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The map label for this gene is lon2 [H]

Identifier: 55981080

GI number: 55981080

Start: 1056766

End: 1059180

Strand: Reverse

Name: lon2 [H]

Synonym: TTHA1111

Alternate gene names: 55981080

Gene position: 1059180-1056766 (Counterclockwise)

Preceding gene: 55981082

Following gene: 55981075

Centisome position: 57.26

GC content: 67.91

Gene sequence:

>2415_bases
ATGCTACCGGAAACCATGCCCGTCTGCCCGGTGCGGGGCTCGGTCATCTACCCCACCATGGTGATGCCCATAGACGCCGG
GAGGCCCATCTCCATCCGGGCCATTGACGAGGCCCTGGCCCGCGACCGGGTCCTCCTCATCGTGAGCCAGAGGGACAAGG
AGGTGGAGACCCCCAGGCCCTCGGACCTCTTTGAGGTGGGCACGGCCTGCAACATCCTGAAGATGCGCAAGAACCCGGAC
GGCTCCGTCCAGGTCCTGGTGCAGGCCTTCGCCCGGGTCCGGGTGAGGGAGTGGCTGGACCTGGGGGACCACCTCGAGGC
CCGCGGCGAGGTCCTCGCCGACGAGCCCGGGGAGCCCATCCTGGTCAAGGCCCTGGTCCGGGAGGTCAAGGACAAGTTCC
AGGCCCTCCTCAAGGAGGGGAAGTACCTGGCCCCGGAGGTGGCCCAGTTCATCCTGAACCTGGAGGACCCCTCGCAGCTT
GCCGACTACGTCGCCTTCCACATGGACTTCCGCCTCGAGGACAAGCAGAAGGTCCTGGAGACGGCGAACGTGGCCGAGCG
CCTGCGGGCGGTTTTGGTGCTCCTGGAGGCGGAGCTCGCCCTCATTGAGACCCAGCGGCGCATCCAGCAGCAGGTCAAGG
AGGAGATTGACCGCAACCAGCGGGAGTACTTCCTCCGGGAGCAGATGAAGGCCATCCAGCGGGAGCTCCACGGGGAGGAG
GGGGAGCAGGAGGTGGAGGAGTTCCGCAGAAAGCTTGAGGCCCTGGACCTTCCCCCCGTGGTGCGCCAGGAAGCGGAGCG
GGAGCTCAACCGCTTCGCCCGCATGCACCCCGACTCCGCCGAGGCCAGCGTCATCCGCACCTACCTGGACTGGATCGTCA
ACCTCCCCTGGAACACCCGCACCGAGGACAACCTGGACCTGGAGCGGGCCAAGGAGATCCTGGAACGGGACCACTACGGC
CTGGAGAAGGTGAAGGACCGGGTCCTGGAGTACCTGGCGGTGCGCAAGCTCAAGGCGGAACGGGCCAAGCGGGGGGAGAT
CCCGCCCGACGAGGTGAACAAGGGCCCCATCCTCCTCTTCGTGGGGCCGCCGGGGGTGGGGAAGACCTCCATCGCCAAGA
GCATCGCCGAGGCCCTGGGCCGCAAGTACGTGCGCGTCTCCTTGGGCGGCGTCCGGGACGAGTCGGACATCCGGGGCCAC
CGCCGCACCTACATCGGGGCCATGCCGGGCCGGATCATCCAGGGCCTGAGGCAAGCGGGGACCAAGAACCCCGTCTTCCT
CCTGGACGAGGTGGACAAGCTGGGCATCTCCTACCAGGGGGACCCGGCGGCGGCCCTCCTCGAGGTCTTGGACCCCGCCC
AGAACAAGGAGTTCGTGGACCACTACCTGGGGGTGCCCTTTGACCTCAGCGAGGTGATGTTCATCTGCACCGCCAACTTC
CCCCAGAACATCCCCGCCCCCCTCTACGACCGGATGGAGCCCATTGAGTTCACCAGCTACACCGAGCAGGAGAAGCTGGA
GATCGCCAAGCGCTACCTCCTGCCCAGGCAGCTAAAGGAAAACGGCCTCGAGCCCGAGCAGGTGGTGGTGACCGAGGCCG
CCCTCACGCGCCTCATCACCCACTACACCCGGGAGGCGGGGGTGCGGCAGCTGGAGCGGGAGATCGGGGCCCTCCTCCGC
AAGGCCGCCCGCAGGATCCTGGAGGAGGGCAAGAAGCGGGTGCGGATCACGGAGAAGGACCTGGAGGCCTACCTCGGCCC
GCCCCGCTTCCTCCCCGAGACCGAGGCCCGGGAGCCCCAGGTGGGGGTGGCCACGGGGATGTACTACACCCCCGTGGGCG
GGGACATCATGTTCGTGGAGGTCTCCGTGATGCCCGGCAAGGGCAACCTCATCCTCACCGGGCAGCTCGGCGACGTGATG
AAGGAGTCGGCCAGGGCCGCCCTCTCCTACGCCAAGAAGAACGCCCTCCGCTTCGGCATCCCCCTGGAGAAGTTTGACAA
GTCCGACATCCACATCCACGTCCCCGCCGGGGCCATTCCCAAGGAAGGCCCCTCCGCCGGGGTGGCCCTCGTGAGCGCCT
TGGTCTCCGCCCTCACCGAGGTGCCGGTGCGGCACGACATCGCCATGACCGGGGAGATCACCCTCACGGGCAGGGTCCTC
CCCATCGGCGGGGTGAAGGAGAAGGTGCTGGGGGCGAGGCGGGCCGGGATCCGGGAGGTGATCCTGCCCAAGCTCAACGA
GCCCGACCTCTCCGACATCCCCAAGCCCCTCCGGCAGAACATGACCTTCCACTTCGTGGAGCACCTGGACCAGGTTCTGG
ACCTGGCCCTGGTGGGCGGCCTCAAGGCCTTGGAGGAGCGGGGCAGGCGCCCTAGGAGCGCCCGGAAGAAGAAGGAGCTC
GTGGCCCACGCCTAG

Upstream 100 bases:

>100_bases
GTCCGGGCCCTTTGCGTAAAACGGGGATTTGCAGTAAACTTGACATAGGTAGGCTTAGGCTATGGACGAACGCAGAACCG
CCGAAGAAAGGAGGGAACGC

Downstream 100 bases:

>100_bases
CCCAGGGCCTTGGCGTAGACCTCCAGGTAAGCCCGGGTGATCCTTTCCGGGTGGAAGCGCAGGAGGGCCCACTCCCGGGC
CCTCCTCCTTATCTCGGGGA

Product: alternative ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 804; Mature: 804

Protein sequence:

>804_residues
MLPETMPVCPVRGSVIYPTMVMPIDAGRPISIRAIDEALARDRVLLIVSQRDKEVETPRPSDLFEVGTACNILKMRKNPD
GSVQVLVQAFARVRVREWLDLGDHLEARGEVLADEPGEPILVKALVREVKDKFQALLKEGKYLAPEVAQFILNLEDPSQL
ADYVAFHMDFRLEDKQKVLETANVAERLRAVLVLLEAELALIETQRRIQQQVKEEIDRNQREYFLREQMKAIQRELHGEE
GEQEVEEFRRKLEALDLPPVVRQEAERELNRFARMHPDSAEASVIRTYLDWIVNLPWNTRTEDNLDLERAKEILERDHYG
LEKVKDRVLEYLAVRKLKAERAKRGEIPPDEVNKGPILLFVGPPGVGKTSIAKSIAEALGRKYVRVSLGGVRDESDIRGH
RRTYIGAMPGRIIQGLRQAGTKNPVFLLDEVDKLGISYQGDPAAALLEVLDPAQNKEFVDHYLGVPFDLSEVMFICTANF
PQNIPAPLYDRMEPIEFTSYTEQEKLEIAKRYLLPRQLKENGLEPEQVVVTEAALTRLITHYTREAGVRQLEREIGALLR
KAARRILEEGKKRVRITEKDLEAYLGPPRFLPETEAREPQVGVATGMYYTPVGGDIMFVEVSVMPGKGNLILTGQLGDVM
KESARAALSYAKKNALRFGIPLEKFDKSDIHIHVPAGAIPKEGPSAGVALVSALVSALTEVPVRHDIAMTGEITLTGRVL
PIGGVKEKVLGARRAGIREVILPKLNEPDLSDIPKPLRQNMTFHFVEHLDQVLDLALVGGLKALEERGRRPRSARKKKEL
VAHA

Sequences:

>Translated_804_residues
MLPETMPVCPVRGSVIYPTMVMPIDAGRPISIRAIDEALARDRVLLIVSQRDKEVETPRPSDLFEVGTACNILKMRKNPD
GSVQVLVQAFARVRVREWLDLGDHLEARGEVLADEPGEPILVKALVREVKDKFQALLKEGKYLAPEVAQFILNLEDPSQL
ADYVAFHMDFRLEDKQKVLETANVAERLRAVLVLLEAELALIETQRRIQQQVKEEIDRNQREYFLREQMKAIQRELHGEE
GEQEVEEFRRKLEALDLPPVVRQEAERELNRFARMHPDSAEASVIRTYLDWIVNLPWNTRTEDNLDLERAKEILERDHYG
LEKVKDRVLEYLAVRKLKAERAKRGEIPPDEVNKGPILLFVGPPGVGKTSIAKSIAEALGRKYVRVSLGGVRDESDIRGH
RRTYIGAMPGRIIQGLRQAGTKNPVFLLDEVDKLGISYQGDPAAALLEVLDPAQNKEFVDHYLGVPFDLSEVMFICTANF
PQNIPAPLYDRMEPIEFTSYTEQEKLEIAKRYLLPRQLKENGLEPEQVVVTEAALTRLITHYTREAGVRQLEREIGALLR
KAARRILEEGKKRVRITEKDLEAYLGPPRFLPETEAREPQVGVATGMYYTPVGGDIMFVEVSVMPGKGNLILTGQLGDVM
KESARAALSYAKKNALRFGIPLEKFDKSDIHIHVPAGAIPKEGPSAGVALVSALVSALTEVPVRHDIAMTGEITLTGRVL
PIGGVKEKVLGARRAGIREVILPKLNEPDLSDIPKPLRQNMTFHFVEHLDQVLDLALVGGLKALEERGRRPRSARKKKEL
VAHA
>Mature_804_residues
MLPETMPVCPVRGSVIYPTMVMPIDAGRPISIRAIDEALARDRVLLIVSQRDKEVETPRPSDLFEVGTACNILKMRKNPD
GSVQVLVQAFARVRVREWLDLGDHLEARGEVLADEPGEPILVKALVREVKDKFQALLKEGKYLAPEVAQFILNLEDPSQL
ADYVAFHMDFRLEDKQKVLETANVAERLRAVLVLLEAELALIETQRRIQQQVKEEIDRNQREYFLREQMKAIQRELHGEE
GEQEVEEFRRKLEALDLPPVVRQEAERELNRFARMHPDSAEASVIRTYLDWIVNLPWNTRTEDNLDLERAKEILERDHYG
LEKVKDRVLEYLAVRKLKAERAKRGEIPPDEVNKGPILLFVGPPGVGKTSIAKSIAEALGRKYVRVSLGGVRDESDIRGH
RRTYIGAMPGRIIQGLRQAGTKNPVFLLDEVDKLGISYQGDPAAALLEVLDPAQNKEFVDHYLGVPFDLSEVMFICTANF
PQNIPAPLYDRMEPIEFTSYTEQEKLEIAKRYLLPRQLKENGLEPEQVVVTEAALTRLITHYTREAGVRQLEREIGALLR
KAARRILEEGKKRVRITEKDLEAYLGPPRFLPETEAREPQVGVATGMYYTPVGGDIMFVEVSVMPGKGNLILTGQLGDVM
KESARAALSYAKKNALRFGIPLEKFDKSDIHIHVPAGAIPKEGPSAGVALVSALVSALTEVPVRHDIAMTGEITLTGRVL
PIGGVKEKVLGARRAGIREVILPKLNEPDLSDIPKPLRQNMTFHFVEHLDQVLDLALVGGLKALEERGRRPRSARKKKEL
VAHA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=659, Percent_Identity=44.6130500758725, Blast_Score=551, Evalue=1e-157,
Organism=Homo sapiens, GI21396489, Length=635, Percent_Identity=43.9370078740157, Blast_Score=551, Evalue=1e-156,
Organism=Escherichia coli, GI1786643, Length=776, Percent_Identity=48.9690721649485, Blast_Score=745, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=699, Percent_Identity=39.1988555078684, Blast_Score=487, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17556486, Length=547, Percent_Identity=44.6069469835466, Blast_Score=463, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6319449, Length=723, Percent_Identity=38.4508990318119, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24666867, Length=675, Percent_Identity=41.9259259259259, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221513036, Length=675, Percent_Identity=41.9259259259259, Blast_Score=520, Evalue=1e-147,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90484; Mature: 90484

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPETMPVCPVRGSVIYPTMVMPIDAGRPISIRAIDEALARDRVLLIVSQRDKEVETPRP
CCCCCCCCCCCCCCEECCEEEEEECCCCCEEHHHHHHHHCCCCEEEEEECCCCCCCCCCC
SDLFEVGTACNILKMRKNPDGSVQVLVQAFARVRVREWLDLGDHLEARGEVLADEPGEPI
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHH
LVKALVREVKDKFQALLKEGKYLAPEVAQFILNLEDPSQLADYVAFHMDFRLEDKQKVLE
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHH
TANVAERLRAVLVLLEAELALIETQRRIQQQVKEEIDRNQREYFLREQMKAIQRELHGEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
GEQEVEEFRRKLEALDLPPVVRQEAERELNRFARMHPDSAEASVIRTYLDWIVNLPWNTR
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
TEDNLDLERAKEILERDHYGLEKVKDRVLEYLAVRKLKAERAKRGEIPPDEVNKGPILLF
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
VGPPGVGKTSIAKSIAEALGRKYVRVSLGGVRDESDIRGHRRTYIGAMPGRIIQGLRQAG
ECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHCCCHHHHHHCCCCHHHHHHHHHCC
TKNPVFLLDEVDKLGISYQGDPAAALLEVLDPAQNKEFVDHYLGVPFDLSEVMFICTANF
CCCCEEEEECHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHEEEECCC
PQNIPAPLYDRMEPIEFTSYTEQEKLEIAKRYLLPRQLKENGLEPEQVVVTEAALTRLIT
CCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHH
HYTREAGVRQLEREIGALLRKAARRILEEGKKRVRITEKDLEAYLGPPRFLPETEAREPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEECCHHHHHHHCCCCCCCCCCCCCCCC
VGVATGMYYTPVGGDIMFVEVSVMPGKGNLILTGQLGDVMKESARAALSYAKKNALRFGI
CEEECCEEEECCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCEEECC
PLEKFDKSDIHIHVPAGAIPKEGPSAGVALVSALVSALTEVPVRHDIAMTGEITLTGRVL
CHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECEEEEEEEEE
PIGGVKEKVLGARRAGIREVILPKLNEPDLSDIPKPLRQNMTFHFVEHLDQVLDLALVGG
ECCCHHHHHHHHHHHCHHHHHCCCCCCCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHH
LKALEERGRRPRSARKKKELVAHA
HHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLPETMPVCPVRGSVIYPTMVMPIDAGRPISIRAIDEALARDRVLLIVSQRDKEVETPRP
CCCCCCCCCCCCCCEECCEEEEEECCCCCEEHHHHHHHHCCCCEEEEEECCCCCCCCCCC
SDLFEVGTACNILKMRKNPDGSVQVLVQAFARVRVREWLDLGDHLEARGEVLADEPGEPI
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHH
LVKALVREVKDKFQALLKEGKYLAPEVAQFILNLEDPSQLADYVAFHMDFRLEDKQKVLE
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHH
TANVAERLRAVLVLLEAELALIETQRRIQQQVKEEIDRNQREYFLREQMKAIQRELHGEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
GEQEVEEFRRKLEALDLPPVVRQEAERELNRFARMHPDSAEASVIRTYLDWIVNLPWNTR
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
TEDNLDLERAKEILERDHYGLEKVKDRVLEYLAVRKLKAERAKRGEIPPDEVNKGPILLF
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
VGPPGVGKTSIAKSIAEALGRKYVRVSLGGVRDESDIRGHRRTYIGAMPGRIIQGLRQAG
ECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHCCCHHHHHHCCCCHHHHHHHHHCC
TKNPVFLLDEVDKLGISYQGDPAAALLEVLDPAQNKEFVDHYLGVPFDLSEVMFICTANF
CCCCEEEEECHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHEEEECCC
PQNIPAPLYDRMEPIEFTSYTEQEKLEIAKRYLLPRQLKENGLEPEQVVVTEAALTRLIT
CCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHH
HYTREAGVRQLEREIGALLRKAARRILEEGKKRVRITEKDLEAYLGPPRFLPETEAREPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEECCHHHHHHHCCCCCCCCCCCCCCCC
VGVATGMYYTPVGGDIMFVEVSVMPGKGNLILTGQLGDVMKESARAALSYAKKNALRFGI
CEEECCEEEECCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCEEECC
PLEKFDKSDIHIHVPAGAIPKEGPSAGVALVSALVSALTEVPVRHDIAMTGEITLTGRVL
CHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECEEEEEEEEE
PIGGVKEKVLGARRAGIREVILPKLNEPDLSDIPKPLRQNMTFHFVEHLDQVLDLALVGG
ECCCHHHHHHHHHHHCHHHHHCCCCCCCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHH
LKALEERGRRPRSARKKKELVAHA
HHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA