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The map label for this gene is moeA [H]

Identifier: 55980079

GI number: 55980079

Start: 109949

End: 111160

Strand: Reverse

Name: moeA [H]

Synonym: TTHA0110

Alternate gene names: 55980079

Gene position: 111160-109949 (Counterclockwise)

Preceding gene: 55980080

Following gene: 55980078

Centisome position: 6.01

GC content: 71.62

Gene sequence:

>1212_bases
ATGCGGACGAACCTCTCCGTGGAGGAAGCCCTGGAGGCGGTCCTCGAGGCGGCCCAGGGGGAGCTAGCCGTGGAGGAGCT
CCCCCTAAAGGAGGCCTTTGGCCGCGTCCTGGCCGAGGACCTGGCCTCCCTGGTGGACCATCCCGACCAGGACGACACCG
CCATAGACGGCTACGCCTGCCGGGCGGAGGACACCCTGGGGGCCTCCCCCGAGGCCCCGGTGCGCCTCAGGGTCGTCGGC
GAGGCCCCCGCGGGCAGGCCCTTCCCCGGCGAGGTGGGGCGGGGCGAGGCCGTGGCCGTCTACACCGGGGCCCCCATCCC
CAAGGGGGCGGACGCGGTGGTGCGCGTGGAGGACACGAGGCGGGAAGGGGACGAGGTCCTCCTCTTCGCTCCGGCAAGCC
CCAAGGACATCCGCCCCAAGGGGGACGACCTCCGGCGGGGGGAGGTGTACTTAAGGCGGGGGGACCTCCTCACCCCGGGG
AGGCTCGGCCTGGCGGCGGCCATGGGCCACCCCCGCCTAAAGGTCTTCCGGAAGCCCCGGGTGGGGATCCTCTCCACGGG
GGACGAGGTGGTGGAGCCGGGGGAGCCCCTGCCCTTTGGCGGGGTGTACAACTCCAACGCCTACAGCCTCCTGGGCCTGG
TCCTCGAGGCGGGCGGGGAGCCCGTCCTCCTGGGCAAGGTGCCGGACCAGCCCGAAGCGGTGCTGGAGAGGCTTGAGGGC
GCGGGGCCCTTGGACCTCCTCCTCACCTCGGGGGGCGTGTCCATGGGGGAGTACGACGTGGTGCGCAAGGTCTTGGAGCG
CCACGGGGAGGTGGTCTTCTGGAAGGTGCGGCAGCAGCCCGGGGGACCCCTCCTCTTCGCCAGGCTAGGGGGGCTTCCCG
TTCTCGGCCTTCCCGGGAACCCGGTCTCCAGCATGGTGACCTTCTTCCTTTACGGAAGGCCCTTCCTCTACAAGCTCCTC
CAGCGCACTGAGCCCCCCTACGGCCGCCTCGAGGCCCGGGCCCTCACCCCCTTCAAGGGGGCCAAGGGGAAGAAGGTCTT
CCGCCGGGGGGTGCTCTCCGTGGCCGAAAAGACGGTGCGGAGCACGGGGAACCAGAGTAGTGGGGTCCTCCGCTCCATGG
CCTTCGGCAACGCCCTGGTGGTCCTTCCCCCGGACCGGGACGCCCGGGAGGGGGAGGAGGTGGAGGTCATCCCCTTGACT
TTCGTGCCCTAG

Upstream 100 bases:

>100_bases
CTTTGACCTCCTCTTCGGGGGGACCCTGGCCCTCTACGCCCTGGGCATCCTGCTCTGGCCCTGGGCCTTCCGGGGGCTTG
AGCGGGTAGACTGAGGTCCG

Downstream 100 bases:

>100_bases
TTCACTAAGCTAGTAAGGTTTACGGGCGCTACCCCCCTTTTCGGGCGCAGGTGGGCCCGGAAAGGCAGAGCATGGAGTTT
AAAGACTTTCCCCTGAAGCC

Product: molybdopterin biosynthesis MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MRTNLSVEEALEAVLEAAQGELAVEELPLKEAFGRVLAEDLASLVDHPDQDDTAIDGYACRAEDTLGASPEAPVRLRVVG
EAPAGRPFPGEVGRGEAVAVYTGAPIPKGADAVVRVEDTRREGDEVLLFAPASPKDIRPKGDDLRRGEVYLRRGDLLTPG
RLGLAAAMGHPRLKVFRKPRVGILSTGDEVVEPGEPLPFGGVYNSNAYSLLGLVLEAGGEPVLLGKVPDQPEAVLERLEG
AGPLDLLLTSGGVSMGEYDVVRKVLERHGEVVFWKVRQQPGGPLLFARLGGLPVLGLPGNPVSSMVTFFLYGRPFLYKLL
QRTEPPYGRLEARALTPFKGAKGKKVFRRGVLSVAEKTVRSTGNQSSGVLRSMAFGNALVVLPPDRDAREGEEVEVIPLT
FVP

Sequences:

>Translated_403_residues
MRTNLSVEEALEAVLEAAQGELAVEELPLKEAFGRVLAEDLASLVDHPDQDDTAIDGYACRAEDTLGASPEAPVRLRVVG
EAPAGRPFPGEVGRGEAVAVYTGAPIPKGADAVVRVEDTRREGDEVLLFAPASPKDIRPKGDDLRRGEVYLRRGDLLTPG
RLGLAAAMGHPRLKVFRKPRVGILSTGDEVVEPGEPLPFGGVYNSNAYSLLGLVLEAGGEPVLLGKVPDQPEAVLERLEG
AGPLDLLLTSGGVSMGEYDVVRKVLERHGEVVFWKVRQQPGGPLLFARLGGLPVLGLPGNPVSSMVTFFLYGRPFLYKLL
QRTEPPYGRLEARALTPFKGAKGKKVFRRGVLSVAEKTVRSTGNQSSGVLRSMAFGNALVVLPPDRDAREGEEVEVIPLT
FVP
>Mature_403_residues
MRTNLSVEEALEAVLEAAQGELAVEELPLKEAFGRVLAEDLASLVDHPDQDDTAIDGYACRAEDTLGASPEAPVRLRVVG
EAPAGRPFPGEVGRGEAVAVYTGAPIPKGADAVVRVEDTRREGDEVLLFAPASPKDIRPKGDDLRRGEVYLRRGDLLTPG
RLGLAAAMGHPRLKVFRKPRVGILSTGDEVVEPGEPLPFGGVYNSNAYSLLGLVLEAGGEPVLLGKVPDQPEAVLERLEG
AGPLDLLLTSGGVSMGEYDVVRKVLERHGEVVFWKVRQQPGGPLLFARLGGLPVLGLPGNPVSSMVTFFLYGRPFLYKLL
QRTEPPYGRLEARALTPFKGAKGKKVFRRGVLSVAEKTVRSTGNQSSGVLRSMAFGNALVVLPPDRDAREGEEVEVIPLT
FVP

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=416, Percent_Identity=36.7788461538462, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI66932975, Length=416, Percent_Identity=36.7788461538462, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1787049, Length=388, Percent_Identity=37.3711340206186, Blast_Score=235, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI25147659, Length=325, Percent_Identity=32.6153846153846, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17562606, Length=325, Percent_Identity=26.7692307692308, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136978, Length=399, Percent_Identity=30.5764411027569, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24638841, Length=399, Percent_Identity=30.5764411027569, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43156; Mature: 43156

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTNLSVEEALEAVLEAAQGELAVEELPLKEAFGRVLAEDLASLVDHPDQDDTAIDGYAC
CCCCCCHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
RAEDTLGASPEAPVRLRVVGEAPAGRPFPGEVGRGEAVAVYTGAPIPKGADAVVRVEDTR
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCC
REGDEVLLFAPASPKDIRPKGDDLRRGEVYLRRGDLLTPGRLGLAAAMGHPRLKVFRKPR
CCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEECCCC
VGILSTGDEVVEPGEPLPFGGVYNSNAYSLLGLVLEAGGEPVLLGKVPDQPEAVLERLEG
CCEEECCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCC
AGPLDLLLTSGGVSMGEYDVVRKVLERHGEVVFWKVRQQPGGPLLFARLGGLPVLGLPGN
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCCEEEECCCC
PVSSMVTFFLYGRPFLYKLLQRTEPPYGRLEARALTPFKGAKGKKVFRRGVLSVAEKTVR
CHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
STGNQSSGVLRSMAFGNALVVLPPDRDAREGEEVEVIPLTFVP
HCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MRTNLSVEEALEAVLEAAQGELAVEELPLKEAFGRVLAEDLASLVDHPDQDDTAIDGYAC
CCCCCCHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
RAEDTLGASPEAPVRLRVVGEAPAGRPFPGEVGRGEAVAVYTGAPIPKGADAVVRVEDTR
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCC
REGDEVLLFAPASPKDIRPKGDDLRRGEVYLRRGDLLTPGRLGLAAAMGHPRLKVFRKPR
CCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEECCCC
VGILSTGDEVVEPGEPLPFGGVYNSNAYSLLGLVLEAGGEPVLLGKVPDQPEAVLERLEG
CCEEECCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCC
AGPLDLLLTSGGVSMGEYDVVRKVLERHGEVVFWKVRQQPGGPLLFARLGGLPVLGLPGN
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCCEEEECCCC
PVSSMVTFFLYGRPFLYKLLQRTEPPYGRLEARALTPFKGAKGKKVFRRGVLSVAEKTVR
CHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
STGNQSSGVLRSMAFGNALVVLPPDRDAREGEEVEVIPLTFVP
HCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]