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The map label for this gene is ldh [H]

Identifier: 55981082

GI number: 55981082

Start: 1060141

End: 1061073

Strand: Reverse

Name: ldh [H]

Synonym: TTHA1113

Alternate gene names: 55981082

Gene position: 1061073-1060141 (Counterclockwise)

Preceding gene: 55981086

Following gene: 55981080

Centisome position: 57.36

GC content: 73.74

Gene sequence:

>933_bases
ATGAAGGTCGGCATCGTGGGAAGCGGCATGGTGGGGAGCGCCACCGCCTACGCCCTGGCCCTCCTCGGCGTGGCGCGGGA
GGTGGTCCTCGTGGACCTGGACCGGAAGCTGGCCCAGGCCCACGCCGAGGACATCCTCCACGCCACGCCCTTCGCCCACC
CGGTCTGGGTGCGGGCGGGGTCGTACGGGGACCTCGAGGGGGCCCGGGCGGTGGTGCTCGCCGCCGGGGTGGCCCAGCGC
CCCGGGGAGACCCGCCTGCAGCTTCTGGACCGCAACGCCCAGGTCTTCGCCCAGGTGGTGCCCCGGGTTTTAGAGGCGGC
CCCGGAGGCGGTGCTCCTCGTGGCCACGAACCCGGTGGACGTGATGACCCAGGTGGCCTACCGCCTCTCCGGCCTGCCCC
CGGGGCGGGTGGTGGGCTCGGGGACGATCCTGGACACGGCCCGCTTCCGGGCCCTTCTGGCGGAGTACCTCCGGGTGGCC
CCCCAGTCGGTCCACGCCTACGTGCTGGGGGAGCACGGGGACTCGGAGGTGCTGGTCTGGTCCAGCGCCCAGGTGGGCGG
GGTGCCCCTCCTGGAGTTCGCCGAGGCCCGGGGGCGGGCCCTTTCCCCGGAGGACCGGGCCCGCATTGACGAAGGGGTCC
GCCGGGCCGCCTACCGGATCATTGAGGGGAAGGGGGCCACCTACTACGGCATCGGGGCGGGCCTCGCCCGGCTTGTGCGG
GCCATCCTCACCGACGAAAAGGGGGTGTACACCGTGAGCGCCTTCACCCCCGAGGTGGAGGGGGTCTTGGAGGTGAGCCT
CTCCCTGCCCCGCATCCTGGGCGCGGGGGGCGTGGAGGGGACCGTCTACCCGAGCCTGAGCCCGGAGGAGCGGGAGGCCT
TGCGGCGGAGCGCCGAGATCCTCAAGGAGGCGGCCTTCGCCCTGGGGTTTTAG

Upstream 100 bases:

>100_bases
TCTCCCAGTCGGTGAAGTCTCCGATGAGGGCGGCGGCCCCTTCCGGCGGGTAAAAGGTGGCGCTCCTTCGTCCTACCCGT
ACCACGGGTATACTCTACCC

Downstream 100 bases:

>100_bases
AGCTTTTCCAGATTTGGGTAGAGGGCGAGGAGCTCCTCCTCCGTGAGGCCCTCGCCCTCCTTCTCCGGCGTCCAGGCCAG
GTGGAAGGCGAGGAGGGTGA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKVGIVGSGMVGSATAYALALLGVAREVVLVDLDRKLAQAHAEDILHATPFAHPVWVRAGSYGDLEGARAVVLAAGVAQR
PGETRLQLLDRNAQVFAQVVPRVLEAAPEAVLLVATNPVDVMTQVAYRLSGLPPGRVVGSGTILDTARFRALLAEYLRVA
PQSVHAYVLGEHGDSEVLVWSSAQVGGVPLLEFAEARGRALSPEDRARIDEGVRRAAYRIIEGKGATYYGIGAGLARLVR
AILTDEKGVYTVSAFTPEVEGVLEVSLSLPRILGAGGVEGTVYPSLSPEEREALRRSAEILKEAAFALGF

Sequences:

>Translated_310_residues
MKVGIVGSGMVGSATAYALALLGVAREVVLVDLDRKLAQAHAEDILHATPFAHPVWVRAGSYGDLEGARAVVLAAGVAQR
PGETRLQLLDRNAQVFAQVVPRVLEAAPEAVLLVATNPVDVMTQVAYRLSGLPPGRVVGSGTILDTARFRALLAEYLRVA
PQSVHAYVLGEHGDSEVLVWSSAQVGGVPLLEFAEARGRALSPEDRARIDEGVRRAAYRIIEGKGATYYGIGAGLARLVR
AILTDEKGVYTVSAFTPEVEGVLEVSLSLPRILGAGGVEGTVYPSLSPEEREALRRSAEILKEAAFALGF
>Mature_310_residues
MKVGIVGSGMVGSATAYALALLGVAREVVLVDLDRKLAQAHAEDILHATPFAHPVWVRAGSYGDLEGARAVVLAAGVAQR
PGETRLQLLDRNAQVFAQVVPRVLEAAPEAVLLVATNPVDVMTQVAYRLSGLPPGRVVGSGTILDTARFRALLAEYLRVA
PQSVHAYVLGEHGDSEVLVWSSAQVGGVPLLEFAEARGRALSPEDRARIDEGVRRAAYRIIEGKGATYYGIGAGLARLVR
AILTDEKGVYTVSAFTPEVEGVLEVSLSLPRILGAGGVEGTVYPSLSPEEREALRRSAEILKEAAFALGF

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI15082234, Length=304, Percent_Identity=38.4868421052632, Blast_Score=228, Evalue=4e-60,
Organism=Homo sapiens, GI47059044, Length=304, Percent_Identity=38.4868421052632, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI221136809, Length=304, Percent_Identity=38.4868421052632, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI291575128, Length=302, Percent_Identity=38.0794701986755, Blast_Score=214, Evalue=7e-56,
Organism=Homo sapiens, GI4557032, Length=302, Percent_Identity=38.0794701986755, Blast_Score=214, Evalue=7e-56,
Organism=Homo sapiens, GI5031857, Length=311, Percent_Identity=37.620578778135, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI260099723, Length=311, Percent_Identity=37.620578778135, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI9257228, Length=311, Percent_Identity=37.2990353697749, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI4504973, Length=311, Percent_Identity=37.2990353697749, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI260099725, Length=229, Percent_Identity=38.4279475982533, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI260099727, Length=221, Percent_Identity=38.0090497737557, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI207028494, Length=198, Percent_Identity=39.8989898989899, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI103472011, Length=301, Percent_Identity=27.2425249169435, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI103472015, Length=182, Percent_Identity=29.1208791208791, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1789632, Length=320, Percent_Identity=29.6875, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17535107, Length=293, Percent_Identity=39.2491467576792, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6320125, Length=193, Percent_Identity=29.5336787564767, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17136226, Length=311, Percent_Identity=39.5498392282958, Blast_Score=231, Evalue=4e-61,
Organism=Drosophila melanogaster, GI45550422, Length=314, Percent_Identity=32.8025477707006, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24663599, Length=318, Percent_Identity=27.3584905660377, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24647881, Length=259, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 32795; Mature: 32795

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGIVGSGMVGSATAYALALLGVAREVVLVDLDRKLAQAHAEDILHATPFAHPVWVRAG
CEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEC
SYGDLEGARAVVLAAGVAQRPGETRLQLLDRNAQVFAQVVPRVLEAAPEAVLLVATNPVD
CCCCCCCCCEEEEECCHHCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCHH
VMTQVAYRLSGLPPGRVVGSGTILDTARFRALLAEYLRVAPQSVHAYVLGEHGDSEVLVW
HHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEE
SSAQVGGVPLLEFAEARGRALSPEDRARIDEGVRRAAYRIIEGKGATYYGIGAGLARLVR
ECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHH
AILTDEKGVYTVSAFTPEVEGVLEVSLSLPRILGAGGVEGTVYPSLSPEEREALRRSAEI
HHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHH
LKEAAFALGF
HHHHHHHHCC
>Mature Secondary Structure
MKVGIVGSGMVGSATAYALALLGVAREVVLVDLDRKLAQAHAEDILHATPFAHPVWVRAG
CEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEC
SYGDLEGARAVVLAAGVAQRPGETRLQLLDRNAQVFAQVVPRVLEAAPEAVLLVATNPVD
CCCCCCCCCEEEEECCHHCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCHH
VMTQVAYRLSGLPPGRVVGSGTILDTARFRALLAEYLRVAPQSVHAYVLGEHGDSEVLVW
HHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEE
SSAQVGGVPLLEFAEARGRALSPEDRARIDEGVRRAAYRIIEGKGATYYGIGAGLARLVR
ECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHH
AILTDEKGVYTVSAFTPEVEGVLEVSLSLPRILGAGGVEGTVYPSLSPEEREALRRSAEI
HHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHH
LKEAAFALGF
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3533539 [H]