald [H]

Identifier: 55981416

GI number: 55981416

Start: 1374715

End: 1375752

Strand: Direct

Name: ald [H]

Synonym: TTHA1447

Alternate gene names: 55981416

Gene position: 1374715-1375752 (Clockwise)

Preceding gene: 55981415

Following gene: 55981417

Centisome position: 74.32

GC content: 73.89

Gene sequence:

>1038_bases
ATGGAGTTCGGCGTGCCCAGAGAACGGTCGGGCGGGGAGATCCCGGAAAGGCGGGTGCCCCTCACGCCCCAGGGGGTGCG
GGAGCTCGTCGCCTCGGGGCACCGGGTCTACGTGGAGCGGGGCGCGGGGGAAGGGGCGGGCTTTCCCGACGAGGCCTACG
AGGAAGCGGGGGCCAGGCTCGTGGGCCGGGAGGAGGCCTTCGGCCGCCCCCAGGTGGTGCTCAAGGTGGCCCGCCCCACC
CTCGAGGAGGTGGGGCTCATGCGCAAAAACGCCGTTCTCATGGCCTTCCTCCACCTGGCGGTGGCGGAAAGCCCCCTCGT
GGAGGCCATGGCCCAAAAGGGCCTCACCGCCATCGGCTACGAGCTGGTGGGCGAGGAGGGCCGCCGCCCCGTCCTGAAGG
CCATGAGCGAGATCGCCGGGCGCATGGCCCCCCAGCTCGCCGGGCGGCTCCTCGAGGCCCCCCAGGGCCCGGGCATCCTC
CTCTCCGGCCTGGTGGGCATCCCCCCGGCGGACGTGGTCGTCCTGGGGGCGGGGGTCCTGGGCCGGGCGGCGGCGCGGGC
CTTTCTGGGCGCGGGGGCCTCGGTCCACCTCCTGGACCGGGCCCTTCCCCCGCTGGAGGAGGCCGCCCGGGAGGCCCCGG
GGGCCATCACCGCCCTCGTCACCCAGGACCGCCTGGAGCGGTACGTGGCCTTCGCCGACGTCCTGGTGGGGGCGGTGGCC
GTCCCTGGGGAGCGCACCCCCCTTCTCCTCACCCGCGGCCTCCTCGCCCGCATGCGCCCCGGAAGCGTCCTCCTGGACTT
CTCCATAGACCAGGGGGGCGTCTCGGAAACCAGCCGCCCTGGGGTCTACCAGGAGATGGGCGTCACCCACTTCTGCCTCC
CCAACGTCCCCGCCCTCGTCCCCCGCACCGCAAGCCACGCCCTCACCCTCACCCTCCTCCCCTACCTGCTCCGGATCCAG
GAAGACCCCCTGGCCCTTCCCGGGCTCCGCCAGGGGGCCTACCTCCTCTTCGGCGAGAAAGGAGGCCACCTAGAATGA

Upstream 100 bases:

>100_bases
GAACGCAGGGGGCGAAACGCCCAAGCGCCCCGGCGGCCGCCACGTGGGGGCCTCTTCCCCAAGGACATCCGCCCCGGGGC
TTTCGGCGTAGGCTTGGGGC

Downstream 100 bases:

>100_bases
GCTACCGCAAGAAGCTCACCTCCCCCGAGGACGCCGTGGGCCTGATCCGCTCGGGGATGCGGGTCTTCGTCTCCGGCAAC
GCCGCCACCCCCACGCCCCT

Product: alanine dehydrogenase

Products: NA

Alternate protein names: Stage V sporulation protein N [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MEFGVPRERSGGEIPERRVPLTPQGVRELVASGHRVYVERGAGEGAGFPDEAYEEAGARLVGREEAFGRPQVVLKVARPT
LEEVGLMRKNAVLMAFLHLAVAESPLVEAMAQKGLTAIGYELVGEEGRRPVLKAMSEIAGRMAPQLAGRLLEAPQGPGIL
LSGLVGIPPADVVVLGAGVLGRAAARAFLGAGASVHLLDRALPPLEEAAREAPGAITALVTQDRLERYVAFADVLVGAVA
VPGERTPLLLTRGLLARMRPGSVLLDFSIDQGGVSETSRPGVYQEMGVTHFCLPNVPALVPRTASHALTLTLLPYLLRIQ
EDPLALPGLRQGAYLLFGEKGGHLE

Sequences:

>Translated_345_residues
MEFGVPRERSGGEIPERRVPLTPQGVRELVASGHRVYVERGAGEGAGFPDEAYEEAGARLVGREEAFGRPQVVLKVARPT
LEEVGLMRKNAVLMAFLHLAVAESPLVEAMAQKGLTAIGYELVGEEGRRPVLKAMSEIAGRMAPQLAGRLLEAPQGPGIL
LSGLVGIPPADVVVLGAGVLGRAAARAFLGAGASVHLLDRALPPLEEAAREAPGAITALVTQDRLERYVAFADVLVGAVA
VPGERTPLLLTRGLLARMRPGSVLLDFSIDQGGVSETSRPGVYQEMGVTHFCLPNVPALVPRTASHALTLTLLPYLLRIQ
EDPLALPGLRQGAYLLFGEKGGHLE
>Mature_345_residues
MEFGVPRERSGGEIPERRVPLTPQGVRELVASGHRVYVERGAGEGAGFPDEAYEEAGARLVGREEAFGRPQVVLKVARPT
LEEVGLMRKNAVLMAFLHLAVAESPLVEAMAQKGLTAIGYELVGEEGRRPVLKAMSEIAGRMAPQLAGRLLEAPQGPGIL
LSGLVGIPPADVVVLGAGVLGRAAARAFLGAGASVHLLDRALPPLEEAAREAPGAITALVTQDRLERYVAFADVLVGAVA
VPGERTPLLLTRGLLARMRPGSVLLDFSIDQGGVSETSRPGVYQEMGVTHFCLPNVPALVPRTASHALTLTLLPYLLRIQ
EDPLALPGLRQGAYLLFGEKGGHLE

Specific function: This enzyme is a key factor in the assimilation of L- alanine as an energy source through the tricarboxylic acid cycle during sporulation [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=347, Percent_Identity=29.971181556196, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI122939153, Length=347, Percent_Identity=29.971181556196, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1787887, Length=350, Percent_Identity=30.5714285714286, Blast_Score=117, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17550456, Length=350, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 36471; Mature: 36471

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFGVPRERSGGEIPERRVPLTPQGVRELVASGHRVYVERGAGEGAGFPDEAYEEAGARL
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHCCEE
VGREEAFGRPQVVLKVARPTLEEVGLMRKNAVLMAFLHLAVAESPLVEAMAQKGLTAIGY
ECCHHHCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHH
ELVGEEGRRPVLKAMSEIAGRMAPQLAGRLLEAPQGPGILLSGLVGIPPADVVVLGAGVL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEECCCHH
GRAAARAFLGAGASVHLLDRALPPLEEAAREAPGAITALVTQDRLERYVAFADVLVGAVA
HHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHC
VPGERTPLLLTRGLLARMRPGSVLLDFSIDQGGVSETSRPGVYQEMGVTHFCLPNVPALV
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHCCEEEECCCCCHHC
PRTASHALTLTLLPYLLRIQEDPLALPGLRQGAYLLFGEKGGHLE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MEFGVPRERSGGEIPERRVPLTPQGVRELVASGHRVYVERGAGEGAGFPDEAYEEAGARL
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHCCEE
VGREEAFGRPQVVLKVARPTLEEVGLMRKNAVLMAFLHLAVAESPLVEAMAQKGLTAIGY
ECCHHHCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHH
ELVGEEGRRPVLKAMSEIAGRMAPQLAGRLLEAPQGPGILLSGLVGIPPADVVVLGAGVL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEECCCHH
GRAAARAFLGAGASVHLLDRALPPLEEAAREAPGAITALVTQDRLERYVAFADVLVGAVA
HHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHC
VPGERTPLLLTRGLLARMRPGSVLLDFSIDQGGVSETSRPGVYQEMGVTHFCLPNVPALV
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHCCEEEECCCCCHHC
PRTASHALTLTLLPYLLRIQEDPLALPGLRQGAYLLFGEKGGHLE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226620; 9384377 [H]