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The map label for this gene is iscS [H]

Identifier: 55980425

GI number: 55980425

Start: 427283

End: 428407

Strand: Direct

Name: iscS [H]

Synonym: TTHA0456

Alternate gene names: 55980425

Gene position: 427283-428407 (Clockwise)

Preceding gene: 55980424

Following gene: 55980426

Centisome position: 23.1

GC content: 73.69

Gene sequence:

>1125_bases
GTGCGGGGCGTCTACCTGGACTACGCGGCCACCACGCCCCTGGATCCCGAGGTCCGGGAGGCCATGCGGGCGGTGGAGGA
GGTCTTCGGCAACCCCAGCAGCATCCACCGCTTCGGCCAGGAGGCCCGTAAGGTCTTGGAGGAGGCCCGGGAACGGGTGG
CGGAGGCGCTCGGGGCGCGGCCCCGGGAGGTGGTCTTCACCGCAGGGGGCTCCGAGGCCGACGCCCTCGCCCTCCTGGGC
CCGGCCCTGGCCCGGGGCCGGGGGCACGTGGTGAGCACGGCGGTGGAGCACGCCGCCGTGCTCGGGGCCCTGCGCCTCTT
GGAGCGGCTGGGCTTCGCCGTGACCCTCCTCAAGCCCGATTCCCTAGGGATGGTCTACCCCGAGCAGGTGGAGGAGGCCC
TGCGCCCCGACACCTTCCTGGTGAGCGTCATGACGGCGAACAACGAGCTCGGCAACCTCTACCCGGTGCGGGAGATCGCC
GAGGTGGCCCACCGGCACGGGGCCCTCTTCCACACCGACGCCGTCCAGGCGGTGGGGCAGGTCCCCTTCCGCATGGACGA
GGTGGGGGCGGACCTGGTCTCCTTGAGCGCCCACAAGTTCTACGGGCCCAAGGGCGTGGGGGCGCTCCTCGTCCGCCAGG
GGGTGGAGCTTATGGCCGTTGTGCCGGGGAAGCAGGAGGGGGGTAGGCGGGGCGGCACGCAGAGCCCCGTTTTGGCCCAC
GGGATGGCCGTGGCCCTGGAGCTCGCCCTGAAGCGCCTTCCCGAGGAGGCGGCGCGCCTTGCGGCCTTGCGGCGGCGCCT
CGAGGCGGGGCTTCTCGCGGTGGAGGGGGTGGAGCTCAACGGCCACCCCGAGCGCCGCCTCCCCAAGCTCGTCAACGTCA
CCGTGAAGGGGGCGGACGGGGAGGCCCTGCTCCTCGCCATGGACCTCCTGGGCGTGGCCGTCTCCTCGGGCTCCGCCTGC
AGCGCCGGGAACCTCGAGCCCTCCCACGTCCTCCTCGCCATCGGCCGCAGCTACGCCGAGGCCAAGGCCTCCTTGCGCTT
CTCCCTGGGCCGCTTCACCACCGAGGAGGAGGTGGACCGGGCGGTGGCGGTCTTCCGGGAGGCCGTGGCCCGGGCCCGGG
CTTGA

Upstream 100 bases:

>100_bases
GGGCACCACCCTTAAGGACCTCATTGAGGAGAGGCGGCTTTTGGAGGCCAGGGGGGTCATCCCCCTCGAGGCCCGCGTCT
CCTGAGGGCCGGGAGGCGGC

Downstream 100 bases:

>100_bases
CCGGGCCCGAGCGGAACGGAAGACTAGGGGGGATGGACGCGTTCCGCCTCGCGCCTTGTGGTCCCTTGCGGGGGCGCCTC
CGCGTCCCCGGGGACAAGTC

Product: cysteine desulfurase/cysteine sulfinate desulfinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MRGVYLDYAATTPLDPEVREAMRAVEEVFGNPSSIHRFGQEARKVLEEARERVAEALGARPREVVFTAGGSEADALALLG
PALARGRGHVVSTAVEHAAVLGALRLLERLGFAVTLLKPDSLGMVYPEQVEEALRPDTFLVSVMTANNELGNLYPVREIA
EVAHRHGALFHTDAVQAVGQVPFRMDEVGADLVSLSAHKFYGPKGVGALLVRQGVELMAVVPGKQEGGRRGGTQSPVLAH
GMAVALELALKRLPEEAARLAALRRRLEAGLLAVEGVELNGHPERRLPKLVNVTVKGADGEALLLAMDLLGVAVSSGSAC
SAGNLEPSHVLLAIGRSYAEAKASLRFSLGRFTTEEEVDRAVAVFREAVARARA

Sequences:

>Translated_374_residues
MRGVYLDYAATTPLDPEVREAMRAVEEVFGNPSSIHRFGQEARKVLEEARERVAEALGARPREVVFTAGGSEADALALLG
PALARGRGHVVSTAVEHAAVLGALRLLERLGFAVTLLKPDSLGMVYPEQVEEALRPDTFLVSVMTANNELGNLYPVREIA
EVAHRHGALFHTDAVQAVGQVPFRMDEVGADLVSLSAHKFYGPKGVGALLVRQGVELMAVVPGKQEGGRRGGTQSPVLAH
GMAVALELALKRLPEEAARLAALRRRLEAGLLAVEGVELNGHPERRLPKLVNVTVKGADGEALLLAMDLLGVAVSSGSAC
SAGNLEPSHVLLAIGRSYAEAKASLRFSLGRFTTEEEVDRAVAVFREAVARARA
>Mature_374_residues
MRGVYLDYAATTPLDPEVREAMRAVEEVFGNPSSIHRFGQEARKVLEEARERVAEALGARPREVVFTAGGSEADALALLG
PALARGRGHVVSTAVEHAAVLGALRLLERLGFAVTLLKPDSLGMVYPEQVEEALRPDTFLVSVMTANNELGNLYPVREIA
EVAHRHGALFHTDAVQAVGQVPFRMDEVGADLVSLSAHKFYGPKGVGALLVRQGVELMAVVPGKQEGGRRGGTQSPVLAH
GMAVALELALKRLPEEAARLAALRRRLEAGLLAVEGVELNGHPERRLPKLVNVTVKGADGEALLLAMDLLGVAVSSGSAC
SAGNLEPSHVLLAIGRSYAEAKASLRFSLGRFTTEEEVDRAVAVFREAVARARA

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=381, Percent_Identity=42.5196850393701, Blast_Score=285, Evalue=5e-77,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=33.8164251207729, Blast_Score=191, Evalue=1e-48,
Organism=Escherichia coli, GI48994898, Length=379, Percent_Identity=43.7994722955145, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI1787970, Length=361, Percent_Identity=27.4238227146814, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1789175, Length=216, Percent_Identity=28.2407407407407, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25143064, Length=379, Percent_Identity=41.688654353562, Blast_Score=270, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI17533177, Length=315, Percent_Identity=29.5238095238095, Blast_Score=114, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6319831, Length=379, Percent_Identity=42.2163588390501, Blast_Score=296, Evalue=3e-81,
Organism=Drosophila melanogaster, GI20129463, Length=380, Percent_Identity=42.6315789473684, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 39811; Mature: 39811

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGVYLDYAATTPLDPEVREAMRAVEEVFGNPSSIHRFGQEARKVLEEARERVAEALGAR
CCCEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PREVVFTAGGSEADALALLGPALARGRGHVVSTAVEHAAVLGALRLLERLGFAVTLLKPD
CCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
SLGMVYPEQVEEALRPDTFLVSVMTANNELGNLYPVREIAEVAHRHGALFHTDAVQAVGQ
CCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHC
VPFRMDEVGADLVSLSAHKFYGPKGVGALLVRQGVELMAVVPGKQEGGRRGGTQSPVLAH
CCCHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHH
GMAVALELALKRLPEEAARLAALRRRLEAGLLAVEGVELNGHPERRLPKLVNVTVKGADG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEECEECCCCCHHHCCHHHEEEEECCCC
EALLLAMDLLGVAVSSGSACSAGNLEPSHVLLAIGRSYAEAKASLRFSLGRFTTEEEVDR
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AVAVFREAVARARA
HHHHHHHHHHHHCC
>Mature Secondary Structure
MRGVYLDYAATTPLDPEVREAMRAVEEVFGNPSSIHRFGQEARKVLEEARERVAEALGAR
CCCEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PREVVFTAGGSEADALALLGPALARGRGHVVSTAVEHAAVLGALRLLERLGFAVTLLKPD
CCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
SLGMVYPEQVEEALRPDTFLVSVMTANNELGNLYPVREIAEVAHRHGALFHTDAVQAVGQ
CCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHC
VPFRMDEVGADLVSLSAHKFYGPKGVGALLVRQGVELMAVVPGKQEGGRRGGTQSPVLAH
CCCHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHH
GMAVALELALKRLPEEAARLAALRRRLEAGLLAVEGVELNGHPERRLPKLVNVTVKGADG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEECEECCCCCHHHCCHHHEEEEECCCC
EALLLAMDLLGVAVSSGSACSAGNLEPSHVLLAIGRSYAEAKASLRFSLGRFTTEEEVDR
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AVAVFREAVARARA
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA