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The map label for this gene is copA [H]

Identifier: 54293269

GI number: 54293269

Start: 361797

End: 363338

Strand: Reverse

Name: copA [H]

Synonym: lpl0317

Alternate gene names: 54293269

Gene position: 363338-361797 (Counterclockwise)

Preceding gene: 54293271

Following gene: 54293266

Centisome position: 10.86

GC content: 38.07

Gene sequence:

>1542_bases
ATGACCAATACAACAGACTTTTATCGACTTACTCCCCTCACCGAAGTCCATTGGAAAAAAATTCTAATCAATAAAATTAC
AGTGCGGACTTTGAGTCAAATATCTTTTTTTATCATGATAGCAACTATCATGATAACTCCTTTTAAGCCCTCTTATGCAA
CAGATAACAAACGTAAACTGACGGTCATAACCGTCAGTGAGGAAGAATTCCAAGTCGATGGTAAAGGAGAAAAAACAAAG
GAATTTAAACTAACTTTCACCCATCCGGACGGCACAAAAGACAACAAAGGGTACTTTGCCAATAAAGGAGATATGTTTCA
TGTTTTAGTTGAAAATAAAAGTGCATCACCAATAACTCTTCATTGGCATGGATTAATTGTCCCAAGCGATCAGGATGGAG
TACCTGACGTGAGTCAAATCCTGATTCAGCCAGGGCAAAATAAATTGTTTAACTACAGATTATTACAAGCAGGAACCTAT
TGGATGCACTCGCATCAAAAATTTCAAGAGCAAAAGCAACTTTCTGCCCCTTTGATTATTTATGACAAGGATGACCCGCA
TAAAAACTTACAAGAAGTCATTCTGTTTTTAGAGGATTTTACTTACAAGGATCCCCAGTTAATATTTGATCAGTTAAGAA
CCTCTAAAATGGACATGAAGAAAATGGATGCTGGTAACGATTTGAATGACGTGACCTATGATGCGTTTCTCGCCAACAAA
AAAACATTGGCAGCACCTGATGTAATTTCAGTTCAAGCCTCTAAAAAAGTAAGGTTACGAATCATCAATGCGTCTTCCTC
CACCAATTTTAAAATTGATGCCGGGAAACTGTCAGCCACTTTGATTGCTGTTGATGGTGAAAACATTGAGCCTATTGTGG
ATAGTTCTTTTCCTATTGGCGTTGGTAATCGTATGGATTTGATTGTTGAGATTCCTTCTGAAGGCGGAGCATTCCCTATT
AAAGCCCTGGCAGAAGGAACAAACAAACAAACCGGTCTAATTCTAAAAACAGATAACACACCTACCCCGATACTATCTCC
CAATACCACGAATAAAACGGGACGTGTCAACTACTATGAGTTAGAAAAAAAACTAAAAGGAAAAAATACTTTAACCAATA
AAAAAATAAATGCTCGTTTGCACTATGTGCTTGATGGCAAGATGAATGGTTATATTTGGACCATGAACAAGCAAAGCTGG
CCAGATGTCACGCCAAAAGTAATCCATTTCGGCGATCGTGTTGAAATGATCTATGAAAATAAATCCTCTATGTCTCACCC
CATGCATTTCCATGGTCATGTCTTTCAAGTAACCGAAATTGATGGTCAGCCATTGGATGGAGCCATGCGCGATACCCTGT
TAGTCCAGCCACATTCGACAGTGAAAATACAGTTTGATGCGCTAAACCCTGGCATCTGGGCTAACCACTGCCATAATTTA
TATCATTTAAACGCAGGAATGTTTACAACGTTTGAATACCAACACTACCCAAAACCCGATTTTTATTTAAAAACAATAGG
GCAATCCAAAAGTAAAAATTAA

Upstream 100 bases:

>100_bases
CAAAATTAATCCTAATAACCCCTAAAATCAGCGATTTGCTTACTGCGTTATTAACTGATAAAAATAATAGAACTATCATG
TACATGGAAAGACCATAAAA

Downstream 100 bases:

>100_bases
AGGCTGAATATAAGCTCCTACATACATTACTCGCATAAAGATCTATGCCCTTATTTATGGCGCAGCAATTAATTGTTTTA
CTTTTTTAACGAAAGTTGGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTNTTDFYRLTPLTEVHWKKILINKITVRTLSQISFFIMIATIMITPFKPSYATDNKRKLTVITVSEEEFQVDGKGEKTK
EFKLTFTHPDGTKDNKGYFANKGDMFHVLVENKSASPITLHWHGLIVPSDQDGVPDVSQILIQPGQNKLFNYRLLQAGTY
WMHSHQKFQEQKQLSAPLIIYDKDDPHKNLQEVILFLEDFTYKDPQLIFDQLRTSKMDMKKMDAGNDLNDVTYDAFLANK
KTLAAPDVISVQASKKVRLRIINASSSTNFKIDAGKLSATLIAVDGENIEPIVDSSFPIGVGNRMDLIVEIPSEGGAFPI
KALAEGTNKQTGLILKTDNTPTPILSPNTTNKTGRVNYYELEKKLKGKNTLTNKKINARLHYVLDGKMNGYIWTMNKQSW
PDVTPKVIHFGDRVEMIYENKSSMSHPMHFHGHVFQVTEIDGQPLDGAMRDTLLVQPHSTVKIQFDALNPGIWANHCHNL
YHLNAGMFTTFEYQHYPKPDFYLKTIGQSKSKN

Sequences:

>Translated_513_residues
MTNTTDFYRLTPLTEVHWKKILINKITVRTLSQISFFIMIATIMITPFKPSYATDNKRKLTVITVSEEEFQVDGKGEKTK
EFKLTFTHPDGTKDNKGYFANKGDMFHVLVENKSASPITLHWHGLIVPSDQDGVPDVSQILIQPGQNKLFNYRLLQAGTY
WMHSHQKFQEQKQLSAPLIIYDKDDPHKNLQEVILFLEDFTYKDPQLIFDQLRTSKMDMKKMDAGNDLNDVTYDAFLANK
KTLAAPDVISVQASKKVRLRIINASSSTNFKIDAGKLSATLIAVDGENIEPIVDSSFPIGVGNRMDLIVEIPSEGGAFPI
KALAEGTNKQTGLILKTDNTPTPILSPNTTNKTGRVNYYELEKKLKGKNTLTNKKINARLHYVLDGKMNGYIWTMNKQSW
PDVTPKVIHFGDRVEMIYENKSSMSHPMHFHGHVFQVTEIDGQPLDGAMRDTLLVQPHSTVKIQFDALNPGIWANHCHNL
YHLNAGMFTTFEYQHYPKPDFYLKTIGQSKSKN
>Mature_512_residues
TNTTDFYRLTPLTEVHWKKILINKITVRTLSQISFFIMIATIMITPFKPSYATDNKRKLTVITVSEEEFQVDGKGEKTKE
FKLTFTHPDGTKDNKGYFANKGDMFHVLVENKSASPITLHWHGLIVPSDQDGVPDVSQILIQPGQNKLFNYRLLQAGTYW
MHSHQKFQEQKQLSAPLIIYDKDDPHKNLQEVILFLEDFTYKDPQLIFDQLRTSKMDMKKMDAGNDLNDVTYDAFLANKK
TLAAPDVISVQASKKVRLRIINASSSTNFKIDAGKLSATLIAVDGENIEPIVDSSFPIGVGNRMDLIVEIPSEGGAFPIK
ALAEGTNKQTGLILKTDNTPTPILSPNTTNKTGRVNYYELEKKLKGKNTLTNKKINARLHYVLDGKMNGYIWTMNKQSWP
DVTPKVIHFGDRVEMIYENKSSMSHPMHFHGHVFQVTEIDGQPLDGAMRDTLLVQPHSTVKIQFDALNPGIWANHCHNLY
HLNAGMFTTFEYQHYPKPDFYLKTIGQSKSKN

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Drosophila melanogaster, GI18859919, Length=230, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 58255; Mature: 58124

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTTDFYRLTPLTEVHWKKILINKITVRTLSQISFFIMIATIMITPFKPSYATDNKRKL
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEE
TVITVSEEEFQVDGKGEKTKEFKLTFTHPDGTKDNKGYFANKGDMFHVLVENKSASPITL
EEEEECCHHEEECCCCCCCEEEEEEEECCCCCCCCCCEEECCCCEEEEEEECCCCCEEEE
HWHGLIVPSDQDGVPDVSQILIQPGQNKLFNYRLLQAGTYWMHSHQKFQEQKQLSAPLII
EEEEEEEECCCCCCCHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEE
YDKDDPHKNLQEVILFLEDFTYKDPQLIFDQLRTSKMDMKKMDAGNDLNDVTYDAFLANK
ECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEHEECCC
KTLAAPDVISVQASKKVRLRIINASSSTNFKIDAGKLSATLIAVDGENIEPIVDSSFPIG
CCCCCCCEEEEECCCEEEEEEEECCCCCCEEEECCCEEEEEEEECCCCCCCEECCCCCCC
VGNRMDLIVEIPSEGGAFPIKALAEGTNKQTGLILKTDNTPTPILSPNTTNKTGRVNYYE
CCCCEEEEEEECCCCCCCCHHHHHCCCCCCCEEEEEECCCCCCEECCCCCCCCCCEEHEE
LEKKLKGKNTLTNKKINARLHYVLDGKMNGYIWTMNKQSWPDVTPKVIHFGDRVEMIYEN
HHHHHCCCCCCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCHHEEEECCEEEEEEEC
KSSMSHPMHFHGHVFQVTEIDGQPLDGAMRDTLLVQPHSTVKIQFDALNPGIWANHCHNL
CCCCCCCEEECCEEEEEEECCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCHHHHCCCE
YHLNAGMFTTFEYQHYPKPDFYLKTIGQSKSKN
EEECCCEEEEEEECCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
TNTTDFYRLTPLTEVHWKKILINKITVRTLSQISFFIMIATIMITPFKPSYATDNKRKL
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEE
TVITVSEEEFQVDGKGEKTKEFKLTFTHPDGTKDNKGYFANKGDMFHVLVENKSASPITL
EEEEECCHHEEECCCCCCCEEEEEEEECCCCCCCCCCEEECCCCEEEEEEECCCCCEEEE
HWHGLIVPSDQDGVPDVSQILIQPGQNKLFNYRLLQAGTYWMHSHQKFQEQKQLSAPLII
EEEEEEEECCCCCCCHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEE
YDKDDPHKNLQEVILFLEDFTYKDPQLIFDQLRTSKMDMKKMDAGNDLNDVTYDAFLANK
ECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEHEECCC
KTLAAPDVISVQASKKVRLRIINASSSTNFKIDAGKLSATLIAVDGENIEPIVDSSFPIG
CCCCCCCEEEEECCCEEEEEEEECCCCCCEEEECCCEEEEEEEECCCCCCCEECCCCCCC
VGNRMDLIVEIPSEGGAFPIKALAEGTNKQTGLILKTDNTPTPILSPNTTNKTGRVNYYE
CCCCEEEEEEECCCCCCCCHHHHHCCCCCCCEEEEEECCCCCCEECCCCCCCCCCEEHEE
LEKKLKGKNTLTNKKINARLHYVLDGKMNGYIWTMNKQSWPDVTPKVIHFGDRVEMIYEN
HHHHHCCCCCCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCHHEEEECCEEEEEEEC
KSSMSHPMHFHGHVFQVTEIDGQPLDGAMRDTLLVQPHSTVKIQFDALNPGIWANHCHNL
CCCCCCCEEECCEEEEEEECCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCHHHHCCCE
YHLNAGMFTTFEYQHYPKPDFYLKTIGQSKSKN
EEECCCEEEEEEECCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]