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The map label for this gene is lvhB10 [H]

Identifier: 54293121

GI number: 54293121

Start: 190088

End: 191179

Strand: Direct

Name: lvhB10 [H]

Synonym: lpl0160

Alternate gene names: 54293121

Gene position: 190088-191179 (Clockwise)

Preceding gene: 54293120

Following gene: 54293122

Centisome position: 5.68

GC content: 46.25

Gene sequence:

>1092_bases
ATGAGTATGGATGATAAAAAGCGGGAAGATTCTTTGGGCAATCGGACTCAGGTTGCTAAAAATCCAAAACACACAGCAAT
CAAAGACAAGTTATTGCTCGCAGGCGTTGTAGCGATTTGTATTGTCATCGGCATTGGCGGGTTATTCCCTAAGCAAAAAG
CAAATACAGTAAATGAACCAGATGAAAAACAAAGTTTAAGCATGGCCCTAAACCAAAATCTGGAACTGATTGCAGCCCTT
AAGGAGAAGAATGCCAAAGCGCAGTCGGGTTATAAAGGTGGCGACCCAAGGCATCCTCCTTTACTTAAAACCATGCAAAC
CCAAACGGTTAGCAAGGAAACTCTAGCTCGAATGAATGCACCCTCCACCTTTTTTAGCTCAGGCGGTAATGAGGTGATAA
GTAATACAACGGGTGGCGAAGCTCAAGCCAGCAAAACCCTGACAGGCCGTGATGGAAATTCTGAGTTTTTGAATCAGCAA
AATGACATCACTTCAGTTTCTGCAAAACGATTACCGCATCCTGCGATGACTGTACCTGCAGGTGAAATGATTCCAGCGAC
ACTCGAAACGGCCATTAATTCGGAACTGGCGGGTATGGTGCGGGCAATTACAACACGGGACATCTTTGCTTTGGAAGGCA
GCAAGTTATTAATCCCTAAAGGCTCCACGCTAGTTGGACAATTTAATACCGCAATTACCCAAAGCCAGAGCCGGATATTT
GTCGTATGGAACCGTCTGCAGATGACCAACGGCGTAATTGTGACCTTAAATAGCCCCGGCAGTGATCCAATAGGTCGTTC
AGGACAAGCGGCCGACTACATAGACCGCCATTTCTTTGAGCGTTTTGGCAGTGGTGCGCTTTTGTCTGTTTTGGGTGCGT
ATACCGCAACAGGTGGTGTTCATGGTCAGGACGAATACAACTCCATGTCACAATACCGCATGAACATTGCGAGCAGTTTC
CAACAAGCTGCAAATCAAACACTACAGCAAGACATGCAAACACGCCCGACTTTGCAAATCAATCAGGGAGCTGCCATTAA
CGTATTTGTAGCTCACGATCTTGATTTCTACCGAGTGGCTGGGAGGGCATAA

Upstream 100 bases:

>100_bases
AGCGTTTAGCCCCGCAATTTACTTTAAGGCAAGGTGGCCTTACGGCATCGGTCTTTAACGCTCCGGAAATCAATCGTATC
AAAGCAAACAGGAGGCCAAA

Downstream 100 bases:

>100_bases
TATGGAAGCTATTAAAGCCTGCTTCTCGCCCGGCGCAACAGGTCTGCTCTCGCCATTGCAGGATTTTCTGGAAGATGAGC
ACGTCTCTGAAATTTTAATC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSMDDKKREDSLGNRTQVAKNPKHTAIKDKLLLAGVVAICIVIGIGGLFPKQKANTVNEPDEKQSLSMALNQNLELIAAL
KEKNAKAQSGYKGGDPRHPPLLKTMQTQTVSKETLARMNAPSTFFSSGGNEVISNTTGGEAQASKTLTGRDGNSEFLNQQ
NDITSVSAKRLPHPAMTVPAGEMIPATLETAINSELAGMVRAITTRDIFALEGSKLLIPKGSTLVGQFNTAITQSQSRIF
VVWNRLQMTNGVIVTLNSPGSDPIGRSGQAADYIDRHFFERFGSGALLSVLGAYTATGGVHGQDEYNSMSQYRMNIASSF
QQAANQTLQQDMQTRPTLQINQGAAINVFVAHDLDFYRVAGRA

Sequences:

>Translated_363_residues
MSMDDKKREDSLGNRTQVAKNPKHTAIKDKLLLAGVVAICIVIGIGGLFPKQKANTVNEPDEKQSLSMALNQNLELIAAL
KEKNAKAQSGYKGGDPRHPPLLKTMQTQTVSKETLARMNAPSTFFSSGGNEVISNTTGGEAQASKTLTGRDGNSEFLNQQ
NDITSVSAKRLPHPAMTVPAGEMIPATLETAINSELAGMVRAITTRDIFALEGSKLLIPKGSTLVGQFNTAITQSQSRIF
VVWNRLQMTNGVIVTLNSPGSDPIGRSGQAADYIDRHFFERFGSGALLSVLGAYTATGGVHGQDEYNSMSQYRMNIASSF
QQAANQTLQQDMQTRPTLQINQGAAINVFVAHDLDFYRVAGRA
>Mature_362_residues
SMDDKKREDSLGNRTQVAKNPKHTAIKDKLLLAGVVAICIVIGIGGLFPKQKANTVNEPDEKQSLSMALNQNLELIAALK
EKNAKAQSGYKGGDPRHPPLLKTMQTQTVSKETLARMNAPSTFFSSGGNEVISNTTGGEAQASKTLTGRDGNSEFLNQQN
DITSVSAKRLPHPAMTVPAGEMIPATLETAINSELAGMVRAITTRDIFALEGSKLLIPKGSTLVGQFNTAITQSQSRIFV
VWNRLQMTNGVIVTLNSPGSDPIGRSGQAADYIDRHFFERFGSGALLSVLGAYTATGGVHGQDEYNSMSQYRMNIASSFQ
QAANQTLQQDMQTRPTLQINQGAAINVFVAHDLDFYRVAGRA

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG2948

COG function: function code U; Type IV secretory pathway, VirB10 components

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbI/virB10 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005498 [H]

Pfam domain/function: PF03743 TrbI [H]

EC number: NA

Molecular weight: Translated: 39101; Mature: 38970

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMDDKKREDSLGNRTQVAKNPKHTAIKDKLLLAGVVAICIVIGIGGLFPKQKANTVNEP
CCCCCCHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DEKQSLSMALNQNLELIAALKEKNAKAQSGYKGGDPRHPPLLKTMQTQTVSKETLARMNA
HHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
PSTFFSSGGNEVISNTTGGEAQASKTLTGRDGNSEFLNQQNDITSVSAKRLPHPAMTVPA
CCHHHHCCCCCEECCCCCCCCHHCCEECCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCCC
GEMIPATLETAINSELAGMVRAITTRDIFALEGSKLLIPKGSTLVGQFNTAITQSQSRIF
CCCCHHHHHHHHHHHHHHHHHHHHHHCEEEECCCEEEECCCCEEEEHHHHHHHCCCCEEE
VVWNRLQMTNGVIVTLNSPGSDPIGRSGQAADYIDRHFFERFGSGALLSVLGAYTATGGV
EEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
HGQDEYNSMSQYRMNIASSFQQAANQTLQQDMQTRPTLQINQGAAINVFVAHDLDFYRVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEECCCCHHHHC
GRA
CCC
>Mature Secondary Structure 
SMDDKKREDSLGNRTQVAKNPKHTAIKDKLLLAGVVAICIVIGIGGLFPKQKANTVNEP
CCCCCHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DEKQSLSMALNQNLELIAALKEKNAKAQSGYKGGDPRHPPLLKTMQTQTVSKETLARMNA
HHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
PSTFFSSGGNEVISNTTGGEAQASKTLTGRDGNSEFLNQQNDITSVSAKRLPHPAMTVPA
CCHHHHCCCCCEECCCCCCCCHHCCEECCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCCC
GEMIPATLETAINSELAGMVRAITTRDIFALEGSKLLIPKGSTLVGQFNTAITQSQSRIF
CCCCHHHHHHHHHHHHHHHHHHHHHHCEEEECCCEEEECCCCEEEEHHHHHHHCCCCEEE
VVWNRLQMTNGVIVTLNSPGSDPIGRSGQAADYIDRHFFERFGSGALLSVLGAYTATGGV
EEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
HGQDEYNSMSQYRMNIASSFQQAANQTLQQDMQTRPTLQINQGAAINVFVAHDLDFYRVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEECCCCHHHHC
GRA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]