Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 55980466

GI number: 55980466

Start: 463159

End: 464256

Strand: Reverse

Name: hemN [H]

Synonym: TTHA0497

Alternate gene names: 55980466

Gene position: 464256-463159 (Counterclockwise)

Preceding gene: 55980467

Following gene: 55980464

Centisome position: 25.1

GC content: 69.85

Gene sequence:

>1098_bases
GTGGCTAGCCTCTACGTCCACGTCCCCTTCTGCCCCACCCTCTGCCCCTACTGCGACTTCCACGTGGTCCGCCGGGGGCC
GGGGTGGGTGGAGGCCTACCTAAGGCGCCTGAAGGAAGAGGCCCAAGCCCTCCACGAGCGCTTCCCCAAACCCCTACGCA
CCCTCTACCTGGGCGGGGGGACGCCGAGCTACCTAAGGGACCGGGAGCTTGTGGCCCTCTTCCAAAGCCTTCCCTGGGCG
CTCGCCGAGGGCGCCGAGGTGACCCTGGAGGCCAACCCCGGGACCCTCTCCCCTGGCCGCCTCCGGCTCCTCCAAGACCT
CGGGGTGAACCGCCTCTCCCTGGGGGTGCAGAGCTTCCAGGAGCTGGTCCTCAAGTTCCTGGGGCGGGCCCACGGGAGGA
AGGGGGCGCTTAGGGCGGTGGAGATGGCCCTGGAATGGGGCTTTCGCGTCTCCATAGACCTCATCCTGGGCCTTCCCATG
CAGGACGTGGAAGCCGACCTGAAGGAGGCGGCCCGCCTCGGGGTGGGGCACGTCTCCGCCTACACCCTCCAGGTGGAGAA
GGGCACCCCCTTCGCCCTCCTGGGCCTAAAGGAAGACCCCGAGCGGGAGGCCTGGGCCATGGAGCGGGCGGAGGAGGTGC
TGGGAGAAACGGGGCTTTTCCGGTACGAGGTCTCCAACTTCGCCAGGGAAGGGGAGGAGGCCCGGCACAACCTCGTCTAC
TGGCGGGCGGGCTTCTGGCTCGCCCTGGGCCCTGCGGCCACGGGGCAGTACCCGGGGGAAGGGGGGGCCTACGCCCTGAG
GCGCACGGCCCCGCCCCTTCCCCGCTGGCTCCGAGGGGAGGCCCCGAAGGAGGAGGCCATTTCCCCGCTGGAACACGCCA
AGGAAAGCCTCATGCTGGGCCTAAGGCTCCGGGAAGGGGTGGACGTGGGGGCCGTGGAGGAGAGGACGGGGCTCGCCCTC
TTCCCCCTCCTCCAAGGGAGGGCGGTGGAGCTCGCCCAAGAAGGCCTCCTCCAGGTCCTGGGGAAAAGGCTTCTTCCCAC
CCCGAAGGCCTTTCCCCTCCTCCACCGGGTGGTCCTGGCCCTCTGGGAGGCGCTTTAG

Upstream 100 bases:

>100_bases
CCAGGGGACCTCCCGGAAGCCACGGAAGAGGACTGGAGGGAAGCTCTCGCGCTCGCGGAGCGGGCCGTGGCCTGGGTGGA
GGAGGTCTTAAAAAGCAGCC

Downstream 100 bases:

>100_bases
GGTTAGGCGAAGGCCAAAGCCTCCCGCGCCCGGTCCGCCAGGGCGAAGAAGCGCTCCTTGGTGAGGGGGATCTTCCCCGT
GACCAGGCCCTTTCCCGGCT

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MASLYVHVPFCPTLCPYCDFHVVRRGPGWVEAYLRRLKEEAQALHERFPKPLRTLYLGGGTPSYLRDRELVALFQSLPWA
LAEGAEVTLEANPGTLSPGRLRLLQDLGVNRLSLGVQSFQELVLKFLGRAHGRKGALRAVEMALEWGFRVSIDLILGLPM
QDVEADLKEAARLGVGHVSAYTLQVEKGTPFALLGLKEDPEREAWAMERAEEVLGETGLFRYEVSNFAREGEEARHNLVY
WRAGFWLALGPAATGQYPGEGGAYALRRTAPPLPRWLRGEAPKEEAISPLEHAKESLMLGLRLREGVDVGAVEERTGLAL
FPLLQGRAVELAQEGLLQVLGKRLLPTPKAFPLLHRVVLALWEAL

Sequences:

>Translated_365_residues
MASLYVHVPFCPTLCPYCDFHVVRRGPGWVEAYLRRLKEEAQALHERFPKPLRTLYLGGGTPSYLRDRELVALFQSLPWA
LAEGAEVTLEANPGTLSPGRLRLLQDLGVNRLSLGVQSFQELVLKFLGRAHGRKGALRAVEMALEWGFRVSIDLILGLPM
QDVEADLKEAARLGVGHVSAYTLQVEKGTPFALLGLKEDPEREAWAMERAEEVLGETGLFRYEVSNFAREGEEARHNLVY
WRAGFWLALGPAATGQYPGEGGAYALRRTAPPLPRWLRGEAPKEEAISPLEHAKESLMLGLRLREGVDVGAVEERTGLAL
FPLLQGRAVELAQEGLLQVLGKRLLPTPKAFPLLHRVVLALWEAL
>Mature_364_residues
ASLYVHVPFCPTLCPYCDFHVVRRGPGWVEAYLRRLKEEAQALHERFPKPLRTLYLGGGTPSYLRDRELVALFQSLPWAL
AEGAEVTLEANPGTLSPGRLRLLQDLGVNRLSLGVQSFQELVLKFLGRAHGRKGALRAVEMALEWGFRVSIDLILGLPMQ
DVEADLKEAARLGVGHVSAYTLQVEKGTPFALLGLKEDPEREAWAMERAEEVLGETGLFRYEVSNFAREGEEARHNLVYW
RAGFWLALGPAATGQYPGEGGAYALRRTAPPLPRWLRGEAPKEEAISPLEHAKESLMLGLRLREGVDVGAVEERTGLALF
PLLQGRAVELAQEGLLQVLGKRLLPTPKAFPLLHRVVLALWEAL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=275, Percent_Identity=39.2727272727273, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1789325, Length=312, Percent_Identity=36.8589743589744, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI87082341, Length=247, Percent_Identity=30.3643724696356, Blast_Score=93, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 40533; Mature: 40401

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLYVHVPFCPTLCPYCDFHVVRRGPGWVEAYLRRLKEEAQALHERFPKPLRTLYLGGG
CCEEEEECCCCCCCCCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHEEEECCC
TPSYLRDRELVALFQSLPWALAEGAEVTLEANPGTLSPGRLRLLQDLGVNRLSLGVQSFQ
CHHHHHHHHHHHHHHHCCHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHH
ELVLKFLGRAHGRKGALRAVEMALEWGFRVSIDLILGLPMQDVEADLKEAARLGVGHVSA
HHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEE
YTLQVEKGTPFALLGLKEDPEREAWAMERAEEVLGETGLFRYEVSNFAREGEEARHNLVY
EEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCHHHHHCEEE
WRAGFWLALGPAATGQYPGEGGAYALRRTAPPLPRWLRGEAPKEEAISPLEHAKESLMLG
EECCEEEEECCCCCCCCCCCCCCEEEECCCCCCCHHHCCCCCHHHHCCHHHHHHHHHHHH
LRLREGVDVGAVEERTGLALFPLLQGRAVELAQEGLLQVLGKRLLPTPKAFPLLHRVVLA
HHHHCCCCCCCCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LWEAL
HHHCC
>Mature Secondary Structure 
ASLYVHVPFCPTLCPYCDFHVVRRGPGWVEAYLRRLKEEAQALHERFPKPLRTLYLGGG
CEEEEECCCCCCCCCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHEEEECCC
TPSYLRDRELVALFQSLPWALAEGAEVTLEANPGTLSPGRLRLLQDLGVNRLSLGVQSFQ
CHHHHHHHHHHHHHHHCCHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHH
ELVLKFLGRAHGRKGALRAVEMALEWGFRVSIDLILGLPMQDVEADLKEAARLGVGHVSA
HHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEE
YTLQVEKGTPFALLGLKEDPEREAWAMERAEEVLGETGLFRYEVSNFAREGEEARHNLVY
EEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCHHHHHCEEE
WRAGFWLALGPAATGQYPGEGGAYALRRTAPPLPRWLRGEAPKEEAISPLEHAKESLMLG
EECCEEEEECCCCCCCCCCCCCCEEEECCCCCCCHHHCCCCCHHHHCCHHHHHHHHHHHH
LRLREGVDVGAVEERTGLALFPLLQGRAVELAQEGLLQVLGKRLLPTPKAFPLLHRVVLA
HHHHCCCCCCCCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LWEAL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]