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The map label for this gene is lipB [H]

Identifier: 54294445

GI number: 54294445

Start: 1687108

End: 1687707

Strand: Reverse

Name: lipB [H]

Synonym: lpl1514

Alternate gene names: 54294445

Gene position: 1687707-1687108 (Counterclockwise)

Preceding gene: 54294446

Following gene: 54294444

Centisome position: 50.44

GC content: 37.83

Gene sequence:

>600_bases
ATGATAATTCATAATTTAGGCATAAAAGATTATACTGAAATATGGGAGCAGATGAAGGAGTTCACTGCAGTCCGCGACAG
CAATTCTTATGATGAGCTTTGGTTATTAGAGCATTATCCTGTATATACTCAGGGGCAGGCAGGGAAACCAGAGCATGTAC
TTAATCCCAACTCTATAAAAATTGTGCAATCAGATCGCGGCGGACAAGTTACATATCATGGCCCAGGTCAACTAGTAGCC
TATGTTTTAATGGATATTCGCCGCAGAAACCTGGGCATAAGAACTTTAGTAGCAAAACTGGAAGAAATATTAATTTCGGT
TTTAGAACATTATAGAATTCCAGCAAACATTCGCAGTGGGGCGCCTGGAGTTTACGTAGGTGAAAAAAAAATCGCATCGA
TAGGACTGAGGGTGAAAAATGGGTGTACCTATCATGGTATAGCATTAAATGTGAACATGGATTTGAGTCCATTTTTAGGC
ATTAACCCATGTGGTTTTGCTAAAATGGAAATGACACAGATGAGTCATTTCCATCCTAATATTCAGTTAGAAGAAGTAAG
CCAACATTTTGTACAGTATTTTTTGACTCAATTTAAATAA

Upstream 100 bases:

>100_bases
ACTTGGCTATTACTGTGACGGTGTATGCAGAAAATCAAATCTCGCTGGATGGATTATATCAGGATTTAAGTCAACATCCT
GCTGTGAAAATGGTTTTATA

Downstream 100 bases:

>100_bases
TAGGAAATTATGAATTTGTTAGCAGACTATGTGCAACCACTGACTTATTGGCTACAAGCAAACCCACATTGGTCCCTGTT
TATTACTTTCTTAATCGCTT

Product: lipoyltransferase

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MIIHNLGIKDYTEIWEQMKEFTAVRDSNSYDELWLLEHYPVYTQGQAGKPEHVLNPNSIKIVQSDRGGQVTYHGPGQLVA
YVLMDIRRRNLGIRTLVAKLEEILISVLEHYRIPANIRSGAPGVYVGEKKIASIGLRVKNGCTYHGIALNVNMDLSPFLG
INPCGFAKMEMTQMSHFHPNIQLEEVSQHFVQYFLTQFK

Sequences:

>Translated_199_residues
MIIHNLGIKDYTEIWEQMKEFTAVRDSNSYDELWLLEHYPVYTQGQAGKPEHVLNPNSIKIVQSDRGGQVTYHGPGQLVA
YVLMDIRRRNLGIRTLVAKLEEILISVLEHYRIPANIRSGAPGVYVGEKKIASIGLRVKNGCTYHGIALNVNMDLSPFLG
INPCGFAKMEMTQMSHFHPNIQLEEVSQHFVQYFLTQFK
>Mature_199_residues
MIIHNLGIKDYTEIWEQMKEFTAVRDSNSYDELWLLEHYPVYTQGQAGKPEHVLNPNSIKIVQSDRGGQVTYHGPGQLVA
YVLMDIRRRNLGIRTLVAKLEEILISVLEHYRIPANIRSGAPGVYVGEKKIASIGLRVKNGCTYHGIALNVNMDLSPFLG
INPCGFAKMEMTQMSHFHPNIQLEEVSQHFVQYFLTQFK

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipB family [H]

Homologues:

Organism=Homo sapiens, GI221554520, Length=168, Percent_Identity=35.1190476190476, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI87081767, Length=196, Percent_Identity=54.0816326530612, Blast_Score=240, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6323268, Length=183, Percent_Identity=30.6010928961749, Blast_Score=91, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21355483, Length=173, Percent_Identity=33.5260115606936, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR000544
- InterPro:   IPR020605 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB [H]

EC number: =2.3.1.181 [H]

Molecular weight: Translated: 22687; Mature: 22687

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS01313 LIPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIHNLGIKDYTEIWEQMKEFTAVRDSNSYDELWLLEHYPVYTQGQAGKPEHVLNPNSIK
CEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCEE
IVQSDRGGQVTYHGPGQLVAYVLMDIRRRNLGIRTLVAKLEEILISVLEHYRIPANIRSG
EEECCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
APGVYVGEKKIASIGLRVKNGCTYHGIALNVNMDLSPFLGINPCGFAKMEMTQMSHFHPN
CCCEEECCHHHHHCCEEECCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCC
IQLEEVSQHFVQYFLTQFK
CCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIIHNLGIKDYTEIWEQMKEFTAVRDSNSYDELWLLEHYPVYTQGQAGKPEHVLNPNSIK
CEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCEE
IVQSDRGGQVTYHGPGQLVAYVLMDIRRRNLGIRTLVAKLEEILISVLEHYRIPANIRSG
EEECCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
APGVYVGEKKIASIGLRVKNGCTYHGIALNVNMDLSPFLGINPCGFAKMEMTQMSHFHPN
CCCEEECCHHHHHCCEEECCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCC
IQLEEVSQHFVQYFLTQFK
CCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA