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The map label for this gene is cymR [H]

Identifier: 55980424

GI number: 55980424

Start: 426818

End: 427267

Strand: Direct

Name: cymR [H]

Synonym: TTHA0455

Alternate gene names: 55980424

Gene position: 426818-427267 (Clockwise)

Preceding gene: 55980423

Following gene: 55980425

Centisome position: 23.07

GC content: 71.33

Gene sequence:

>450_bases
ATGTGGGTGTCCACGAAGGCCCAGTACGGCCTCCGCGCCCTGGTGGAGATCGGCCTTAGGGCGCCGAGGGCGGTGCCCCT
GAAGGAGGTGGCCGAGGCCCAGGGCATCAGCCAGCACTACCTGGAGCAGATCGCCGCCCAGCTCCGCAACGCGGGCTTCA
TCCGCTCCGTGCGGGGGGCGAAGGGGGGGTACCGGCTCGCCCGCCCCCCGGAGAAGGTCACCGCCCTCGAGGTGGTGGAG
GCCCTGGAGGGGAGCCTGGCCCCGGTGAGCTGCCTGGAGGACCCGGAGAGCTGCGACAAGGTGGGGCGGTGCTCCACCGA
GCTTTTGTGGCGGCGGGTGGACCTCGCCATGCGCCAGGTCCTCGGGGGCACCACCCTTAAGGACCTCATTGAGGAGAGGC
GGCTTTTGGAGGCCAGGGGGGTCATCCCCCTCGAGGCCCGCGTCTCCTGA

Upstream 100 bases:

>100_bases
GGCCAGCGTGGTCCTGGCCCAGGCCCTCCTCTTCGGCCTCGCCTTCCTTAAAACCGCGTTTTCCGGGGGGAAATAGCCGC
TTTTGGGGTATACTGGGGGC

Downstream 100 bases:

>100_bases
GGGCCGGGAGGCGGCGTGCGGGGCGTCTACCTGGACTACGCGGCCACCACGCCCCTGGATCCCGAGGTCCGGGAGGCCAT
GCGGGCGGTGGAGGAGGTCT

Product: rrf2 family protein, transcriptional regulator

Products: NA

Alternate protein names: Cysteine metabolism repressor [H]

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MWVSTKAQYGLRALVEIGLRAPRAVPLKEVAEAQGISQHYLEQIAAQLRNAGFIRSVRGAKGGYRLARPPEKVTALEVVE
ALEGSLAPVSCLEDPESCDKVGRCSTELLWRRVDLAMRQVLGGTTLKDLIEERRLLEARGVIPLEARVS

Sequences:

>Translated_149_residues
MWVSTKAQYGLRALVEIGLRAPRAVPLKEVAEAQGISQHYLEQIAAQLRNAGFIRSVRGAKGGYRLARPPEKVTALEVVE
ALEGSLAPVSCLEDPESCDKVGRCSTELLWRRVDLAMRQVLGGTTLKDLIEERRLLEARGVIPLEARVS
>Mature_149_residues
MWVSTKAQYGLRALVEIGLRAPRAVPLKEVAEAQGISQHYLEQIAAQLRNAGFIRSVRGAKGGYRLARPPEKVTALEVVE
ALEGSLAPVSCLEDPESCDKVGRCSTELLWRRVDLAMRQVLGGTTLKDLIEERRLLEARGVIPLEARVS

Specific function: Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulate

COG id: COG1959

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH rrf2-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788880, Length=141, Percent_Identity=31.9148936170213, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1790621, Length=135, Percent_Identity=31.8518518518519, Blast_Score=67, Evalue=5e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000944 [H]

Pfam domain/function: PF02082 Rrf2 [H]

EC number: NA

Molecular weight: Translated: 16389; Mature: 16389

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWVSTKAQYGLRALVEIGLRAPRAVPLKEVAEAQGISQHYLEQIAAQLRNAGFIRSVRGA
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHCC
KGGYRLARPPEKVTALEVVEALEGSLAPVSCLEDPESCDKVGRCSTELLWRRVDLAMRQV
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHH
LGGTTLKDLIEERRLLEARGVIPLEARVS
HCCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MWVSTKAQYGLRALVEIGLRAPRAVPLKEVAEAQGISQHYLEQIAAQLRNAGFIRSVRGA
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHCC
KGGYRLARPPEKVTALEVVEALEGSLAPVSCLEDPESCDKVGRCSTELLWRRVDLAMRQV
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHH
LGGTTLKDLIEERRLLEARGVIPLEARVS
HCCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]