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The map label for this gene is merA [H]

Identifier: 54294395

GI number: 54294395

Start: 1630568

End: 1632712

Strand: Reverse

Name: merA [H]

Synonym: lpl1464

Alternate gene names: 54294395

Gene position: 1632712-1630568 (Counterclockwise)

Preceding gene: 54294396

Following gene: 54294392

Centisome position: 48.8

GC content: 39.53

Gene sequence:

>2145_bases
ATGATAAAAAAAATACATCGTTGGTTGCCTTTGCTTGTATTAATCGGACTATTGGTACTTTTCTTCAGCCTGCACCTTGA
TAAATACTTAAGTTTTAATGCATTAAGAGAAAATCATGCTTTACTCATTGCGTGGACCCAAACACATTATTTTATTGCGC
CACTGATTTTTATTGTTTTTTATACCACTGCTGTAGCCATCTCTATTCCAGGAGCAGTTCTGCTTACTTTAACTGGAGGA
TTTTTATTCGGAGTATTCTGGGGCGTGTTATTTGTAGTCATCAGTGCTACGCTTGGGGCTACCATACTGTTTTTTGCGGT
TCGCTCTGCTTTGGGCGACTGGTTTGCCCAAAAGGCATCTGGATGGATAGAGCGTATGCGTCGGGGATTTCAGCATAATG
CTTTTTCTTACTTGGTTACACTGCGATTAATTCCATTATTTCCCTTTTGGGCAGTTAATATTGTACCTGCTCTTTTAAAT
ATTCGAGCAAAAACATTCGTTACAGCGACTTTTCTTGGCATTATTCCAGGAACAACAGTATATGTAATGGTTGGAAATGG
TTTAAGCCAAATATTTGCAGCCAATCAGACGCCTAATCTTGGGATTATATTTGAACTGCAAATATTAGGTCCACTGCTCG
CGTTGGCTGTTCTCTCTCTAATGCCAGTTCTTTATCAATTCTCAACTCGAAAGCATCAGAATCATCACAGTTTCTCAGAT
ATTAGTCGAGTAATAAATTGTGATTTAGCCATTATAGGCGGTGGAGCTGGAGGTTTGAGTTTGGCTTCCGGTTGTTCACA
ATTAGGGCTCAAAGTTGTTTTGGTTGAGTCAGGGAAAATGGGAGGAGACTGTTTAAATTACGGTTGCATCCCATCCAAAT
CCTTACTTGCTGCAGCCAAGACGTTTTATTATGCAAAACATGCAACACATTTTGGAGTACATACTGAAGCAATAAAAGTT
AATTTTGAACAAGTAATGCAACATGTGCACCAAATCATAGACAATATTTCTGAACATGATTCTGTCCAACGTTTTGAGTC
GCTAGGAGTACAGGTTATTAAACAAGTTGGGAAATTTTTAACTCCCGATACATTACAAGCTGGCGATAGTATTATTAAAG
CGAAGCGTTTCGTGATTGCAACAGGCTCATCACCATTTATCCCACCCATTCCCGGATTGGATGCAGTCTCTTACTTCACC
AATGAAACGATTTTTGATTTAAAGGAACAACCTGAGCACTTGATTGTCATCGGTGGGGGCCCTATTGGTTGTGAACTTGC
TCAAGCGTTCGCCATGCTTGGTTCTAAAGTTACTCTGCTCGAAGGATTGAATCTTCTTCCCAAGGACGATCCTGATTGTG
TTGCTGTTCTACGCACACAGATGAAATCGATGAATATCCTCATTTATGAACAAATTGAGATTACCCAAATAAACTCTCAC
CCTGATAAGGGTATTTCCGTATGTTTTGAATTTCAAAACACACAATTCATAATTACAGCCAGTCATCTGCTCATTGCAAC
TGGACGTCGGGCGAATGTAAAGCCACTTGATTTGGAAAAAGCAGGGGTTAAACTCACCAGCAAAGGTGTCGAAGTAAATA
AATACCTACAAACCAGTAATAAAAAAATCTATGCACTGGGTGATGTAACAGGGCTTTATCAGTTTACTCATATGGCGAGT
TATCAGGCTGGTATAGTGCTTCGTAATATTGTTTTTAAACTACCGTCTAAAGTAGATTATAGAGCGATTCCATGGGTCAC
TTATACTGATCCCGAATTAGCTCATGTTGGAATAGGAGTCAGTGATGCCTTGAGGCACCCTGATACCCAAATAATCGAAT
GGCCATTTGTCGATAATGATCGAGCACAAACTGAGCATACATTAAATGGAAAAATAAAAATCATCACGGACAAAAAAGCA
AGGATCCTCGGAGTCACCATAGTTGGCCCACATGCCGGAGAACTCATTTTACCTTGGGTTATGGCGATTCGTGAGAAAAA
AACTCTCCGAAGTTTTACTGATGTAATCGTTCCTTACCCTACTCTGAGTGAAATCAGCAAACGAGTTGCTGGTAGTTTTT
ATGCACCTAAATTATTTTCCAATAAAACACGAATGTTAGTTCGCTGGTTGCAAAAAATTGGATAA

Upstream 100 bases:

>100_bases
TATTTTTCCCATCGACAATTAAGGCATGGATTTAATGTCAATTAATGATAGGATCTATATAAAATGCCTAACTATTTACC
GAGTTAAAGGAATAACATGA

Downstream 100 bases:

>100_bases
GTAGATTTTTAACTAACTATATGCTTTTTAGCTGAAAGAAAAAATTACAAGCTATTTAATTCAATCTTAAACGATATTTA
ACTTCTTTTTCATCAGATAA

Product: hypothetical protein

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVFYTTAVAISIPGAVLLTLTGG
FLFGVFWGVLFVVISATLGATILFFAVRSALGDWFAQKASGWIERMRRGFQHNAFSYLVTLRLIPLFPFWAVNIVPALLN
IRAKTFVTATFLGIIPGTTVYVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFSTRKHQNHHSFSD
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAKTFYYAKHATHFGVHTEAIKV
NFEQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFLTPDTLQAGDSIIKAKRFVIATGSSPFIPPIPGLDAVSYFT
NETIFDLKEQPEHLIVIGGGPIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMNILIYEQIEITQINSH
PDKGISVCFEFQNTQFIITASHLLIATGRRANVKPLDLEKAGVKLTSKGVEVNKYLQTSNKKIYALGDVTGLYQFTHMAS
YQAGIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGIGVSDALRHPDTQIIEWPFVDNDRAQTEHTLNGKIKIITDKKA
RILGVTIVGPHAGELILPWVMAIREKKTLRSFTDVIVPYPTLSEISKRVAGSFYAPKLFSNKTRMLVRWLQKIG

Sequences:

>Translated_714_residues
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVFYTTAVAISIPGAVLLTLTGG
FLFGVFWGVLFVVISATLGATILFFAVRSALGDWFAQKASGWIERMRRGFQHNAFSYLVTLRLIPLFPFWAVNIVPALLN
IRAKTFVTATFLGIIPGTTVYVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFSTRKHQNHHSFSD
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAKTFYYAKHATHFGVHTEAIKV
NFEQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFLTPDTLQAGDSIIKAKRFVIATGSSPFIPPIPGLDAVSYFT
NETIFDLKEQPEHLIVIGGGPIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMNILIYEQIEITQINSH
PDKGISVCFEFQNTQFIITASHLLIATGRRANVKPLDLEKAGVKLTSKGVEVNKYLQTSNKKIYALGDVTGLYQFTHMAS
YQAGIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGIGVSDALRHPDTQIIEWPFVDNDRAQTEHTLNGKIKIITDKKA
RILGVTIVGPHAGELILPWVMAIREKKTLRSFTDVIVPYPTLSEISKRVAGSFYAPKLFSNKTRMLVRWLQKIG
>Mature_714_residues
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVFYTTAVAISIPGAVLLTLTGG
FLFGVFWGVLFVVISATLGATILFFAVRSALGDWFAQKASGWIERMRRGFQHNAFSYLVTLRLIPLFPFWAVNIVPALLN
IRAKTFVTATFLGIIPGTTVYVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFSTRKHQNHHSFSD
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAKTFYYAKHATHFGVHTEAIKV
NFEQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFLTPDTLQAGDSIIKAKRFVIATGSSPFIPPIPGLDAVSYFT
NETIFDLKEQPEHLIVIGGGPIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMNILIYEQIEITQINSH
PDKGISVCFEFQNTQFIITASHLLIATGRRANVKPLDLEKAGVKLTSKGVEVNKYLQTSNKKIYALGDVTGLYQFTHMAS
YQAGIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGIGVSDALRHPDTQIIEWPFVDNDRAQTEHTLNGKIKIITDKKA
RILGVTIVGPHAGELILPWVMAIREKKTLRSFTDVIVPYPTLSEISKRVAGSFYAPKLFSNKTRMLVRWLQKIG

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=497, Percent_Identity=29.9798792756539, Blast_Score=183, Evalue=5e-46,
Organism=Homo sapiens, GI50301238, Length=469, Percent_Identity=26.0127931769723, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI33519430, Length=450, Percent_Identity=25.7777777777778, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI33519428, Length=450, Percent_Identity=25.7777777777778, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI33519426, Length=450, Percent_Identity=25.7777777777778, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI148277065, Length=450, Percent_Identity=25.7777777777778, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI148277071, Length=450, Percent_Identity=25.7777777777778, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI291045266, Length=451, Percent_Identity=24.6119733924612, Blast_Score=98, Evalue=4e-20,
Organism=Homo sapiens, GI22035672, Length=467, Percent_Identity=24.6252676659529, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI66392190, Length=190, Percent_Identity=27.8947368421053, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI291045268, Length=444, Percent_Identity=23.4234234234234, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=30.9210526315789, Blast_Score=182, Evalue=9e-47,
Organism=Escherichia coli, GI87081717, Length=446, Percent_Identity=29.1479820627803, Blast_Score=155, Evalue=9e-39,
Organism=Escherichia coli, GI87082354, Length=470, Percent_Identity=27.2340425531915, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=29.0023201856148, Blast_Score=132, Evalue=8e-32,
Organism=Escherichia coli, GI1789065, Length=182, Percent_Identity=30.2197802197802, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32565766, Length=483, Percent_Identity=30.6418219461698, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17557007, Length=468, Percent_Identity=25.6410256410256, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71983419, Length=436, Percent_Identity=25.9174311926606, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71983429, Length=436, Percent_Identity=25.9174311926606, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982272, Length=475, Percent_Identity=27.1578947368421, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17532687, Length=236, Percent_Identity=23.728813559322, Blast_Score=73, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=502, Percent_Identity=31.0756972111554, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=26.8240343347639, Blast_Score=120, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=25.9574468085106, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21358499, Length=476, Percent_Identity=29.6218487394958, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=26.6949152542373, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=26.6949152542373, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=26.6949152542373, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=23.6786469344609, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI18859941, Length=195, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 78895; Mature: 78895

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHH
YTTAVAISIPGAVLLTLTGGFLFGVFWGVLFVVISATLGATILFFAVRSALGDWFAQKAS
HHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GWIERMRRGFQHNAFSYLVTLRLIPLFPFWAVNIVPALLNIRAKTFVTATFLGIIPGTTV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
YVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFSTRKHQNHHSFSD
EEEECCCHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAK
HHHHHCCCEEEEECCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
TFYYAKHATHFGVHTEAIKVNFEQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFL
HHHHHHHCCCCCCCHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPDTLQAGDSIIKAKRFVIATGSSPFIPPIPGLDAVSYFTNETIFDLKEQPEHLIVIGGG
CCCHHHCCHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCCCCEEEEECCC
PIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMNILIYEQIEITQINSH
CCHHHHHHHHHHHCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEEEECCC
PDKGISVCFEFQNTQFIITASHLLIATGRRANVKPLDLEKAGVKLTSKGVEVNKYLQTSN
CCCCEEEEEEECCCEEEEEECEEEEECCCCCCCCCCCCHHCCCEEECCCCCHHHHHHCCC
KKIYALGDVTGLYQFTHMASYQAGIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGIGV
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEECCCCCEEECCCH
SDALRHPDTQIIEWPFVDNDRAQTEHTLNGKIKIITDKKARILGVTIVGPHAGELILPWV
HHHHCCCCCCEEECCCCCCCCCCCCEECCCEEEEEECCCCEEEEEEEECCCCCCHHHHHH
MAIREKKTLRSFTDVIVPYPTLSEISKRVAGSFYAPKLFSNKTRMLVRWLQKIG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHH
YTTAVAISIPGAVLLTLTGGFLFGVFWGVLFVVISATLGATILFFAVRSALGDWFAQKAS
HHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GWIERMRRGFQHNAFSYLVTLRLIPLFPFWAVNIVPALLNIRAKTFVTATFLGIIPGTTV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
YVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFSTRKHQNHHSFSD
EEEECCCHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAK
HHHHHCCCEEEEECCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
TFYYAKHATHFGVHTEAIKVNFEQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFL
HHHHHHHCCCCCCCHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPDTLQAGDSIIKAKRFVIATGSSPFIPPIPGLDAVSYFTNETIFDLKEQPEHLIVIGGG
CCCHHHCCHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCCCCEEEEECCC
PIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMNILIYEQIEITQINSH
CCHHHHHHHHHHHCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEEEECCC
PDKGISVCFEFQNTQFIITASHLLIATGRRANVKPLDLEKAGVKLTSKGVEVNKYLQTSN
CCCCEEEEEEECCCEEEEEECEEEEECCCCCCCCCCCCHHCCCEEECCCCCHHHHHHCCC
KKIYALGDVTGLYQFTHMASYQAGIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGIGV
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEECCCCCEEECCCH
SDALRHPDTQIIEWPFVDNDRAQTEHTLNGKIKIITDKKARILGVTIVGPHAGELILPWV
HHHHCCCCCCEEECCCCCCCCCCCCEECCCEEEEEECCCCEEEEEEEECCCCCCHHHHHH
MAIREKKTLRSFTDVIVPYPTLSEISKRVAGSFYAPKLFSNKTRMLVRWLQKIG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]