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The map label for this gene is glmS [H]

Identifier: 54295660

GI number: 54295660

Start: 3144315

End: 3146129

Strand: Reverse

Name: glmS [H]

Synonym: lpl2748

Alternate gene names: 54295660

Gene position: 3146129-3144315 (Counterclockwise)

Preceding gene: 54295661

Following gene: 54295659

Centisome position: 94.04

GC content: 41.16

Gene sequence:

>1815_bases
ATGTGCGGGATTATGGGGGCTGTTTCAGAACGGGATATTAGCAAAGTTTTATTGGAAGGCTTGCGCCGATTGGAATATAG
AGGGTACGATTCTGCAGGTATTGCCGTCATAGATAGTCAAGATCGTTTAAAGCGAGTAAGGATCCAGGGGAAAGTGCAGA
ATTTGGCGGATGCTATGCAAGAGACTGCTATCGCTGGAAATACAGGTATAGCTCATACTCGTTGGGCGACGCATGGTAAA
CCCTCCGAACAAAATGCTCATCCTCATTTATCTCATGGAGAAATCGCATTAGTTCACAATGGCATTATTGAAAATCATGA
ACATTTGCGTCAACAACTTATTACTTATGGTTATCAATTCACATCTGAAACTGATACAGAGGTTGCTGCGCATTTAATTC
ATTATCATTACCAGCAGCATGAGAATTTATTACTTGCTGTACAAAAATCTGCTGCAGAAATGCAAGGGGCTTTTGCATTA
GGAGTGATTCATCAGAAAAGACCAGAAGAATTGGTTGCAATTCGTAAAGGGAGTCCTTTGGTTTTGGGATTTGGAATTGG
TGAGAATTTCATTGCATCTGATGCCTTGGCACTCAGATCTTTCGCACAATCAGTTATTTACATGGAAGAGGGTGACAGTG
CTTGTGTCACAACACAGGATATTAAGGTCTATGATTCCAATCGAATACTTGTTCAAAGAGCGACTCATCCGTTGAACAGT
GATTCTGAGATAGTGAATAAAGGGCCATACAGGCATTTTATGCTGAAAGAAATATTTGAACAATCGAAGGTAATTACAGA
CACGTTAGAAAGTCGAATTAATAGCATTGATGTGCTAAGAGCGAGTTTTGGTGAGAAAGCATCCCATATTTTTCCAATGG
TAAAAAATATTCACATTGTGGCATGTGGAACCAGTTATCATGCTGGAATGATTGCCAAATATTGGCTTGAATCACTTGCC
GGCCTACCTACACAGGTTGAAATTGCAAGTGAATATCGATACCGAGATGTTGTTGTCCCCGACAATACCTTATTTATCAC
TGTATCTCAGTCAGGAGAAACAGCTGATACTCTTGCTGCCCTATTTAAGGCAAAGCAATCGAATTATTTGGCTAGTTTAG
CTATATGCAATGTTGCAACCAGTACTTTAGTGAGAGAGGCGGATTGTGTTTTTTTAACTCGGGCAGGTATTGAGATTGGT
GTAGCATCTACCAAAGCTTTTACTACACAGTTGGCAGCCTTCCTGATGTTGGCAGCAGCACTTTGTAAGGACAATCGTGC
GCAGGAAGTTTTAAGACAATTACAAGAGCTGCCCGCCTGTTGTGAGCGTGTTTTGCAGATGAATGAAGAAGTCGAATCAT
TGGCCTCTTTGTTTGTAAATAAAGTTCATGCCTTGTTTTTAGGTCGAGGGGTTCAATATCCCGTAGCCCTGGAAGGTGCA
TTAAAACTTAAGGAAATATCTTATATACATGCGGAAGCTTATCCTGCCGGTGAATTAAAGCATGGTCCATTGGCTTTGGT
TGATAAGGATATGCCTGTGATTGCAGTAGCCCCTAATGATGAGCTTTTGGATAAATTAAAATCCAATTTACATGAAGTGA
GCGCCAGAGGCGGGCAGTTATTTGTATTTGTTGATGATTCACAAAATTGGAAAGCGAATGGCGCTCGTTTAATCAAAGTT
CCATCCTGTGGTGCTTGGCTTGCGCCTATTATTTACACTATTCCTTTGCAATTGCTGGCCTATCATGTTGCTGTAGCTAA
AGGGACTGATGTGGATCAACCTAGAAACCTTGCAAAATCGGTGACTGTGGAGTGA

Upstream 100 bases:

>100_bases
GCATTCTTATGCGTTTCACTCTTTATTTATATACAGTAGATGAACCGAGAATGAAAAAGCTTATTTCTACAAAAACAGTT
GCTGAAAAGAGGAGCAGGTT

Downstream 100 bases:

>100_bases
ACAAAGGCCAATATTTTTGGAATGAGTTATGGTGCGAGGGACGTATTTCTTTTCATAAAAAAGAAGTAAATCCGGATTTG
ATAGCCTATGTCTCTTCCTT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MCGIMGAVSERDISKVLLEGLRRLEYRGYDSAGIAVIDSQDRLKRVRIQGKVQNLADAMQETAIAGNTGIAHTRWATHGK
PSEQNAHPHLSHGEIALVHNGIIENHEHLRQQLITYGYQFTSETDTEVAAHLIHYHYQQHENLLLAVQKSAAEMQGAFAL
GVIHQKRPEELVAIRKGSPLVLGFGIGENFIASDALALRSFAQSVIYMEEGDSACVTTQDIKVYDSNRILVQRATHPLNS
DSEIVNKGPYRHFMLKEIFEQSKVITDTLESRINSIDVLRASFGEKASHIFPMVKNIHIVACGTSYHAGMIAKYWLESLA
GLPTQVEIASEYRYRDVVVPDNTLFITVSQSGETADTLAALFKAKQSNYLASLAICNVATSTLVREADCVFLTRAGIEIG
VASTKAFTTQLAAFLMLAAALCKDNRAQEVLRQLQELPACCERVLQMNEEVESLASLFVNKVHALFLGRGVQYPVALEGA
LKLKEISYIHAEAYPAGELKHGPLALVDKDMPVIAVAPNDELLDKLKSNLHEVSARGGQLFVFVDDSQNWKANGARLIKV
PSCGAWLAPIIYTIPLQLLAYHVAVAKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_604_residues
MCGIMGAVSERDISKVLLEGLRRLEYRGYDSAGIAVIDSQDRLKRVRIQGKVQNLADAMQETAIAGNTGIAHTRWATHGK
PSEQNAHPHLSHGEIALVHNGIIENHEHLRQQLITYGYQFTSETDTEVAAHLIHYHYQQHENLLLAVQKSAAEMQGAFAL
GVIHQKRPEELVAIRKGSPLVLGFGIGENFIASDALALRSFAQSVIYMEEGDSACVTTQDIKVYDSNRILVQRATHPLNS
DSEIVNKGPYRHFMLKEIFEQSKVITDTLESRINSIDVLRASFGEKASHIFPMVKNIHIVACGTSYHAGMIAKYWLESLA
GLPTQVEIASEYRYRDVVVPDNTLFITVSQSGETADTLAALFKAKQSNYLASLAICNVATSTLVREADCVFLTRAGIEIG
VASTKAFTTQLAAFLMLAAALCKDNRAQEVLRQLQELPACCERVLQMNEEVESLASLFVNKVHALFLGRGVQYPVALEGA
LKLKEISYIHAEAYPAGELKHGPLALVDKDMPVIAVAPNDELLDKLKSNLHEVSARGGQLFVFVDDSQNWKANGARLIKV
PSCGAWLAPIIYTIPLQLLAYHVAVAKGTDVDQPRNLAKSVTVE
>Mature_604_residues
MCGIMGAVSERDISKVLLEGLRRLEYRGYDSAGIAVIDSQDRLKRVRIQGKVQNLADAMQETAIAGNTGIAHTRWATHGK
PSEQNAHPHLSHGEIALVHNGIIENHEHLRQQLITYGYQFTSETDTEVAAHLIHYHYQQHENLLLAVQKSAAEMQGAFAL
GVIHQKRPEELVAIRKGSPLVLGFGIGENFIASDALALRSFAQSVIYMEEGDSACVTTQDIKVYDSNRILVQRATHPLNS
DSEIVNKGPYRHFMLKEIFEQSKVITDTLESRINSIDVLRASFGEKASHIFPMVKNIHIVACGTSYHAGMIAKYWLESLA
GLPTQVEIASEYRYRDVVVPDNTLFITVSQSGETADTLAALFKAKQSNYLASLAICNVATSTLVREADCVFLTRAGIEIG
VASTKAFTTQLAAFLMLAAALCKDNRAQEVLRQLQELPACCERVLQMNEEVESLASLFVNKVHALFLGRGVQYPVALEGA
LKLKEISYIHAEAYPAGELKHGPLALVDKDMPVIAVAPNDELLDKLKSNLHEVSARGGQLFVFVDDSQNWKANGARLIKV
PSCGAWLAPIIYTIPLQLLAYHVAVAKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=38.0116959064327, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=37.956204379562, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI29570798, Length=202, Percent_Identity=28.7128712871287, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=56.5573770491803, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=224, Percent_Identity=29.4642857142857, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082251, Length=313, Percent_Identity=22.3642172523962, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=715, Percent_Identity=34.4055944055944, Blast_Score=367, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17532899, Length=714, Percent_Identity=33.6134453781513, Blast_Score=349, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI17532897, Length=429, Percent_Identity=37.2960372960373, Blast_Score=264, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6322745, Length=445, Percent_Identity=37.9775280898876, Blast_Score=270, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6323731, Length=435, Percent_Identity=30.1149425287356, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=37.2549019607843, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323958, Length=166, Percent_Identity=25.9036144578313, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=36.8804664723032, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI28573187, Length=141, Percent_Identity=32.6241134751773, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24659598, Length=141, Percent_Identity=30.4964539007092, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66411; Mature: 66411

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIMGAVSERDISKVLLEGLRRLEYRGYDSAGIAVIDSQDRLKRVRIQGKVQNLADAMQ
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
ETAIAGNTGIAHTRWATHGKPSEQNAHPHLSHGEIALVHNGIIENHEHLRQQLITYGYQF
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCEEE
TSETDTEVAAHLIHYHYQQHENLLLAVQKSAAEMQGAFALGVIHQKRPEELVAIRKGSPL
CCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCEEEEHHHCCCCCHHEEEECCCCE
VLGFGIGENFIASDALALRSFAQSVIYMEEGDSACVTTQDIKVYDSNRILVQRATHPLNS
EEEECCCCHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCEEEEECCEEEEEECCCCCCC
DSEIVNKGPYRHFMLKEIFEQSKVITDTLESRINSIDVLRASFGEKASHIFPMVKNIHIV
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCEEEE
ACGTSYHAGMIAKYWLESLAGLPTQVEIASEYRYRDVVVPDNTLFITVSQSGETADTLAA
EECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCEEEEEEECCCCHHHHHHH
LFKAKQSNYLASLAICNVATSTLVREADCVFLTRAGIEIGVASTKAFTTQLAAFLMLAAA
HHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCHHHHHHHHHHHHHHHHH
LCKDNRAQEVLRQLQELPACCERVLQMNEEVESLASLFVNKVHALFLGRGVQYPVALEGA
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
LKLKEISYIHAEAYPAGELKHGPLALVDKDMPVIAVAPNDELLDKLKSNLHEVSARGGQL
EEHHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHCCCCEE
FVFVDDSQNWKANGARLIKVPSCGAWLAPIIYTIPLQLLAYHVAVAKGTDVDQPRNLAKS
EEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
VTVE
CCCC
>Mature Secondary Structure
MCGIMGAVSERDISKVLLEGLRRLEYRGYDSAGIAVIDSQDRLKRVRIQGKVQNLADAMQ
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
ETAIAGNTGIAHTRWATHGKPSEQNAHPHLSHGEIALVHNGIIENHEHLRQQLITYGYQF
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCEEE
TSETDTEVAAHLIHYHYQQHENLLLAVQKSAAEMQGAFALGVIHQKRPEELVAIRKGSPL
CCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCEEEEHHHCCCCCHHEEEECCCCE
VLGFGIGENFIASDALALRSFAQSVIYMEEGDSACVTTQDIKVYDSNRILVQRATHPLNS
EEEECCCCHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCEEEEECCEEEEEECCCCCCC
DSEIVNKGPYRHFMLKEIFEQSKVITDTLESRINSIDVLRASFGEKASHIFPMVKNIHIV
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCEEEE
ACGTSYHAGMIAKYWLESLAGLPTQVEIASEYRYRDVVVPDNTLFITVSQSGETADTLAA
EECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCEEEEEEECCCCHHHHHHH
LFKAKQSNYLASLAICNVATSTLVREADCVFLTRAGIEIGVASTKAFTTQLAAFLMLAAA
HHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCHHHHHHHHHHHHHHHHH
LCKDNRAQEVLRQLQELPACCERVLQMNEEVESLASLFVNKVHALFLGRGVQYPVALEGA
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
LKLKEISYIHAEAYPAGELKHGPLALVDKDMPVIAVAPNDELLDKLKSNLHEVSARGGQL
EEHHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHCCCCEE
FVFVDDSQNWKANGARLIKVPSCGAWLAPIIYTIPLQLLAYHVAVAKGTDVDQPRNLAKS
EEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
VTVE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA