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The map label for this gene is tpm [H]

Identifier: 54295659

GI number: 54295659

Start: 3143653

End: 3144318

Strand: Reverse

Name: tpm [H]

Synonym: lpl2747

Alternate gene names: 54295659

Gene position: 3144318-3143653 (Counterclockwise)

Preceding gene: 54295660

Following gene: 54295658

Centisome position: 93.98

GC content: 38.14

Gene sequence:

>666_bases
GTGAACAAAGGCCAATATTTTTGGAATGAGTTATGGTGCGAGGGACGTATTTCTTTTCATAAAAAAGAAGTAAATCCGGA
TTTGATAGCCTATGTCTCTTCCTTAAATATACCTGCCAAGGGAAGGGTTCTGGTTCCTTTATGTGGAAAAAGTGTCGATA
TGCTTTGGTTAGTTCGCCAAGGGTATCATGTGGTTGGTATAGAACTGGTTGAAAAGGCTATTCTTCAGTTTGTTCAGGAG
CACCAAATCACTGTTCGGGAGAATACGATAGGTCAAGCAAAACAATATTTTACAGATAATTTGAATTTATGGGTTACCGA
TATTTTTGCTTTAAACTCGGCTTTAATAGAACCAGTTGATGCTATCTATGACAGAGCAGCTTTGGTTGCTTTGCCAAAAA
AATTGCGACCAGCGTATGTAGATATTTGCCTCAAGTGGCTTAAGCCTGGGGGAAGTATTCTGTTAAAGACTTTGCAATAT
AATCAAGAGAAAGTGCAGGGTCCTCCGTATAGTGTTTCCCCAGAAGAAATCGCTTTATCGTATCAGCAATGTGCCAAAAT
AAAGTTGTTGAAATCGCAAAAACGAATTCAGGAGCCTAATGATCATTTATTTAATTTTGGTATTAGTGAAGTGAATGATT
CTGTCTGGTGTATCAGAAAGGGGTAA

Upstream 100 bases:

>100_bases
TTTACACTATTCCTTTGCAATTGCTGGCCTATCATGTTGCTGTAGCTAAAGGGACTGATGTGGATCAACCTAGAAACCTT
GCAAAATCGGTGACTGTGGA

Downstream 100 bases:

>100_bases
AACGCAGTACAGTGTTACGCATAAGGACAATTTGTATATATATTAGCTTAATTTCTATATCGCATTATAGTATCTGATGA
GTATATAATGAGACGATTTT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MNKGQYFWNELWCEGRISFHKKEVNPDLIAYVSSLNIPAKGRVLVPLCGKSVDMLWLVRQGYHVVGIELVEKAILQFVQE
HQITVRENTIGQAKQYFTDNLNLWVTDIFALNSALIEPVDAIYDRAALVALPKKLRPAYVDICLKWLKPGGSILLKTLQY
NQEKVQGPPYSVSPEEIALSYQQCAKIKLLKSQKRIQEPNDHLFNFGISEVNDSVWCIRKG

Sequences:

>Translated_221_residues
MNKGQYFWNELWCEGRISFHKKEVNPDLIAYVSSLNIPAKGRVLVPLCGKSVDMLWLVRQGYHVVGIELVEKAILQFVQE
HQITVRENTIGQAKQYFTDNLNLWVTDIFALNSALIEPVDAIYDRAALVALPKKLRPAYVDICLKWLKPGGSILLKTLQY
NQEKVQGPPYSVSPEEIALSYQQCAKIKLLKSQKRIQEPNDHLFNFGISEVNDSVWCIRKG
>Mature_221_residues
MNKGQYFWNELWCEGRISFHKKEVNPDLIAYVSSLNIPAKGRVLVPLCGKSVDMLWLVRQGYHVVGIELVEKAILQFVQE
HQITVRENTIGQAKQYFTDNLNLWVTDIFALNSALIEPVDAIYDRAALVALPKKLRPAYVDICLKWLKPGGSILLKTLQY
NQEKVQGPPYSVSPEEIALSYQQCAKIKLLKSQKRIQEPNDHLFNFGISEVNDSVWCIRKG

Specific function: Unknown

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

Organism=Homo sapiens, GI4507653, Length=197, Percent_Identity=30.9644670050761, Blast_Score=100, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 25259; Mature: 25259

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKGQYFWNELWCEGRISFHKKEVNPDLIAYVSSLNIPAKGRVLVPLCGKSVDMLWLVRQ
CCCCHHHHHHHEECCCCEEECCCCCHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHC
GYHVVGIELVEKAILQFVQEHQITVRENTIGQAKQYFTDNLNLWVTDIFALNSALIEPVD
CCEEEHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHH
AIYDRAALVALPKKLRPAYVDICLKWLKPGGSILLKTLQYNQEKVQGPPYSVSPEEIALS
HHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHCCHHHCCCCCCCCCHHHHHHH
YQQCAKIKLLKSQKRIQEPNDHLFNFGISEVNDSVWCIRKG
HHHHHHHHHHHHHHHCCCCCCHHHCCCHHHCCCCEEEEECC
>Mature Secondary Structure
MNKGQYFWNELWCEGRISFHKKEVNPDLIAYVSSLNIPAKGRVLVPLCGKSVDMLWLVRQ
CCCCHHHHHHHEECCCCEEECCCCCHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHC
GYHVVGIELVEKAILQFVQEHQITVRENTIGQAKQYFTDNLNLWVTDIFALNSALIEPVD
CCEEEHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHH
AIYDRAALVALPKKLRPAYVDICLKWLKPGGSILLKTLQYNQEKVQGPPYSVSPEEIALS
HHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHCCHHHCCCCCCCCCHHHHHHH
YQQCAKIKLLKSQKRIQEPNDHLFNFGISEVNDSVWCIRKG
HHHHHHHHHHHHHHHCCCCCCHHHCCCHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA