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The map label for this gene is ribD [H]

Identifier: 55981033

GI number: 55981033

Start: 1010313

End: 1011446

Strand: Reverse

Name: ribD [H]

Synonym: TTHA1064

Alternate gene names: 55981033

Gene position: 1011446-1010313 (Counterclockwise)

Preceding gene: 55981034

Following gene: 55981032

Centisome position: 54.68

GC content: 73.81

Gene sequence:

>1134_bases
TTGCGCGACCTGGACGAGCGCTTTCTGCGAAGGGCCCTGCAGCTTGCCGAAAGGGCCCGGGGCCACACGAGCCCGAACCC
CCTGGTGGGGGCGGTCCTGGTAAGGGAAGGCCGGATCGTGGGCGAGGGGTTTCACCCCCGGGCGGGAGAGCCCCACGCCG
AGGTCTTCGCCCTCCAGCAGGCGGGGGAGCTCGCCCGGGGGGCCACGGCCTACGTGACCCTCGAGCCCTGCGACCACTTC
GGGCGCACCCCGCCCTGCTCCCTGGCCCTCCTCCAGGCGGGGGTTTCCCGGGTGGTGGTGGCGGCCCGGGAGGAAAACCC
CGTGGCCAAGGGGGGGCTTGAGCGCCTGCGGGCGGGGGGGGTCCAGGTGGAGGCGGGCCTTTTGGAGGCCGAGGCCCGGG
CCCAGAACGAGGTCTTCTTCGCCGTGCAGAAAAAGGGCCTTCCCTTCGTCCTCCTCAAGGCGGCCCTCACCCTGGACGGG
AAGGTGGCCGCCCCTTCGGGGGACGCCCGCTGGATCTCCTCGGAGGCGAGCCGCCGCGTGGCCCACGCCTACCGGCAGTG
GCTTCCCGCCGTGATGGTGGGGGTGGGGACTGTCCTAAAGGACGACCCCGCCCTCACCGTGCGGGAACCCGACTTCCGCC
CCTTTCCCCTCATGGTGGAGCCCCCGCCCCTCCGCGACCCCCTCAAGGTGGTCCTGGACACCGAGGCGAGGACGCCCCCC
ACGGCCCGCCTCTTCCGGAAGGGCCCCAGGGGCGAGCCCGCCCGGGTTCTGGTCTTCGTGGGGGAGGGGGCCCCAGGGGC
GCGGGTTTCGGCCCTGGAGGAGGCGGGGGCCCGGGTGGTGGCCCTCCCCCGGGAAGGGGGGCGGGTGGACCCGGAAAGGG
CCCTCGCCTTCCTCCTGGAGGAGGGGGTGGACGGGGTGCTCCTGGAGGGGGGGCCGAGGCTTGCCGGGGCCTTTCTGGAA
AGGGGCCTGGTGGACAAGCTCGCCCTCTTCCTCGCCCCCCGGATCCTGGGGGAGGGGAGGGGGCTTGCCGAGGGCTTTAG
GGTGGAGCGGGTGGCGGAGGCCCTCCGCCTTCGCCTTGCCCGCAGGGAGTGGCTGGGGGAGAACCTCTGGCTCGAGGCCT
ACCCGGAGGGATAG

Upstream 100 bases:

>100_bases
TCCCCACCGGCGGTGAAAGCCCGCGAAGCCCCCAAAGGGGCCCGACCCGGTGGAATTCCGGGGCCGACGGTGAAAGTCCG
GATGGGAGAAGGAGGGCCAC

Downstream 100 bases:

>100_bases
ATGTTCACGGGACTCGTGGAGGAAACGGGGGAGATCCTGAAGGTGGAGGAAGGGCCCTTCCTCCGGGTCTACATAGGTGC
CCGGAAGGTGCTGGAGGACC

Product: diaminohydroxyphosphoriboxylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MRDLDERFLRRALQLAERARGHTSPNPLVGAVLVREGRIVGEGFHPRAGEPHAEVFALQQAGELARGATAYVTLEPCDHF
GRTPPCSLALLQAGVSRVVVAAREENPVAKGGLERLRAGGVQVEAGLLEAEARAQNEVFFAVQKKGLPFVLLKAALTLDG
KVAAPSGDARWISSEASRRVAHAYRQWLPAVMVGVGTVLKDDPALTVREPDFRPFPLMVEPPPLRDPLKVVLDTEARTPP
TARLFRKGPRGEPARVLVFVGEGAPGARVSALEEAGARVVALPREGGRVDPERALAFLLEEGVDGVLLEGGPRLAGAFLE
RGLVDKLALFLAPRILGEGRGLAEGFRVERVAEALRLRLARREWLGENLWLEAYPEG

Sequences:

>Translated_377_residues
MRDLDERFLRRALQLAERARGHTSPNPLVGAVLVREGRIVGEGFHPRAGEPHAEVFALQQAGELARGATAYVTLEPCDHF
GRTPPCSLALLQAGVSRVVVAAREENPVAKGGLERLRAGGVQVEAGLLEAEARAQNEVFFAVQKKGLPFVLLKAALTLDG
KVAAPSGDARWISSEASRRVAHAYRQWLPAVMVGVGTVLKDDPALTVREPDFRPFPLMVEPPPLRDPLKVVLDTEARTPP
TARLFRKGPRGEPARVLVFVGEGAPGARVSALEEAGARVVALPREGGRVDPERALAFLLEEGVDGVLLEGGPRLAGAFLE
RGLVDKLALFLAPRILGEGRGLAEGFRVERVAEALRLRLARREWLGENLWLEAYPEG
>Mature_377_residues
MRDLDERFLRRALQLAERARGHTSPNPLVGAVLVREGRIVGEGFHPRAGEPHAEVFALQQAGELARGATAYVTLEPCDHF
GRTPPCSLALLQAGVSRVVVAAREENPVAKGGLERLRAGGVQVEAGLLEAEARAQNEVFFAVQKKGLPFVLLKAALTLDG
KVAAPSGDARWISSEASRRVAHAYRQWLPAVMVGVGTVLKDDPALTVREPDFRPFPLMVEPPPLRDPLKVVLDTEARTPP
TARLFRKGPRGEPARVLVFVGEGAPGARVSALEEAGARVVALPREGGRVDPERALAFLLEEGVDGVLLEGGPRLAGAFLE
RGLVDKLALFLAPRILGEGRGLAEGFRVERVAEALRLRLARREWLGENLWLEAYPEG

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=371, Percent_Identity=40.7008086253369, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI145693172, Length=154, Percent_Identity=35.0649350649351, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 40751; Mature: 40751

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00903 CYT_DCMP_DEAMINASES ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDLDERFLRRALQLAERARGHTSPNPLVGAVLVREGRIVGEGFHPRAGEPHAEVFALQQ
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCHHHHHHHHH
AGELARGATAYVTLEPCDHFGRTPPCSLALLQAGVSRVVVAAREENPVAKGGLERLRAGG
HHHHHCCCEEEEEECCHHHCCCCCCHHHHHHHHCHHHEEEEECCCCCCHHHHHHHHHCCC
VQVEAGLLEAEARAQNEVFFAVQKKGLPFVLLKAALTLDGKVAAPSGDARWISSEASRRV
EEEEHHHHHHHHHCCCCEEEEEECCCCCEEEEHHHHHCCCEEECCCCCCHHHHHHHHHHH
AHAYRQWLPAVMVGVGTVLKDDPALTVREPDFRPFPLMVEPPPLRDPLKVVLDTEARTPP
HHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEECCCCCCCCHHEEEECCCCCCC
TARLFRKGPRGEPARVLVFVGEGAPGARVSALEEAGARVVALPREGGRVDPERALAFLLE
HHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHH
EGVDGVLLEGGPRLAGAFLERGLVDKLALFLAPRILGEGRGLAEGFRVERVAEALRLRLA
HCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RREWLGENLWLEAYPEG
HHHHCCCCCEEEECCCC
>Mature Secondary Structure
MRDLDERFLRRALQLAERARGHTSPNPLVGAVLVREGRIVGEGFHPRAGEPHAEVFALQQ
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCHHHHHHHHH
AGELARGATAYVTLEPCDHFGRTPPCSLALLQAGVSRVVVAAREENPVAKGGLERLRAGG
HHHHHCCCEEEEEECCHHHCCCCCCHHHHHHHHCHHHEEEEECCCCCCHHHHHHHHHCCC
VQVEAGLLEAEARAQNEVFFAVQKKGLPFVLLKAALTLDGKVAAPSGDARWISSEASRRV
EEEEHHHHHHHHHCCCCEEEEEECCCCCEEEEHHHHHCCCEEECCCCCCHHHHHHHHHHH
AHAYRQWLPAVMVGVGTVLKDDPALTVREPDFRPFPLMVEPPPLRDPLKVVLDTEARTPP
HHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEECCCCCCCCHHEEEECCCCCCC
TARLFRKGPRGEPARVLVFVGEGAPGARVSALEEAGARVVALPREGGRVDPERALAFLLE
HHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHH
EGVDGVLLEGGPRLAGAFLERGLVDKLALFLAPRILGEGRGLAEGFRVERVAEALRLRLA
HCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RREWLGENLWLEAYPEG
HHHHCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]